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Ascites and alpha-fetoprotein improve prognostic performance of Barcelona Clinic Liver Cancer staging

World Journal of Gastroenterology 2015年第18期21卷 5654-5662页

作者： Asmaa I Gomaa alzhraa Al-Khatib Wael Abdel-Razek mohammed Saad Hashim Imam Waked Hepatology Department National Liver Institute Menoufiya University Oncology Department National Liver Institute Menoufiya University

AIm: To assess how ascites and alpha-fetoprotein(AFP) added to the Barcelona Clinic Liver Cancer(BCLC) staging predict hepatocellular carcinoma ***: The presence of underlying cirrhosis, ascites and encephalopathy, Child-Turcotte-Pugh(CTP) score, the number of nodules, and the maximum diameter of the largest nodule were determined at diagnosis for 1060 patients with hepatocellular carcinoma at a tertiary referral center for liver disease in Egypt. Demographic information, etiology of liver disease, and biochemical data(including serum bilirubin, albumin, international normalized ratio, alanine and aspartate aminotransferases, and AFP) were evaluated. Staging of the tumor was determined at the time of diagnosis using the BCLC staging system; 496 patients were stage A and 564 patients were stage B. Patients with mild ascites on initial ultrasound, computed tomography, or clinical examination, and who had a CTP score ≤ 9 were included in this analysis. All patients received therapy according to the recommended treatment based on the BCLC stage, and were monitored from the time of diagnosis to the date of death or date of data collection. The effect of the presence of ascites and AFP level on survival was ***:At the time the data were censored,123/496(24.8%)and 218/564(38.6%)patients with BCLC stages A and B,respectively,had *** mean survival of the BCLC A and B patients during a three-year follow-up period was 31 mo[95%confidence interval(95%CI):29.7-32.3]and 22.7mo(95%CI:20.7-24.8),*** presenceof ascites,multiple focal lesions,large tumor size,AFP level and CTP score were independent predictors of survival for the included patients on multivariate analysis(Pmong stage A patients,18%had ascites,33%had AFP≥200 ng/m L,and 8%had *** median survival in the presence of ascites was shorter if AFP was≥200 ng/m L(19 mo vs 24 mo),and in the absence of ascites,patients with AFP≥200 ng/m L had a shorter survival(28mo

关键词： Alpha-fetoprotein Ascites Barcelona Clinic Liver Cancer Hepatocellular carcinoma Survival

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COVID-19 Patients with Hepatic Complications During the Third Wave of Pandemic in Egypt

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Journal of Clinical and Nursing Research 2022年第3期6卷 108-121页

作者： alzhraa m.fahm. marwa O Elgendy Ahmed m Khalaf mona A Abdelrahman mohamed EA Abdelrahim Ahmed O El-Gendy Tropical medicine and Infectious Diseases Department Faculty of MedicineBeni-Suef UniversityBeni-SuefEgypt Department of Clinical Pharmacy Teaching Hospital of Faculty of MedicineFaculty of MedicineBeni-Suef UniversityBeni-Sueft Egypt Department of Clinical Pharmacy Faculty of PharmacyNahda University(NUB)Egypt Internal medicine Department Faculty of MedicineBeni-Suef University Beni-SuefEgypt Clinical Pharmacy Department Faculty of PharmacyBeni-Suef University Beni-SuefEgypt Department of microbiology and Immunology Faculty of PharmacyBeni-Suef University Beni-SuefEgypt

COVID-19 is a respiratory infection that has lately begun to affect other vital organs,including the heart,kidney,and *** purpose of this study was to investigate the hepatic complications in COVID-19 patients and the risk of being admitted to ICU or facing ***:Comorbidities(hypertension and diabetes),COVID-19 symptoms,laboratory findings(ALT level,AST level,and albumin),complications during hospitalization,treatment protocol used,and survival outcomes were all studied in 200 COVID-19 infected Egyptian patients who had virological symptoms and were followed up until they recovered or *** was found that older people and those with higher blood glucose levels have a higher risk of developing liver-associated COVID-19 ***,the majority of patients who developed liver complications in the course of the infection had high mortality *** with diabetes,hypertension,or hepatic disease are at higher risk of ICU admission or ***,it is important to pay attention to these problems in the diagnosis and treatment of COVID-19 to develop a suitable individualized treatment *** was also a correlation between the mortality in COVID-19 patients and both,high blood glucose and liver enzyme *** can be attributed to the correlation between diabetes and liver disease as every disease may be a complication to the other;moreover,COVID-19 may lead to increased blood sugar levels in addition to ALT and AST *** theory is that COVID-19 may afiect the liver and hence people with chronic liver disease.

关键词： COVID-19 Hepatic complications Third wave

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