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Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver

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World Journal of Gastroenterology 2008年第33期14卷 5204-5209页

作者： Fahrettin Yildiz Sacit Coban alpaslan terzi Mustafa Ates Nurten Aksoy Hale Cakir Ali Riza Ocak Muharrem Bitiren Harran University Medical Faculty Department of General SurgerySanli Urfa 63300 Turkey Gaziantep University Medical Faculty Department of General SurgeryGaziantep 27310 Turkey Malatya State Hospital Department of General Surgery Malatya 44100 Turkey Harran University Medical Faculty Department of BiochemistrySanli Urfa 63300 Turkey Harran University Medical Faculty Department of Pathology Sanli Urfa 63300 Turkey

AIM: To determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver. METHODS: Thirty rats were divided into three groups as sham (Group 1), control (Group 2), and Nigella sati-va (NS) treatment group (Group 3). All rats underwent hepatic ischemia for 45 min followed by 60 min period of reperfusion. Rats were intraperitoneally infused with only 0.9% saline solution in group 2. Rats in group 3 received NS (0.2 mL/kg) intraperitoneally, before isch-emia and before reperfusion. Blood samples and liver tissues were harvested from the rats, and then the rats were sacrifi ced. Serum aspartate aminotransfera-se (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxida-tive status (TOS), oxidative stress index (OSI) and my-eloperoxidase (MPO) in hepatic tissue were measured. Also liver tissue histopathology was evaluated by light microscopy. RESULTS: The levels of liver enzymes in group 3 weresignifi cantly lower than those in the group 2. TAC in liver tissue was significantly higher in group 3 than in group 2. TOS, OSI and MPO in hepatic tissue were signifi cantly lower in group 3 than the group 2. Histo-logical tissue damage was milder in the NS treatment group than that in the control group. CONCLUSION: Our results suggest that Nigella sa-tiva treatment protects the rat liver against to hepatic ischemia-reperfusion injury.

关键词： Nigella sativa Ischemia reperfusion injury Liver

Dithiothreitol and PEG Induced Combined Stress May Affect the Expressions of ABA Aldehyde Oxidase, Sucrose Synthase and Proline Metabolic Genes in Maize Seedlings

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 487-495页

作者： Cansu Altuntas Rabiye terzi Faculty of Science Department of BiologyKaradeniz Technical UniversityTrabzon61080Turkey

The endoplasmic reticulum(ER)is an organelle in the cell where proteins are created and *** is a very elaborate process that is often interrupted by various biotic and abiotic stresses,leading to the formation of unfolded and misfolded proteins called ER ***(DTT)-induced unfolded protein response(UPR)in endoplasmic reticulum(ER)has been recently reported in ***,previous studies demonstrated that treatment with polyethylene glycol(PEG 6000)could stimulate water deficit in ***,further researches should be conducted to elucidate the molecular mechanism of ER stress response and the relationship between water deficiency and *** this study,we examined the expressions of sucrose synthase(SuS)gene,proline metabolic genes and abscisic aldehyde oxidase(AAO3)gene in maize seedlings that were subjected to DTT and PEG induced combined stresses by using quantitative real-time *** weeks old detached maize seedlings were treated with or without DTT and PEG 6000 for 12 *** treatment with DTT increased about 2-fold the expression of gene encoding proline synthesis enzyme,pyrroline-5-carboxylate synthetase(P5CS)but no statistically affected the proline catabolism enzyme,proline dehydrogenase(ProDH)in comparison with un-treated *** treatment was also up-regulated P5CS while it was down-regulated *** relative expression levels of SuS and AAO3 genes statistically enhanced about 2.5 fold under the DTT-induced ER ***,the expression levels of SuS and AAO3 genes were up-regulated in the detached seedlings exposed to PEG-induced water ***,the induced gene expressions were down-regulated under the combined stress,the DTT-induced ER stress and PEG-induced water deficit in comparison with the singular stress responses(DTT or PEG).The results indicated that the expressions of genes,related to the synthesis of some signal osmolyte compounds such as proline and sucrose can be suppressed when ER s

关键词： ER stress water deficit sucrose proline metabolism ABA synthesis gene expression

Extraskeletal symptoms and comorbidities of diffuse idiopathic skeletal hyperostosis

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World Journal of Clinical Cases 2014年第9期2卷 422-425页

作者： Rabia terzi Derince Training and Research Hospital Department of Physical Medicine and RehabilitationKocaeli 41 300 Turkey

Diffuse idiopathic skeletal hyperostosis(DISH) is a noninflammatory disease characterized by calcification and ossification of soft tissues, mainly enthesis and spinal ligaments. The clinical presentation primarily includes spinal involvement-induced pain and range of motion. Although rare, life-threatening gastrointestinal, respiratory or neurological events or severe morbidity due to bone compression on the adjacent structures may develop. There is a limited amount of data on DISHrelated events in the literature. In recent years, comorbid metabolic disorders are of great interest in patients with DISH. The early diagnosis of these conditions as well as rare entities allows an effective multidisciplinary approach for the treatment of DISH. In this article, we review extraskeletal symptoms and associated comorbidities in patients with DISH.

关键词： Diffuse idiopathic skeletal hyperostosis Swallowing Respiratory symptoms Neurological symptoms Comorbidities

Performance of fluoride and boron compounds against drywood and subterranean termites and decay and mold fungi

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Journal of Forestry Research 2020年第4期31卷 1425-1434页

作者： S.Nami Kartal Evren terzi Tsuyoshi Yoshimura Faculty of Forestry Istanbul University-Cerrahpas¸a34473 BahcekoyIstanbulTurkey RISH Kyoto UniversityUjiKyoto 611-1100Japan

Sodium fluoride(NaF)and disodium octaborate tetrahydrate(DOT)are well-known fungicides for preventing and remediating decay in wood and wood structures,due to their excellent diffusion properties in *** efficacy of both compounds against drywood termites is,however,inadequately studied;there is a lack of information on the development of proper protection and control methods against drywood termites using these diffusible *** this study,the threshold values of fluoride and boron against drywood and subterranean termites and decay and mold fungi were assessed in laboratory *** Cryptomeria japonica ***(sugi)sapwood specimens with four different concentrations of NaF and DOT applied by either dipping or vacuum processes were subjected to attack by drywood termites,Incisitermes minor(Hagen)for 6 *** specimens were also tested against subterranean termites,Coptotermes formosanus Shiraki for 3 *** decay and mold resistance tests were then performed to determine the efficacy of the compounds against fungal *** showed 80%or greater drywood termite mortality in wood specimens treated with NaF at a retention level of1.7 kg m-3 or *** DOT treated groups,higher retention levels(greater than 6.8 kg m-3)were needed to reach up to 80%or more termite *** general,weight losses in NaF-treated specimens were slightly lower than those in DOT-treated *** levels of around1.2 kg m-3 for NaF and 1.6 kg m-3 for DOT were high enough to reach the JIS K 1571 threshold requirement of weight loss less than 3%in subterranean termite resistance *** higher termite mortality values were seen in the DOT than NaF treatments at respective retention *** decay resistance tests,no weight losses were seen at a NaF retention level of 2.3 kg m-3;however,a retention level of nearly 4 kg m-3 for DOT was needed for complete protection against both test *** most cases,lower weight losses were obtained i

关键词： NaF DOT Remedial treatments Termites Fungi

Movement of boron from ulexite and colemanite minerals in sapwood and heartwood of Cryptomeria japonica

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Journal of Forestry Research 2020年第6期31卷 2597-2603页

作者： Saip Nami Kartal Evren terzi Aysel Kanturk Figen Tsuyoshi Yoshimura Department of Forest Biology and Wood Protection Technology Faculty of Forestry Istanbul University-Cerrahpaşa34473 BahcekoyIstanbulTurkey Department of Chemical Engineering Faculty of Chemistry-MetallurgicalYıldız Technical UniversityDavutpasa Esenler34210 IstanbulTurkey Laboratory of Innovative Humano-Habitability Research Institute for Sustainable Humanosphere(RISH)Kyoto UniversityUjiKyoto 611-0011Japan

This study evaluated boron diff usion from raw boron minerals ulexite and colemanite with low water solubility in comparison to disodium octaborate tetrahydrate(DOT).Tests were conducted using sugi(Cryptomeria japonica(L.)***)sapwood and heartwood blocks conditioned to 30,60,and 90%target moisture *** blocks were fi lled with the boron compounds through treatment holes and diff usion was observed at three assay zones across the blocks after 7,30,60 or 90-day incubation period at room *** comparison,ethylene glycol was also introduced into the holes to elevate boron diff *** expected,diff usion increased with increased moisture content and levels were higher at the 60%and 90%moisture levels compared to the 30%*** some exceptions,boron levels did not follow consistent gradients with distance away from the treatment *** of ethylene glycol helped increase boron levels,even in heartwood *** levels were higher from the ulexite source than from colemanite;however,DOT treatments resulted in the highest boron diff usion rates as a result of greater water solubility compared to both raw boron *** results suggest that ulexite together with ethylene glycol may be useful in both sapwood and heartwood materials when kept at high moisture levels for extended periods.

关键词： Boron Remedial Ulexite Colemanite DOT Distribution Sapwood Heartwood

Peritoneal carcinomatosis of gastrointestinal tumors: Where are we now?

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World Journal of Gastroenterology 2014年第39期20卷 14371-14380页

作者： Cem terzi Naciye Cigdem Arslan Aras Emre Canda Department of Colorectal and Pelvic Surgery Dokuz Eylul University School of MedicineInciraltIzmir 35340Turkey

The peritoneal stromal tissue which provides a rich source of growth factors and chemokines is a favorable environment for tumor proliferation. The pathophysiological mechanism of peritoneal carcinomatosis is an individual sequence consisting of genetic and environmental factors and remains controversial. The natural history of the disease reveals a poor median prognosis of approximately 6 mo; however aggressive surgery and multimodal treatment options can improve oncologic outcomes. Considering peritoneal carcinomatosis as though it is a locoregional disease but not a metastatic process, cytoreductive surgery and and intraperitoneal chemotherapy has been a curative option during recent years. Cytoreductive surgery implies a series of visceral resections and peritonectomy procedures. Although the aim of cytoreductive surgery is to eliminate all macroscopic disease, viable tumor cells may remain in the peritoneal cavity. At that point, intraperitoneal chemotherapy can extend the macroscopic disease elimination to microscopic disease elimination. The successful treatment of peritoneal carcinomatosis requires a comprehensive management plan including proper patient selection, complete resection of all visible disease, perioperative intraperitoneal chemotherapy and postoperative systemic chemotherapy. Surgical and oncologic outcomes are strictly associated with extent of the tumor, completeness of cytoreduction and patientrelated factors as well as multidisciplinary management and experience of the surgical team. In this review, pathophysiology and current management of peritoneal carcinomatosis originating from gastrointestinal tumors are discussed according to the latest literature.

关键词： Peritoneal carcinomatosis Gastrointestinal tumors Cytoreductive surgery Intraperitoneal chemotherapy Oncologic surgery

Biological performance,water absorption,and swelling of wood treated with nano-particles combined with the application of Paraloid B72~

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Journal of Forestry Research 2017年第2期28卷 381-394页

作者： Damla Muhcu Evren terzi S.Nami Kartal Tsuyoshi Yoshimura Department of Forest Biology and Wood Protection Technology Faculty of ForestryIstanbul University Laboratory of Innovative Humano-habitability Research Institute for Sustainable Humanosphere (RISH)Kyoto University

We evaluated fungal decay and mold resistance,leaching, and water absorption of nano-compounds and Paraloid B72-（PB72） in treated wood specimens to develop new methods of consolidation by combining nanoparticles and consolidants. Scots pine wood specimens were treated with dispersions of nano-Cu O, nano-Zn O,nano-B2O3, nano-Ti O2, and nano-Ce O2. PB72 treatments of nano-particle-treated wood specimens were then carried out by either vacuum or immersion for 24 h. Previously,decayed wood specimens were also consolidated with the nano-compounds and PB72. PB72 treatments reduced element release from treated wood specimens. Nearly all nano-compounds ？ PB72 treatments increased the biological performance of treated wood specimens against decay fungi tested. PB72-only treated wood specimens had the highest weight losses in decay tests. No improvements were obtained in mold resistance tests when the nanocompounds and PB72 were combined. In nano-compoundonly treatments, unleached specimens showed slightly lower water absorption values compared to untreated control specimens. Incorporation of PB72 into nano-compound-treated wood specimens resulted in considerably lower water absorption and volumetric swell. In previously decayed specimens treated with the nano-compounds and PB72 solution, water absorption after 2-h immersion declined compared to control specimens.

关键词： leaching declined untreated retention fungi versicolor fungal fungus leached decay

Transfemoral aortic valve implantation in the case of pre-existing mitral prosthesis and pure aortic regurgitation: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3549-3552页

作者： Aysun Erdem Aycan Esen Zencirci Kivilcim Ozden Sait terzi Department of Cardiology Dr Siyami Ersek Thoracic and Heart Surgery Education and Research Hospital

BACKGROUND Transcatheter aortic valve replacement(TAVR)is recommended in patients with severe aortic stenosis who have high surgical ***,in the pre-existing mechanical mitral valve prosthesis and natural pure aortic regurgitation,TAVR is relatively *** this report,we described one case of TAVR with native aortic regurgitation in the presence of mechanical mitral valve *** SUMMARY A 64-year-old man with a medical history of mitral valve replacement had severe dyspnea and was symptomatic even at rest for 3 *** echocardiography showed severe native pure aortic *** euroscore was 15.A TAVR procedure with an evolut R was planned.A 34 mm evolut R was placed by transesophageal *** mitral prosthesis was functioning normally,and mild-moderate paravalvular leakage was evident by transesophageal *** patient recovered without any *** 1 mo follow up,the patient was well,and no paravalvular leakage was *** TAVR for pure aortic regurgitation in the presence of prosthetic mitral valve can be a safe procedure.

关键词： Transcatheter aortic valve replacement Prosthetic Mitral stenosis Aortic regurgitation Case report

Biological performance of particleboard incorporated with boron minerals

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Journal of Forestry Research 2017年第1期28卷 195-203页

作者： Evren terzi S.Nami Kartal Philippe Gerardin Claudia Marcela Ibanez Tsuyoshi Yoshimura Department of Forest Biology and Wood Protection Technology Faculty of ForestryIstanbul University34473 BahcekoyIstanbulTurkey Faculte des Sciences et Technologies Universite de Lorraine54506 Vandoeuvre-les-Nancy CedexFrance Unidad Academica de Gestion Tecnologica Departamento TecnologicoFacultad de QuimicaUniversidad de la Republica UruguayMontevideoUruguay Laboratory of Innovative Humano-Habitability Research Institute for Sustainable Humanosphere(RISH)Kyoto UniversityUjiKyoto 611-0011Japan

We compared resistance to decay, mold fungi, termites and insect larvae of particleboards incorporated with the raw boron minerals ulexite and colemanite to that of particleboards impregnated with the commercial boron preservative zinc borate, or boric acid plus a borax mixture. We also quantified water absorption, thickness swell and boron release of particleboards. Ulexite had the best decay resistance, and colemanite had the best termite resistance. However, ulexite and colemanite were not as effective as zinc borate or the boric acid/borax mixture in preventing mold growth. In general, the boric acid/borax mixture combination was more effective against Anobium larvae than the other treatments. Less boron was released by specimens containing zinc borate and colemanite than by those containing ulexite or the boric acid/borax mixture. In general, water absorption and thickness swell were similar among the different treatments, but both were slightly higher in the ulexite-incorporated specimens. Further mechanical tests will be needed to evaluate the particle- board properties and thereby the compatibility of these boron minerals with various manufacturing processes.

关键词： Biological resistance Borax Boric acid Colemanite Particleboard Ulexite