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The Prevalence of Celiac Disease in Patients with Diabetes Mellitus

International Journal of Clinical Medicine 2011年第3期2卷 201-205页

作者： Deniz Gokalp Senay Arikan Mustafa Yakut Yekta Tüzün alparslan kemal tuzcu Mithat Bahceci Senay Arikan Irfan Soykan Endocrinology Dicle University Medical SchoolDiyarbakirTurkey Gastroenterology Ankara University Medical School AnkaraTurkey Gastroenterology Dicle University Medical SchoolDiyarbakirTurkey

AIM: To determine the prevalence of celiac disease related autoantibodies in patients with type 1 and 2 diabetes mellitus (DM), and to compare these results with the general population. METHODS: In total, 137 consecutive patients with type 1 DM, 172 with type 2 DM and 113 age-sex matched control subjects were included into the study. Antigliadin-autoantibodies (AGA) IgG and IgA, and endomysial-antibodies(EMA) IgG and IgA antibodies were determined. Patients who were positive for one or more were offered a gastroduodenoscopic examination. RESULTS: AGA IgG positivity was detected in 38.7% (53/137) patients with type 1 DM in 26.2% (45/172) patients with type 2 DM and in 16.8% (19/113) control subjects (significant differences). AGA IgA positivity was detected in 24.8% (34/137) patients with type 1 DM, in 9.3% (16/172) patients with type 2 DM and in 3.5% (4/113) control subjects (significant differences). EMA IgG positivity was detected in 10.2% (14/137) patients with type 1 DM in 0.6% (1/176) patients with type 2 DM and 0.9% (1/113) control subjects (significant differences). EMA IgA positivity was detected in 11.7% (16/137) patients with type 1 DM in 0.6% (1/172) patients with type 2 DM and in none of control subjects. EMA IgA positivity was sig- nificantly higher in patients with type 1 DM as compared with patients with type 2 DM and controls. CONCLUSION: High prevalence of celiac disease at the diagnosis of type 1 DM is observed. Serological markers are useful for identifying celiac disease patients with type 1 DM.

关键词： Celiac Disease Diabetes Mellitus AGA IgA AGA IgG EMA IgA EMA IgG

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Importance and Risk Prediction of ABO Blood Group and Rh Factor in Papillary Thyroid Cancer

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Journal of Endocrinology Research 2022年第1期4卷 8-13页

作者： Dilek Geneş Zafer Pekkolay MehmetŞimşek Hüsna Saraçoğlu Mehmet Turgut Alpaslan kemal tuzcu Dicle University Faculty of Medicine Department of Adult Endocrinology and MetabolismDiyarbakir21090Turkey

Objective:There are limited data in the literature regarding the potential relationship between thyroid cancer and ABO blood types and Rh *** aim of our study was to investigate whether papillary thyroid cancer(PTC)is associated with blood *** and Methods:The present study included patients who presented to Dicle University Faculty of Medicine between June 2009 and December 2020 and were diagnosed with PTC as a result of postoperative(thyroidectomy)histopathological *** control group consisted of individuals whose blood type was analyzed at a random blood ***:Of the 223 patients diagnosed with PTC,163(73.1%)were females and 60(26.9%)were *** the comparison of patients based on ABO blood types and Rh factor,A Rh positive blood type was found 31%less frequently in the PTC group compared with the control group,and thus it was associated with a lower risk of PTC(OR:0.69;95%Confidence Interval:0.50-0.96,p=0.029).Conclusions:In our study,we found A Rh positive blood type to be significantly less frequent among patients with PTC.A Rh positive blood type can be considered as a protective factor indicating a reduced risk of PTC.

关键词： Papillary thyroid cancer Blood types ABO Rh

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