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循证药物治疗依从性和急性心肌梗死远期死亡率的关系

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世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 4-5页

作者： Rasmussen J.N. alter d.a. 黄浙勇 Institute for Clinical Evaluative Sciences 2075 Bayview Ave Toronto Ont. M4N 3M5 Canada Dr.

背景：药物依从性对存活率的影响程度如何尚不为人知，部分原因在于死亡率差异可能更多地源自“健康遵从效应”行为特性，而不是药物治疗作用。目的：探讨药物治疗依从性与急性心肌梗死（AMI）存活患者死亡率的关系。设计、地点和参与... 详细信息

背景：药物依从性对存活率的影响程度如何尚不为人知，部分原因在于死亡率差异可能更多地源自“健康遵从效应”行为特性，而不是药物治疗作用。目的：探讨药物治疗依从性与急性心肌梗死（AMI）存活患者死亡率的关系。设计、地点和参与者：该观察性纵向人群研究纳入1999-2003年加拿大安大略省31455例老年AMI存活者。所有患者被予以他汀类药物、β受体阻断剂或钙通道阻断剂（钙通道阻断剂缺乏改善存活率的循证医学证据，作为对照）。主要观察指标：患者被分为依从性高（依从天数百分比≥80％）、中（依从天数百分比40％～79％）和低（依从天数百分比〈40％）三类。应用多因素生存分析和倾向分析比较其远期死亡率（中位随访2．4年），分析中校正了社会人口统计学因素、疾病严重性、共病和同时采用的循证治疗手段等因素。

关键词：药物治疗依从性远期死亡率急性心肌梗死循证医学证据钙通道阻断剂社会人口统计学 β受体阻断剂药物依从性

WHEELBASE PREVIEW OPTIMAL CONTROL FOR ACTIVE VEHICLE SUSPENSIONS

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Chinese Journal of Mechanical Engineering 1998年第2期11卷 43-50页

作者： Yu, Fan Crolla, d.a. Jilin Univ of Technology China

An algorithm in which the optimal control law takes the ad.a.tage of the correlation between front and rear inputs, i.e., wheelbase preview information, for an active vehicle suspension design is described. Based on s... 详细信息

关键词： Active suspension Preview control

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nad.a.d.a.brosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or d.a.h is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individ.a.s and.a.fecting 5.4 per 100,000 individ.a.s overall.

关键词： STAT3 dissection sclerosis

Anti-amyloid.a.tibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lyd.a.Jiménez-d.a. Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and.a.cumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.a.and tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.a.meida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Experiments and modelling of phenanthrene biodegradation in the aqueous phase by a mixed culture

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Journal of Environmental Sciences 2006年第1期18卷 147-153页

作者： LIU Xiang MAO Xiao-min YANG Jian-gang d.a. Barry LI Ling department of Environmental Science and Engineering Tsinghua University Beijing 100084 China Contaminated Land.a.sessment and Remed.a.ion Research Centre Institute for Infrastructure and Environment School of Engineering and Electronics The University of Edinburgh Edinburgh EH9 3JL United Kingdom Chinese Academy of Transportation Sciences Ministry of Communications Beijing 100029 China Environmental Engineering division School of Engineering the University of Queensland St. Lucia QLD 4072 Australia Centre for Eco-Environmental Modelling Hohai University Nanjing 210098. China

Pollution by polycyclic aromatic hydrocarbons（PAHs） is widespread due to tmsuitable disposal of industrial waste. They are mostly defined.a. priority pollutants by environmental protection authorities worldwide. Phenanthrene, a typical PAH, was selected.a. the target in this paper. The PAH-degrading mixed culture, named ZM, was collected from a petroleum contaminated river bed. This culture was injected into phenanthrene solutions at different concentrations to quantify the biodegradation process. Results show near-complete removal of phenanthrene in three days of biodegradation if the initial phenanthrene concentration is low. When the initial concentration is high, the removal rate is increased but 20%-40% of the phenanthrene remains at the end of the experiment. The biomass shows a peak on the third day due to the combined effects of microbial growth and decay. Another peak is evident for cases with a high initial concentration, possibly due to production of an intermed.a.e metabolite. The pH generally decreased during biodegradation because of the production of organic acid. Two phenomenological models were designed to simulate the phenanthrene biodegradation and biomass growth. A relatively simple model that does not consider the intermed.a.e metabolite and its inhibition of phenanthrene biodegradation cannot fit the observed data. A modified Monod model that considered.a. intermed.a.e metabolite （organic acid） and its inhibiting reversal effect reasonably depicts the experimental results.

关键词： biodegradation model phenanthrene microbial growth and decay Monod growth model

Numerical and Experimental Studies of Working Processesin a Cryogenic Fuelling Tank Coupled with Energy Plant

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Journal of Thermal Science 2024年第6期33卷 2190-2202页

作者： UGLANOV d.a. SHIMANOVA A.B. SHIMANOV A.A. BLAGIN E.V. SARMIN d.V. LIU Junjie ZHENG Guanghua Cryogenics Laboratory Samara UniversitySamara 443086Russian Federation School of Power and Energy Northwestern Polytechnical UniversityXi'an 710129China

This article presents a device for the storage and gasification of cryogenic working fluid,which is named.a.cryogenic fuelling tank.A cryogenic fuel tank can serve both as a fuel vessel and.a.pressure accumulator due to the regasification process that takes place *** of this tank is slowed by the lack of theoretical and experimental research on its working *** article d.a.s with an investigation of the working process of the energy plant based on a cryogenic fuel tank coupled with a rotor-vane *** mathematical models include evaporation and condensation processes within the tank,heat exchange between gas chambers and between the tank and environment,and changes in energy due to incoming and leaving *** work used to determine the efficiency of a power plant is generated by a steam *** shows that it is possible to achieve specific work outputs up to 110-160 kJ/kg with relative deviation of power and specific work determination equal to 1.4% and 1.9%correspondingly.

关键词： cryogenic fuelling tank gasification liquid natural gas low-temperature energy plant

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with ad.a.ced.a.yotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial d.a.nosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded.a.cess treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised.a.d pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

development of Pasteuria penetrans in Meloidogyne javanica females as affected by constantly high vs fluctuating temperature in an in-vivo system

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第3期6卷 155-157页

作者： dARBAN d.a. GOWEN S.R PEMBROKE B. MAHAR A.N department of Agriculture School of Agriculture Policy and development The University of Reading UK Department of Agriculture School of Agriculture Policy and Development The University of Reading UKDepartment of Agriculture School of Agriculture Policy and Development The University of Reading UKDepartment of Agriculture School of Agriculture Policy and Development The University of Reading UK

Growth room and glasshouse experiment was conducted to investigate the effect of constant and fluctuating tem- peratures on the development of Pasteuria penetrans a hyperparasite of root-knot nematodes. Tomato plants (Lycopersicon es- culentum Mill) were inoculated with Meloidogyne javanica second-stage juveniles attached with endospores of P. penetrans and were grown in growth room at 26?29 °C and in glasshouse at 20?32 °C. The tomato plants were sampled from the growth room after 600 degree-days based on 17 °C/d, accumulating each day above a base temperature of 10 °C and from the glasshouse after 36 calendar days. Temperature affected the development of P. penetrans directly. The rate of development at constant temperature in growth room was faster than that in the glasshouse at fluctuating temperatures.

关键词： Pasteuria penetrans Meloidogyne javanica development and tomato plants