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Imaging atomic-scale chemistry from fused multi-modal electron microscopy

npj Computational Materials 2022年第1期8卷 164-171页

作者： jonathan Schwartz Zichao Wendy Di Yi jiang alyssa j.fielitz Don-Hyung Ha Sanjaya D.Perera Ismail El Baggari Richard D.Robinson jeffrey A.Fessler Colin Ophus Steve Rozeveld Robert Hovden Department of Materials Science and Engineering University of MichiganAnn ArborMIUSA Mathematics and Computer Science Division Argonne National LaboratoryLemontILUSA Advanced Photon Source Facility Argonne National LaboratoryLemontILUSA Dow Chemical Co. MidlandMIUSA Department of Material Science and Engineering Cornell UniversityIthacaNew YorkUSA School of Integrative Engineering Chung-Ang UniversitySeoulRepublic of Korea Department of Physics Cornell UniversityIthacaNYUSA The Rowland Institute at Harvard CambridgeMAUSA Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMIUSA National Center for Electron Microscopy Lawrence Berkeley National LaboratoryMolecular FoundryBerkeleyCAUSA Applied Physics Program University of MIchiganAnn ArborMIUnited States

Efforts to map atomic-scale chemistry at low doses with minimal noise using electron microscopes are fundamentally limited by inelastic ***,fused multi-modal electron microscopy offers high signal-to-noise ratio(SNR)recovery of material chemistry at nano-and atomic-resolution by coupling correlated information encoded within both elastic scattering(high-angle annular dark-field(HAADF))and inelastic spectroscopic signals(electron energy loss(EELS)or energy-dispersive x-ray(EDX)).By linking these simultaneously acquired signals,or modalities,the chemical distribution within nanomaterials can be imaged at significantly lower doses with existing detector *** many cases,the dose requirements can be reduced by over one order of *** high SNR recovery of chemistry is tested against simulated and experimental atomic resolution data of heterogeneous nanomaterials.

关键词： materials chemistry fused

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Apparent redox potential discontinuity(aRPD) depth as a relative measure of sediment oxygen content and habitat quality

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International journal of Sediment Research 2015年第1期30卷 74-80页

作者： Travis G.GERWING alyssa M.ALLEN GERWING Diana j.HAMILTON Myriam A.BARBEAU Department of Biology University of New Brunswick Department of Biology Mount Allison University

As hypoxic conditions spread in our oceans,indices that quickly and efficiently assess oxygen content in sediment pore water,and habitat quality are increasingly becoming *** to the apparent redox potential discontinuity(aRPD) in sediment is one such index;however,the relationship between aRPD depth and oxygen content is still *** quantified oxygen content in sediment pore water with a dissolved oxygen(DO) probe,utilizing luminescent technology,to determine how DO concentration varies with depth in the sediment,and with position relative to the aRPD(above versus below) on an intertidal mudflat in the Bay of Fundy,*** on generalized linear regression models,we found that depth in the sediment was a poor predictor of pore water DO concentration,while position in the sediment relative to the aRPD was a good ***,sediment above the aRPD had higher DO content than sediment *** maintain that aRPD depth is a good measure of relative oxygen content in sediment pore water,as well as habitat ***,we recommend caution as the factors that influence aRPD depth arc numerous and variable;therefore,the relationship between aRPD depth and DO content should be experimentally confirmed in any system of interest before aRPD depth is used as an indicator.

关键词： Anoxia Apparent redox potential discontinuity(aRPD) Dissolved oxygen Habitat quality Hypoxia Intertidal Marine benthos Sediment pore water.

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Macrophage-targeted single walled carbon nanotubes stimulate phagocytosis via pH-dependent drug release

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Nano Research 2021年第3期14卷 762-769页

作者： Yapei Zhang jianqin Ye Niloufar Hosseini-Nassab alyssa Flores Irina Kalashnikova Sesha Lakshmi Paluri Mozhgan Lotfi Nicholas j.Leeper Bryan Ronain Smith Department of Biomedical Engineering Michigan State UniversityEast LansingMI48824USA Institute for Quantitative Health Science and Engineering Michigan State UniversityEast LansingMI48824USA Department of Surgery Division of Vascular SurgeryStanford University School of MedicineStanfordCA94305USA Department of Medicine Division of Cardiovascular MedicineStanford University School of MedicineStanfordCA94305USA Stanford Cardiovascular Institute StanfordCA94305USA Department of Radiology Stanford University School of MedicineStanfordCA94305USA

Atherosclerotic cardiovascular disease is the leading cause of mortality in the world.A driving feature of atherosclerotic plaque formation is dysfunctional *** the“don’t eat me”molecule CD47 is upregulated in atherosclerotic plaque cores,CD47-blocking strategies can stimulate the efferocytic clearance of apoptotic cells and thereby help prevent the progression of plaque ***,these therapies are generally costly and,in clinical and murine trials,they have resulted in side effects including anemia and ***,we developed and characterized an intracellular phagocytosis-stimulating treatment in the CD47-SIRPα*** loaded a novel monocyte/macrophage-selective nanoparticle carrier system with a small molecule enzymatic inhibitor that is released in a pH-dependent manner to stimulate macrophage efferocytosis of apoptotic cell debris via the CD47-SIRPαsignaling *** demonstrated that single-walled carbon nanotubes(SWNTs)can selectively deliver tyrosine phosphatase inhibitor 1(TPI)intracellularly to macrophages,which potently stimulates efferocytosis,and chemically characterized the ***,SWNT-delivered TPI can stimulate macrophage efferocytosis,with the potential to reduce or prevent atherosclerotic disease.

关键词： macrophages phagocytosis single-walled carbon nanotubes tyrosine phosphatase 1(SHP1)inhibitor atherosclerosis

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ezQTL:A Web Platform for Interactive Visualization and Colocalization of QTLs and GWAS Loci

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 541-548页

作者： Tongwu Zhang alyssa Klein jian Sang jiyeon Choi Kevin M.Brown Division of Cancer Epidemiology and Genetics National Cancer InstituteBethesdaMD 20892USA

Genome-wide association studies(GWAS)have identified thousands of genomic loci associated with complex diseases and traits,including *** vast majority of common traitassociated variants identified via GWAS fall in non-coding regions of the genome,posing a challenge in elucidating the causal variants,genes,and mechanisms *** quantitative trait locus(eQTL)and other molecular QTL studies have been valuable resources in identifying candidate causal genes from GWAS loci through statistical colocalization *** QTL colocalization is becoming a standard analysis in post-GWAS investigation,an easy web tool for users to perform formal colocalization analyses with either user-provided or public GWAS and eQTL datasets has been ***,we present ezQTL,a web-based bioinformatic application to interactively visualize and analyze genetic association data such as GWAS loci and molecular QTLs under different linkage disequilibrium(LD)patterns(1000 Genomes Project,UK Biobank,or user-provided data).This application allows users to perform data quality control for variants matched between different datasets,LD visualization,and two-trait colocalization analyses using two state-of-the-art methodologies(eCAVIAR and HyPrColoc),including batch *** is a free and publicly available cross-platform web tool,which can be accessed online at https://***/ezqtl.

关键词： Genome-wide association study Expression quantitative trait locus Colocalization Linkage disequilibrium Visualization

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Improving antibiotic prescribing in the emergency department for uncomplicated community-acquired pneumonia

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World journal of Emergency Medicine 2020年第4期11卷 199-205页

作者： Rebekah Shaw Erica Popovsky alyssa Abo Marni jacobs Nicole Herrera james Chamberlain AndreaHahn Division of Pediatrics Children’s National Health SystemWashingtonDCUSA Division of Emergency Medicine Children’s National Health SystemWashingtonDCUSA Department of Pediatrics George Washington University School of Medicine and Health SciencesWashingtonDCUSA Division of Biostatistics and Epidemiology Children’s National Health SystemWashingtonDCUSA Division of Infectious Diseases Children’s National Health SystemWashingtonDCUSA

BACKGROUND:The Pediatric Infectious Disease Society(PIDS)and Infectious Disease Society of America(IDSA)published an evidence-based guideline for the treatment of uncomplicated communityacquired pneumonia(CAP)in children,recommending aminopenicillins as the first-line *** guideline compliance with 10%–50%of patients admitted to the hospital receiving narrow-spectrum antibiotics has been reported.A new clinical practice guideline(CPG)was implemented in our emergency department(ED)for uncomplicated *** aim of this study was to examine baseline knowledge and ED provider prescribing patterns pre-and post-CPG ***:Prior to CPG-implementation,an anonymous case-based survey was distributed to evaluate knowledge of the current PIDS/IDSA guideline.A retrospective chart review of patients treated in the ED for CAP from january 2015 to February 2017 was performed to assess prescribing patterns for intravenous(IV)antibiotics in the ED at Children’s National Health System pre-and post-CPG ***:ED providers were aware of the PIDS/IDSA guideline recommendations,with 86.4%of survey responders selecting ampicillin as the initial antibiotic of ***,only 41.2%of patients admitted to the hospital with uncomplicated CAP pre-CPG received ampicillin(P<0.01).There was no statistically signifi cant increase in ampicillin prescribing post-CPG(P=0.40).CONCLUSIONS:Providers in the ED are aware of the PIDS/IDSA guideline regarding the first-line therapy for uncomplicated CAP;however,this knowledge does not translate into clinical *** of a CPG in isolation did not significantly change prescribing patterns for uncomplicated CAP.

关键词： Antibiotics Community-acquired pneumonia Emergency department Pediatrics

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Sturgeon and paddlefish:Review of research on broodstock and early life stage management

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Aquaculture and Fisheries 2024年第6期9卷 871-882页

作者： Victor P.Lobanov joe Pate alyssa joyce Department of Marine Sciences University of GothenburgGothenburg40530Sweden Regen Aquaculture WaltonKY41094USA

Sturgeon aquaculture has taken a parallel yet unique path relative to other teleost *** of the driving factors has been the fact that virtually all extant species are facing extinction;thus,laws concerning the transport and processing of sturgeon are *** a result,most sturgeon companies vertically integrate the farming process from hatchery to harvest,in contrast to the production of other commercial fish species(e.g.,trout,sea bass,salmon),where farmers tend to purchase fry from producers specialized only in the production of that life stage and sell product to unaffiliated fish *** aquaculture is furthermore unique in the extremely high value of the main product(caviar).The secondary product(meat)also surpasses other finfish aquaculture products’average price per *** expensive outputs reveal the greatest challenge in production-an exceptionally long time to market from larvae to harvestable *** all their rigor and robustness as juveniles and adults,sturgeon species are highly fragile during larval *** to the unique legal framework around sturgeon cultivation,aquaculturists often specialize in regional species,although some hybrids have achieved global *** lends to a heterogenous swath of literature on best cultivation and management practices,especially at early growth ***,the role of aquaculture as both a food source and restocking program to thwart further extinction of sturgeon species has hardly been fully *** light of the many challenges,this review examines recent advances in sturgeon farming with an emphasis on broodstock and early life-stage management to summarize studies that can help researchers and farmers assess the industry’s current state.

关键词： Sturgeon Paddlefish Sturgeon aquaculture Sturgeon fishery

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Changes in physical activity,sedentary behavior,and self-reported cognitive function in cancer survivors before and during the COVID-19 pandemic:A cross-sectional study

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journal of Sport and Health Science 2023年第6期12卷 653-663页

作者： Linda Trinh Allyson Tabaczynski Denise Bastas alyssa R.Neville M.Lauren Voss Alexis Whitehorn Faculty of Kinesiology&Physical Education University of TorontoTorontoOT M5S 2W6Canada

Background Physical activity(PA)and reductions in sedentary behavior(SED)may mitigate cancer-related cognitive *** purpose of this study was to examine(a)the associations between changes in PA,SED,and cognitive function in cancer survivors before and during the coronavirus disease 2019(COVID-19)pandemic;and(b)clinical subgroups that moderate this *** A cross-sectional survey was administered online to adult cancer survivors globally between july and November of *** was a secondary analysis of a cross-sectional survey examining changes in self-reported PA and quality of life in cancer survivors before and during the COVID-19 ***-reported Questionnaires assessed moderate-to-vigorous PA(MVPA)using the modified Godin Leisure Time Exercise Questionnaire,cognitive function using the Functional Assessment of Cancer Therapy-Cognitive Function(FACT-Cog)scale,and SED using the Domain-specific Sitting Time *** survivors were classified into no change in behavior,desirable change(i.e.,increase MVPA to meet PA guidelines or decrease SED by≥60 min/day),and undesirable change(i.e.,decrease MVPA to<150 min/week or increase SED by≥60 min/day).Analysis of covariance examined differences in FACT-Cog scores across the activity change *** contrasts compared differences in FACT-Cog scores between cancer survivors with(a)no meaningful change *** change,and(b)a desirable change *** undesirable *** There were no significant differences in FACT-Cog scores across activity-change categories in the full sample of cancer survivors(n=371;age=48.6±15.3 years(mean±SD)).However,cancer survivors who were diagnosed≥5 years ago(t(160)=–2.15,p=0.03)or who received treatment≥5 years ago(t(102)=–2.23,p=0.03)and who had a desirable change in activity reported better perceived cognitive abilities than those who had an undesirable *** PA promotion efforts should consider reducing SED in addition to mainta

关键词： Cancer-related cognitive impairment Cancer survivorship Exercise Sedentary time

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Pharmacokinetic profile and sub-chronic toxicity of coenzyme Q_(10) loaded whey protein nanoparticles

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Food Bioscience 2023年第2期52卷 215-223页

作者： Cuina Wang Ru Zhao Keyi He Siyu Zhang alyssa H.Kemp Mingruo Guo Department of Food Science Jilin UniversityChangchunChina Department of Food Science Northeast Agriculture UniversityHarbinChina Department of Nutrition and Food Sciences College of Agriculture and Life SciencesUniversity of VermontBurlingtonVT05405USA

Coenzyme Q_(10)(CoQ_(10))is a crucial endogenous lipophilic antioxidant,and encapsulation is often used to improve its solubility and ***,information about the bioavailability and safety assessment of constructed formulations is *** this study,in vivo pharmacokinetics profile and sub-chronic toxicity of CoQ_(10) loaded whey protein concentrate(WPC)and polymerized whey protein concentrate(PWPC)nanoparticles were *** data showed that CoQ_(10) concentrations in the plasma of rats fed with nanoparticles were higher than that of the free ***_(10) concentration reached its maximum level after 12 h when orally administered with WPC and PWPC based encapsulation,which was delayed compared with free CoQ_(10)(8 h).Sub-chronic toxicity evaluation for PWPC-CoQ_(10) was conducted with 28-day feeding *** indicated that no adverse toxicological reactions in term of physical examination,body weight,food intake,hematology,serum chemistry,organ weight or histopathology excepted for blood potassium were observed after oral administration of feed with incorporated PWPC-CoQ_(10) *** maximum concentration of nanoparticle powder in diet of no adverse effect on the male and female rats was up to 2%(w/w).Results denoted a potential application of whey protein as a safe natural polymer to fabricate delivery systems to enhance bioavailability of nutritional supplements like CoQ_(10).

关键词： Coenzyme CoQ_(10) Whey protein Pharmacokinetic study Sub-chronic toxicity

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Searching for Bacterial Biofilm in Recurrent Cholangitis in Primary Sclerosing Cholangitis:A Case Presentation and Introduction of an Unexplored Disease Mechanism

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journal of Clinical and Translational Hepatology 2018年第1期6卷 114-118页

作者： alyssa Y. Choi Florencia jalikis Maria Westerhoff Sarag Boukhar Elinor Pulcini Chris Damman Lei Yu Department of Internal Medicine University of WashingtonSeattleWashingtonUSA Department of Pathology University of WashingtonSeattleWashingtonUSA Department of Pathology University of IowaIowa CityIowaUSA Center for Biofilm Engineering Montana State UniversityBozemanMontanaUSA Division of Gastroenterology University of WashingtonSeattleWashingtonUSA

Inflammation and fibrosis of the bile ducts are the defining pathological characteristics of primary sclerosing cholangitis(PSC).A previously unexplored mechanism for recurrent cholangitis,one of PSC's most common presentations,is bacterial colonization of the biliary epithelium in the form of biofilm,which may confer resistance to antibiotics and host phagocytic *** aim of the current study was to assess whether bacteria could be seen on the liver explant and whether they organized in the form of *** explanted PSC liver from a 60-year-old male who suffered from recurrent cholangitis was formalin-fixed,paraffinembedded and Gram *** specimens were observed under light *** bacteria nor biofilm were *** did not detect bacteria or biofilm in the liver explant of a single PSC patient with recurrent cholangitis using standard light *** suspect this may be in part due to techniques related to tissue preservation and microscopy.

关键词： Primary sclerosing cholangitis Recurrent cholangitis Biofilm

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Relationship between apparent redox potential discontinuity (aRPD) depth and environmental variables in soft-sediment habitats

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International journal of Sediment Research 2017年第4期32卷 472-480页

作者： Travis G.Gerwing alyssa M.Allen Gerwing Kieran Cox Francis juanes Sarah E.Dudas Ecosystem Science and Management Program University of Northern British Columbia Department of Biology University of Victoria Department of Biology Vancouver Island University

As global temperatures increase and dissolved oxygen(DO) content decreases in marine systems, indices assessing sediment DO content in benthic habitats are becoming increasingly useful. One such measure is the depth to the apparent redox potential discontinuity(aRPD), a transition of sediment color that serves as a relative measure of sediment DO content. We examined spatiotemporal variation of aRPD depth, and the nature of the relationships between aRPD depth and biotic(infauna and epibenthic predators) and abiotic variables(sediment properties), as well as the availability of resources(chlorophyll a concentration, and organic matter content) in the intertidal mudflats of the Bay of Fundy, Canada. aRPD depth varied significantly through space and time, and a combination of biotic(sessile and errant infauna, as well as epibenthic predators), and abiotic(exposure time of a plot, sediment particle size,penetrability, and water content) variables, as well as the availability of resources(sediment organic matter content, and chlorophyll a concentration) were correlated with aRPD depth. As such, knowledge of both biotic and abiotic variables are required for a holistic understanding of sediment DO *** variables likely dictate a suite of potential aRPD depth conditions, while biota and resource availability, via bioturbation and respiration, strongly influence the observed aRPD depth. As DO conditions in marine systems will continue to change due to global climate change, elucidating these relationships are a key first step in predicting the influence decreasing DO content may have upon marine benthos.

关键词： Relationship between apparent redox potential discontinuity depth and environmental variables in soft-sediment habitats DO

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