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Chinese Journal of Chemistry 2003年第3期21卷 339-346页

作者： aly，A.A DepartmentofChemistry FacultyofScienceBenhaUniversityBenhaEgypt

Quinazoline isothiocyanate 1 reacts with various nucleophiles (nitrogen nucleophiles, oxygen nucleophiles and sulphur nucleophiles) to afford heterocyclic systemes 2–13. Also, the [4 + 2] cycloaddition reaction of 1 with phenyl isocyanate, benzylidene aryl amine and cinnamic acid derivatives gave novel heterocyclic compounds 14–16. Moreover, the reaction of 1 with active methylene compounds under Michael reaction conditions also was investigated to yield 17 and 18 and it was found that all these reactions proceeded via isothiocyanate heterocyclization to furnish non-condensed heterocyclic compounds. Some of the newly synthesized compounds were tested for their antimicrobial activities.

关键词： quinazoline congeners quinazoline isothiocyanate antimicrobial activity

Spondyloarthritis Associated with Inflammatory Bowel Disease: Study of 15 Observations in Guinea

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第2期11卷 89-95页

作者： Condé Kaba Awada Mohamed Carlos Othon Guelngar Adjibaye Emmanuel Sanni Yaya Aminou Mamadou Hady Diallo Touré Moriba kamissoko aly badra Konaté Ibrahima Sory Fodé Abass Cissé Department of Rheumatology Academic Hospital University of Conakry Guinea Department of Neurology Academic Hospital University of Conakry Guinea Department of infectious disease Reference Hospital Ndjamena Chad

Objective: Rheumatologic disorders of chronic inflammatory bowel disease (IBD) and reactive arthritis with a digestive origin are part of the spondyloarthritis family. In black Africa, the prevalence of SpA associated with IBD is not clearly established. Thus the objective of our study was to describe the clinical and radiological characteristics of spondyloarthritis associated with IBD. Patients and Method: We carried out a prospective study in the rheumatology department of CHU Ignace Deen between January and December 2019. The diagnosis of SpA was based on clinical and biological arguments in accordance with the criteria of Amor and ASAS. Results: Fifteen observations of spondyloarthritis associated with IBD were collected in patients mean age 52 years with extremes of 32 and 65 years. 9 (53.33%) were female. Ten patients had Crohn’s disease (CD) and 5 had ulcerative colitis (UC). The mean number of pushes was 2.5 ± 1.2. The average diagnostic time was 46 months. Sacroiliitis was present in 73.3% of cases and the mean mSASSS score at diagnosis was 32.11/72. In total, corticosteroids were used in 9 (60%) of patients, NSAIDs in 26.6% while DMARDs salazopyrine and methotrexate in 33.3% and 20% of patients, respectively. Conclusion: The MICI and SpA association is undoubtedly underestimated in our regions. Better collaboration between rheumatologists and gastroenterologists could facilitate diagnosis and improve care.

关键词： Spondyloarthritis Chronic Inflammatory Bowel Disease Guinea

Synthesis and Pharmacological Activity of Annelated Pyrimidine Derivatives

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Chinese Journal of Chemistry 2005年第2期23卷 211-217页

作者： aly,A.A.. ChemistryDepartment FacultyofScienceBenhaUniversityBenha-Egypt

A series of 1-glycosyl-2-glycosylthiopyrimidine (4), annelated pyrimidinederivatives, pyrazolo[3,4-d]-pyrimidine (8), ditetrazolo[1,5-a;1′,5′-c]pyrimidine (9),2,9a,10-triazaanthracene (12), thieno[2,3-d]pyrimidine (14), 9-thia-1,3,5,7-tetraazafluorene-8-one(15), 7-oxa-9-thia-1,3,5-triazafluorene-8-one (16), 5-oxa-9-thia-1,3-diaza-fluorene (21a and 21b)derivatives have been synthesized via a sequence of heterocyclization reactions of suitablyfunctionalized6-[5-(4-bromophenyl)oxazol-4-yl]-1,2,3,4-tetrahydro-2-thioxo-4-oxopyrimidine-5-carbonitrile (2) withdifferent electrophiles and nucleophiles. The new compounds were prepared with the objective tostudy their pharmacological properties.

关键词： 2-methylsulfanylpyrimidine thienopyrimidine azafluorenone pharmacologicalproperty

中国在非洲对外直接投资的决定因素：面板数据分析

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中国在非洲对外直接投资的决定因素：面板数据分析

作者： aly badra I CAMARA 西南财经大学

学位级别：硕士

非洲多年来一直致力于吸引外国直接投资的战略,以鼓励外国公司来其领土投资,深信外国直接投资对其经济发展的重要性。非洲人民越来越羡慕新兴国家的经济成功。非洲新兴国家的投资增长现在是国际经济政策的中心。本研究的目的是确定对中... 详细信息

非洲多年来一直致力于吸引外国直接投资的战略,以鼓励外国公司来其领土投资,深信外国直接投资对其经济发展的重要性。非洲人民越来越羡慕新兴国家的经济成功。非洲新兴国家的投资增长现在是国际经济政策的中心。本研究的目的是确定对中国外国直接投资的进入以及在非洲的投资地点产生重大影响的各种因素。本文使用面板数据分析了2003年至2020年期间中国对外直接投资存量及其对非洲48个不同国家的决定因素。我们的研究得出结论,强大的人力资本、互联网普及率和东道国的金融发展对吸引中国对非洲的外国直接投资有显着影响。另一个核心发现是非内陆国家吸引了更多的中国直接投资。

关键词：中国对外直接投资决定因素中非合作面板数据

BRCA1,PARP,and 53BP1:conditional synthetic lethality and synthetic viability

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Journal of Molecular Cell Biology 2011年第1期3卷 66-74页

作者： Amal aly Shridar Ganesan Cancer Institute of New Jersey Robert Wood Johnson Medical School-UMDNJ195 Little Albany StreetNew BrunswickNJ 08903USA

BRCA1 plays a critical role in the regulation of homologous recombination(HR)-mediated DNA double-strand break ***1-deficient cancers have evolved to tolerate loss of BRCA1 *** renders them vulnerable to agents,such as PARP inhibitors,that are conditionally‘synthetic lethal’with their underlying repair *** studies demonstrate that BRCA1-deficient cells may acquire resistance to these agents by partially correcting their defect in HR-mediated repair,either through reversion mutations in BRCA1 or through‘synthetic viable’loss of *** findings and their clinical implications will be reviewed in this article.

关键词： DNA repair BRCA1 53BP1 PARP

Review of Artificial Neural Networks for Wind Turbine Fatigue Prediction

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Structural Durability & Health Monitoring 2024年第6期18卷 707-737页

作者： Husam AlShannaq aly Mousaad aly Windstorm Impact Science and Engineering(WISE)Research LabLouisiana State UniversityBaton RougeLA 70803USA

Wind turbines have emerged as a prominent renewable energy source *** monitoring and detection methods are crucial to enhance their operational effectiveness,particularly in identifying fatigue-related *** review focuses on leveraging artificial neural networks(ANNs)for wind turbine monitoring and fatigue detection,aiming to provide a valuable reference for researchers in this domain and related *** various ANN techniques,including General Regression Neural Network(GRNN),Support Vector Machine(SVM),Cuckoo Search Neural Network(CSNN),Backpropagation Neural Network(BPNN),Particle Swarm Optimization Artificial Neural Network(PSO-ANN),Convolutional Neural Network(CNN),and nonlinear autoregressive networks with exogenous inputs(NARX),we investigate the impact of average wind speed on stress transfer function and fatigue damage in wind turbine *** findings indicate significant precision levels exhibited by GRNN and SVM,making them suitable for practical *** demonstrates superiority over BPNN and PSO-ANN in predicting blade fatigue life,showcasing enhanced accuracy,computational speed,precision,and convergence rate towards the global ***,CNN and NARX models display exceptional accuracy in classification *** results underscore the potential of ANNs in addressing challenges in wind turbine monitoring and fatigue ***,it’s important to acknowledge limitations such as data availability and model *** research should explore integrating real-time data and advanced optimization techniques to improve prediction accuracy and applicability in real-world *** summary,this review contributes to advancing the understanding of ANNs’efficacy in wind turbine monitoring and fatigue detection,offering insights and methodologies that can inform future research and practical applications in renewable energy systems.

关键词： Wind turbine fatigue prediction artificial neural network