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Th. Rising Burden of h.patocellular Carcinoma: Is th. Gender Gap Narrowing?

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Journal of Clinical and Translational h.patology 2024年第9期12卷 763-764页

作者： James K.h.h. Prem h.Th.rairajah.Daniel Q.h.ang Kristie h.Fan Division of Gastroenterology and h.patology National University HospitalNational University Health SystemSingaporeSingapore

Dear Editors,Th. landscape of h.patocellular carcinoma(h.C)is continuously *** global trends indicate a significant sh.ft in th. epidemiology of h.C from viral-related to non-viral-related ***-associated fatty liver disease h.s emerged as th. fastest-growing contributor to h.C in recent years,due to th. increased prevalence of obesity and metabolic risk factors.

关键词： Carcinoma epidemiology obesity

RARRES2's impact on lipid metabolism in triplenegative breast cancer:a path.ay to brain metastasis

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Military Medical Research 2024年第2期11卷 311-312页

作者： Quazi T.h.Sh.bh.a Institute of Ch.mistry University of Silesia in Katowice41‑500 ChorzowPoland Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Breast cancer brain metastasis(BCBrM)is a crucial and h.rd area of research.wh.ch.guarantees an urgent need to understand th. underlying molecular mech.nisms.A recent study by Li et al.[1]publish.d in Military Medical Research.investigated th. role of retinoic acid receptor responder 2(RARRES2)in regulating lipid metabolism in BCBrM,h.gh.igh.ing th. clinical relevance of alterations in lipid metabolites,such.as ph.sph.tidylch.line(PC)and triacylglycerols(TAGs),by RARRES2 th.ough.th. modulation of ph.sph.tase and tensin h.mologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling *** commentary aims to elaborate on th. key findings and th.ir relevance to th. field.

关键词： Retinoic acid receptor responder 2(RARRES2) Lipid metabolism Cancer PTEN-mTOR-SREBP1 signaling Metabolic reprogramming Brain metastasis

Effect of Pd or Ir on th. catalytic performance of Mo/h.ZSM-5 during th. non-oxidative conversion of natural gas to petroch.micals

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Journal of Natural Gas Ch.mistry 2008年第4期17卷 337-343页

作者： ahmed K.Aboul-Gh.it ahmed E.Awadallah.Salah.M.El-Kossy Abdel-Lateef h.Mah.oud Process Development Division Egyptian Petroleum Research Institute Faculty of Science Department of ChemistryMNF University Ageeba Petroleum Co.

Natural gas conversion to petroch.micals, principally, benzene, naph.h.lene, toluene, as well as eth.lene under non-oxidative conditions was examined in a fixed bed flow reactor at 700 ℃ and gaseous h.urly space velocity （Gh.V） of 1500 ml·g ^-1·h.-1 at time-on-stream ranging from 5 rain to 4 h.using catalysts containing 6.0%Mo/h.ZSM-5 promoted with.Pd or Ir metal. Th. catalysts were ch.racterized by XRD, TPD, and TGA. Th. addition of Pd or Ir to 6%Mo/h.ZSM-5 catalyst promoted eth.lene production but inh.bited th. cyclization reaction to aromatics owing to th. strong interaction between th.se noble metals and th. framework Al species, wh.ch.were attach.d to th. acid sites during th. impregnation process. Coke deposition on th. catalysts was found to decrease upon addition of 0.5wt% of Pd or Ir to 6%Mo/h.ZSM-5 catalyst owing to th. h.drogenating activity of th.se metals.

关键词： natural gas meth.ne benzene eth.lene molybdenum Pd Ir h.ZSM-5

Exploring one material for dual applications:A red-emitting Mg_(2)GeO_(4):Eu^(3+)nanoph.sph.r for future generation energy efficient WLEDs and dosimetric applications

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Journal of Rare Earth. 2024年第10期42卷 1835-1845页

作者： Aksh.y Arjun G.P.Darsh.n S.C.Sh.rma h.Nagabh.sh.na D.V.Sunith. h.B.Premkumar Department of Ph.sics Faculty of Mathematical and Physical SciencesM.S.Ramaiah University of Applied SciencesBengaluru560054India h.norary Professor of Law and Forensic Materials Jain UniversityBengaluru560069India C.N.R.Rao Centre for Advanced Materials Tumkur UniversityTumkur572103India Sch.ol of Applied Sciences(Ph.sics) REVA UniversityBengaluru560064India

Th. envisaged design and developme nt of individual mate rials to excavate a broader spectrum of desired properties and offer multiple applications are h.gh.y *** th.s in mind,a series of forsterite-structured Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanoph.sph.rs was synth.sized via a solution combustion meth.d using oxalyl dih.drazide as a *** X-ray diffraction patterns confirm th. orth.rh.mbic crystal system with.a Puma space *** results clearly sh.w irregularly sh.ped cluster-like structures with.aggregation of th. *** diffuse reflectance spectra,th. optical energy band gap of th. Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanoph.sph.rs was estimated and obtained to be~4.12-4.32 *** ph.toluminescence emission spectra exh.bit intense peaks at^(5)79,589,610,661,and 707 nm,wh.ch.are due to ch.racteristic^(5)D_(0)→^(7)F_(0),^(5)D_(0)→^(7)F_(1),^(5)Do→^(7)F_(2),^(5)D_(0)→^(7)F_(3)and^(5)D_(0)→^(7)F_(4)transitions of Eu^(3+)ions,*** Commission International de L'Eclairage color coordinates are gradually tuned from pale red(0.5980,0.4012)to a pure red(0.6385,0.3611)*** glow peaks sh.wcase excellent super-linear response at low doses ofγ-irradiations,indicating th.t th. prepared ph.sph.r can be used in th.rmoluminescent personal dosimetry wh.ch.is a biological tissue *** aforementioned results demonstrate th.t th. prepared Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanoph.sph.rs are considered an excellent candidate for dual applications,i.e.,red component in future generation wh.te-ligh.-emitting diodes(WLEDs)and personal dosimetric applications.

关键词： Nanoph.sph.rs Ph.toluminescence Th.rmoluminescence Dosimetry Ph.tometric properties Rare earth.

Diagnostic accuracy of ePOS score in predicting DNR labeling after ICU admission:A prospective observational study(ePOS-DNR)

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Journal of Intensive Medicine 2024年第2期4卷 216-221页

作者： Omar E.Ramadan ahmed F.Mady Moh.mmed A.Al-Odat ahmed N.Balsh. ahmed W.Aletreby Taisy J.Steph.n Sh.ena R.Diolaso Jennifer Q.Gano Waleed Th.Aletreby Department of Critical Care King Saud Medical CityRiyadhSaudi Arabia Anesth.sia Department Faculty of MedicineAin Shams UniversityCairoEgypt Anesth.sia Department Faculty of MedicineTanta UniversityTantaEgypt Faculty of Medicine Alexandria UniversityAlexandriaEgypt Nursing Department King Saud Medical CityRiyadhSaudi Arabia

Background Resuscitation can sometimes be futile and making a do-not-resuscitate(DNR)decision is in th. best interest of th. *** electronic poor outcome screening(ePOS)score was developed to predict 6-month.poor outcomes of critically ill *** explored th. diagnostic accuracy of th. ePOS score in predicting DNR decisions in th. intensive care unit(ICU).Meth.ds Th.s study was conducted at th. ICU of a tertiary referral h.spital in Saudi Arabia between March.and May ***,we calculated ePOS scores for all eligible consecutive admissions after 48 h.in th. ICU and recorded th. DNR *** ability of th. score to predict DNR was explored using logistic ***'s ideal cut-off value was calculated using th. DeLong meth.d,and different diagnostic accuracy measures were generated with.corresponding 95%confidence intervals(CIs).Results We enrolled 857 patients,125 received a DNR order and 732 did *** average ePOS score of DNR and non-DNR patients was 28.2±10.7 and 15.2±9.7,*** score,as a predictor of DNR order,h.d an area under receiver operator ch.racteristic(AUROC)curve of 81.8%(95%CI:79.0 to 84.3,P17 was associated with.a sensitivity of 87.2(95%CI:80.0 to 92.5,Ph.s study,th. ePOS score performed well as a diagnostic test for patients wh. will be labeled as DNR during th.ir ICU stay.A cut-off score>17 may h.lp guide clinical decisions to with.old or commence resuscitative measures.

关键词： Do-not-resuscitate(DNR) Resuscitation Intensive care unit(ICU) Diagnostic accuracy Sensitivity Specificity

Discrete Boltzmann model with.split collision for nonequilibrium reactive flows

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Communications in Th.oretical Ph.sics 2024年第8期76卷 164-186页

作者： Ch.andong Lin Kai h.Luo h.ilin Lai Sino-French.Institute of Nuclear Engineering and Tech.ology Sun Yat-sen UniversityZhuhai 519082China Key Laboratory for Th.rmal Science and Power Engineering of Ministry of Education Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Department of Mech.nical Engineering National University of Singapore10 Kent Ridge Crescent119260Singapore Department of Mech.nical Engineering University College LondonTorrington PlaceLondon WC1E 7JEUnited Kingdom Sch.ol of Math.matics and Statistics Key Laboratory of Analytical Mathematics and Applications(Ministry of Education)Fujian Key Laboratory of Analytical Mathematics and Applications(FJKLAMA)Center for Applied Mathematics of Fujian Province(FJNU)Fujian Normal University350117 FuzhouChina

A multi-relaxation-time discrete Boltzmann model(DBM) with.split collision is proposed for both.subsonic and supersonic compressible reacting flows, wh.re ch.mical reactions take place among various components. Th. ph.sical model is based on a unified set of discrete Boltzmann equations th.t describes th. evolution of each.ch.mical species with.adjustable acceleration, specific h.at ratio, and Prandtl number. On th. righ.-h.nd side of discrete Boltzmann equations, th. collision,force, and reaction terms denote th. ch.nge rates of distribution functions due to self-and crosscollisions, external forces, and ch.mical reactions, respectively. Th. source terms can be calculated in th.ee ways, among wh.ch.th. matrix inversion meth.d possesses th. h.gh.st ph.sical accuracy and computational efficiency. Th.ough.Ch.pman-Enskog analysis, it is proved th.t th. DBM is consistent with.th. reactive Navier-Stokes equations, Fick's law and th. Stefan-Maxwell diffusion equation in th. h.drodynamic limit. Compared with.th. one-step-relaxation model, th. split collision model offers a detailed and precise description of h.drodynamic, th.rmodynamic, and ch.mical nonequilibrium effects. Finally, th. model is validated by six bench.arks, including multicomponent diffusion, mixture in th. force field, Kelvin-h.lmh.ltz instability, flame at constant pressure, opposing ch.mical reaction, and steady detonation.

关键词： discrete Boltzmann meth.d reactive flow detonation nonequilibrium effect

Building Custom Spreadsh.et Functions with.Pyth.n: End-User Software Engineering Approach

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Journal of Software Engineering and Applications 2024年第5期17卷 246-258页

作者： Tamer Bah.at Elserwy Atef Tayh.Nour El-Din Raslan Tarek Ali Mervat h. Gh.ith Department of Software Engineering Faculty of Graduate Studies for Statistical Research (FGSSR) Cairo University Giza Egypt Department of Information Systems Higher Institute of Advanced Studies Giza Egypt

End-user computing empowers non-developers to manage data and applications, enh.ncing collaboration and efficiency. Spreadsh.ets, a prime example of end-user programming environments widely used in business for data analysis. h.wever, Excel functionalities h.ve limits compared to dedicated programming languages. Th.s paper addresses th.s gap by proposing a prototype for integrating Pyth.n’s capabilities into Excel th.ough.on-premises desktop to build custom spreadsh.et functions with.Pyth.n. Th.s approach.overcomes potential latency issues associated with.cloud-based solutions. Th.s prototype utilizes Excel-DNA and IronPyth.n. Excel-DNA allows creating custom Pyth.n functions th.t seamlessly integrate with.Excel’s calculation engine. IronPyth.n enables th. execution of th.se Pyth.n (CSFs) directly with.n Excel. C# and VSTO add-ins form th. core components, facilitating communication between Pyth.n and Excel. Th.s approach.empowers users with.a potentially open-ended set of Pyth.n (CSFs) for tasks like math.matical calculations, statistical analysis, and even predictive modeling, all with.n th. familiar Excel interface. Th.s prototype demonstrates smooth.integration, allowing users to call Pyth.n (CSFs) just like standard Excel functions. Th.s research.contributes to enh.ncing spreadsh.et capabilities for end-user programmers by leveraging Pyth.n’s power with.n Excel. Future research.could explore expanding data analysis capabilities by expanding th. (CSFs) functions for complex calculations, statistical analysis, data manipulation, and even external library integration. Th. possibility of integrating mach.ne learning models th.ough.th. (CSFs) functions with.n th. familiar Excel environment.

关键词： End-User Software Engineering Custom Spreadsh.et Functions (CSFs)

Validation of th. TOPAS Monte-Carlo Code of th. Off-Field Dose of a 6 MV Synergy Linac

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Journal of Biosciences and Medicines 2024年第7期12卷 38-54页

作者： Kodjo Joel Fabrice N’Guessan Ibrah.ma Sakh. Bogbé D. L. h. Gogon Department of Ph.sics and Ch.mistry Faculty of Sciences and Technology Iba Der Thiam University of This This Senegal International Cancer Center of Dakar Dakar Senegal Department of Ph.sics Faculty of Sciences and Technology Flix Houphouet Boigny University of Abidjan Abidjan Cte dIvoire

Th. risk of radiation-induced second cancer and th. late tissue loss due to Off-field doses in radioth.rapy remain a serious concern. Monte Carlo (MC) simulation is currently one of th. most accurate meth.ds for calculating th.se doses. MC simulation model based on th. Particle Simulation Tool (TOPAS) h.s been developed to simulate th. off-field dose of an Elekta Synergy linear accelerator (Linac) emitting 6 MV ph.tons. Measurements were taken in a water ph.ntom using an ionization ch.mber to validate th.s model. Th. Percentage Depth.Dose (PDD) at th. depth.of 0.0, 5.0, 10.0 and 15.0 cm from th. beam axis for a 10 × 10 cm2 field size was measured and simulated. Off-field dose profiles at th. depth.of 1.5 (dmax), 5.0 and 10.0 cm for field sizes of 5 × 5, 10 × 10, 15 × 15, and 20 × 20 cm2 respectively were measured and simulated. Comparison of measured and simulated off-field dose values sh.wed a good agreement. Th. average gamma passing rate of th. PDDs and profiles curves for off-field doses were 87.5% and 98.11% respectively. Th. local dose difference based on th. PDD curve between th. measured and simulated was less th.n 6.0 % for all locations. For all field size considered in th.s study, th. average difference between profile curves for off-field dose measured and simulated was 9.1%. PDDs and Profiles curves for off-field dose simulation uncertainties were less th.n 2.0% and 1.0% respectively. TOPAS-MC simulation model developed is a good representation of our 6 MV Linac Elekta Synergy for assessing off-field dose, wh.ch.would be th. primary cause of some secondary cancers.

关键词： Radioth.rapy Off-Field Dose Secondary Cancer TOPAS-MC Simulation Dosimetry

Assessment of Appropriateness of Diagnostic Lymph.Node Tissue Collection from th. Operating Th.ater and by Interventional Radiologist. A Clinical Audit

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Advances in Infectious Diseases 2024年第3期14卷 541-548页

作者： Kowth.r Salman h.ssan Divya Deodh.r Abdullah.T. Al-Rawah. Mah.ood h. Al Abri Department of Medicine Infectious Diseases Sultan Qaboos University Hospital Muscat Oman Department of Infection Control Sultan Qaboos University Hospital Muscat Oman Department of Radiology and Molecular Imaging Sultan Qaboos University Hospital Muscat Oman

Background: Appropriate sample requesting, collecting and timely dispatch.to th. appropriate laboratory is essential in establish.ng diagnosis of path.logies with.lesions. Much.time and effort may be wasted if th.s is not done according to certain standards. We conducted th.s study to assess th. route of lymph.node samples from requests to reach.ng th. laboratories. Meth.ds: We conducted an audit over a period from 4th.June until 10th.Aug 2023. Data for all th. procedures performed over th.s period on lymph.node samples (was entered into and analysed using Excel. Results: A total of eigh.een samples for sixteen patients were obtained during th.s period. Median age of th. patients was 34 years (19 - 73) with.a M:F ratio of 5:11. Among th. IR samples, nine samples were from th. neck, th.ee from inguinal area and one from axilla. Seven samples (53.8%) were tru-cut biopsies, six samples (46.15%) were FNA. All samples were sent to th. path.logy laboratory fixed in formalin. Samples for TB were sent only for five cases (31.25%) and for only two cases (12.5%) were samples sent for bacterial culture. For th. OR samples, none were sent for eith.r bacterial culture or TB. Overall, eigh. patients (50%) were not investigated for any infectious etiologies like brucella, toxoplasmosis, CMV, EBV plus oth.r possible causes. Repeat sampling was required for 25% of patients (with.n and out of th. audit period). Conclusions: to avoid delays in making diagnoses, it is paramount to consider infectious etiologies as possible diagnosis for lymph.denopath. and request appropriate investigations. Th.s requires liaising with.infectious diseases/clinical microbiology experts to guide regarding types of samples, types of media and timely dispatch.to th. correct laboratory.

关键词： Clinical Audit Clinical Samples Biopsies Lymph.Nodes Saline Formalin Quality Improvement