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一种新的嫌色性肾细胞癌肿瘤分级系统：预后价值和与Fuhrman核分级比较

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临床与实验病理学杂志 2010年第5期26卷 522-522页

作者： Paner G P Amin M B alvarado-cabrero i 黄文斌(摘译) 不详南京医科大学附属南京第一医院病理科南京210006

Fuhrman核分级是目前最广泛应用于肾细胞癌的核分级系统,该分级系统主要根据细胞核大小、形状和核仁是否明显而分为4级。虽然Fuhrman分级系统对经典型RCC具有很好的预测预后价值,但对其他类型肾细胞癌特别是嫌色性RCC有很大争议。[第一段]

关键词：分级系统肾细胞癌预后价值核分级嫌色性癌肿瘤 RCC 细胞核

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微乳头状宫颈腺癌:44例临床病理分析

临床与实验病理学杂志 2019年第9期35卷 1012-1012页

作者： alvarado-cabrero i McCluggage W G Estevez-Castro R 王巍伟(摘译) 方三高(审校) 不详山东省诸城市妇幼保健院诸城262200 中国人民解放军陆军特色医学中心病理科重庆400042

微乳头状腺癌或伴微乳头成分的腺癌是侵袭性腺癌的一种变异型。可发生于乳腺、泌尿道、甲状腺、肺和卵巢等器官,常与其他类型腺癌混合,主要位于肿瘤的侵袭边缘,临床预后较差。肿瘤细胞小而紧凑抱团,形似血管间隙,界限清晰,有时形成实性... 详细信息

微乳头状腺癌或伴微乳头成分的腺癌是侵袭性腺癌的一种变异型。可发生于乳腺、泌尿道、甲状腺、肺和卵巢等器官,常与其他类型腺癌混合,主要位于肿瘤的侵袭边缘,临床预后较差。肿瘤细胞小而紧凑抱团,形似血管间隙,界限清晰,有时形成实性巢团或小管,但缺乏真正的纤维血管轴心。

关键词：乳头状腺癌宫颈腺癌临床预后病理分析肿瘤细胞侵袭性变异型微乳头

Solar-assisted photocatalytic water splitting using defective UiO-66 solids from modulated synthesis

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Nano Research 2024年第5期17卷 4134-4150页

作者： Celia M.Rueda-Navarro María cabrero-Antonino Paula Escamilla Valentín Díez-Cabanes Dong Fan Pedro Atienzar Belén Ferrer ignacio Vayá Guillaume Maurin Herme G.Baldoví Sergio Navalón Departamento de Química Universitat Politècnica de ValènciaCamino de Vera s/nValencia 46022Spain instituto de Ciencia Molecular(iCMOL) Universitat de ValènciaPaterna 46980Spain iCGM Univ.MontpellierCNRSENSCMMontpellier34095France instituto de Tecnología Química(UPV-CSiC) Universitat Politècnica de ValènciaAvenida de los Naranjos s/nValencia 46022Spain

Metal-organic frameworks(MOFs)are attracting increasing interests as photocatalysts for solar-driven hydrogen production from water.This paper reports on a comparative study of using either acetic acid(AA)or trifluoroacetic acid(TFA)as the representative UiO-66 organic modulators for synthesizing visible light responsive UiO-66(Zr)-X(X:NH_(2) or NO_(2))photocatalysts for water splitting.The results show that photocatalytic hydrogen generation from a water/methanol mixture can be improved by varying the nature and amount of the modulator employed to prepare the different UiO-66(Zr)-X(X:NH_(2) or NO_(2))solid derivatives.UiO-66(Zr)-NH_(2) was the most active photocatalyst,followed by UiO-66(Zr)-NO_(2),both prepared with 12 equivalents of AA with respect to the organic ligand.This UiO-66(Zr)-NH_(2) solid was more active than the parent MOF in photocatalytic overall water splitting(OWS)(H_(2) and O_(2) production of 450 and 160μmol·g^(-1),respectively,in 5 h;apparent quantum yield(AQY)at 400 nm of 0.06%)in the absence of methanol and compares favourably with analogous reports.information on the photocatalytic activity of the most active solids of both series was obtained by means of a series of techniques,including ultraviolet-visible(UV-vis)diffuse reflectance,X-ray photoelectron spectroscopy(XPS),laser flash photolysis(LFP),electron spin resonance(ESR),photoluminescence and photoelectrochemical measurements together with density functional theory(DFT)calculations.The results showed that organic acid modulators can be used to enhance the photocatalytic activity of missing linker UiO-66 defective materials in solar-powered water splitting.

关键词： heterogeneous photocatalysis metal-organic frameworks(MOFs) UiO-66 materials carboxylic acid modulators water splitting solar light

Detection of 4p16.3 deletion and 11p15.5p15.4 gain in a boy by comparative genomic hybridization array:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1517-1522页

作者： işın Kaya Medical Genetics Bakırçay UniversityÇiğli Education ve Training Hospitalİzmir 35620Turkey

BACKGROUND Nonallelic homologous recombination(NAHR)of segmental duplications or low copy repeats(LCRs)result in DNA gain/loss and play an important role in the origin of genomic disorders.CASE SUMMARY A 3-year-old boy was referred for genetic analysis.Comparative genomic hybrid-ization array analysis revealed a loss of 3776 kb in the 4p16.3 chromosomal region and a gain of 3201 kb in the 11p15.5p15.4 chromosomal region.CONCLUSiON Genomic imbalances caused by NAHR in LCRs result in deletion and duplication syndromes.

关键词： Wolf-Hirschhorn syndrome Silver-Russell syndrome Recurrent rearrangements Case report

Taxonomy,distribution,and contemporary exposure of terrestrial mammals to floods and human pressure across different areas for biodiversity conservation in China

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integrative Zoology 2024年第3期19卷 458-467页

作者： Roman SHARNUUD Eric i.AMECA MOE Key Laboratory for Biodiversity Science&Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijingChina Climate Change Specialist Group Species Survival CommissionInternational Union for Conservation of NatureGlandSwitzerland

A significant research focus is placed on identifying animal species and areas at future risk to human-induced alterations of the environment and long-term changes in climatic conditions.Yet,the extent to which exposure to extreme climatic events and intense human pressure can increase the risk of harmful impacts on species remains poorly investigated.Focusing on terrestrial mammals in China,one of the world’s megadiverse countries,we investigated patterns of contemporary exposure to floods and human pressures and determined their taxonomic representation and distribution across three major area-based conservation schemes,namely,national nature reserves(NNRs),priority areas for biodiversity conservation(PABCs),and key biodiversity areas(KBAs).Among the 440 species assessed with moderate or high exposure to floods,327(∼75%)also qualified as moderate or high in exposure to intense human pressure.These species mainly belong to the orders Chiroptera,Eulipotyphla,and Rodentia.Likewise,there were 305,311,and 311 species with moderate or high exposure to flood and intense human pressure represented across NNRs,PABCs,and KBAs,respectively.Our findings support the prioritization of KBAs for expansion of site-based protection efforts such as NNRs in China,considering threats to species from exposure to adverse effects from both extreme climate and human pressure.

关键词： conservation floods human pressure mammals taxonomy

Are population cycles recovering?

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integrative Zoology 2024年第3期19卷 538-547页

作者： Vasily D.YAKUSHOV Boris i.SHEFTEL A.N.Severtsov institute of Ecology and Evolution of the Russian Academy of Sciences MoscowRussia

The dynamics of populations of small mammals of Central Siberia was analyzed.The studies were carried out at the Yenisei ecological station“Mirnoye”of the A.N.Severtsov institute of Ecology and Evolution,Russian Academy of Sciences.The time series analysis was performed by the wavelet transform using the statistical data processing language R.in the 20th century,the dynamics of the population of the community and some of its constituent species(Sorex araneus;S.caecutiens;S.isodon;S.tundrensis;S.minutus;Craseomys rufocanus;Clethrionomys rutilus;Microtus oeconomus;M.agrestis)were characterized by a 4-year periodicity.The type of dynamics changed to noncyclic by the nineties,but by 2022,four species(S.araneus,S.isodon,C.rutilus,and M.oeconomus)and the community as a whole showed a tendency toward recovery of population cycles.The remaining species were characterized by consistently low numbers with irregular low amplitude fluctuations.

关键词： population cycles small mammals time-series analysis wavelet transform

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嫌色细胞型肾细胞癌

临床与实验病理学杂志 2009年第3期25卷 231-231页

作者： Paner G P alvarado-cabrero i et al. 李磊(摘译) 李岩(摘译) 张仁亚(审校) 不详济宁医学院附属医院病理科济宁272029

许多文献显示嫌色细胞型肾细胞癌(RCC)是一种具有低恶潜能生物学特性的肿瘤,其5年和10年生存率分别为78%～100%和80%一90%.决定肿瘤预后的常规参数包括肿瘤发展过程中的所有特征.145例的临床病理特征与预后相关.患者的平均年龄59岁(27-8... 详细信息

许多文献显示嫌色细胞型肾细胞癌(RCC)是一种具有低恶潜能生物学特性的肿瘤,其5年和10年生存率分别为78%～100%和80%一90%.决定肿瘤预后的常规参数包括肿瘤发展过程中的所有特征.145例的临床病理特征与预后相关.患者的平均年龄59岁(27-82岁),男女比例1.1:1.

关键词：嫌色细胞型肾细胞癌嗜酸性细胞 10年生存率肿瘤发展临床病理特征生物学特性常规参数肿瘤预后

Using fracture-based continuum modeling of coupled geomechanical-hydrological processes for numerical simulation of hydraulic fracturing

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1582-1599页

作者： Goodluck i.Ofoegbu GNO Modeling Research LLC. San AntonioTX78253USA

This paper describes numerical simulation of hydraulic fracturing using fracture-based continuum modeling(FBCM)of coupled geomechanical-hydrological processes to evaluate a technique for high-density fracturing and fracture caging.The simulations are innovative because of modeling discrete fractures explicitly in continuum analysis.A key advantage of FBCM is that fracture initiation and propagation are modeled explicitly without changing the domain grid(i.***.no re-meshing).Further,multiple realizations of a preexisting fracture distribution can be analyzed using the same domain grid.The simulated hydraulic fracturing technique consists of pressurizing multiple wells simultaneously:initially without permeating fluids into the rock,to seed fractures uniformly and at high density in the wall rock of the wells;followed by fluid injection to propagate the seeded fracture density hydraulically.FBCM combines the ease of continuum modeling with the potential accuracy of modeling discrete fractures and fracturing explicitly.Fractures are modeled as piecewise planar based on intersections with domain elements;fracture geometry stored as continuum properties is used to calculate parameters needed to model individual fractures;and rock behavior is modeled through tensorial aggregation of the behavior of discrete fractures and unfractured rock.Simulations are presented for previously unfractured rock and for rock with preexisting fractures of horizontal,shallow-dipping,steeply dipping,or vertical orientation.Simulations of a single-well model are used to determine the pattern and spacing for a multiple-well design.The results illustrate high-density fracturing and fracture caging through simultaneous fluid injection in multiple wells:for previously unfractured rock or rock with preexisting shallow-dipping or horizontal fractures,and in situ vertical compressive stress greater than horizontal.if preexisting fractures are steeply dipping or vertical,and considering the same in situ stress condition,well pressurization without fl

关键词： Discrete fracture Fracture-based continuum modeling Fracture caging High-density fracturing Hydraulic fracturing Preexisting fracture

Radiative loss of coherence in free electrons:a long-range quantum phenomenon

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Light(Science & Applications) 2024年第2期13卷 294-301页

作者： Cruz i.Velasco Valerio Di Giulio F.Javier García de Abajo iCFO-institut de Ciencies Fotoniques The Barcelona Institute of Science and Technology08860Castelldefels(Barcelona)Spain iCREA-institucióCatalana de Recerca i Estudis Avançats Passeig Lluís Companys 2308010BarcelonaSpain

Quantum physics rules the dynamics of small objects as they interact over microscopic length scales.Nevertheless,quantum correlations involving macroscopic distances can be observed between entangled photons as well as in atomic gases and matter waves at low temperatures.The long-range nature of the electromagnetic coupling between charged particles and extended objects could also trigger quantum phenomena over large distances.Here,we reveal a manifestation of quantum mechanics that involves macroscopic distances and results in a nearly complete depletion of coherence associated with which-way free-electron interference produced by electron-radiation coupling in the presence of distant extended objects.This is a ubiquitous effect that we illustrate through a rigorous theoretical analysis of a two-path electron beam interacting with a semi-infinite metallic plate and find the inter-path coherence to vanish proportionally to the path separation at zero temperature and exponentially at finite temperature.The investigated regime of large distances originates in the coupling of the electron to radiative modes assisted by diffraction at material structures but without any involvement of material excitations.Besides the fundamental interest of this macroscopic quantum phenomenon,our results suggest an approach to measuring the vacuum temperature and nondestructively sensing the presence of distant objects.

关键词： temperature quantum macroscopic