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Post-transplant biliary complications using liver grafts from deceased donors older than 70 years:Retrospective case-control study

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世界胃肠外科杂志:英文版(电子版) 2023年第8期15卷 1615-1628页

作者： Carlos Jimenez-Romero Iago Justo-Alonso Pilar del Pozo-Elso Alberto Marcacuzco-Quinto Cristina Martín-Arriscado-Arroba Alejandro Manrique-municio Jorge Calvo-Pulido alvaro García-Sesma Ricardo San Román Oscar Caso-Maestro Unit of HPB Surgery and Abdominal Organs Transplantation `12 de Octubre´University HospitalMadrid 28041Spain Clinical Research Unit(I+12) `12 de Octubre´University HospitalMadrid 28041Spain Department of Radiology `12 de Octubre´University HospitalMadrid 28041Spain

BACKGROUND The shortage of liver grafts and subsequent waitlist mortality led us to expand the donor pool using liver grafts from older *** To determine the incidence,outcomes,and risk factors for biliary complications(BC)in liver transplantation(LT)using liver grafts from donors aged>70 *** Between January 1994 and December 31,2019,297 LTs were performed using donors older than 70 *** excluding 47 LT for several reasons,we divided 250 LTs into two groups,namely post-LT BC(n=21)and without BC(n=229).This retrospective case-control study compared both *** Choledocho-choledochostomy without T-tube was the most frequent technique(76.2%in the BC group vs 92.6%in the non-BC group).Twenty-one patients(8.4%)developed BC(13 anastomotic strictures,7 biliary leakages,and 1 nonanastomotic biliary stricture).Nine patients underwent percutaneous balloon dilation and nine required a Rouxen-Y hepaticojejunostomy because of dilation *** incidence of post-LT complications(graft dysfunction,rejection,renal failure,and non-BC reoperations)was similar in both *** were no significant differences in the patient and graft survival between the ***,only three deaths were attributed to *** female donors were protective factors for BC,donor cardiac arrest was a risk *** The incidence of BC was relatively low on using liver grafts>70 *** could be managed in most cases by percutaneous dilation or Roux-en-Y hepaticojejunostomy,without significant differences in the patient or graft survival between the groups.

关键词： Older liver Liver transplant Biliary complications Biliary strictures Septuagenarian donors Octogenarian donors

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A Look at Sequential Normal Scores and How They Apply to Financial Data Analysis

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Journal of Applied Mathematics and Physics 2018年第4期6卷 787-816页

作者： W. J. Conover Víctor G. Tercero-Gomez alvaro E. Cordero-Franco Texas Tech University LubbockTexasUSA Tecnologico de Monterrey MonterreyMéxico Universidad Autonoma de Nuevo Leon MonterreyMéxico

Statistical methods for analyzing economic data need to be timely, accurate and easy to compute. To accomplish this, parametric models are often assumed, but they are at best approximate, and often lack a good fit in the tails of the distribution where much of the interesting data are concentrated. Therefore, nonparametric methods have been extensively examined as alternatives to the constrictive assumptions of parametric models. This paper examines the use of Sequential Normal Scores (SNS) for transforming time series data with unknown distributions into time series data that are approximately standard-normally distributed. Particular attention is directed toward detecting outliers (out-of-control values), and applying subsequent analytic methods such as CUSUMs and Exponentially Weighted Moving Average (EWMA) schemes. Two examples of stock market data are presented for illustration.

关键词： Sequential Analysis Sequential Ranks Transformation Extreme Values Outliers

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厨房的快乐时光

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现代装饰（家居） 2014年第7期 66-71页

作者： alvaro Uribe Design 伏平

电视主持人刘仪伟以其诙谐、幽默的语言主持了《我爱厨房》节目,自播出后广受观众的好评外,也让许多远离厨房的人从此爱上了烹饪。中国有句俗话,要想拴住男人的心就要先拴住他的胃,颇有几分道理。对于现代女性来说,会自己做饭的并不多,... 详细信息

电视主持人刘仪伟以其诙谐、幽默的语言主持了《我爱厨房》节目,自播出后广受观众的好评外,也让许多远离厨房的人从此爱上了烹饪。中国有句俗话,要想拴住男人的心就要先拴住他的胃,颇有几分道理。对于现代女性来说,会自己做饭的并不多,但一旦掌握这项本领,并将做饭当成一种情调来对待,无疑会为自己的魅力增色不少。尤其是如果和心爱的人一起下厨、一起品尝,对于两个人的感情也是一种很好的促进。

关键词：厨房厨艺家居空间家庭管理

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Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over

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World Journal of Gastroenterology 2018年第47期24卷 5391-5402页

作者： Oscar Caso-Maestro Carlos Jiménez-Romero Iago Justo-Alonso Jorge Calvo-Pulido David Lora-Pablos Alberto Marcacuzco-Quinto Félix Cambra-Molero alvaro García-Sesma Marina Pérez-Flecha Carlos munoz- Arce Carmelo Loinaz-Segurola Alejandro Manrique-municio Unit of HBP Surgery and Abdominal Organs Transplantation Department of General Surgery“12 de octubre” University HospitalMadrid 28041Spain Clinical Research Department Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP)“12 de octubre” University HospitalMadrid 28041Spain

AIM To increase the number of available *** This is a single-center comparative analysis performed between April 1986 and May 2016. Two hundred and twelve liver transplantation(LT) were performed with donors ≥ 70 years old(study group). Then, we selected the first cases that were performed with donors must be avoided in order to obtain the best results in LT with donors ≥ 70 years old.

关键词： Liver transplantation Aged donors Old donors Marginal donors Donor age

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突然死亡

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作者： (墨)阿尔瓦罗·恩里克(alvaro Enrigue)

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Axillary Lymph Node Metastasis of Colon Cancer—Case Report and Literature Review

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Case Reports in Clinical Medicine 2014年第12期3卷 669-673页

作者： Helena Devesa Luísa Pereira alvaro Goncalves Telma Brito Teresa Almeida Rui Torres Alberto Midoes Servico de Cirurgia Geral Unidade Local de Saúde do Alto MinhoViana do CasteloPortugal

The most common metastatic sites of colon cancer are local lymph nodes, liver and lungs. Lymph node metastasis at distant sites is rare. In this article, we describe the case of a patient with ascending colon cancer with a metastasis in an axillary lymph node. The clinical presentation of this tumor was with an intestinal obstruction, and an emergency resection surgery was undertaken. The patient died at the third post-operative month, with lymph node and hepatic metastasis, and implants in the abdominal fat and in the mesentery, near the ileocolic anastomosis.

关键词： Lymphangioleiomyomatosis Everolimus Angiomyolipoma Lung Transplant

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遗忘的终结

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新东方英语（中英文版） 2017年第11期 48-52页

作者： alvaro Dominguez 何方琳

当约书亚叔叔（彼得·德弗里斯1959年的小说《邪恶的帐篷》中的人物）说，回忆“已跟过去不同了”，他说这话是想达到幽默的效果：他想告诉沉浸于过去的人，没有什么能够经受时间的考验，即便是记忆本身也不行。不过，约书亚叔叔的话已... 详细信息

当约书亚叔叔（彼得·德弗里斯1959年的小说《邪恶的帐篷》中的人物）说，回忆“已跟过去不同了”，他说这话是想达到幽默的效果：他想告诉沉浸于过去的人，没有什么能够经受时间的考验，即便是记忆本身也不行。不过，约书亚叔叔的话已相当过时了：虽然技术在一往无前地朝着未来前进，但也不断改变着我们看待过去的方式。

关键词：遗忘 1959年邪恶彼得时间记忆

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Two disulfide mutants in domain I of <i>Bacillus thuringiensis</i>Cry3Aa δ-endotoxin increase stability with no effect on toxicity

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Advances in Biological Chemistry 2012年第2期2卷 123-131页

作者： Sheng-Jiun Wu alvaro M. Florez Bradley J. Homoelle Donald H. Dean Oscar Alzate Biochemistry Department Ohio State University Columbus USA Department of Cell and Developmental Biology University of North Carolina Chapel Hill USA Laboratorio de Biología Molecular y Biotecnología Facultad de Medicina Universidad de Santander (UDES) Campus Univer- sitario Bucaramanga Colombia

To increase protein stability and test protein function, three double-cysteine mutations were individually introduced by protein engineering into the cysteine-free Cry3Aa δ-endotoxin from Bacillus thuringiensis. These mutations were designed to create disulfide bonds between α-helices 2 and 5 (positions 110 - 193), and α-helices 5 and 7 (positions 195 - 276 and 198 - 276). Comparison of the CD spectra of the wild-type and the double-cysteine mutant proteins indicates a tighter helical packing consistent with formation of at least two of the disulfide bonds between the central and the outer helices. Thermal stability analysis indi-cates that potential covalent linkages between the central α-helix 5 and the other helices increase resistance to thermal denaturation by 10?C to 14?C com-pared to the thermal stability of the wild-type protein. Spectroscopic analysis of the disulfide-specific absorbance band indicates that the double mutant proteins are more stable to temperature and denaturant (guanidine hydrochloride) than the wild-type protein, as a result of the formation of two of the disulfide bridges. These results indicate that the double muta-tions M110C/F193C and A198C/V276C successfully established disulfide bonds, resulting in a more stable structure of the entire toxin. Despite the increase in stability and structural changes introduced by the disulfide bonds, no effect on toxicity was observed. A possible mechanism involving the insertion of all of domain I of Cry3Aa toxin into the target membrane accounts for these observations.

关键词： Disulfide Bonds CD Spectra Cry3Aa Site Directed mutagenesis

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Implementation of an enhanced recovery after surgery protocol for head and neck cancer patients:Considerations and best practices

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第2期8卷 91-95页

作者： Aman Prasad Kevin Chorath Louis-Xavier Barrette Beatrice Go Jie Deng alvaro Moreira Karthik Rajasekaran Perelman School of Medicine University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Otorhinolaryngology-Head and Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA School of Nursing Laboratory of Innovative&Translational Nursing ResearchUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Pediatrics University of Texas Health San AntonioSan AntonioTexasUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Enhanced recovery after surgery(ERAS)protocols have been developed in numerous surgical specialties as a means of systematically improving patient recovery,functional outcomes,cost savings,and resource *** multidisciplinary initiatives seek to minimize variability in several aspects of perioperative patient care,helping to reduce inpatient length of hospital stay,complications,and the overall resource and financial burden of surgical *** and neck oncology patients stand to benefit from the implementation of comprehensive ERAS protocols,as these patients have complex medical needs that may dramatically impact multiple aspects of their recovery,including breathing,eating,nutrition,pain,speech,swallowing,and *** ERAS protocols for head and neck cancer patients may present unique challenges,and require significant interdisciplinary coordination and *** therefore sought to provide a comprehensive guide to the planning and institution of such ERAS systems at institutions undertaking care of head and neck cancer *** elements to consider in the implementation of successful ERAS protocols for this population include organizing a team consisting of frontline leaders such as nursing staff,medical specialists,and associated health professionals;designing interventions based on systematically evaluated,high-quality literature;and instituting a clear methodology for regularly updating protocols and auditing the success or potential limitations of a given *** obstacles to the success of ERAS interventions for head and neck cancer patients include challenges in systematically tracking progress of the protocol,as well as resource limitations in a given health system.

关键词： enhanced recovery after surgery ERAS head and neck oncology quality improvement

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Range-Doppler image processing in linear FMCW radar and FPGA based real-time implementation

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通讯和计算机（中英文版） 2009年第4期6卷 55-59页

作者： WANG Zong-bo Javier Carretero Moya alvaro Blanco del Campo Javier Glsmero Menoyo GAO Mei-guo Department of Electronic Engineering Beijing Institute of Technology Beijing 100081 China Department of Signals Systems and Radio Communications Universidad Politecnica de Madrid 28040 Spain

The paper introduces an FPGA based signal processing system to perform Range-Doppler processing in real-time for Linear FMCW (frequency Modulated Continuous Wave) radar systems. Novel design architecture in FPGA is proposed and experimental results indicate that the design can verify the correct operation of the processing flow. The Ping-Pang architecture in FPGA saves the resources in chip and the system has been designed so as to allow future addition of complex target detection algorithms.

关键词： FPGA执行实时系统多普勒过程 LFMCW雷达

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