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Ponseti method compared with soft-tissue release for the management of clubfoot:A meta-analysis study

World Journal of Orthopedics 2013年第3期4卷 144-153页

作者： Marios G Lykissas alvin h crawford Emily A Eismann Junichi Tamai Division of Pediatric Orthopaedic Surgery Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45229United States

AIM: To compare the functional outcomes of patients who underwent open surgery vs Ponseti method for the management of idiopathic clubfoot and to determine whether correlations exist between functional outcome and radiographic ***: A meta-analysis of the literature was conducted for studies concerning primary treatment of patients with idiopathic clubfoot. We searched PubM ed Medline, EMBASE, and the Cochrane Library databases from January 1950 to October 2011. Meta-analyses were performed on outcomes from 12 studies. Pooled means, SDs, and sample sizes were either identified in the results or calculated based on the results of each ***: Overall, 835 treated idiopathic clubfeet in 516 patients were reviewed. The average follow-up was 15.7 years. Patients managed with Ponseti method did have a higher rate of excellent or good outcome than patients treated with open surgery(0.76 and 0.62, respectively), but not quite to the point of statistical significance(Q = 3.73, P = 0.053). Age at surgery wasnot correlated with the functional outcome for the surgically treated patients(r =-0.32, P = 0.68). A larger anteroposterior talocalcaneal angle was correlated with a higher rate of excellent or good outcomes(r = 0.80, P = 0.006). There were no other significant correlations between the functional and radiographic ***: The Ponseti method should be considered the initial treatment of idiopathic clubfeet, and open surgery should be reserved for clubfeet that cannot be completely corrected.

关键词： Idiopathic clubfoot Congenital talipes equinovarus Ponseti method Surgical release Ponseti-Laaveg score

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Redox therapeutics in hepatic ischemia reperfusion injury

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World Journal of hepatology 2014年第1期6卷 1-8页

作者： Rakesh P Patel John D Lang alvin B Smith Jack h crawford Department of Pathology Center for Free Radical Biology University of Alabama at Birmingham Department of Anesthesiology and Pain Medicine University of Washington School of Medicine Department of Anesthesiology University of Alabama Birmingham Division of Cardiothoracic Anesthesia Department of Anesthesiology University of Alabama Birmingham

Ischemia-reperfusion plays a major role in the injury experienced by the liver during transplantation. Much work has been done recently investigating the role of redox species in hepatic ischemia-reperfusion. As animal models are better characterized and developed, and more insights are gained into the pathophysiology of hepatic ischemia reperfusion injury in humans the questions into exactly how oxidants participate in this injury are becoming more refined. These questions include effects of cellular location, timing of injury, and ability of therapeutics to access this site are increasing our appreciation of the complexity of ischemia reperfusion and improving attempts to ameliorate its effects. In this review, we aim to discuss the various methods to alter redox chemistry during ischemia reperfusion injury and future prospects for preventing organ injury during hepatic ischemia reperfusion.

关键词： Ischemia Reperfusion Pre-conditioning Nitrite

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