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Dormancy studies on Indian horse-chestnut (Aesculus indica Colebr.) under Kashmir conditions

Forestry Studies in China 2010年第1期12卷 41-44页

作者： Mumtaz MAJEED M. A. KHAN altamash bashir A. H. MUGHAL Faculty of Forestry Sher-e-Kashmir University of Agricultural Science & Technology of Kashmir

Studies were carried out in the Faculty of Forestry, Sher-e-Kashrnir University of Agricultural Sciences ＆ Technology of Kashmir, Shalimar of India during 2006 and 2007. The Indian horse-chestnut （Aesculus indica Colebr.）, locally known as ＂Hanudun＂, is one of the more important broad-leaved tree species of the Kashmir valley. No deep dormancy was observed in mature seeds. However, the seeds remained dormant due to unfavorable environmental conditions prevailing after seed dispersal. Both treatments of cold stratification were significantly superior to the control conditions, i.e., no stratification which showed no germination during the test period of 30 d. The effects of the two treatments （cold stratification for 15 or 30 d） also differed significantly. Germination was found to increase with an increase in the time of cold stratification. Chilling treatments of seeds for 30 d showed maximum ger- mination of 80%, requiring the shortest time for germination, i.e., 20.51 d with a maximum evaluated germination value of 14.88. The other treatment with 15 d chilling showed lower germination of 60%, requiring a maximum number of germination days （27.31 d） with lower germination value of 3.26.

关键词： Aesculus indica Colebr. seeds dormancy stratification germination

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Maturity indices of Indian horse-chestnut (Aesculus indica Colebr.) seeds under temperate Kashmir conditions

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Forestry Studies in China 2010年第1期12卷 45-48页

作者： Mumtaz MAJEED M. A. KHAN altamash bashir K. N. QAISAR Faculty of Forestry Sher-e-Kashmir University of Agricultural Science & Technology of Kashmir

Our study on maturity indices of Aesculus indica Colebr. seeds was conducted under temperate Kashmir conditions in 2006. Seed collection was started from 15 July and continued until the maturation of seeds in December. The seeds were harvested fortnightly from identified trees and on each collection date maturity indices, viz. seed color, seed weight, moisture content, seed dimension, specific gravity and germination percentage were recorded. The study revealed that at the time of maturity （Nov.-Dec.） the seed color was a shiny chocolate brown, with a moisture content of 58.37% and a specific gravity of 0.82. Germination was maximum （80%） at its maturity with a maximum seed weight of 52.03 g per seed. We recommend that the seeds should be collected before their natural disposal.

关键词： Aesculus indica Colebr. maturity indices seed weight seed color specific gravity

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Benefit-cost analysis of raising Pinus wallichiana seedlings in different capacities/sizes of root trainers in the nursery

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Forestry Studies in China 2009年第2期11卷 118-121页

作者： altamash bashir K. N. QAISAR M. A. KHAN Mumtaz MAJEED Faculty of Forestry Sher-e-Kashmir University of Agricultural Science and Technology of KashmirShalimarSrinagar

Modern nursery methods of seedling production in different sized root trainers, were compared by raising seedlings of Pinus wallichiana involving costs incurred and benefits received. In order to provide a common basis for the comparisons, the study involved the raising of 1000 seedlings annually on a continuous basis for seven years. A relative economic analysis of raising P. wallichiana seedlings in 300, 150 and 100 cm^3 root trainers was carried out and we estimated that the root trainers of 300 cm^3 capacity recorded the highest total input cost of Rs. 35571 and Rs. 40018 for 1000 seedlings produced annually at discount rates of 12% and 6%. Seedlings raised in 100 cm^3 root trainers recorded the lowest total input cost of Rs. 23390 and Rs. 27737 per 1000 seedlings annually at discount rates of 12% and 6%. Hence, returns per rupee invested in raising seedlings in the 100 cm^3 root trainers accounted for the maximum benefit-cost ratio （i.e., 1.56 and 1.61） at discount rates of 12% and 6%. Thus seedlings raised in 100 cm^3 and 150 cm^3 root trainers were found to be most cost effective when compared with seedlings grown in 300 cm^3 root trainers. The results can be attributed to the larger number of cells per tray （higher growth density） in the 100 and 150 cm^3 root trainers, compared to the number of seedlings in the 300 cm^3 root trainers.

关键词： economics Pinus wallichiana root trainer benefit-cost ratio nursery

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Risk factors for development of pneumothorax in patients with COVID-19 at a government health facility in North India:An exploratory case-control study

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Journal of Acute Disease 2023年第6期12卷 238-243页

作者： Manabendra Baidya Sandeep Kumar Pandey Hariom Kumar Solanki Ankur Deep Singh Samaksh Giri Syed altamash Government Institute of Medical Sciences Greater NoidaUttar PradeshIndia201310

Objective:To explore risk factors for the development of pneumothorax in patients with COVID-19 during the second COVID-19 wave at a northern Indian level 2 health ***:Patients suffering from SARS-CoV-2 infection during the second wave of the COVID-19 pandemic in India(January-June 2021)at a tertiary care teaching hospital and level 2 COVID care facility were *** who suffered from SARS-CoV-2 infection but did not develop pneumothorax were selected as matched *** details regarding demographics,clinical presentation,treatment,and outcome were recorded in a semi-structured ***:Eleven patients with COVID-19 developed pneumothorax during the study period and 40 controls were included in the *** cases were smokers in comparison to only two in the control *** 2 diabetes mellitus was the most common comorbidity among both *** change in C-reactive protein overall for cases and controls were around+14.0 and-41.9 and was statistically ***:Inflammatory markers like C-reactive protein have significant correlations with the development of pneumothorax in COVID-19-infected *** is no sex predisposition to develop pneumothorax among patients with COVID-19.

关键词： COVID-19 Pneumothorax Chest tube Correlates Risk factors Inflammatory marker C-reactive protein

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In silico evaluation of kuwanon compounds as antiviral agents targeting H9N2 influenza virus

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Infectious Diseases Research 2024年第4期5卷 42-53页

作者： Ansari Vikhar Danish Ahmad Yasar Qazi Subur Wadood Khan Mohd Mukhtar Khan altamash Ansari Sarfaraz Khan Syed iftequar Ahmed Y.B.Chavan College of Pharmacy Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431001India.

Background:The threat of avian influenza a subtype avian influenza A(H9N2)virus remains a significant concern,necessitating the exploration of novel antiviral *** study employs network pharmacology and computational analysis to investigate the potential of kuwanons,a natural compounds against H9N2 influenza ***:Leveraging comprehensive databases and bioinformatics tools,we elucidate the molecular mechanisms underlying Kuwanons pharmacological effects against H9N2 influenza *** pharmacology identifies H9N2 influenza virus targets and compounds through integrated protein-protein interaction and Kyoto Encyclopedia of Genes and Genomes *** docking studies were performed to assess the binding affinities and structural interactions of Kuwanon analogues with key targets,shedding light on their potential inhibitory effects on viral replication and ***:Compound-target network analysis revealed complex interactions(120 nodes,163 edges),with significant interactions and an average node degree of *** Encyclopedia of Genes and Genomes analysis revealed pathways such as Influenza A,Cytokine-cytokine receptor interaction pathway in H9N2 influenza *** docking studies revealed that the binding free energy for the docked ligands ranged between-5.2 and-9.4 kcal/mol for the human interferon-beta crystal structure(IFNB1,Protein Data Bank:1AU1)and-5.4 and-9.6 kcal/mol for Interleukin-6(IL-6,PDB:4CNI).Conclusion:Our findings suggest that kuwanon exhibits promising antiviral activity against H9N2 influenza virus by targeting specific viral proteins,highlighting its potential as a natural therapeutic agent in combating avian influenza infections.

关键词： network pharmacology molecular docking kuwanons H9N2 influenza virus natural compounds

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Network pharmacology and computational analysis of berberine and kuwanon Z as possible natural antiviral compounds in COVID-19

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Pharmacology Discovery 2024年第1期4卷 31-43页

作者： Ansari Vikhar Danish Ahmad Qazi Yasar Subur W Khan Syed Ayaz Ali Ansari altamash Mohd Mukhtar Khan Nikhil S Sakle y.2.chavan college of pharmacy dr.babasaheb ambedkar marathwada universityaurangabad 431001india

Background:Global efforts to discover effective therapeutic agents for combating coronavirus disease 19(COVID-19)have intensified the exploration of natural compounds with potential antiviral *** this study,we utilized network pharmacology and computational analysis to investigate the antiviral effects of Berberine and Kuwanon Z against severe acute respiratory syndrome coronavirus 2,the viruses responsible for ***:Utilizing comprehensive network pharmacology approaches,we elucidated the complex interactions between these compounds and the host biological system,highlighting their multitarget *** pharmacology identifies COVID-19 targets and compounds through integrated protein‒protein interaction and KEGG pathway *** docking simulation studies were performed to assess the binding affinities and structural interactions of Berberine and Kuwanon Z with key viral proteins,shedding light on their potential inhibitory effects on viral replication and ***:Network-based analyses revealed the modulation of crucial pathways involved in the host antiviral ***-target network analysis revealed complex interactions(122 nodes,121 edges),with significant interactions and an average node degree of *** analysis revealed pathways such as the COVID-19 pathway,chemokines and Jak-sat in *** studies revealed that Kuwanon Z had binding energies of-10.5 kcal/mol for JAK2 and-8.1 kcal/mol for the main ***:The findings of this study contribute to the understanding of the pharmacological actions of Berberine and Kuwanon Z in the context of COVID-19,providing a basis for further experimental *** natural compounds exhibit promise as potential antiviral agents,offering a foundation for the development of novel therapeutic strategies in the ongoing battle against the global pandemic.

关键词： COVID-19 kuwanon Z berberine network pharmacology SARS-CoV-2 molecular docking

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