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Gender analysis of the top classic papers in otolaryngology head and neck surgery

World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 160-167页

作者： Beatrice Go Neeraj Suresh Cammille Go Kevin Chorath Natasha Mirza Erica Thaler alvaro moreira Karthik Rajasekaran Department of Otorhinolaryngology University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Perelman School of Medicine University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Pediatrics Division of NeonatologyThe University of Texas Health Science Center at San AntonioSan AntonioTexasUSA

Objective:The aim of this study was to identify and analyze the gender breakdown of first authorship contributing to the most-cited papers in the field of otolaryngology,with a goal of identifying trends in gender representation in ***:The top 150 most-cited papers were identified using the Science Citation Index of the Institute for Scientific *** the first authors,gender,h-index,percentage of first,last,and corresponding authorship positions,total publications,and citations were ***:The majority of papers were in the English language,from the United States,of clinical nature,and on otologic ***-one percent of papers(n=122)had men who were first authors,although there was no difference inh-index score,authorship position,number of publications,citations,and average citations/year between men and women first *** subgroup analysis by decade(1950s-2010s),there was no difference in the number of articles by women first authors(P=0.11);however,there was a statistically significant increase in the percentage of women authors(P=0.001)in papers published later compared to those published ***:While a promising number of women otolaryngologists are publishing high-powered articles,future initiatives to promote academic inclusivity of women should be considered.

关键词： authorship bibliometrics citations gender otolaryngology publications

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Nonopioid perioperative analgesia in head and neck cancer surgery:A systematic review

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第2期8卷 107-117页

作者： Beatrice C.Go Cammille C.Go Kevin Chorath alvaro moreira Karthik Rajasekaran Department of Otorhinolaryngology University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Perelman School of Medicine University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Pediatrics Division of NeonatologyUniversity of Texas Health-San AntonioSan AntonioTexasUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:Management of postoperative pain after head and neck cancer surgery is a complex issue,requiring a careful balance of analgesic properties and side *** objective of this review is to discuss the efficacy and safety of multimodal analgesia(MMA)for these ***:Pubmed,Cochrane,Embase,Scopus,and *** were systematically searched for all comparative studies of patients receiving MMA(nonsteroidal anti-inflammatory drugs(NSAIDs),acetaminophen,anticonvulsants,local anesthetics,and corticosteroids)for head and neck cancer *** primary outcome was additional postoperative opioid usage,and secondary outcomes included subjective pain scores,complications,adverse effects,and 30-day ***:A total of five studies representing 592 patients(MMA,n=275;non-MMA,n=317)met inclusion *** most commonly used agents were gabapentin,NSAIDs,and acetaminophen(n=221),NSAIDs(n=221),followed by corticosteroids(n=35),dextromethorphan(n=40),and local nerve block(n=19).Four studies described a significant decrease in overall postoperative narcotic usage with two studies reporting a significant decrease in hospital *** pain scores widely varied with two studies reporting reduced pain at postoperative day *** were no differences in surgical outcomes,medical complications,adverse effects,or 30-day mortality and readmission ***:MMA is an increasingly popular strategy that may reduce dependence on opioids for the treatment of postoperative pain.A variety of regimens and protocols are available for providers to utilize in the appropriate head and neck cancer patient.

关键词： analgesia head and neck neoplasm NSAID opioids pain management

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Enhanced recovery after surgery protocols for outpatient operations in otolaryngology:Review of literature

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第2期8卷 96-106页

作者： Kevin Chorath Sara Hobday Neeraj V.Suresh Beatrice Go alvaro moreira Karthik Rajasekaran Department of Otorhinolaryngology University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Pediatrics University of Texas Health-San AntonioSan AntonioTexasUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:Enhanced recovery after surgery(ERAS)protocols are patient-centered,evidence-based pathways designed to reduce complications,promote recovery,and improve outcomes following *** protocols have been successfully applied for the management of head and neck cancer,but relatively few studies have investigated the applicability of these pathways for other outpatient procedures in *** goal was to perform a systematic review of available evidence reporting the utility of ERAS protocols for the management of patients undergoing outpatient otolaryngology ***:A systematic literature review was conducted using MEDLINE,EMBASE,SCOPUS,and gray *** identified studies that evaluated ERAS protocols among patients undergoing otologic,laryngeal,nasal/sinus,pediatric,and general otolaryngology *** assessed the outcomes and ERAS components across protocols as well as the study design and ***:A total of eight studies fulfilled the inclusion criteria and were included in the *** of procedures evaluated with ERAS protocols included tonsillectomy and adenoidectomy,functional endoscopic sinus surgery,tympanoplasty and mastoidectomy,and septoplasty.A reduction in postoperative length of stay and hospital costs was reported in two and three studies,*** studies between ERAS and control groups showed persistent improvement in pre-and postoperative anxiety and pain levels,without an increase in postoperative complications and readmission ***:A limited number of studies discuss implementation of ERAS protocols for outpatient operations in *** clinical pathways appear promising for these procedures as they may reduce length of stay,decrease costs,and improve pain and anxiety postoperatively.

关键词： enhanced recovery after surgery otolaryngology outpatient surgery patient safety PSQI

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Implementation of an enhanced recovery after surgery protocol for head and neck cancer patients:Considerations and best practices

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第2期8卷 91-95页

作者： Aman Prasad Kevin Chorath Louis-Xavier Barrette Beatrice Go Jie Deng alvaro moreira Karthik Rajasekaran Perelman School of Medicine University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Otorhinolaryngology-Head and Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA School of Nursing Laboratory of Innovative&Translational Nursing ResearchUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Pediatrics University of Texas Health San AntonioSan AntonioTexasUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Enhanced recovery after surgery(ERAS)protocols have been developed in numerous surgical specialties as a means of systematically improving patient recovery,functional outcomes,cost savings,and resource *** multidisciplinary initiatives seek to minimize variability in several aspects of perioperative patient care,helping to reduce inpatient length of hospital stay,complications,and the overall resource and financial burden of surgical *** and neck oncology patients stand to benefit from the implementation of comprehensive ERAS protocols,as these patients have complex medical needs that may dramatically impact multiple aspects of their recovery,including breathing,eating,nutrition,pain,speech,swallowing,and *** ERAS protocols for head and neck cancer patients may present unique challenges,and require significant interdisciplinary coordination and *** therefore sought to provide a comprehensive guide to the planning and institution of such ERAS systems at institutions undertaking care of head and neck cancer *** elements to consider in the implementation of successful ERAS protocols for this population include organizing a team consisting of frontline leaders such as nursing staff,medical specialists,and associated health professionals;designing interventions based on systematically evaluated,high-quality literature;and instituting a clear methodology for regularly updating protocols and auditing the success or potential limitations of a given *** obstacles to the success of ERAS interventions for head and neck cancer patients include challenges in systematically tracking progress of the protocol,as well as resource limitations in a given health system.

关键词： enhanced recovery after surgery ERAS head and neck oncology quality improvement

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Monoclonal antibodies and aptamers:The future therapeutics for Alzheimer’s disease

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2795-2814页

作者： alvaro Barrera-Ocampo Facultad de Ingenierıa Diseno y Ciencias AplicadasDepartamento de Ciencias Farmaceuticas y QuimicasGrupo NaturaUniversidad IcesiCali 760031Colombia

Alzheimer’s disease(AD)is considered the most common and prevalent form of dementia of adult-onset with characteristic progressive impairment in cognition and *** cure for AD has not been found yet and the treatments available until recently were only *** of multidisciplinary approaches and efforts made by pharmaceutical companies,it was only in the past two years that new drugs were approved for the treatment of the *** beta(Aβ)immunotherapy is at the core of this therapy,which is one of the most innovative approaches looking to change the course of *** technology is based on synthetic peptides or monoclonal antibodies(mAb)to reduce Ab levels in the brain and slow down the advance of ***,this article reviews the state of the art about AD neuropathogenesis,the traditional pharmacologic treatment,as well as the modern active and passive immunization describing approved drugs,and drug prototypes currently under investigation in different clinical *** addition,future perspectives on immunotherapeutic strategies for AD and the rise of the aptamer technology as a non-immunogenic alternative to curb the disease progression are discussed.

关键词： Aβ Monoclonal antibody DNA aptamers Cognitive impairment Alzheimer’s disease Clinical trials Immunotherapy Machine learning

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Smoothed particle hydrodynamics based numerical study of hydroplaning considering permeability characteristics of runway surface

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 319-333页

作者： Yang YANG Xingyi ZHU Denis JELAGIN alvaro GUARIN Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 200092China Auto Engineering Research Institute BYD Auto Industry Company LimitedShenzhen 518118China Department of Civil and Architectural Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden

The presence of water films on a runway surface presents a risk to the landing of *** tire of the aircraft is separated from the runway due to a hydrodynamic force exerted through the water film,a phenomenon called *** a lot of numerical investigations into hydroplaning have been conducted,only a few have considered the impact of the runway ***,computational problems,such as excessive distortion and computing efficiency decay,may arise with such numerical models when dealing with the thin water *** paper presents a numerical model comprising of the tire,water film,and the interaction with the runway,applying a mathematical model using the smoothed particle hydrodynamics and finite element(SPH-FE)*** material properties and geometric features of the tire model were included in the model framework and water film thicknesses from 0.75 mm to 7.5 mm were used in the numerical ***,this work investigated the impacts of both surface texture and the runway *** interaction between tire rubber and the rough runway was analyzed in terms of frictional force between the two *** SPH-FE model was validated with an empirical equation proposed by the National Aeronautics and Space Administration(NASA).Then the computational efficiency of the model was compared with the traditional coupled Eulerian-Lagrangian(CEL)*** on the SPH-FE model,four types of the runway(Flat,SMA-13,AC-13,and OGFC-13)were *** simulation of the asphalt runway shows that the SMA-13,AC-13,and OGFC-13 do not present a hydroplaning risk when the runway permeability coefficient exceeds 6%.

关键词： SPH-FE approach hydroplaning numerical simulation surface texture runway surface reconstruction

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Multiple scales method for analyzing a forced damped rotational pendulum oscillatorwithgallows

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Communications in Theoretical Physics 2024年第5期76卷 58-67页

作者： Haifa A Alyousef alvaro H Salas B M Alotaibi S A El-Tantawy Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Mathematics and Statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Department of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research Center for Physics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

This study reports the analytical solution for a generalized rotational pendulum system with gallows and periodic excited *** multiple scales method(MSM)is applied to solve the proposed *** types of rotational pendulum oscillators are studied and talked about in *** include the forced damped rotating pendulum oscillator with gallows,the damped standard simple pendulum oscillator,and the damped rotating pendulum oscillator without *** MSM first-order approximations for all the cases mentioned are derived in *** obtained results are illustrated with concrete numerical *** first-order MSM approximations are compared to the fourth-order Runge-Kutta(RK4)numerical ***,the maximum error is estimated for the first-order approximations obtained through the MSM,compared to the numerical approximations obtained by the RK4 ***,we conducted a comparative analysis of the outcomes obtained by the used method(MSM)and He-MSM to ascertain their respective levels of *** proposed method can be applied to analyze many strong nonlinear oscillatory equations.

关键词： rotational pendulum system multiple scales method approximate solution damped oscillations forced pendulum with gallows he-multiple scales method

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Pancreatic neuroendocrine tumors:Are tumors smaller than 2 cm truly indolent?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1756-1762页

作者： Sergio Hoyos Pablo Posada-Moreno Natalia Guzman-Arango Romario Chanci-Drago Jaime Chavez alvaro Andrés-Duarte Santiago Salazar-Ochoa Hepatobilary and Liver Transplant Unit Hospital Pablo Tobon Uribe and Gastrohepathology Group Universidad de AntioquiaMedellin 050034AntioquiaColombia Department of General Surgery Universidad Pontificia BolivarianaMedellín 050034AntioquiaColombia

BACKGROUND Pancreatic neuroendocrine tumors(PNETs)are relatively rare but rank as the second most common pancreatic *** can be functional,causing early metabolic disturbances due to hormone secretion,or non-functional and diagnosed later based on tumor size-related *** diagnoses of PNETs under 2 cm in size have sparked debates about their management;some practitioners advocate for surgical removal and others suggest observation due to the tumors’lower potential for ***,it is unclear whether managing these small tumors expectantly is truly *** To evaluate poor prognostic factors in PNETs based on tumor size(>2 cm or<2 cm)in surgically treated *** This cohort study included 64 patients with PNETs who underwent surgical resection between 2006 and 2019 at a high-complexity reference hospital in Medellín,*** assess patient survival,quarterly follow-ups were conducted during the first year after surgery,followed by semi-annual con-sultations at the hospital's hepatobiliary surgery *** variables were described using absolute and relative frequencies,and quantitative variables were expressed using measures of central tendency and their corresponding measures of *** The presence of lymph node involvement,neural involvement,and lymphovascular invasion were all associated with an increased risk of mortality,with hazard ratios of 5.68(95%CI:1.26–25.61,P=0.024),6.44(95%CI:1.43–28.93,P=0.015),and 24.87(95%CI:2.98–207.19,P=0.003),*** involvement and lymphovascular invasion were present in tumors smaller than 2 cm in diameter and those larger than 2 cm in *** recurrence rates between the two tumor groups were furthermore similar:18.2%for tumors smaller than 2 cm and 21.4%for tumors larger than 2 *** survival was additionally comparable between the two tumor *** Tumor size does not dictate prognosis;lymph node and lymphovascular involvement a

关键词： Neuroendocrine tumor Pancreatic neoplasm Pancreas Pancreatic neuroendocrine neoplasm Pancreatic neuroendocrine tumors

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Quantum-mechanical effects in photoluminescence from thin crystalline gold films

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Light(Science & Applications) 2024年第4期13卷 783-794页

作者： Alan R.Bowman alvaro Rodríguez Echarri Fatemeh Kiani Fadil Iyikanat Ted V.Tsoulos Joel D.Cox Ravishankar Sundararaman F.Javier García de Abajo Giulia Tagliabue Laboratory of Nanoscience for Energy Technologies(LNET) STIÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland ICFO–Institut de Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)Spain. MBI–Max-Born-Institut BerlinGermany. POLIMA–Center for Polariton-driven Light–Matter Interactions University of Southern DenmarkOdense MDenmark. Danish Institute for Advanced Study University of Southern DenmarkOdense MDenmark. Department of Materials Science&Engineering Rensselaer Polytechnic InstituteTroyNYUSA. Department of Physics Applied Physicsand AstronomyRensselaer Polytechnic InstituteTroyNYUSA. ICREA–Institucio Catalana de Recerca i Estudis Avancats BarcelonaSpain

Luminescence constitutes a unique source of insight into hot carrier processes in metals,including those in plasmonic nanostructures used for sensing and energy ***,being weak in nature,metal luminescence remains poorly understood,its microscopic origin strongly debated,and its potential for unraveling nanoscale carrier dynamics largely ***,we reveal quantum-mechanical effects in the luminescence emanating from thin monocrystalline gold ***,we present experimental evidence,supported by first-principles simulations,to demonstrate its photoluminescence origin(i.e.,radiative emission from electron/hole recombination)when exciting in the interband *** model allows us to identify changes to the measured gold luminescence due to quantum-mechanical effects as the gold film thickness is ***,such effects are observable in the luminescence signal from flakes up to 40 nm in thickness,associated with the out-of-plane discreteness of the electronic band structure near the Fermi *** qualitatively reproduce the observations with first-principles modeling,thus establishing a unified description of luminescence in gold monocrystalline flakes and enabling its widespread application as a probe of carrier dynamics and light-matter interactions in this *** study paves the way for future explorations of hot carriers and charge-transfer dynamics in a multitude of material systems.

关键词： luminescence quantum crystalline

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Potential role of transmembrane 9 superfamily member 1 as a biomarker in urothelial cancer

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World Journal of Clinical Oncology 2024年第8期15卷 965-967页

作者： alvaro Pinto Abrahams Ocanto Felipe Couñago Department of Medical Oncology University Hospital La PazPaseo Castellana 261Madrid 28046Spain Department of Radiation Oncology GenesisCareHospital Universitario San Francisco de AsísMadrid 28002Spain Department of Radiation Oncology GenesisCareVithas La Milagrosa University HospitalMadrid 28010Spain National Director GenesisCare Madrid 28043Spain

Bladder cancer is a urological tumor with high rates of recurrence despite recent advances in novel *** proteins involved in the molecular mechanisms are currently an enigma,especially the transmembrane 9 superfamily member 1 which has an unclear *** et al published the function and mechanism of this protein,and showed that it could participate in the proliferation,migration and invasion of tumor cells in bladder cancer,therefore treatments directed against this protein may be beneficial in avoiding this condition.

关键词： Bladder cancer Transmembrane 9 superfamily member 1 Biomarker Urothelial cancer Protein

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