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World Journal of Gastroenterology 2010年第29期16卷 3697-3703页

作者： Jose Perea Edurne alvaro Yolanda Rodríguez Cristina Gravalos Eva Sánchez-Tomé Barbara Rivera Francisco Colina Pablo Carbonell Rogelio González-Sarmiento Manuel Hidalgo Miguel Urioste Department of Surgery Hospital Universitario 12 de Octubre Department of Pathology Hospital Universitario 12 de Octubre Medical Oncology Hospital Universitario 12 de Octubre Human Genetics Group Human Cancer Genetics ProgramSpanish National Cancer Centre Molecular Genetics Unit Centro de Bioquímicay Genética ClínicaHospital Virgen de la Arrixaca Department of Medicine Medicine SchoolSalamanca University

AIM:To characterize clinicopathological and familial features of early-onset colorectal cancer(CRC) and compare features of tumors with and without microsatellite instability(MSI).METHODS:Forty-five patients with CRC aged 45 or younger were included in the *** information,a three-generation family history,and tumor samples were *** status was analyzed and mismatch repair genes were examined in the MSI *** were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected ***:Early onset CRC is characterized by advanced stage at diagnosis,right colon location,low-grade of differentiation,mucin production,and presence of *** forms represent at least 21% of ***-one percent of patients who died during followup showed a lack of expression of cyclin E,which could be a marker of poor prognosis.β-catenin expression was normal in a high percentage of ***:Early-onset CRC has an important familial component,with a high proportion of tumors showing microsatellite *** E might be a poor prognosis factor.

关键词： Early onset colorectal cancer Microsatellite instability Lynch syndrome Microsatellite stable colorectal cancer

Immunotherapy and immunoescape in colorectal cancer

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World Journal of Gastroenterology 2007年第44期13卷 5822-5831页

作者： Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia alvaro Gonzalez Ignacio Melero Liver Unit Facultad de Ciencias Biomédicas Universidad Austral Presidente Perón 1500 (1635) Derqui-Pilar Buenos Aires Argentina Centro de Investigación Médica Aplicada and Clínica Universitaria Universidad de Navarra Pamplona Spain

Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.

关键词： Colorectal carcinoma Immunotherapy Gene therapy interleukin-12 Dendritic cells CD137 indoleamine 2, 3 dioxygenase

Experimental salt cavern in offshore ultra-deep water and well designevaluation for CO_(2) abatement

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International Journal of Mining Science and Technology 2019年第5期29卷 641-656页

作者： alvaro Maia da Costa Pedro V.M.Costa Antonio C.O.Miranda Mariana B.R.Goulart Okhiria D.Udebhulu Nelson F.F.Ebecken Ricardo C.Azevedo Sérgio M.de Eston Giorgio de Tomi Andre B.Mendes Julio R.Meneghini Kazuo Nishimoto Claudio Mueller Sampaio Camila Brandao Alexandre Breda University of Sao Paulo(USP) Sao Paulo 01000-000Brazil Modecom-Technology in Geomechanics and Computing Modeling Rio de Janeiro 27570-000Brazil Department of Civil and Environment Engineering University of Brasília(UnB)Brasília 70000-000Brazil COPPE Federal University of Rio de JaneiroRio de Janeiro 27570-000Brazil Technology Division of Shell Shell BrazilRio de Janeiro 27570-000Brazil

This paper presents a proposal for an experimental salt cavern in offshore ultra-deep water for CO2 abatement,including the instrumentation plan and well conceptual design evaluated for carbon capture and storage(CCS)*** studies are based on applied computational mechanics associated with field experimentation that has contributed to the technical feasibility of the underground potash mine at the State of Sergipe in *** knowhow allowed the stability analysis of several salt caverns for brine production at the State of Alagoas in Brazil and to the drilling through stratified thick layers of salt of the pre-salt reservoirs in Santos ***,this knowledge has been applied in the design of onshore and offshore salt caverns opened by dissolution for storage of natural gas and *** geomechanical study,through the application of computational mechanics,of offshore giant salt caverns of 450 m high by 150 m in diameter,shows that one cavern can store about 4 billion Sm3 or 7.2 million tons of *** the construction of the giant cavern,which will be the first gas storage offshore in the world,it has been decided to develop an experimental one,with smaller size,to obtained field *** experimental cavern will allow the calibration of parameters to be used in the structural integrity analysis of the cavern and well for storage of natural gas which is rich in CO2 under high pressure.

关键词： Salt cavern Pre-salt reservoir Geomechanical study Carbon capture and storage

Fluorosis and Dental Caries in the Hydrogeological Environments of Southeastern Communities in the State of Morelos, Mexico

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Journal of Environmental Protection 2013年第9期4卷 994-1001页

作者： Gricelda G. Varela-González alvaro García-Pérez Rafael Huizar-Alvarez Maria Esther Irigoyen-Camacho Maria M. Espinoza-Jaramillo Departamento de Atención a la Salud Universidad Autónoma Metropolitana Xochimilco Mexico City Mexico Departamento de Geología Regional Instituto de Geología Universidad Nacional Autónoma de México Mexico City Mexico División de Estudios de Posgrado e Investigación Facultad de Odontología Universidad Nacional Autónoma de México Mexico City Mexico

Objectives: 1) To identify the hydrogeological characteristics and fluoride (F-) concentration in drinking water in the southeast of the state of Morelos, Mexico, and 2) to estimate the association between the prevalence and severity of fluorosis, dental caries, and water F-?concentration. Methods: A hydrogeological model was developed to determine the vertical distribution of lithostratigraphic units, rocks’ hydraulic conductivities, and groundwater flow characteristics. A total of 649 schoolchildren from two communities received oral examinations. One community was located in an area with 0.75 mg F-/L in the water supply and the other in an area with 1.6 mg F-/L. Fluorosis was assessed using the Thylstrup & Fejerskov Index (TFI) and the dental caries were assessed with the decayed, missing, and filled teeth (DMFT) index. The region groundwater was extracted from an inter-granular aquifer consisting of volcano clasts of intermediate volcanic chemical composition. Results: Oral examinations showed that 32.35% of the children had severe forms of fluorosis (TFI ≥ 4) in the community with 1.60 mg F-/L and 7.8% in the 0.75 mg F-/L community (p < 0.0001). DMFT = 0.53 (±1.28) and 0.42 (±0.95) in the community with 1.60 mg F-/L and 0.75 mg F-/L, respectively (p = 0.2259). Conclusions: The increasing extraction of underground water was associated with deeper water flows and higher F-?concentration. In the community with high F-concentration, a third of the children showed objectionable levels of fluorosis. Adequate groundwater management actions are required to reduce fluorosis risk.

关键词： Fluoride Drinking Water Fluorosis Dental Caries México

一针注射疗法可减少猪群的应激,增加畜牧场的收益

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国外畜牧学（猪与禽） 2007年第3期27卷 42-43,70页

作者： alvaro Aldaz DVM 杨智满（摘译）舒畅（校）欧洲／非洲／中东 Pfizer动物保健公司猪市场部高级市场经理不详

毫无疑问,应激是影响肉食品动物生产一个重要因素。处于应激的动物对疾病更敏感,生产低质量的肉类产品,生长速度和生产性能很可能达不到其正常的指标。避免非必要的应激并不是仅仅对动物福利有利:它也能确保养猪场取得良好的商业利润。

关键词：应激畜牧场猪群疗法注射收益动物生产肉类产品

陆地卫星TM图像用于巴西中西部热液蚀变填图的评价

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黄金地质科技 1993年第4期 46-50页

作者： alvaro P.Crsta 张义彬曲家惠

本文介绍了陆地卫星TM图像用于非干旱或干旱环境中与金矿化有关的热液蚀变(绢英岩化型)填图。在分析研究区用TM图像进行热液蚀变填图具有干扰因素的情况下,采用“特征定向主成分选择”的主成分分析技术,对热液蚀变图像进行增强处理,之... 详细信息

本文介绍了陆地卫星TM图像用于非干旱或干旱环境中与金矿化有关的热液蚀变(绢英岩化型)填图。在分析研究区用TM图像进行热液蚀变填图具有干扰因素的情况下,采用“特征定向主成分选择”的主成分分析技术,对热液蚀变图像进行增强处理,之后进行增强解译,为确定蚀变带和圈定靶区提供了依据。

关键词：遥感 TM图像热液蚀变填图

Dietary patterns and risk of cervical cancer: a case-control study in Uruguay

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Open Journal of Obstetrics and Gynecology 2011年第2期1卷 25-30页

作者： Eduardo De Stefani Gisele Acosta Hugo Deneo-Pellegrini alvaro L. Ronco María Mendilaharsu Gabriel Landó María E. Luaces Cecilia Silva 不详

In the time period 1996-2004, a case-control study on diet and cervical cancer was conducted at the National Cancer Institute in Uruguay. The study included 268 cases and 536 controls with non-neoplastic diseases. The foods and beverages in the food-frequency questionnaire were included in a factor analytic model. This method retained three factors which were labeled as the drinker, red meat, and prudent patterns. The model explained 60% of the variance. Whereas the red meat and drinker patterns were directly associated with the risk of cervical cancer (OR for red meat pattern 1.79, 95% CI 1.12-2.86), on the other hand, the prudent pattern was inversely associated with cervical cancer (OR 0.60, 95% CI 0.38-0.93). To our knowledge, this study was the first one using factor analysis in order to elucidate the role of the diet in relation with cervical cancer.

关键词： Dietary Patterns Cervical Cancer

Organomineral Phosphorus Fertilization in the Production of Corn,Soybean and Bean Cultivated in Succession

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American Journal of Plant Sciences 2017年第10期8卷 2407-2421页

作者： Denize Carvalho Martins alvaro Vilela De Resende Joao Carlos Cardoso Galvao Eduardo De Paula Simao José Paulo Da Costa Ferreira Gabriela De Oliveira Almeida Department of Plant Science Federal University of VicosaVicosaBrazil Embrapa Maize and Sorghum Sete LagoasBrazil Federal University of Sao Joao Del Rei Sete LagoasBrazil

The use of organic waste in agriculture has been used aiming at greater productivity, decrease in the cost of production and sustainable use of resources. The present study aimed at evaluating the effect of phosphate fertilization with the maintenance of organomineral fertilizers, combining poultry manure and soluble or reactive phosphate, in the production of grains in corn culture and the residual effect for subsequent crops of beans and soybeans. The experiment was conducted in Sete Lagoas, MG, in 2015, using three fertilizers with sources of different phosphorus sources (triple super phosphate—STP, organomineral with STP and organomineral with Bayovar phosphate) applied at the doses of 65, 130, 195 and 260 kg·ha¯1 of P2O5 total, and compared to the control without phosphate fertilization. We evaluated the contents of foliar P, P accumulation in the grains, yields of corn grains, beans and soy, accumulated productivity and export of accumulated P of the three cultures. The three cultures assessed presented higher productivity when compared to the average of the factorial treatments that received phosphate fertilization relative to the control. Organomineral fertilizers increased grain production, obtaining average productivity equal to or greater than those obtained with the exclusive use of STP.

关键词： Reactive Phosphate Poultry Manure New Fertilizers

Bioequivalence Study of Two Hydrochlorothiazide Formulations after Oral Administration in Healthy Chilean Volunteers

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Journal of Pharmacy and Pharmacology 2016年第12期4卷 679-685页

作者： Fierro Humberto Rojas Romina Yanez Sebastian Acufia Paola Rosales Katherine Yevenes Paulina Yzoard Marcia Tapia Claudia Rivas Violeta Caba alvaro Copaja Miguel Jorge Fuentealba Center for Advanced Research on Biomedicine (CIAB-UdeC) University of Concepcion Concepcion 4070038 Chile Area Health and Safety AGQ Santiago 8590829 Chile Regional Hospital Guillermo Grant Benavente Concepcion 4070038 Chile Laboratory of Screening of Neuroactive Compounds Department of Physiology Faculty of Biological Sciences University ofConcepcion Concepcion 4070038 Chile

The study was carried out in healthy Chilean volunteers in order to compare the pharmacokinetics （rate and extent absorption） of two commercial oral formulations of 50 mg hydrochlorothiazide. Thirty nine subjects were administered hydrochlorothiazide tablets of test （T） and reference （R） formulation in a single blind, randomized, fasting, 2 × 2 crossover study, seven washout days. Blood samples were taken during a 48 h period after drug administration. Plasma concentrations were quantified by HPLC-MS/MS. The primary parameters log-transformed Cmax （maximum plasma concentration）, A UC0-t and A UC0-∞ （area under the plasma concentration-time curve from zero to the last time and zero to infinity） were tested for bioequivalence considering the ratios of geometric means （test/reference）; whereas tmax （the time of maximum plasma concentration） was analyzed nonparametrically. The 90% confidence intervals for the geometric mean values of test/reference ratios for Cmax, A UCo.t and A UC0-∞ were 95.37%, 93.59% and 96.34%, respectively, and were located within the bioequivalence acceptance range of 80-125%, as were tmax and elimination constants. Together, we conclude that the test formulation of the hydrochlorothiazide 50 mg tablet is bioequivalent to the reference product and suitable for generic prescription.

关键词： Bioequivalence hydrochlorothiazide interchangeable.

Carpal Tunnel Syndrome: A Marker for Amyloidosis

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World Journal of Neuroscience 2024年第3期14卷 92-101页

作者： Luciana León Cejas Miguel Saucedo Mayra Aldecoa Gustavo Teruya Fabricio Silva alvaro Muratore Gonzalo Viollaz Cintia Marchesoni Ana Pardal Pablo Dezanzo Alejandro Iotti Ricardo Reisin Neurology Department Hospital Britnico de Buenos Aires Buenos Aires Argentina Orthopedics Department Hospital Britnico de Buenos Aires Buenos Aires Argentina Pathology Department Hospital Britnico de Buenos Aires Buenos Aires Argentina

Introduction: Amyloidosis are systemic conditions and carpal tunnel syndrome (CTS) precedes the principal systemic complications and can be used as an early marker. Our objective was to determine the frequency of amyloid deposition in idiopathic CTS and its systemic impact. Methods: We retrospectively evaluated patients with CTS between September 2019 to January 2020. Samples from the anterior carpal ligament were pathologically evaluated and amyloid deposition was confirmed by apple-green birefringence on polarized light using Congo red stain. When amyloid was detected we performed genetic testing for transthyretin variants (ATTRv), immunofixation electrophoresis in serum and urine for light chains and multidisciplinary evaluation. Results: Thirty consecutive patients were included, 19 women, 11 men, mean age 70 years old (range 42 - 89 years). We identified 3 patients (10%) with amyloid deposits (mean age: 78.6 years, 2 men, 1 woman). Genetic testing for ATTRv and light chains studies were negative. During follow-up: The first patient required aortic valve replacement. The second patient developed progressive cardiac failure with syncopal episodes, atrioventricular block and atrial fibrillation and required a pacemaker and anticoagulation. The third patient had unexplained chronic edemas. The cardiac evaluation in all 3 patients revealed left ventricular hypertrophy and myocardial uptake (Perugini Score > 2) in their nuclear bone scintigraphies with technetium pyrophosphate. Two patients were treated with tafamidis and one patient died due to refractory cardiac insufficiency. Discussion: Our findings underline the importance of investigating amyloidosis in idiopathic CTS. The identification of deposits allows early diagnosis of cardiac amyloidosis leading to timely intervention and treatment.

关键词： Carpal Tunnel Amyloid Transthyretin Amyloid Cardiac Transthyretin Variants Light Chains