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Indirect determination of shear wave velocity in slow formations using full-wave sonic logging technique

Journal of Rock Mechanics and Geotechnical Engineering 2020年第6期12卷 1226-1233页

作者： Francisco Beltran alvaro Yañez-gonzalez María J.Crespo Belgar Engineering Consultants Gabriel García Márquez 9Collado-Villalba28400Spain ESTEYCO Menéndez Pidal 17Madrid28036Spain Principia Engineering Consuxltants Velázquez 94Madrid28006Spain

This article presents a case study concerning a seismic characterization ***-wave sonic logging was used to characterize the shallow compressional wave and shear wave velocity profiles in the *** values of the Poisson’s ratio derived from the velocity profiles suggested that the boreholes might have traversed slow formations(*** shear wave velocity smaller than the borehole fluid compressional wave velocity or“mud-wave speed”)and that conventional processing of the sonic logs might have misinterpreted the direct arrivals of fluid acoustic waves as arrivals caused by shear wave propagation in the ***,the shear wave velocity profiles provided by the contractor were considered to be unreliable by the project *** address these problems,a non-conventional determination of the shear wave velocity was implemented,based on the relationship between the Poisson’s ratio of the rock formation and the shape of the first train of sonic waves which arrived to the receivers in the sonic *** relationship was determined based on several hundreds of finite element simulations of the acoustic wave propagation in boreholes with the same diameter as used in the *** present article describes how this non-conventional approach was developed and implemented to obtain the shear wave velocity profiles from the raw sonic *** approach allows an extension of the range of applicability of full-wave sonic logging to determination of shear wave velocity profiles in formations with low compressional wave *** method could be used to obtain shear wave velocity profiles where compressional wave velocity is as low as slightly larger than the mud-wave speed.A sample sonic log in Log ASCII Standard(LAS)format is provided as supplementary material to this paper via Mendeley Data,together with the FORTRAN source code used to process the log following the approach described in this study.

关键词： Sonic logging Slow formation Shear wave velocity Poisson’s ratio P-wave packet

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Immunotherapy and immunoescape in colorectal cancer

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World Journal of Gastroenterology 2007年第44期13卷 5822-5831页

作者： Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia alvaro gonzalez Ignacio Melero Liver Unit Facultad de Ciencias Biomédicas Universidad Austral Presidente Perón 1500 (1635) Derqui-Pilar Buenos Aires Argentina Centro de Investigación Médica Aplicada and Clínica Universitaria Universidad de Navarra Pamplona Spain

Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.

关键词： Colorectal carcinoma Immunotherapy Gene therapy interleukin-12 Dendritic cells CD137 indoleamine 2, 3 dioxygenase

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Diagnostic Yield of Non-Invasive Testing in Patients with Anomalous Aortic Origin of Coronary Arteries:A Multicentric Experience

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Congenital Heart Disease 2022年第4期17卷 375-385页

作者： Alberto Cipriani Pietro Bernardo Dall’Aglio Laura Mazzotta Domenico Sirico George Sarris Mark Hazekamp Thierry Carrel Alessandro Frigiola Vladimir Sojak Mauro Lo Rito Jurgen Horer Regine Roussin Julie Cleuziou Bart Meyns Jose Fragata Helena Telles Anastasios C.Polimenakos Katrien Francois Altin Veshti Jukka Salminen alvaro gonzalez Rocafort Matej Nosal Eleftherios Protopapas Roberto Tumbarello Patrizio Sarto Cinzia Pegoraro Raffaella Motta Giovanni Di Salvo Domenico Corrado Vladimiro LVida Massimo A.Padalino Department of Cardio-Thoracic Vascular Sciences and Public HealthUniversity of PadovaPadovaItaly Department of Woman and Child’s Health Pediatric CardiologyUniversity of PadovaPadovaItaly Athens Heart Surgery Institute and Iaso Children’s Hospital AthensGreece Department for Cardiovascular Surgery University Medical CenterLeidenThe Netherlands Department for Cardiovascular Surgery University Hospital BernBernSwitzerland Department of Congenital Cardiac Surgery IRCCS Policlinico San DonatoSan Donato MilaneseItaly Department of Pediatric Cardiology and Congenital Heart Disease Hôpital Marie LannelongueUniversitéParis-SudLe Plessis-RobinsonFrance Deutsch Herz Zentrum MunichGermany Katholieke Universiteit Leuven LeuvenBelgium Cardiothoracic Surgery Hospital de Santa Marta Rua LisbonPortugal Department of Pediatric Cardiothoracic Surgery Children’s Hospital of GeorgiaGeorgiaUSA Department of Cardiac Surgery University Hospital GhentGhentBelgium Division of Cardiac Surgery University Hospital Center of TiranaTiranaAlbania Department of Pediatric Cardiac Surgery Hospital for Children and AdolescentsUniversity of HelsinkiHelsinkiFinland Congenital Cardiac Surgery Department Hospital Universitario La PazMadridSpain Department of Pediatric Cardiac Surgery National Institute of Cardio-Vascular Diseases-Children’s Heart CenterBratislavaSlovakia Division of Pediatric Cardiology Ospedale BrotzuCagliariItaly Division of Sport Medicine Ospedale Ca’FoncelloTrevisoItaly Department of Medicine Radiology ClinicUniversity of Padua Medical SchoolPadovaItaly

Background:Anomalous aortic origin of a coronary artery(AAOCA)is a congenital heart disease with a 0.3%−0.5%*** is challenging due to nonspecific clinical *** stratification and treatment are currently based on expert consensus and single-center case ***:Demographical and clinical data of AAOCA patients from 17 tertiary-care centers were *** imaging studies(Bidimensional echocardiography,coronary computed tomography angiography[CCTA]were *** correlations with anomalous coronary course and origin were ***:Data from 239 patients(42%males,mean age 15 y)affected by AAOCA were collected;154 had AAOCA involving the right coronary artery(AAORCA),62 the left(AAOLCA),23 other anomalies.211(88%)presented with an inter-arterial *** electrocardiogram(ECG)was abnormal in 37(16%).AAOCA was detected by transthoracic echocardiography and CCTA in 53%and 92%of patients,*** of the patients reported cardiac symptoms(119/239;50%),mostly during exercise in 121/178(68%).An ischemic response was demonstrated in 37/106(35%)and 16/31(52%)of patients undergoing ECG stress test and stress-rest single positron emission cardiac *** with AAORCA,patients with AAOLCA presented more frequently with syncope(18%vs.5%,P=0.002),in particular when associated with inter-arterial course(22%vs.5%,P<0.001).Conclusion:Diagnosis of AAOCA is a clinical challenge due to nonspecific clinical presentations and low sensitivity of first-line cardiac screening *** seems to be strictly correlated to AAOLCA with inter-arterial course.

关键词： Anomalous coronary arteries congenital echocardiography coronary computed tomography angiography

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Cardiovascular impact of COVID-19 with a focus on children: A systematic review

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World Journal of Clinical Cases 2020年第21期8卷 5250-5283页

作者： Moises Rodriguez-gonzalez Ana Castellano-Martinez Helena Maria Cascales-Poyatos alvaro Antonio Perez-Reviriego Pediatric Cardiology Division Puerta del Mar University HospitalCadiz 11009Spain Biomedical Research and Innovation Institute of Cadiz Puerta del Mar University HospitalCadiz 11009Spain Pediatric Nephrology Division Puerta del Mar University HospitalCadiz 11009Spain Pediatrics Division Motril-San Antonio Primary Care CenterMotril 18600Spain Pediatrics Division UGC Pediatria AG Sur GranadaSanta Ana HospitalMotril 18600Spain

BACKGROUND Since the beginning of the pandemic,coronavirus disease-2019(COVID-19)in children has shown milder cases and a better prognosis than *** the respiratory tract is the primary target for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),cardiovascular involvement is emerging as one of the most significant and life-threatening complications of SARS-CoV-2 infection in *** To summarize the current knowledge about the potential cardiovascular involvement in pediatric COVID-19 in order to give a perspective on how to take care of them during the current pandemic *** Multiple searches in MEDLINE,PubMed were performed using the search terms“COVID-19”or“SARS-CoV-2"were used in combination with“myocardial injury”or"arrhythmia"or“cardiovascular involvement”or"heart disease"or"congenital heart disease"or“pulmonary hypertension”or"long QT"or“cardiomyopathies”or“channelopathies”or"Multisystem inflammatory system"or"PMIS"or“MIS-C”or”Pediatric multisystem inflammatory syndrome"or"myocarditis"or"thromboembolism to identify articles published in English language from January 1st,2020 until July 31st,*** websites of World Health Organization,Centers for Disease control and Prevention,and the Johns Hopkins Coronavirus Resource Center were reviewed to provide up to date numbers and infection control *** lists from the articles were reviewed to identify additional pertinent *** manuscripts concerning the subject were reviewed by the authors,and the data were extracted using a standardized collection *** were subsequently analyzed with descriptive *** Pediatric multisystemic inflammatory syndrome temporally associated with COVID-19(PMIS),multiple meta-analyses were conducted to summarize the pooled mean proportion of different cardiovascular variables in this population in pseudo-cohorts of observed *** A total of 193 articles were *** publications used in

关键词： COVID-19 SARS-CoV-2 Congenital heart diseases Myocardial dysfunction Pediatric Multisystem Inflammatory Syndrome Cardiac Biomarkers

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Effectiveness of dry needling on reducing pain intensity in patients with myofascial pain syndrome： a Meta-analysis

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Journal of Traditional Chinese Medicine 2016年第1期36卷 1-13页

作者： Juan Rodriguez-Mansilla Blanca gonzalez-Sanchez alvaro De Toro Garcia Enrique Valera-Donoso Elisa Maria Garrido-Ardila Maria Jimenez-Palomares Maria Victoria gonzalez Lopez-Arza Department of Medicine and Surgery University of Extremadura School of MedicineAdolor Research Group of the University of ExtremaduraBadajoz 06006Spain IMC Physiotherapy clinic Department of Physiotherapy.Caceres 10001Spain Physical and Rehabilitation Medicine Department Complutense University School of MedicineMadrid 28040Spain

OBJECTIVE: To summarize the literature about the effectiveness of dry needling(DN) on relieving pain and increasing range of motion(ROM) in individuals with myofascial pain syndrome(MPS).METHODS: Papers published from January 2000 to January 2013 were identified through an electronic search in the databases MEDLINE, Dialnet, Cochrane Library Plus, Physiotherapy Evidence Database(PEDro) and Spanish Superior Council of Scientific Research(CSIC). The studies included were randomized controlled trials written in English and/or Spanish about the effectiveness of DN on pain and ROM in individuals with ***: Out of 19 clinical trials that were potentially relevant, a total of 10 were included in the Meta-analysis. Regarding pain intensity reduction when measured before and immediately after the intervention, DN achieved improvement compared with the placebo treatment [d =-0.49; 95% CI(-3.21, 0.42)] and with the control group [d =-9.13;95% CI(- 14.70,- 3.56)]. However, other treatments achieved better results on the same variable compared with DN, considering the measurements for pre-treatment and immediately after [d = 2.54;95% CI(-0.40, 5.48)], as well as the pre-treatment and after 3-4 weeks [d = 4.23; 95% CI(0.78, 7.68)].DN showed a significantly increased ROM when measured before the intervention and immediately after, in comparison with the placebo [d = 2.00;95% CI(1.60, 2.41)]. However, other treatments achieved a significant better result regarding ROM when it was measured before the intervention and immediately after, as compared with DN [d =-1.42;95% CI(-1.84,-0.99)].CONCLUSION: DN was less effective on decreasing pain comparing to the placebo group. Other treatments were more effective than DN on reducing pain after 3-4 weeks. However, on increasing ROM,DN was more effective comparing to that of placebo group, but less than other treatments.

关键词： Dry needling Myofascial pain syndromes Rehabilitation Meta-analysis

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Culturable aerobic and facultative bacteria from the gut of the polyphagic dung beetle Thorectes lusitanicus

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Insect Science 2015年第2期22卷 178-190页

作者： Noemi Hernandez Jose A. Escudero alvaro San Millan Bruno gonzalez-Zorn Jorge M. Lobo Jose R. Verdu Monica Suarez Department Sanidad Animal Facultad de Veterinaria Universidad Complutense de Madrid Avenida Puerta de Hierro sin Madrid CP28040 Department Biogeografia y Cambio Global Museo Nacional de Ciencias Naturales CSIC Jose Gutierrez Abascal 2 Madrid28006 I.U.I. CIBIO (Centro Iberoamericano de la Biodiversidad) Universidad de Alicante Carretera de San Vicente del Raspeigsin Alicante 03080 Spain

Unlike other dung beetles, the Iberian geotrupid, Thorectes lusitanicus, exhibits polyphagous behavior; for example, it is able to eat acorns, fungi, fruits, and carrion in addition to the dung of different mammals. This adaptation to digest a wider diet has physiological and developmental advantages and requires key changes in the composition and diversity of the beetle＇s gut microbiota. In this study, we isolated aerobic, facultative anaerobic, and aerotolerant microbiota amenable to grow in culture from the gut contents of T. lusitanicus and resolved isolate identity to the species level by sequencing 16S rRNA gene fragments. Using BLAST similarity searches and maximum likelihood phylogenetic analyses, we were able to reveal that the analyzed fraction （culturable, aerobic, facultative anaerobic, and aerotolerant） of beetle gut microbiota is dominated by the phyla Pro- teobacteria, Firmicutes, and Actinobacteria. Among Proteobacteria, members of the order Enterobacteriales （Gammaproteobacteria） were the most abundant. The main functions associated with the bacteria found in the gut of T. lusitanicus would likely include nitrogen fixation, denitrification, detoxification, and diverse defensive roles against pathogens.

关键词： actinobacteria firmicutes geotrupidae gut microbiota polyphagy,proteobacteria

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Practical Universal Method for Designing Single-Layer Electromagnetic Wave Absorbers

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Open Journal of Antennas and Propagation 2018年第4期6卷 84-92页

作者： Benjamin Jacard alvaro Valenzuela Manuel gonzalez Department of Electrical Engineering University of Chile Santiago Chile

A simple design method for electromagnetic wave absorbers under normal incidence is presented. For the fabrication of the microwave absorbing material a novel design chart is used, including curves of constant ?ratio in a? plane. The practical use of the chart is explained and, as example, a microwave absorber fabricated with magnetite-impregnated plastisol is designed and tested at X-band frequencies.

关键词： Permittivity Permeability Single Layer Microwave Absorption Reflection Loss

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3D printed tacrolimus suppositories for the treatment of ulcerative colitis

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Asian Journal of Pharmaceutical Sciences 2021年第1期16卷 110-119页

作者： Iria Seoane-Viano Jun Jie Ong Asteria Luzardo-Alvarez Miguel gonzalez-Barcia Abdul W.Basit Francisco J.Otero-Espinar alvaro Goyanes Department of Pharmacology Pharmacy and Pharmaceutical TechnologyFaculty of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Department of Pharmaceutics UCL School of PharmacyUniversity College LondonLondon WC1N 1AXUK Pharmacy Department University Clinical Hospital Santiago de Compostela(SERGAS)(CHUS)Santiago de Compostela 15706Spain FabRx Ltd. AshfordKent TN240RWUK Departamento de Farmacologia Farmacia y Tecnologia FarmaceuticaI+D Farma Group(GI-1645)Universidade de Santiago de CompostelaSantiago de Compostela 15782Spain

Ulcerative colitis is a global health problem,affecting millions of individuals *** an inflammatory condition localised in the large intestine,rectal delivery of immunosuppressive therapies such as tacrolimus is a promising strategy to maximise drug concentration at the site of action whilst minimising systemic side ***,for the first time,self-supporting 3D-printed tacrolimus suppositories were prepared without the aid of moulds using a pharmaceutical semi-solid extrusion(SSE)3D *** suppositories were printed vertically in three different sizes using combinations of two lipid pharmaceutical excipients(Gelucire 44/14 or Gelucire 48/16)and coconut *** both suppository formulations had the appropriate viscosity characteristics for printing,the Gel 44 formulation required less energy and force for extrusion compared to the Gel 48 *** Gel 44 disintegrated more rapidly but released tacrolimus more slowly than the Gel 48 *** the tacrolimus release profiles were significantly different,both suppository systems released more than 80% drug within 120 *** and XRD analysis was inconclusive in determining the solid-state properties of the drug in the *** summary,this article reports on the fabrication of 3D printed selfsupporting suppositories to deliver personalised doses of a narrow therapeutic index drug,with potential benefits for patients with ulcerative colitis.

关键词： 3D printed drug products Semi-solid extrusion 3D printing Inflammatory bowel disease Suppository drug delivery Pressure assisted syringe M3dimaker

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Tropical forest canopies and their relationships with climate and disturbance： results from a global dataset of consistent field-based measurements

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Forest Ecosystems 2018年第1期5卷 77-90页

作者： marion pfeifer alemu gonsamo william woodgate luis cayuela andrew r.marshall alicia ledo timothy c.e.paine rob marchant andrew burt kim calders colin courtney-mustaphi aida cuni-sanchez nicolas j.deere dereje denu jose gonzalez de tanago robin hayward alvaro lau manuel j.macía pieter i.olivier petri pellikka hamidu seki deo shirima rebecca trevithick beatrice wedeux charlotte wheeler pantaleo k.t.munishi thomas martin abdul mustari philip j.platts school of natural and environmental sciences newcastle universityUpon TyneNewcastle NE1 7RUUK department of geography and planning university of torontoONCanada land and water commonwealth scientific and industrial research organisationYarralumlaACTAustralia school of mathematical and geospatial sciences rmit universityGPO Box 2476VMelbourneVIC 3001Australia department of biology geologyphysics and inorganic chemistryuniversidad rey juan carlosE-28933 MostolesMadridSpain tropical forest and peopleresearch centre university of the sunshine coastsippy DownsAustralia environment department university of yorkYorkUK flamingo land ltd. MaltonUK the institute of biological and environmental sciences environmental modelling groupuniversity of aberdeenAberdeenUK biological and environmental sciences university of stirlingStirling FK9 4L AUK york institute for tropical ecosystems environment departmentuniversity of yorkYork YO10 5NGUK department of geography university college londonGower StreetLondon WC1E 6BTUK earth observation climate and optical groupnational physical laboratoryHampton RoadTeddingtonMiddlesex TW11 0LWUK department of archaeology and ancient history uppsala universitetP.O.Box 256-751 05 UppsalaSESweden center for macroecology evolution and climateuniversity of copenhagenUniversitetsparken 152100 CopenhagenDKDenmark durrell institute of conservation and ecology(dice) school of anthropology and conservationuniversity of kentCanterbury CT2 7NRUK department of biology college of natural sciencesjimma universityJimmaEthiopia wageningen university&research laboratory of geo-information science and remote sensingDroevendaalsesteeg 36708 PB Wageningenthe Netherlands center for international forestry research(cifor) Situ GedeSindang BarangBogor 16680Indonesia departamento de biología área de botánicauniversidad autónoma de madridcalle Darwin 2-28049 MadridESSpain conservation ecology research unit university of pretoriaHatfieldPretoriaSouth Af

Background： Canopy structure, defined by leaf area index （LAI）, fractional vegetation cover （FCover） and fraction of absorbed photosynthetically active radiation （fAPAR）, regulates a wide range of forest functions and ecosystem services. Spatially consistent field-measurements of canopy structure are however lacking, particularly for the tropics. Methods： Here, we introduce the Global LAI database： a global dataset of field-based canopy structure measurements spanning tropical forests in four continents （Africa, Asia, Australia and the Americas）. We use these measurements to test for climate dependencies within and across continents, and to test for the potential of anthropogenic disturbance and forest protection to modulate those dependences. Results： Using data collected from 887 tropical forest plots, we show that maximum water deficit, defined across the most arid months of the year, is an important predictor of canopy structure, with all three canopy attributes declining significantly with increasing water deficit. Canopy attributes also increase with minimum temperature, and with the protection of forests according to both active （within protected areas） and passive measures （through topography）. Once protection and continent effects are accounted for, other anthropogenic measures （e.g. human population） do not improve the model. Conclusions： We conclude that canopy structure in the tropics is primarily a consequence of forest adaptation to the maximum water deficits historically experienced within a given region. Climate change, and in particular changes in drought regimes may thus affect forest structure and function, but forest protection may offer some resilience against this effect.

关键词： Leaf area index Fractional vegetation cover Fraction of absorbed photosynthetically active radiation,Human population pressure Protected areas Drought Climate change

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赫尔辛基古根海姆博物馆

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现代装饰 2015年第3期 122-125页

作者： Peru Caada Xabler Arranz Alejandro Iturbe Julen Quevedo Jon Andonl Iparragulrre Ubay Calle alvaro Arbina Igor gonzalez Iigo Salaburu Nagila Ramos Martín García 姜敏华

波罗的海的女儿——赫尔辛基是芬兰最大的港口城市,人口密集,有着地球上极少数城市所特有的活力与创造力,而这创造力,尤其体现在它的建筑和设计上。赫尔辛基一直鼓励和致力于现代化高科技的蓬勃发展。但是,尽管赫尔辛基这个城市现已具... 详细信息

波罗的海的女儿——赫尔辛基是芬兰最大的港口城市,人口密集,有着地球上极少数城市所特有的活力与创造力,而这创造力,尤其体现在它的建筑和设计上。赫尔辛基一直鼓励和致力于现代化高科技的蓬勃发展。但是,尽管赫尔辛基这个城市现已具备大都会的魅力和高标准的生活条件,但实际上,芬兰整体上仍然处于农业社会,

关键词：赫尔辛基博物馆港口城市波罗的海人口密集农业社会创造力高科技

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