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Isolated Ventricular Septal Defect: Ultrasound, Therapeutic and Evolutionary Aspects of 85 Cases in the Cardiology Department of the Ignace Deen National Hospital in Conakry

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World Journal of Cardiovascular Diseases 2024年第8期14卷 465-479页

作者： Mamadou Bassirou Bah Amadou Diouldé Doumbouya Elhdj Yaya Balde Mamadou Aliou Balde alpha kone Ibrahima Sory Sylla Mamadou Dian Bah Aboulaye Bah Mamadou Diallo Thierno Siradjo Balde Abdoulaye Camara Morlaye Soumaoro Ibrahima Sory Barry Souleymane Diakité Mamadou Dadhi Balde Cardiology Department of the Ignace Deen Hospital Conakry Guinea Cardiology Department Donka Hospital Conakry Guinea

Introduction: Ventricular septal defect (VSD) is the most common congenital heart disease of all congenital heart defects. The aim of this study was to investigate the echographic, therapeutic and evolutionary aspects of ventricular septal defects (VSD) in the general cardiology department of the Hôpital National Ignace Deen. Methods: A retrospective data collection was carried out from January 2018 to December 2023 including 85 cases of isolated IVC was performed. The variables studied were epidemiological, clinical, paraclinical, therapeutic and evolutionary. Results: Of the 320 patients seen during the study period for congenital heart disease, 85 (26.556%) were isolated IVCs. Age at diagnosis ranged from 3 months to 16 years, with an average age of 3.59 years. The most represented ethnic group was the Fulani (50.58%). The 8.24% came from consanguineous marriage versus 22.35%. 91.76% of children had a history of bronchitis. The most common clinical signs found were systolic murmur (90.58%), growth retardation (51.76%). Only 4 cases (4.70%) had a malformation associated with IVC represented by DiGeorges disease (2.35%) and trisomy 21 (2.35%). Nearly half the patients had type IIb VIC (44.71%). The other half were represented by type 1 (18.82%), type IIa (20%), type III (10.59%) and type IV (5.88%). According to site more than two-thirds of VICs (71.64%) were perimembranous in location, followed by infundibular (16.47%) and muscular (11.76%) VICs. In our study 55.29% presented an indication for both surgical intervention and medical treatment, while 16.47% required only medical treatment. In contrast, 28.23% were placed under exclusive surveillance. Of the 47 patients for whom surgery was indicated, 29 (61.17%) underwent surgical repair, while 18 (38.83%) were awaiting confirmation for surgery. Conclusion: VIC is the most common congenital heart disease. An early detection strategy and the establishment of specialized centers could improve the outcome of these chil

关键词： Ventricular Septal Defect Congenital Heart Disease Ignace Deen

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Family Dyslipidemia Revealed by a Cornean Bow in a Guinean

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World Journal of Cardiovascular Diseases 2020年第7期10卷 455-459页

作者： Bah Mamadou Bassirou Balde El Hadj Yaya Balde alpha Ibrahima Beavogui Mariame Camara Abdoulaye Barry Ibrahima Sory Balde Mamadou Aliou Sylla Ibrahima Sory kone alpha Ngaide Alhassane Aliou Mamy Adrien Balde Mamadou Dadh Ignace Deen National Hospital Cardiology Department Conakry Republic of Guinea Department of Ophthalmology Department of the Armed Forces Conakry Republic of Guinea Cardiology Department of Donka National Hospital Conakry Republic of Guinea Department of Hospital Cardiology of Grand Yoff Dakar Senegal

Object: The aim of this study was to describe a familial dyslipidemia revealed by a corneal arch. Familial hypercholesterolemia is a rare and severe hereditary dyslipidemia with an exceptional homozygous form. He was a 43-year-old patient admitted with visual disturbance, xanthomatous papule and orange coloring at the level evolving for 5 years, no personal history of cardiovascular disease, having a family history of lipid disorders in siblings, as a cardiovascular risk factor: age over 50 and the male gender, normal cardio pulmonary examination, blood pressure at 120/80 mmhg, heart rate 78 bpm, in whom the ophthalmological examination shows a yellowish spot on the cornea (Figure 1). We report the case of familial dyslipidemia revealed by a corneal spot in Guinea.More recent studies increasingly suggest that it is much more widespread than previously thought: 1/200 to 1/400. Familial dyslipidemia is a rare and severe metabolic abnormality. It should be screened as early as possible like any other cardiovascular risk factor for atheroma to avoi

关键词： Corneal Arch Familial Dyslipidemia Guinea

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Clinical, Therapeutic and Evolutionary Profiles of Hypertensive Emergencies in the Cardiology Department of the Ignace Deen National Hospital (Conakry)

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World Journal of Cardiovascular Diseases 2023年第12期13卷 827-836页

作者： Balde Elhadj Yaya Bah Mamadou Bassirou Barry Ibrahima Sory kone alpha Keita Fatoumata Binta Soumaoro Morlaye Toure Aboubacar Doumbouya Amadou Dioulde Sylla Ibrahima Sory Diakite Souleymane Balde Mamadou Dadhi Cardiology Department of the Ignace Deen Hospital Conakry Guinea

Introduction: Hypertensive emergencies are a reality in the cardiology department of the Ignace Deen National Hospital. The aim of this study was to determine the clinical, therapeutic and evolutionary profile of hypertensive emergencies in the cardiology department of the Ignace Deen National Hospital. Methods: This was a longitudinal descriptive study of patients admitted to the cardiology department of the Ignace Deen National Hospital for hypertensive emergencies, over a period of six (6) months from 1 October 2020 to 31 March 2021. Results: Among the 638 patients admitted to the cardiology department during the study period, 102 cases of hypertensive emergencies were identified, representing a frequency of 15.99%. The mean age of the patients was 56.65 ± 13.33 years, with extremes of 23 and 90 years, and the sex ratio was 1.91 in favour of men. The associated cardiovascular risk factors were: age (76.47%), smoking (41.18%), sedentary lifestyle (31.37%), obesity (16.67%), dyslipidaemia (12.75%), diabetes (11.76%) and excessive alcohol consumption (11.76%). The various clinical pictures found were: acute pulmonary oedema 39 cases (38.23%), acute coronary syndrome 31 cases (30.39%), stroke 17 cases (16.67%), hypertensive encephalopathy 11 cases (10.78%), acute renal failure 3 cases (2.94%) and aortic dissection 1 case (0.98%). The drugs used on admission were calcium antagonists (Nicardipine 10mg) in 58 cases (56.86%), diuretics (Furosemide 20mg) in 44 cases (43.13%), nitrates (Risordan 20mg) in 39 cases (38.23%) and beta-blockers in 31 cases (30.39%). In terms of outcome, 88 (86.27%) patients had improved. However, 12 (11.76%) deaths were recorded. Conclusion: Hypertensive emergencies are a worrying condition with a high prevalence in the cardiology department of the Ignace Deen National Hospital.

关键词： Emergency Hypertension Prevalence National Hospital Ignace Deen

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Atypical Coarctation of the Aorta Revealed by Arterial Hypertension in a 22-Year-Old Young Man

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World Journal of Cardiovascular Diseases 2023年第7期13卷 359-365页

作者： Mamadou Bassirou Bah Elhdj Yaya Balde Thierno Hamidou Balde Fatoumata Biro Bah Aissatou Tiguidanké Balde Amadou Diouldé Doumbouya Mamadou Diallo alpha kone Ibrahima Sory Sylla Thierno Siradjo Balde Abdoulaye Camara Mamadou Dadhi Balde Cardiology Department Ignace Deen Hospital Conakry Guinea Department of Imaging Ignace Deen Hospital Conakry Guinea Cardiology Department Donka Hospital Conakry Guinea

Non-isthmic coarctation of the aorta is a rare congenital malformation in adults. Arterial hypertension is a frequent circumstance of discovery. We reported the case of a 22-year-old Guinean man who had been followed for 5 years for hypertension. Clinically, he presented with hypertension of the upper limbs with a systolic pressure gradient of 100 mmHg. The diagnosis was confirmed by thoracic angioscan, which showed a 65.8% coarctation of the abdominal aorta. He was on triple antihypertensive therapy combining Atenolol 100 mg, Amlodipine 10 mg and Perindopril 10 mg. He is awaiting interventional treatment. His blood pressure is stable at around 140/90 mmHg.

关键词： Abdominal Aortic Coarctation Arterial Hypertension Young Subject Congenital Malformation

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Arterial and Venous Thrombosis following Vaccination against COVID-19 with Astra-Zeneca Vaccine Revealing Thrombophilia

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World Journal of Cardiovascular Diseases 2023年第4期13卷 198-204页

作者： Bah Mamadou Bassirou Doumbouya Amadou Dioulde Balde Mamadou Aliou Balde Thierno Hamidou Sylla Ibrahima Sory Balde Elhadj Yaya kone alpha Barry Ibrahima Sory Samoura Sana Beavogui Mariam Diakité Souleymane Balde Mamadou Dadhi Cardiology Department Ignace Deen Hospital Conakry Guinea Imaging Department Ignace Deen Hospital Conakry Guinea

Vaccination against COVID-19 is the most recognised means of containing the pandemic. Vaccines are not without side effects, particularly vascular thrombosis. But before blaming the vaccines, a thorough assessment of thrombotic risk factors is necessary. We report a case of arterial and venous thrombosis after vaccination with AstraZeneca revealing an exaggeration of factor VIII in a 37-year-old female patient. The angioscanner showed a venous thrombosis of the right subclavian, a pulmonary embolism and the presence of a thrombus in the aorta. The biology was in favour of a high level of factor VIII. The patient was treated with an antivitamin K, and the clinical evolution was favourable.

关键词： Thrombophilia Thrombosis Vaccine AstraZeneca

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Deep Vein Thrombosis Revealing Prostate Cancer about a Case in the Cardiology Department of the Ignace Deen National Hospital in Conakry

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World Journal of Cardiovascular Diseases 2020年第8期10卷 608-613页

作者： Ibrahima Sory Barry Hadj Yaya El Balde Diarra Koivogui Abdoulaye Camara Aly Samoura Mamadou Bassirou Bah Mamadou Aliou Balde alpha kone Ibrahima Sory Sylla Souleymane Diakite Moussa Kourouma Kokoulo Koivogui Mariam Beavogui Mamadou Dadhi Balde Mamadi Conde Cardiology Service of Ignace Deen National Hospital Conakry Guinea Cardiology Department of DONKA National Hospital Conakry Guinea Military Health Service at the Battalion of the Headquarters Camp Almamy Samory TOURE Conakry Guinea

Introduction: Deep vein thrombosis is a frequent disease, its origin is most often multifactorial. Venous thromboembolic disease (MVTE) and cancer are two frequently entangled pathologies. Here we report the diagnosis of deep vein thrombosis that discovered prostate cancer in an 88-year-old Guinean man. On clinical examination, there was a painful and hot swelling of the right leg, an absence of sloshing of the calf, a positive sign of Homans. The digital rectal examination revealed an enlarged prostate with an irregular surface. Cardiopulmonary auscultation was normal. The electrocardiogram showed a regular sinus rhythm at 65 cycles/min, with no sign of enlarged cavities or conduction disturbance. Venous Doppler ultrasound of the lower limbs showed the presence of an extensive acute deep venous thrombosis of the right sural vein extended to the popliteal and to the homolateral deep femoral. The reino-vesico-prostatic ultrasound concluded in a heterogeneous prostatic hypertrophy with projection of a median lobe associated with a bladder of fight with an important post voiding residue evaluated at 170 ml;the rate of specific antigen of the prostate PSA was at 84.87 ng/ml. The pathology analysis made after a prostate biopsy puncture concluded with an adenocarcinoma with a Gleason score of 3. Conclusion: The association of venous thromboembolic disease (MVTE) and neoplasia is frequent. The existence of active cancer in a patient is a known risk factor for MVTE and, conversely, the discovery of a first episode of deep vein thrombosis (DVT) or pulmonary embolism (PE) may be the mode of revelation of cancer.

关键词： Deep Vein Thrombosis Prostate Cancer Elderly Conakry

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Clinical and Therapeutic Evaluation of Hypertensives According to the Practice of Ambulatory Blood Pressure Measurement (ABPM) at the Bel Air International Clinic in Conakry from January 1, 2019 to November 30, 2022

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World Journal of Cardiovascular Diseases 2023年第6期13卷 327-332页

作者： alpha kone Fousseny Diakite Abel Mansaré Mahamoud Sama Cherif Mamadou Bassirou Bah Sana Samoura Souleymane Diakité Ibrahima Sory Barry Ibrahima Sory Sylla Elhadji Yaya Baldé Abdoulaye Bangoura Mariame Beavogui Mamadou Dadhi Baldé Mohamed Lamine Kaba Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Bel Air International Clinic CIBA Conakry Guinea Cardiology Department of Sino-Guinean Hospital Conakry Guinea Donka National Hemodialysis Center Conakry Guinea Cardiology Department of National Hospital Ignace Deen Conakry Guinea

Introduction: Ambulatory Blood Pressure Measurement (ABPM) is a non- invasive examination recommended for subjects at high cardiovascular risk, and those requiring a nocturnal drop in BP such as elderly and obese subjects, those with secondary hypertension or resistant, diabetics, subjects with metabolic syndrome or sleep apnea syndrome. The objective of this study was to evaluate the contribution of ABPM in the diagnosis and evaluation of the level of control of hypertension under treatment at the Bel Air international clinic. Materials and Methods: This is a retrospective, cross-sectional and descriptive study, carried out at the Bel Air International Clinic in Conakry (Guinea) between January 2019 and November 30, 2022. It included a consecutive series of 180 consenting patients recruited through an ambulatory measurement of 24-hour blood pressure from a FUGADA brand device. Results: We collected 180 patients, with a male predominance (sex-ratio M/F = 2.46). The mean age of the patients was 48.48 ± 14.23 years. The most represented age group was that of 32 to 42 years with 50 cases (27.8%) followed by that of 43 to 52 years with 42 cases or 23.3%. The indication was for diagnostic purposes in 106 cases 58.9%, the therapeutic evaluation in 58 patients (32.2%). The examination was prescribed by a cardiologist in 98 cases (54.4%), a general practitioner in 71 cases (39.4%), a neurologist in 11 cases (6.1%). In the therapeutic evaluation, high blood pressure was controlled in 24 patients (13.3%) and uncontrolled in 34 cases (18.9%). In the diagnostic indication, high blood pressure was confirmed in 79 cases (43.9%) with a statistically significant link (Chi2 = 4.57 and p-value = 0.032). The nycthemeral mean was 187.27 ± 26.22 mmHg for systolic blood pressure (SBP) and 110.37 ± 19.06 mmHg for diastolic blood pressure (DBP), during the day, 151.64 ± 21.45 mmHg for SBP and 71.59 ± 8.67 mmHg for diastolic blood pressure. During the study 65 patients (36.1%) were id

关键词： Ambulatory Blood Pressure Measurement Guinea

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Epidemiological, Clinical and Therapeutic Aspects of Arterial Hypertension at the General Medicine Department of Nzerekore Regional Hospital

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World Journal of Cardiovascular Diseases 2021年第11期11卷 533-538页

作者： Beavogui Mariama Balde Elhadj Yaya Doumbouya Idrissa Barry Ibrahima Sory Samoura Aly Camara Abdoulaye Bah Mamadou Bassirou Mariama Sylla Ibrahima Sory Balde Mamadou Dadhi Bah Abdoul Mazid Mariama kone alpha Balde Mamadou Aliou Conde Mamady Cardiology Department Ignace Deen National Hospital Conakry Guinea Department of Neurology Ignace Deen National Hospital Conakry Guinea Cardiology Department Donka National Hospital Conakry Guinea

Introduction: High blood pressure is a public health problem in Guinea as well as everywhere in Africa. The objective of our study was to assess the epidemiological, clinical and therapeutic aspects of High blood pressure in the general medicine department of the Nzérékoré regional hospital. Methodology:This was a prospective study of a descriptive type, lasting 06 months, from July 1 to December 31, 2014. Results: We recorded 156 cases of High blood pressure among a total of 570 patients, for a hospital frequency of 27%. The 56 - 65 age group was the most affected, at 29.4%, with a predominance of men (sex ratio: 1.5). Alcoholism was the most common cardiovascular risk factor with a frequency of 51.2%, smoking and physical inactivity were found in 35.8% and 30.7% respectively;psychosocial stress was found in 24.3% of patients. The clinic was dominated by headache (100%) and dizziness (57.6%). All our patients were subjected to a healthy diet. Fixed dual therapy was the most widely used treatment regimen, i.e. 91 patients (58.3%) and included a diuretic in 37.1% of cases, a calcium channel blocker in 25% of cases and an ACE inhibitor in 24.3%. Conclusion: This study revealed a high frequency of hypertension in the general medicine department of the regional hospital of N’zérékoré.

关键词： Epidemiology Clinical Therapeutic Hypertension

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Cardiac Amyloidosis: A Case Report of Seven Patients

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World Journal of Cardiovascular Diseases 2022年第3期12卷 160-167页

作者： Ngardjibem Djita Ibrahima Sory2 Sylla Aissatou Barry Murielle Ahodakin Djibril Sylla Elhadj Yaya Balde Mamadou Bachir Bah Houzeiph Abdou Lassissi alpha kone Sana Soumra Mamadou Aliou Balde Mariame Beavogui Mamadou Dadhi Balde Noura Feniche Cardiology Department Alen&#231 on-Mamers Intercommunal Hospital Alen&#231 on France Gamal Abdel Nasser University of Conakry Conakry Republic of Guinea

Introduction: Cardiac amyloidosis is a rare and under-diagnosed disease. The objective of this study was to collect cases of cardiac amyloidosis in patients hospitalized in the cardiology department of the Centre Hospitalier Intercommunal Alençon-Mamers (CHICAM). Patients and Methods: This was a retrospective descriptive study of the records of patients diagnosed with cardiac amyloidosis. The study took place in the cardiology department of the CHICAM over 12 months (from January 1, 2020 to December 31, 2020). We included the files of patients in whom the diagnosis of cardiac amyloidosis was confirmed on the basis of clinical, echocardiographic, biological, scintigraphic and cardiac MRI evidence. Results: Seven patients were included. The mean age was 86.71 years. Six men for one woman. Most of the patients were in heart failure. There was one case of periorbital ecchymosis. Troponinemia was increased in three patients, NTproBNP was always high with a mean of 1000 ng/L. Cardiac echography showed a hyperbright septum in four cases, concentric hypertrophy of the left ventricle with a mean interventricular septum in diastole of 13.85 mm. Six cases were senile transthyretin amyloidosis (TTR), one case was mutated transthyretin amyloidosis (TTRm). Two cases of death were noted. Conclusion: Cardiac amyloidosis has a poor prognosis due to delayed diagnosis.

关键词： Cardiac Amyloidosis Echocardiography Heart Failure Myocardial Scintigraphy

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Farmers’ Knowledge and Perceptions of the Effects of Climate Variability and Pollution on Crop Production and Their Varying Adaptation Strategies in The Gambia

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American Journal of Climate Change 2024年第3期13卷 543-566页

作者： Pierre Anthony Mendy Mawa kone Ado Baba Ahmed Sidat Yaffa alpha Kargbo Afua Amponsah Amankwah Kossi-Messan Jacques Agboka Blessing Chinomso Okorie Assan Sowe Echene Jatta Department of Physical and Natural Sciences School of Arts & Sciences University of The Gambia Banjul The Gambia West African Science Service Centre on Climate Change and Adapted Land Use (WASCAL) Department of Biosciences Universit Flix Houphout-Boigny Abidjan Cte dIvoire School of Agriculture and Environmental Sciences University of The Gambia Banjul The Gambia School of Education University of The Gambia Banjul The Gambia Department of Sociology and Social Work College of Humanities and Social Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

Crop and livestock production is critical to food security in The Gambia. Over the years, the country has experienced a reduced yield due to perceived climate change events with limited studies on how climate change and pollution affect crop production. This study assesses farmers’ knowledge and perceptions of the effects of climate variability and pollution on crop production and their varying adaptation strategies in The Gambia. Both quantitative and qualitative methods were used in this study. The sample size for quantitative data collection was calculated as 432 while the qualitative data involves both the focus group discussions and key informant interviews. The focus group discussions comprised two districts in each of the six agricultural regions and two farming communities engaged in crop production were chosen from each district. Furthermore, eight key informant interviews from relevant institutions were conducted. The study shows that The Gambia is highly vulnerable to extreme climatic events. Although most farmers opined that agricultural land contamination emanates from farm runoff and indiscriminate waste dumping, they had little knowledge of heavy metal pollution and bioremediation. The results showed that farmers experienced constraints such as inadequate access to credit, water, and irrigation facilities, insufficient access to efficient inputs, salt intrusion, etc. which threatened food security. The study concludes that crop farmers acknowledged the existence and impacts of climate change, and therefore recommend the availability and affordability of climate change resilient crops and promote variability awareness campaigns to address climate change impacts in The Gambia.

关键词： Climate Change Extreme Weather Vulnerability Risks Hazards Adaptation Strategies

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