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Developing a.d va.ida.ing a.nestling photogra.hic a.ing guide for ca.ity-nesting birds: a. exa.ple with the Europea. Bee-ea.er(Merops a.ia.ter)

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a.ia. Resea.ch 2020年第1期11卷 57-64页

作者： Joa.a.S.Costa.a.onso D.Rocha.Rica.do a.Correia.Jose a.alves Depa.tment of Biology&CESa. University of AveiroCampus Universitario de Santiago3810-193 AveiroPortugal Institute of Biologica. a.d Hea.th Sciences(ICBS) Federal University of AlagoasMaceioALBrazil University of Icela.d South Iceland Research CentreLindarbraut 4840 LaugarvatnIceland

Ba.kground: a.cura.e estima.ion of nestlings’ a.e is essentia. in a.ia. demogra.hy studies a. well a. in popula.ion ecology a.d conserva.ion. For exa.ple, it ca. be useful for synchronizing nest visits with events of pa.ticula. interest, such a. the a.e a. which young ca. be sa.ely ringed, or in choosing the best period to a.ta.n the most a.cura.e ca.cula.ion of la.ing or ha.ching ***: We constructed a.photogra.hic guide for a.ing Europea. Bee-ea.ers(Merops a.ia.ter) nestlings to 3-da. a.e cla.ses a.d eva.ua.ed the a.ing method by performing a.va.ida.ion exercise with severa. observers with no previous experience in a.ing bee-ea.er ***: The a.ing guide for bee-ea.er nestlings a.lowed estima.ing a.e to within 3 da.s with a. a.era.e a.cura.y of 0.85. We found the optima. period for a.ing nestlings wa. between da.s 13-18(with a.cura.y between 0.94 a.d 0.99), during which the sta.us of fea.her development wa. more ea.ily distinguisha.le from the preceding a.d subsequent a.e cla.ses. During the first 3 da.s a.ter ha.ching, nestlings could a.so be a.ed with high a.cura.y(0.93). The sma.l size of the nestling in rela.ion to the eggs a.d the nestling’s ina.ility to ra.se its hea. during these first da.s a.lowed for good discrimina.ion from the subsequent a.e cla.s. Between da.s 25 a.d 28, nestlings were correctly a.ed in only ha.f of a.signments(0.55 sensitivity) a.d nestlings belonging to cla.s 7(da.s 7-9) were the lea.t correctly identified(0.38 sensitivity). However, by visiting the nests a. 12 da.s interva.s it is possible to a.hieve the highest a.cura.y in a.e estima.ion with the sma.lest disturba.ce a.d logistic ***: This study highlighted how indirect methods a.d a.simple protocol ca. be esta.lished a.d employed to quickly estima.e nestling a.e in ca.es where ha.dling nestlings is cha.lenging or impossible, while minimizing disturba.ce in a.d a.ound the nest.

关键词： a.e estima.ion Chick development Fea.her growth Ima.e guide Nest visit Pluma.e colour

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Unveiling DNa.methyla.ion in a.zheimer’s disea.e:a.review of a.ra.-ba.ed huma. bra.n studies

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Neura. Regenera.ion Resea.ch 2024年第11期19卷 2365-2376页

作者： Victoria.Cunha.alves Eva.Ca.ro Joa.a.Figueiro-Silva Neurodegenera.ive Disea.es Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Network Center for Biomedica. Resea.ch Neurodegenerative Diseases(CIBERNED)MadridSpain PhD Progra. in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurotra.ma.ology a.d Suba.a.hnoid Hemorrha.e Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Neurobiology of a.zheimer’s Disea.e Unit Functional Unit for Research Into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpain Institute of Medica. Genetics University of ZurichZurichSwitzerland Depa.tment of Molecula. Life Science University of ZurichZurichSwitzerland

The intrica.ies of a.zheimer’s disea.e pa.hogenesis a.e being increa.ingly illumina.ed by the explora.ion of epigenetic mecha.isms,pa.ticula.ly DNa.*** review comprehensively surveys recent huma.-centered studies tha. investiga.e whole genome DNa.methyla.ion in a.zheimer’s disea.e *** exa.ina.ion of va.ious bra.n regions revea.s distinctive DNa.methyla.ion pa.terns tha. a.socia.e with the Bra.k sta.e a.d a.zheimer’s disea.e *** entorhina. cortex emerges a. a.foca. point due to its ea.ly histologica. a.tera.ions a.d subsequent impa.t on downstrea. regions like the ***,a.K1 hypermethyla.ion,a.protein implica.ed in neurofibrilla.y ta.gle forma.ion,wa. recurrently identified in the entorhina. ***,the middle tempora. gyrus a.d prefronta. cortex were shown to exhibit significa.t hypermethyla.ion of genes like HOXa.,RHBDF2,a.d MCF2L,potentia.ly influencing neuroinfla.ma.ory *** complex role of BIN1 in la.e-onset a.zheimer’s disea.e is underscored by its a.socia.ion with a.tered methyla.ion *** the dispa.ities a.ross studies,these findings highlight the intrica.e interpla. between epigenetic modifica.ions a.d a.zheimer’s disea.e *** resea.ch efforts should a.dress methodologica. va.ia.ions,incorpora.e diverse cohorts,a.d consider environmenta. fa.tors to unra.el the nua.ced epigenetic la.dsca.e underlying a.zheimer’s disea.e progression.

关键词： a.zheimer’s disea.e a.K1 BIN1 DNa.methyla.ion epigenome-wide a.socia.ion studies HOXa. MCF2L RHBDF2

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Pla.t community on a.volca.o mounta.ntop revea.s unique high-a.titude vegeta.ion in southea.tern Bra.il

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Journa. of Mounta.n Science 2024年第9期21卷 3018-3030页

作者： Igor Musa.er KESSOUS Ruy JoséVa.ka.alves Nílber Gonçalves da.SILVa.a.ilca. Wa.ter Sa.ORETTI JUNIOR Biodiversity La.ora.ory Federal Institute of EducationScience and Technology of Southern Minas Gerais(IFSULDEMINAS)Av.Dirce Pereira Rosa300-Jardim Esperança37713-100Poços de CaldasMGBrazil Depa.tment of Bota.y National MuseumFederal University of Rio de JaneiroQuinta da Boa Vista s.n.São Cristóvão20949-040Rio de JaneiroRJBrazil Gothenburg Globa. Biodiversity Centre Carl Skottsbergs Gata 22BSE 41319GothenburgSweden

Mounta.ns exhibit a.high degree of endemism a.d diversity,however,qua.tifying their biodiversity ca. be *** to isla.ds,species isola.ion in mounta.nous regions results in compa.a.le pa.terns of evolution a.d extinction,rendering their biodiversity unique a.d highly susceptible to a.thropogenic *** topogra.hic relief in mounta.ns pla.s a.crucia. role in crea.ing ha.ita. complexity,which in turn contribute to high pla.t ***,we investiga.ed pla.t diversity in the volca.o mounta.ntop vegeta.ion on the Poços de Ca.da. Pla.ea.,a.region situa.ed in the ecotone between the a.la.tic Forest a.d Cerra.o,cha.a.terized by na.ura. ra.ia.ion a.d significa.t a.thropogenic *** employed a. a.toma.ed a.proa.h through the filtering of georeferenced a.d non-georeferenced da.a.to obta.n a.list of pla.t species in the ***,we sta.istica.ly investiga.ed the simila.ity a.ong different high-a.titude vegeta.ions belonging to the ca.pos de a.titude from the a.la.tic Forest a.d ca.pos rupestres from the *** pla.ea. exhibits high pla.t diversity,including 1,659 specific a.d infra.pecific ta.a.especia.ly belonging to a.tera.ea. a.d *** a.a.yses suggest tha. geogra.hica. dista.ce is a.strong predictor of dissimila.ity a.d tha. the Poços de Ca.da. Pla.ea. is more floristica.ly rela.ed to the ca.pos rupestres,despite being a.socia.ed with ca.pos de *** region possesses a.unique set of biodiversity,indica.ing tha. it ma. be a.distinct ***,we hypothesize tha. Pleistocene events likely influenced the conforma.ion of the current floristic composition in the region through species intercha.ge between the Cerra.o a.d a.la.tic *** study a.so highlights the few ta.a.a.sessed for conserva.ion sta.us a.d a.thropogenic threa.s tha. this ha.ita. is fa.ing.

关键词： a.la.tic Forest Biogeogra.hy Cerra.o Community ecology Gra.sla.d

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Time-Series Embeddings from La.gua.e Models:a.Tool for Wind Direction Nowca.ting

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Journa. of Meteorologica. Resea.ch 2024年第3期38卷 558-569页

作者： Decio alves Fa.io MENDONCa.Sheikh Sha.a.a. MOSTa.a.Ferna.do MORGa.O-DIa. University of Ma.eira Campus Universitário da Penteada9020-105FunchalPortugal Intera.tive Technologies Institute/La.ora.ory for Robotics a.d Engineering Systems a.d a.ência.Regiona. pa.a.o Desenvolvimento da.Investiga.ão Tecnologia e InovaçãoEdif.Madeira TecnopoloCaminho da Penteada piso-29020-105FunchalPortugal

Wind direction nowca.ting is crucia. in va.ious sectors,pa.ticula.ly for ensuring a.ia.ion opera.ions a.d *** this context,the TELMo(Time-series Embeddings from La.gua.e Models)model,a.sophistica.ed deep lea.ning a.chitecture,ha. been introduced in this work for enha.ced wind-direction *** by using three yea.s of da.a.from multiple sta.ions in the complex terra.n of a. interna.iona. a.rport,TELMo incorpora.es the horizonta. u(ea.t-west)a.d v(north-south)wind components to significa.tly reduce foreca.ting *** a.da. with high wind direction va.ia.ility,TELMo a.hieved mea. a.solute error va.ues of 5.66 for 2-min,10.59 for 10-min,a.d 14.79 for 20-min foreca.ts,processed within a.swift 9-ms/step *** degree-ba.ed a.a.ysis,in compa.ison,yielded lower performa.ce,empha.izing the effectiveness of the u a.d v *** contra.t,a.Va.illa.neura. network,representing a.sha.low-lea.ning a.proa.h,underperformed in a.l a.a.yses,highlighting the superiority of deep lea.ning methodologies in wind direction *** is a. efficient model,ca.a.le of a.cura.ely foreca.ting wind direction for a.r tra.fic opera.ions,with a. error less tha. 20°in 97.49%of the predictions,a.igning with recommended interna.iona. *** model design ena.les its a.plica.ility a.ross va.ious geogra.hica. loca.ions,ma.ing it a.versa.ile tool in globa. a.ia.ion meteorology.

关键词： wind nowca.ting wind components wind direction time series prediction deep lea.ning

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a.review on the sca.e-up of high-shea. wet gra.ula.ion processes a.d the impa.t of process pa.a.eters

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Pa.ticuology 2024年第9期92卷 180-195页

作者： a.a.Rita.alves Ma.ta.Filipe Simões Sérgio Simões João Gomes University of Coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepha.ma.Indústria.Fa.ma.êutica São Martinho do BispoCoimbra3045-016Portugal Fa.ulty of Pha.ma.y University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet gra.ula.ion is one of the most importa.t a.glomera.ion processes,a.d high-shea. gra.ula.ion(HSG)one of the most employed technologies in the pha.ma.eutica. *** most critica. process pa.a.eters of HSG a.e discussed in this *** ma.n concern in sca.ing up the wet gra.ula.ion process is the differences between sca.es,which prevent the pa.ticles from ha.ing the sa.e experience a.ross a.l *** sca.e-up of wet gra.ula.ion processes is commonly divided into two ca.egories:engineering a.d a.tribute-ba.ed *** engineering-ba.ed sca.e-up a.proa.h is a.stra.egy ba.ed on dimensiona. a.a.ysis a.d a. a.tribute-ba.ed supported on the principles of“equifina.ity”,where process va.ia.les a.e a.justed to obta.n equiva.ent gra.ule *** work presents the effect of different HSG process pa.a.eters on the sca.e-up,a. well a. the use of process a.a.ytica. tools(Pa.)a.d modelling *** a.m is to review a.plied sca.e-up a.proa.hes in HSG a.d discuss benefits a.d *** is proven why the sca.e-up for ora. solid pha.ma.eutica. products is still considered a.hot topic a.d a.very cha.lenging ta.k for development a.d engineering tea.s.

关键词： High-shea. wetgra.ula.ion Pa.a.etric-ba.ed a.tribute-ba.ed Physics-ba.ed modelling Impeller design Sca.e-up

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Ora. gra.ula. cell tumor： clinicopa.hologic fea.ures of a.ca.e series

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中国口腔颌面外科杂志 2008年第B5期6卷 208-209页

作者： Da.yel E. C. Perez Jose D. Pra.o Fa.bio a. alves Depa.tment of Stoma.ology Hospital A. C. Camargo Sao Paulo Brazil Ora. Pa.hology Division University of Ribeirao Preto (UNA ERP) Ribeirao Preto Brazil

Purpose: Ora. gra.ula. cell tumor (OGCT) is a.ra.e benign lesion origina.es from Schwa.n cells。It occurs most frequently in the tongue of pa.ients between the fourth a.d sixth deca.es of life。Most pa.ers report single ca.es, with few series published。The a.m of the study wa. to describe the clinicopa.hologic fea.ures of a.series of OGCT。Methods: a.l ca.es with dia.nosis of OGCT from files of Depa.tment of Stoma.ology, Hospita. a.C。Ca.a.go, Sa. Pa.lo, Bra.il, were selected for the study。Clinica. da.a.were obta.ned from the medica. records a.d microscopic slides were reviewed to confirm the dia.nosis。Results: There were 18 ca.es of OGCT, 11 (61%) of the ma.e gender a.d 7 (39%) of fema.e gender, with a.mea. a.e of 41 yea.s (ra.ge, 13 to 62)。Sixteen pa.ients (90%) compla.ned of a.pa.nless nodule a.d the mea. time of compla.nts, eva.ua.ed in 15 pa.ients, wa. 11 months (ra.ge, 2 to 60 months)。Sixteen ca.es (90%) occur in the tongue, 1 (5%) in the bucca. mucosa.a.d 1 (5%) in lower gingiva.The mea. size of the tumors wa. 0.9 cm (ra.ge, 0.3 to 2.0 cm)。a.l ca.es were trea.ed by surgica. excision, without recurrence of the lesion。Microscopica.ly, the lesions presented la.ge cells, with gra.ula., eosinophilic, pa.e a.d a.unda.t cytopla.m。The epithelium tha. recovered the lesion showed frequently pseudo-epithelioma.ous hyperpla.ia.Conclusion: The OGCT a.fects predomina.tly the tongue of ma.e pa.ients a.d presents excellent prognosis。Microscopica.ly, the lesions must be ca.efully exa.ined in order to a.oid equivoca. dia.nosis of squa.ous cell ca.cinoma. since tha. pseudo-epithelioma.ous hyperpla.ia.is a.common finding。

关键词：口腔癌细胞癌治疗方法临床病理学

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Cha.a.teriza.ion of the a.lelopa.hic Potentia. of Suga.ca.e Lea.es a.d Roots

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Journa. of a.ricultura. Chemistry a.d Environment 2021年第3期10卷 257-274页

作者： Neria.e Hija.o Ma.iluce P. Nepomuceno Cha.les L. Ca.trell Stephen O. Duke Pedro L. C. a. alves Depa.tment of Biology a.plied to a.riculture School of Agricultural and Veterinarian Sciences Sao Paulo State University (UNESP) Jaboticabal Brazil Na.ura. Products Utiliza.ion Resea.ch Unit Agricultural Research Service United State Department of Agriculture University Mississippi USA Na.iona. Center for Na.ura. Products Resea.ch School of Pharmacy University of Mississippi University Mississippi USA

Suga.ca.e cultiva.s tha. a.e currently pla.ted a.e the result of genetic improvement focused on increa.ed crop yield. However, this selection a.d genetic a.tera.ion reduced the competitive potentia. of suga.ca.e, a. well a. its a.lelopa.hic ca.a.ilities. Ma.y members of the Poa.ea. fa.ily a.e highly a.lelopa.hic. Thus, the objective of this study wa. to cha.a.terize the a.lelopa.hic potentia. of two suga.ca.e cultiva.s (CTC 2 a.d Ia. 91109) by bioa.sa.-guided fra.tiona.ion, isola.ion, a.d identifica.ion of significa.t phytotoxins, including those tha. a.e lipophilic. For both lea.es a.d roots, a.pha.linolenic a.d linoleic a.id were found to be the most phytotoxic compounds found with this a.proa.h. Both compounds were phytotoxic when a.plied in soil a.d ca.sed light-independent cellula. lea.a.e of trea.ed cucumber cotyledon discs. We conclude tha. some of the phytotoxic effects of suga.ca.e residues in soil a.e due to the combined a.tion of a.pha.linolenic a.d linoleic a.id.

关键词： Fa.ty a.id a.lelochemica. a.pha.Linolenic a.id Linoleic a.id Bioa.sa. Weed

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Colorecta. ca.cer screening:a.review of current knowledge a.d progress in resea.ch

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World Journa. of Ga.trointestina. Oncology 2024年第4期16卷 1119-1133页

作者： Sa.a.Ra.os Lopes Cla.dio Ma.tins Inês Costa.Sa.tos Ma.a.ena.Teixeira.Élia.Ga.ito a.a.Luisa.alves Depa.tment of Ga.troenterology Centro Hospitalar de SetúbalSetúbal 2910-446Portugal

Colorecta. ca.cer(CRC)is one of the most preva.ent ma.igna.cies worldwide,being the third most commonly dia.nosed ma.igna.cy a.d the second lea.ing ca.se of ca.cer-rela.ed dea.hs *** the progress in screening,ea.ly dia.nosis,a.d trea.ment,a.proxima.ely 20%-25%of CRC pa.ients still present with meta.ta.ic disea.e a. the time of their initia. ***,the burden of disea.e is still expected to increa.e,especia.ly in individua.s younger tha. 50 yea.s old,a.ong whom ea.ly-onset CRC incidence ha. been *** a.d ea.ly detection a.e pivota. to improve CRC-rela.ed *** is well esta.lished tha. CRC screening not only reduces incidence,but a.so decrea.es dea.hs from *** screening stra.egies ha.e proven effective in decrea.ing both CRC incidence a.d morta.ity,though va.ia.ions in effica.y ha.e been reported a.ross the ***,uncerta.nties persist rega.ding the optima. screening method,a.e interva.s a.d ***,a.herence to CRC screening rema.ns globa.ly *** recent yea.s,emerging technologies,nota.ly a.tificia. intelligence,a.d non-inva.ive bioma.kers,ha.e been developed to overcome these ***,controversy exists over the a.tua. impa.t of some of the new discoveries on CRC-rela.ed outcomes a.d how to effectively integra.e them into da.ly *** this review,we a.m to cover the current evidence surrounding CRC *** will further critica.ly a.sess novel a.proa.hes under investiga.ion,in a. effort to differentia.e promising inno-va.ions from mere novelties.

关键词： Colorecta. ca.cer Screening Review Oncology a.tificia. intelligence

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Increa.ing dieta.y fiber inta.e for type 2 dia.etes mellitus ma.a.ement: a.systema.ic review

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World Journa. of Dia.etes 2024年第5期15卷 1001-1010页

作者： Dougla. Nitzke Julia.a.Czerma.nski Ca.olina.Rosa.Cha.ine Coghetto Sa.rina.alves Ferna.des Ra.dha.l B Ca.teri Depa.tment of Nutrition Centro Universitário CESUCACachoeirinha 94935-630Brazil Depa.tment of Hepa.ology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90430-080Brazil Postgra.ua.e Progra. in Hepa.ology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Postgra.ua.e Progra. in Hepa.ology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil

Ba.KGROUND Type 2 dia.etes is a.chronic,non-communica.le disea.e with a.substa.tia. globa. impa.t,a.fecting a.significa.t number of *** etiology is closely tied to imba.a.ced dieta.y pra.tices a.d sedenta.y ***,increa.ing die-ta.y fiber(DF)inta.e ha. consistently demonstra.ed hea.th benefits in numerous studies,including improvements in glycemic control a.d weight *** To investiga.e the effica.y of DF interventions in the ma.a.ement of type 2 dia.etes mellitus(T2DM).METHODS a.systema.ic litera.ure review wa. conducted to explore the a.socia.ion between DF inta.e a.d the ma.a.ement of *** the inclusion a.d exclusion criteria.a.tota. of 26 studies were included in this *** The ma.n stra.egies implied to increa.ed DF inta.e were:High DF diet plus a.a.bose(2 studies);DF supplements(14 studies);a.d high DF diets(10 studies).Overa.l,most studies indica.ed tha. increa.ed DF inta.e resulted in im-provements in glycemic control a.d weight ma.a.ement in T2DM *** DF represents a.va.ua.le stra.egy in the trea.ment of type 2 dia.etes,improving hea.th *** inta.e offers the potentia. to improve qua.ity of life a.d reduce complica.ions a.d morta.ity a.socia.ed with ***,through supplements or enriched foods,DF contributes significa.tly to the control of severa. ma.kers such a. Hba.c,blood glucose,triglycerides,low-density lipoprotein,a.d body weight.

关键词： Type 2 dia.etes mellitus Soluble fibers Insoluble fibers Probiotics Blood glucose Nutrition

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Histologica. a.sessment of Bone Regenera.ion in the Ma.illa.with Homologous Bone Gra.t:a.Fea.ible Option for Ma.illa.y Bone Reconstruction

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Journa. of Renewa.le Ma.eria.s 2024年第1期12卷 131-148页

作者： Sergio Henrique Gonçalves Motta.a.a.Pa.la.Ra.os Soa.es Julia.a.Ca.pos Ha.se Ferna.des Gusta.o Vicentis Oliveira.Ferna.des Gra.ua.e Center of Fa.ulda.e Redentor CLIVORio de JaneiroBrazil Periodontics a.d Ora. Medicine Depa.tment University of Michigan School of DentistryAnn ArborMI48109USA Centre for Interdisciplina.y Resea.ch in Hea.th(CIIS) Universidade Católica PortuguesaViseu3504-505Portugal

Bone bioma.eria.s ha.e been increa.ingly used to reconstruct ma.illa.y a.rophic ***,the a.m of this study wa. to eva.ua.e bone reconstruction in the ma.illa.using a.homologous cortico-ca.cellous FFB(lyophilized)gra.t a.d verify its *** individua.s were included from 2014 to *** first surgery wa. performed to insta.l homologous bone blocks in the *** period of the second intervention va.ied between 5 months a.d 15 da.s to 11 months(≈7.93 months).The biopsies were ta.en from the centra. region of the ma.ured gra.t during the surgery for impla.t *** pa.ients presented clinica. a.d ra.iogra.hic conditions for the insta.la.ion of denta. *** wa. a.100%of surviva. *** histologica. a.sessment showed tha. the homologous block bone gra.t wa. a. osteoconductive bioma.eria.,with connective tissue present,a.d newly formed bone juxta.osed on its *** were bone tra.ecula. with osteocytes a.d a.tive osteobla.ts with connective tissue in the minera.iza.ion process;the remodeling process ca. be found through the reverse lines.a.limited focus of necrosis with fibrosis wa. detected,with sma.l resorption a.d a.ea. of infla.ma.ory infiltra.e,but without clinica. *** homologous block bone gra.t ca. be considered a.fea.ible option to substitute the a.togenous bone gra.t(gold sta.da.d),with predicta.le clinica. a.d fa.ora.le histologica. *** pa.ients ha. a.shorter surgica. period,low morbidity,a.d a. unlimited a.ount of bioma.eria. a.a.la.le a. a. a.cessible cost.

关键词： Regenera.ion bone gra.t histology homologous a.logenous a.togenous

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