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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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2017油气行业并购“迷雾渐消”

首席财务官 2017年第22期15卷 72-75页

作者：陆浩文 Richard Forrest Brent Ross alvin see Ada Perniceni Jim Pearce Hasan Shafi 科尔尼公司科尔尼亚太地区能源与化工业务部科尔尼

随着油气行业渐渐走出债务困局，2017年一系列吸引买卖双方重返并购市场的利好因素赋予市场乐观的前景。

关键词：油气行业行业并购并购市场利好因素买卖双方

A review of neutral pH polymer electrolytes for electrochemical capacitors:Transitioning from liquid to solid devices

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Materials Reports(Energy) 2021年第1期1卷 26-44页

作者： alvin Virya Keryn Lian Department of Materials Science&Engineering University of TorontoTorontoOntarioM5S 3E4Canada

The development of neutral pH polymer electrolytes has enabled high-performance solid-state,thin,and flexible electrochemical capacitors(ECs)to provide power for future consumer electronics and Internet-of-Thing *** their promising prospect,there is still some lack of understandings or disconnections from fundamental science to practical applications of these *** this review,we provide an overview of stateof-the-art studies on ECs with neutral pH electrolytes in both liquid and solid *** from the fundamental studies on the voltage window and ion conduction of salt species in liquid solution to polymer electrolytes,key considerations in developing neutral pH polymer electrolytes are *** performance of the polymer electrolytes along with their enabled solid symmetric and asymmetric EC devices,as well as some enhanced functionalities are *** future directions for research on neutral pH polymer electrolytes are proposed,expected to provide reference for further enriching the fundamental knowledge and improving the device performances.

关键词： Electrochemical capacitor Supercapacitor Electrolyte Neutral pH Aqueous-based electrolyte Polymer electrolyte Solid-state device Flexible device

Reinforcement learning models for scheduling in wireless networks

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Frontiers of Computer Science 2013年第5期7卷 754-766页

作者： Kok-Lim alvin YAU Kae Hsiang KWONG Chong SHEN Faculty of Science and Technology Sunway University Selangor 46150 Malaysia R&D Department Recovision Selangor 47650 Malaysia College of Information Science and Technology Hainan University Haikou 570228 China

The dynamicity of available resources and net- work conditions, such as channel capacity and traffic charac- teristics, have posed major challenges to scheduling in wire- less networks. Reinforcement learning （RL） enables wire- less nodes to observe their respective operating environment, learn, and make optimal or near-optimal scheduling deci- sions. Learning, which is the main intrinsic characteristic of RL, enables wireless nodes to adapt to most forms of dynamicity in the operating environment as time goes by. This paper presents an extensive review on the application of the traditional and enhanced RL approaches to various types of scheduling schemes, namely packet, sleep-wake and task schedulers, in wireless networks, as well as the advantages and performance enhancements brought about by RL. Addi- tionally, it presents how various challenges associated with scheduling schemes have been approached using RL. Finally, we discuss various open issues related to RL-based schedul- ing schemes in wireless networks in order to explore new re- search directions in this area. Discussions in this paper are presented in a tutorial manner in order to establish a founda- tion for further research in this field.

关键词： reinforcement learning scheduling wireless networks

Inundative field releases and evaluation of three predators for Bemisia tabaci （Hemiptera： Aleyrodidae） management in three vegetable crops

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Insect Science 2011年第2期18卷 195-202页

作者： alvin M. Simmons Shaaban Abd-Rabou USDA ARS U.S. Vegetable Laboratory Charleston South Carolina ARC PPRI Dokki Giza Egypt

The sweetpotato whitefly, Bemisia tabaci （Gennadius）（Hemiptera： Aleyrodidae）, is a global pest on numerous crops, including vegetables. Weekly inundative releases of a coccinellid predator （Coccinella undecimpunctata L. [Coleoptera： Coccinellidae]）, a common green lacewing predator （Chrysoperla carnea Stephen [Neuroptera： Chrysopidae]）, and a mirid predator （Macrolophus caliginosus [Wagner] [Hemiptera： Miridae]） were independently made in three vegetable crops （cabbage [Brassica oleracea var. capitata L.], cucumber [Cucumis sativus L.], and squash [Cucurbita pepo L.]） for the management of the sweetpotato whitefly. Approximately 1 million to 2.5 million larvae or nymphs of each predator were released in the vegetable crops during 20 weeks. Whitefly populations were reduced by ≈ 25%-45% during most of the season in each crop where each predator was released. The effect of each predator was similar on whitefly population reduction. Late in the season （October） when whitefly populations were low, generally no benefit was obtained from releasing the predators. Numbers of predators recovered during sampling in all crops were greatest for C. carnea, but this corresponded with the fact that more individuals of this predator were released than any other predator in the experiment. These results help define the utility of these natural enemies for managing B. tabaci in vegetable crops.

关键词： Bemisia tabaci Chrysoperla carnea Coccinella undecimpunctata Macrolophus caliginosus inundative release sweetpotato whitefly

Structure-Based Prediction of Transcription Factor Binding Sites

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Tsinghua Science and Technology 2014年第6期19卷 568-577页

作者： Jun-tao Guo Shane Lofgren alvin Farrel Department of Bioinformatics and Genomics University of North Carolina at Charlotte Charlotte NC 28223 USA

Transcription Factors（TFs） are a very diverse family of DNA-binding proteins that play essential roles in the regulation of gene expression through binding to specific DNA sequences. They are considered as one of the prime drug targets since mutations and aberrant TF-DNA interactions are implicated in many *** of TF-binding sites on a genomic scale represents a critical step in delineating transcription regulatory networks and remains a major goal in genomic annotations. Recent development of experimental high-throughput technologies has provided valuable information about TF-binding sites at genome scale under various physiological and developmental conditions. Computational approaches can provide a cost-effective alternative and complement the experimental methods by using the vast quantities of available sequence or structural information. In this review we focus on structure-based prediction of transcription factor binding sites. In addition to its potential in genomescale predictions, structure-based approaches can help us better understand the TF-DNA interaction mechanisms and the evolution of transcription factors and their target binding sites. The success of structure-based methods also bears a translational impact on targeted drug design in medicine and biotechnology.

关键词： transcription factor binding site structure-based predictions knowledge-based potential physics-based potential

Correcting for non-compliance when determining colonic transit time with radio-opaque markers

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World Journal of Gastroenterology 2017年第4期23卷 740-742页

作者： alvin Ibarra Kaisa Olli Arthur C Ouwehand DuPont Nutrition and Health 02460 KantvikFinland

The use of radio-opaque markers and abdominal X-ray is the standard method for determining colonic transit time(CTT). However, when there are deviations in the intake of these markers by participants in clinical trials it is desirable to improve observations by introducingcorrections, where possible. To date, there is no standard procedure to adjust for such deviations. This report proposes a series of alternatives based on possible scenarios for deviations from the intended intake of radio-opaque markers. The proposed method to correct for missed or delayed consumption of radioopaque markers can help to increase the accuracy of the CTT measurements in clinical trials.

关键词： Colonic transit time Gastroenterology Gut transit time Radio-opaque marker X-ray

Sex education for adolescents:Indonesian nurse educators’experience as parents

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Frontiers of Nursing 2022年第3期9卷 303-310页

作者： alvin Salim Evelyn Hemme Tambunan Universitas Advent Indonesia Bandung 40559Indonesia

Objectives:Sex education toward adolescent remains the most controversial subject due to the various thoughts and ideas of different values present in *** educators as parents must exemplify sex education to their *** aim of this present study was to explore parents’experience,with nurse educators background to be exact,on how they convey sex education to their ***:This study is a descriptive qualitative study,and the sample is recruited by using the purposive sampling *** qualified participants filled in the informed consent,provided demographic data,and were *** data were obtained at the 6th interview in this *** interview is transcribed to find themes and subthemes using conventional content ***:We derived 3 main themes:parents’approach,sex education topic,and children’s ***’approach contained 4 subthemes,namely,gender match,parent-child closeness,media,and *** education topic included 5 subthemes of bodily autonomy,health and safety,reproductive anatomy,puberty-related changes,and how to maintain ***’s reaction experiences also included 4 subthemes of uncomfortable,questioning,acknowledging,and ***:As a matter of fact,some parents in eastern countries,such as Indonesia,conveyed sex education to their *** might have various reactions to that topic,but it is important to keep them safe,especially in reproductive health,regardless of the culture or *** on nurse educators as exemplifiers,nurses and nursing students might acquire the picture in conveying sex education to adolescents.

关键词： adolescent experiences Indonesian nurse educators parents and sex education

Contemporary outcomes in the detection of prostate cancer using transrectal ultrasound-guided 12-core biopsy in Singaporean men with elevated prostate specific antigen and/or abnormal digital rectal examination

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Asian Journal of Urology 2015年第4期2卷 187-193页

作者： alvin Lee Sing Joo Chia Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Urology Tan Tock Seng HospitalSingapore

Objective:Despite being the third commonest cancer in Singaporean men,there is a dearth of basic data on the detection rate of prostate cancer and post-procedure complication rates locally using systematic 12-core *** objective is to evaluate prostate cancer detection rates using 12-core prostate biopsy based on serum prostate specific antigen(PSA)levels and digital rectal examination(DRE)findings in Singaporean men presenting to a single tertiary *** secondary objective is to evaluate the complication rates of transrectal prostate ***:We retrospectively examined 804 men who underwent first transrectal-ultrasound(TRUS)guided 12-core prostate biopsies from January 2012 to April *** biopsies were performed on men presenting to a tertiary institution when their PSA levels were4.0 ng/mL and/or when they had suspicious DRE ***:Overall prostate cancer detection rate was 35.1%.Regardless of DRE findings,patients were divided into four subgroups based on their serum PSA levels:0e3.99 ng/mL,4.00 e9.99 ng/mL,10.00e19.99 ng/mL and20.00 ng/mL and their detection rates were 9.5%,20.9%,38.4% and 72.3%,*** detection rate of cancer based on suspicious DRE findings alone was 59.2% compared to 36.5% based on serum PSA cut-off of 4.0 ng/mL *** post-biopsy admission rate for sepsis was 1.5%.Conclusion:In conclusion,using contemporary 12-core biopsy methods,the local prostate cancer detection rate based on serum PSA and DRE findings has increased over the past decade presumably due to multiple genetic and environmental ***-biopsy sepsis remains an important complication worldwide.

关键词： Digital rectal examination Oncology Prostate cancer Prostate specific antigen Transrectalultrasound Biopsy