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Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers

World Journal of Gastrointestinal Oncology 2022年第9期14卷 1637-1653页

作者： alya r alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel rifat Hamoudi Wael M Abdel-rahman Sharjah Institute for Medical research University of SharjahSharjah 27272United Arab Emirates College of Medicine University of SharjahSharjah 27272United Arab Emirates Department of Clinical Sciences University of SharjahSharjah 27272United Arab Emirates Department of Basic Medical Sciences University of SharjahSharjah 27272United Arab Emirates Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biomedical Sciences University of SassariSassari 07100Italy University Cancer Center Schleswig-Holstein and Luebeck Institute for Experimental Dermatology University of LuebeckLuebeck 23560Germany Institute of Pathology University Hospital Schleswig-HolsteinLuebeck 23560Germany Division of Surgery and Interventional Science University College LondonLondon WC1E 6BTUnited Kingdom

Colorectal cancer(CrC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CrC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer.

关键词： Bladder cancer CALD1 Caldesmon Chemoresistance Colorectal cancer Gastric cancer Glioma Epithelial to mesenchymal transition Invasion Metastasis

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Nuclear design of an integrated small modular reactor based on the APr-1400 for rO desalination purposes

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Nuclear Science and Techniques 2022年第8期33卷 1-15页

作者： reem rashed alnuaimi Bassam Khuwaileh Muhammad Zubair Donny Hartanto Department of Mechanical and Nuclear Engineering University of SharjahP.O.BOX 27272SharjahUAE Oak ridge National Laboratory 1 Bethel Valley RoadOak RidgeTN 37830USA

The United Arab Emirates lacks conventional water resources and relies primarily on desalination plants powered by fossil fuels to produce fresh *** desalination is a proven technology,cost-competitive,and sustainable option capable of integrating the existing largescale desalination plants to produce both freshwater and ***,Small Modular reactors(SMrs)are promising designs with advanced simplified configurations and inherent safety *** this study,an Integrated Desalination SMr that produces thermal energy compatible with the capacity of a fossil fuel-powered desalination plant in the UAE was ***,the APr-1400 reactor core was used to investigate two 150 MWthconceptual SMr core designs,core A and core B,based on two-dimensional parameters,radius,and ***,the CASMO-4 lattice code was used to generate homogenized few-group constants for optimized fuel assembly loading ***,to find the best core configuration,SIMULATE-3 was used to calculate the core key physics parameters such as power distribution,reactivity coefficients,and critical boron *** addition,different reflector materials were investigated to compensate for the expected high leakage of the small-sized SMr *** pan shape core B model(142.6132 cm diameter,100 cm height,and radially reflected by Stainless Steel)was selected as the best core configuration based on its calculated physics *** B met the design and safety criteria and indicated low total neutron leakage of 11.60%and flat power distribution with 1.50 power peaking *** to core A,it has a more negative MTC value of-6.93 pcm/°F with lower *** a 2-batch scheme,the fuel is discharged at 42.25 GWd/MTU burnup after a long cycle length of 1.58 *** core B model offers the highest specific power of 36.56 kW/kgU while utilizing the smallest heavy metal mass compared with the SMArT and NuScale models.

关键词： Nuclear desalination Small modular reactor(SMr) APr-1400 CASMO-4 SIMULATE-3 Two-step method Homogenized cross sections Optimization

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Time Series Analysis and Forecasting of the Air Quality Index of Atmospheric Air Pollutants in Zahleh, Lebanon

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Atmospheric and Climate Sciences 2022年第4期12卷 728-749页

作者： alya Atoui Kamal Slim Samir Abbad Andaloussi régis Moilleron Zaher Khraibani Leesu Univ Paris Est Creteil Creteil France rammal rammal Laboratory PhyToxE Group Lebanese University Nabatieh Lebanon Lebanese Atomic Energy Commission National Council for Scientific Research (CNRS) Beirut Lebanon Department of Applied Mathematics Faculty of Sciences Lebanese University Hadat Lebanon

During the last decades, air pollution has become a serious environmental hazard. Its impact on public health and safety, as well as on the ecosystem, has been dramatic. Forecasting the levels of air pollution to maintain the climatic conditions and environmental protection becomes crucial for government authorities to develop strategies for the prevention of pollution. This study aims to evaluate the atmospheric air pollution of the city of Zahleh located in the geographic zone of Bekaa. The study aims to determine a relationship between variations in ambient particulate concentrations during a short time. The data was collected from June 2017 to June 2018. In order to predict the Air Quality Index (AQI), Naïve, Exponential Smoothing, TBATS (a forecasting method to model time series data), and Seasonal Autoregressive Integrated Moving Average (SArIMA) models were implemented. The performance of these models for predicting air quality is measured using the Mean Absolute Error (MAE), the root Mean Square Error (rMSE), and the relative Error (rE). SArIMA model is the most accurate in prediction of AQI (rMSE = 38.04, MAE = 22.52 and rE = 0.16). The results reveal that SArIMA can be applied to cities like Zahleh to assess the level of air pollution and to prevent harmful impacts on health. Furthermore, the authorities responsible for controlling the air quality may use this model to measure the level of air pollution in the nearest future and establish a mechanism to identify the high peaks of air pollution.

关键词： Air Pollution Air Quality Index Times Series Prediction

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