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Statistical analysis of geomagnetic field variations during the partial solar eclipse on 2011 January 4 in Turkey

Research in Astronomy and Astrophysics 2015年第5期15卷 742-752页

作者： Abdullah Ates Yunus Levent Ekinci Aydin Buyuksarac Attila Aydemir alper Demirci Ankara University Faculty of Engineering Department of Geophysical Engineering BesevlerTR-06100 Ankara Turkey Bitlis Eren University Faculty of Arts and Sciences Department of Archaeology TR-13000Bitlis Turkey Bitlis Eren University Faculty of Engineering and Architecture Department of Civil Engineering TR-13000 Bitlis Turkey Turkish Petroleum Corp. Sogutozu Mah. 2180. Cad. No: 10 Sogutozu TR-06100 AnkaraTurkey Bitlis Eren University Faculty of Engineering and Architecture Department of Geophysical Engineering TR-13000 Bitlis Turkey

Some geophysical parameters, such as those related to gravitation and the geomagnetic field, could change during solar eclipses. In order to observe geomagnetic fluctuations, geomagnetic measurements were carded out in a limited time frame during the partial solar eclipse that occurred on 2011 January 4 and was observed in Canakkale and Ankara, Turkey. Additionally, records of the geomagnetic field spanning 24 hours, obtained from another observatory （in Iznik, Turkey）, were also analyzed to check for any peculiar variations. In the data processing stage, a polynomial fit, following the application of a running average routine, was applied to the geomagnetic field data sets. Geomagnetic field data sets indicated there was a characteristic decrease at the beginning of the solar eclipse and this decrease can be well-correlated with previous geomagnetic field measurements that were taken during the total solar eclipse that was observed in Turkey on 2006 March 29. The behavior of the geomagnetic field is also consistent with previous observations in the literature. As a result of these analyses, it can be suggested that eclipses can cause a shielding effect on the geomagnetic field of the Earth.

关键词： Sun magnetic field -- eclipses -- methods data analysis -- methods statistics

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Pathway and protein engineering for biosynthesis

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Synthetic and Systems Biotechnology 2022年第4期7卷 1044-1045页

作者： Yongjin Zhou Martin Grininger Hal alper Dalian Institute of Chemical Physics Chinese Academy of SciencesChina Goethe University Frankfurt Germany The University of Texas at Austin USA

Sustainable biosynthesis of chemicals and efforts to create new molecules of interest require efficient enzymes and pathways as well as comprehensive tools and technologies to implement this *** are the key components for construction of efficient biosynthetic pathways,enzyme characterization and engineering can help to identify key enzymes and regulatory factors for construction of biosynthetic pathways,as well as improve enzyme performance;Pathway engineering can help construct biosynthetic pathways and balance metabolic network to improve biosynthetic efficiency;Tools and technologies facilitate the engineering of enzymes,pathways,and whole *** special issue focusing on“Pathway and Protein Engineering for Biosynthesis”comprises eight review articles and nine original research articles,which highlight and showcase current progress on Pathway and Protein Engineering and their application for biosynthesis.

关键词： ring engineering biosynthesis

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Investigation of performance and emission characteristics of waste cooking oil as biodiesel in a diesel engine

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Petroleum Science 2018年第2期15卷 396-404页

作者： Yahya Ulusoy Rldvan Arslan Yucel Tekin Ali Surmen alper Bolat Remzi Sahin Department of Agricultural Machinery/Automotive Technology Uludag UniversityBursaTurkey Department of Automotive Engineering Uludag UniversityBursaTurkey Turk Traktor ve Ziraat Makineleri Co. AnkaraTurkey Department of Mechanical Engineering KTO Karatay UniversityKonyaTurkey

Biodiesel is one of the most popular prospective alternative fuels and can be obtained from a variety of sources. Waste frying oil is one such source along with the various raw vegetable oils. However, some specific technical treatments are required to improve certain fuel properties such as viscosity and calorific value of the biodiesel being obtained from waste cooking oil methyl ester （WCOME）. Various treatments are applied depending on the source and therefore the composition of the cooking oil. This research investigated the performance of WCOME as an alternative biofuel in a four-stroke direct injection diesel engine. An 8-mode test was undertaken with diesel fuel and five WCOME blends. The best compromise blend in terms of performance and emissions was identified. Results showed that energy utilization factors of the blends were similar within the range of the operational parameters （speed, load and WCOME content）. Increasing biodiesel content produced slightly more smoke and NOx for a great majority of test points, while the CO and THC emissions were lower.

关键词： Waste cooking oil Methyl ester Biodiesel Alternative fuels Vehicle emissions

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Predisposing factors and surgical outcome of complicated liver hydatid cysts

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World Journal of Gastroenterology 2010年第24期16卷 3040-3048页

作者： alper Akcan Erdogan Sozuer Hizir Akyildiz Zeki Yilmaz Ahmet Ozturk Altay Atalay Department of General Surgery Erciyes University School of Medicine Department of Biostatistics Erciyes University School of Medicine Department of Microbiology Erciyes University School of Medicine

AIM: To evaluate the predisposing factors for peritoneal perforation and intrabiliary rupture and the effects of these complications on surgical outcome in liver hydatid ***: A total of 372 patients with liver hydatid cysts who had undergone surgical treatment were evaluated retrospectively. Twenty eight patients with peritoneal perforation, 93 patients with spontaneous intrabiliary perforation, and 251 patients with noncomplicated hydatid cysts were treated in our ***: When the predisposing factors for complications were evaluated, younger age, superf icial position, and larger cyst dimensions (P 0.05). The overall recurrence rate was 3.8% (14 patients), but there was not any statistical difference among the patient groups (P = 0.13). The early postoperative mortality rate was 1.1%. CONCLUSION: In peritoneally perforated and intrabiliary ruptured cases, the most important steps are irrigation of the peritoneal cavity and clearance of the cystic material from the biliary tree.

关键词： Complicated liver hydatid cysts Predisposing factors Surgical treatment Surgical outcome

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The frequency of wing damage in a migrating butterfly

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Insect Science 2023年第5期30卷 1507-1517页

作者： Rabiya korkmaz Hamed Rajabi Shahab Eshghi Stanislav N.Gorb Thies H.Büscher Department of Functional Morphology and Biomechanics Zoological InstituteKiel UniversityKielGermany Division of Mechanical Engineering and Design School of EngineeringLondon South Bank UniversityLondonUK

The ability to fly is crucial for migratory ***,the accumulation of damage on the wings over time can affect survival,especially for species that travel long *** examined the frequency of irreversible wing damage in the migratory butterfly Vanessa cardui to explore the effect of wing structure on wing damage frequency,as well as the mechanisms that might mitigate wing *** exceptionally high migration rate driven by high precipitation levels in their larval habitats in the winter of 2018–2019 provided us with an excellent opportunity to collect data on the frequency of naturally occurring wing damage associated with long-distance *** images of 135 individuals of *** were collected and analyzed in *** results show that the hindwings experienced a greater frequency of damage than the ***,forewings experienced more severe damage on the lateral margin,whereas hindwings experienced more damage on the trailing *** frequency of wing margin damage was higher in the painted lady butterfly than in the migrating monarch butterfly and in the butterfly Pontia occidentalis following artificially induced wing *** results of this study could be used in future comparative studies of patterns of wing damage in butterflies and other *** studies are needed to clarify whether the strategies for coping with wing damage differ between migratory and nonmigratory species.

关键词： biomechanics cost of migration flight Lepidoptera Vanessa cardui wing structure

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Loss of Aβ-nerve endings associated with the Merkel cell-neurite complex in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis

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International Journal of Oral Science 2016年第1期8卷 32-38页

作者： Daniela Calderon Carrion Yiiksel korkmaz Britta Cho Marion Kopp Wilhelm Bloch Klaus Addicks Wilhelm Niedermeier Department of Prosthetic Dentistry Dental SchoolUniversity of CologneCologneGermany Center for Biochemistry Institute for Experimental Dental Research and Oral Musculoskeletal BiologyMedical FacultyUniversity of CologneCologneGermany Department of Anatomy University of CologneCologneGermany Department of Molecular and Cellular Sport Medicine German Sport UniversityCologneGermany

The Merkel cell-neurite complex initiates the perception of touch and mediates Ap slowly adapting type I responses. Lichen planus is a chronic inflammatory autoimmune disease with T-cell-mediated inflammation, whereas hyperkeratosis is characterized with or without epithelial dysplasia in the oral mucosa. To determine the effects of lichen planus and hyperkeratosis on the Merkel cell-neurite complex, healthy oral mucosal epithelium and lesional oral mucosal epithelium of lichen planus and hyperkeratosis patients were stained by immunohistochemistry （the avidin-biotin-peroxidase complex and double immunofluorescence methods）using pan cytokeratin, cytokeratin 20 （K20, a Merkel cell marker）, and neurofilament 200 （NF200, a myelinated Aβ- and Aδ-nerve fibre marker） antibodies. N F200-immunoreactive （ir） nerve fibres in healthy tissues and in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis were counted and statistically analysed. In the healthy oral mucosa, K20-positive Merkel cells with and without close association to the intraepithelial NF200-ir nerve fibres were detected. In the lesional oral mucosa of lichen planus and hyperkeratosis patients, extremely rare NF200-ir nerve fibres were detected only in the lamina propria. Compared with healthy tissues, lichen planus and hyperkeratosis tissues had significantly decreased numbers of NF200-ir nerve fibres in the oral mucosal epithelium. Lichen planus and hyperkeratosis were associated with the absence of Aβ-nerve endings in the oral mucosal epithelium. Thus, we conclude that mechanosensation mediated by the Merkel cell-neurite complex in the oral mucosal epithelium is impaired in lichen planus and hvperkeratosis.

关键词： Aβ-nerve fibres hyperkeratosis lichen planus mechanosensation Merkel cell-neurite complex

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Effect of sunitinib on metastatic gastrointestinal stromal tumor in patients with neurofibromatosis type 1: A case report

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World Journal of Gastroenterology 2007年第18期13卷 2629-2632页

作者： M Emin Kalender alper Sevinc Ediz Tutar Akif Sirikci Celalettin Camci Department of Medical Oncology Gaziantep University School of Medicine Gaziantep Oncology Hospital Gaziantep TR-27310 Turkey Department of Pathology Gaziantep University School of Medicine Sahinbey Medical Center Gaziantep TR-27310 Turkey Department of Radiology Gaziantep University School of Medicine Sahinbey Medical Center Gaziantep TR-27310 Turkey

Gastrointestinal stromal tumor （GIST） represents the most common mesenchymal malignancy of the gastrointestinal （GI） tract. In neurofibromatosis （NF）, the increased incidence of tumor needs to be considered even in non-symptomatic individuals. Patients with neurofibromatosis NF type 1 have an increased risk of developing GI tumors including rare types such as GIST. We report a case of GIST in a 53-year-old male patient with neurofibromatosis. The patient was diagnosed with NF four years ago and his medical history revealed that he was hospitalized 5 times with a provisional diagnosis of massive lower gastrointestinal bleeding. GIST was diagnosed at explorative laparotomy and the tumor was 21 cm × 13 cm × 7 cm in size. Immunohistochemical examination showed that vimentin, actin and CDl17 were positive. Computerized tomography showed peritoneal implants three months later. Imatinib mesylate （600 mg/d） was initiated. However, control computerized tomography revealed liver and omental metastasis. The dosage was elevated to 800 mg/d. Despite high dosage, the progression of the metastatic lesions continued in the liver and omentum. The patient started oral sunitinib malate （Sutent~ Pfizer Inc, New York, NY, USA） 50 mg per day for 4 consecutive weeks, followed by 2 wk off per treatment cycle. The metastatic lesions in the liver and omentum were decreased in size after four courses, suggesting that sunitinib is also an effective treatment modality for metastatic GIST in NF patients.

关键词： Neurofibromatosis Gastrointestinal stromal tumors Imatinib Sunitinib

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CRISPR-PIN:Modifying gene position in the nucleus via dCas9-mediated tethering

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Synthetic and Systems Biotechnology 2019年第2期4卷 73-78页

作者： Jyun-Liang Lin Holly Ekas Matthew Deaner Hal S.alper McKetta Department of Chemical Engineering The University of Texas at Austin200 E Dean Keeton St.Stop C0400AustinTX 78712USA Institute for Cellular and Molecular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX 78712USA

Spatial organization of DNA within the nucleus is important for controlling DNA replication and repair,genetic recombination,and gene ***,we present CRISPR-PIN,a CRISPR/dCas9-based tool that allows control of gene Position in the Nucleus for the yeast Saccharomyces *** approach utilizes a cohesindockerin interaction between dCas9 and a perinuclear *** doing so,we demonstrate that a single gRNA can enable programmable interaction of nuclear DNA with the nuclear *** demonstrate the utility of this approach for two applications:the controlled segregation of an acentric plasmid and the re-localization of five endogenous *** both cases,we obtain results on par with prior reports using traditional,more cumbersome genetic ***,CRISPR-PIN offers the opportunity for future studies of chromosome biology and gene localization.

关键词： CRISPR Chromosome organization Chromosome biology Gene positioning Synthetic biology

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He/icobacter py/ori infection in hemodialysis patients: Susceptibility to amoxicillin and clarithromycin

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World Journal of Gastroenterology 2005年第6期11卷 842-845页

作者： Selim Aydemir Sedat Boyacioglu Gurden Gur Muge Demirbilek Fusun Kamber Can Murat korkmaz Ugur Yilmaz Department of Gastroenterology Department of Clinical Microbiology

AIM: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls. METHODS: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age- and sex-matched non-uremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched. The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique. RESULTS: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant (P<0.05). CONCLUSION: Resistance to amoxicillin does not appear to be an important problem in H py/ori-infected ESRD and non-uremic patients in our region. In contrast, the rates of resistance to clarithromycin are high, particularly in the ESRD population.

关键词： Helicobacter pylori Chronic renal failure Antibiotic resistance Clarithromycin Amoxicillin

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A case of isolated hepatic actinomycosis causing right pulmonary empyema

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Chinese Medical Journal 2006年第13期119卷 1133-1135页

作者： Gonenc Kocabay Atahan Cagatay Haluk Eraksoy Betul Tiryaki Aydin alper Semra Calangu Department of Internal Medicine Istanbul Faculty of Medicine Turkey Department of Infectious Diseases and Clinical Microbiology Istanbul Faculty of Medicine Turkey Department of Radiology Istanbul Faculty of Medicine Turkey Department of General Surgery Istanbul Faculty of Medicine Turkey

The clinical picture of actinomycosis was first described in *** agents are found in the natural flora of the oral cavity, upper gastrointestinal system and female genital systems. Actinomyces israelii is usually responsible for the infections and causes chronic suppurative and granulomatous infections. The most common disease form is cervicofascial infection. Liver is involved in 5% of all actinomycosis infections. Liver involvement secondary to any primary infection site in the abdomen frequently occurs. In 15% of abdominal infections the liver is also involved. However, in very rare cases, a primary focus cannot be found, and these cases are called primary or isolated hepatic actinomycosis （IHA）. IHA which is frequently seen as a solitary abscess can be confused with a malignancy both clinically and radiologically.

关键词： A case of isolated hepatic actinomycosis causing right pulmonary empyema oral

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