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Modeling the effect of time delay in implementation of mitigation policies on the control of atmospheric greenhouse gases

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International Journal of Biomathematics 2023年第8期16卷 75-108页

作者： alok kumar verma Maitri verma Department of Mathematics School of Physical and Decision Science Babasaheb Bhimrao Ambedkar University Lucknow India

Mitigation of the enhanced greenhouse gas(GHG)concentrations in the Earth's atmosphere is imperative to meet the climate change mitigation *** of many countries are developing and implementing various mitigation strategies to reduce their GHG ***,a time delay between the formulation and implementation of these mitigation policies can affect their effectiveness in controlling greenhouse gas levels in the *** work presents a nonlinear mathematical model to investigate the effect of application of mitigation strategies and the delay involved in their implementation over the reduction of atmospheric greenhouse *** model formulation,it is assumed that the mitigation strategies work two-fold;first they reduce the GHG emission rate from the anthropogenic source and second they increase the removal rate of greenhouse gas from the atmosphere.A comprehensive stability analysis of the proposed model system is made to examine its long-term *** model analysis shows that an increase in the implementation rate of mitigation strategies and their efficiencies to cut down the GHG emission rate from point sources and increase the GHG uptake rate lead to reduction in equilibrium GHG *** is found that a long delay in the execution of mitigation policies can destabilize the system dynamics and leads to the generation of periodic *** expression for the threshold value of the delay parameter at which periodic oscillations arise via Hopf-bifurcation is *** stability and direction of bifurcating periodic solutions are discussed.A sensitivity analysis is performed to investigate the effect of changes in key parameters over system dynamics.

关键词： Mathematical model greenhouse gases global warming mitigation strategies time delay Hopf-bifurcation

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Pathogenic mechanisms of pancreatitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第1期8卷 10-25页

作者： Murli Manohar alok kumar verma Sathisha Upparahalli Venkateshaiah Nathan L Sanders Anil Mishra Department of Medicine Section of Pulmonary DiseasesTulane Eosinophilic Disorders CenterTulane University School of MedicineNew OrleansLA 70112United States

Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pan-creatitis characterized by marked stroma formation with a high number of infiltrating granulocytes(such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells(PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i.e., a major risk factor for pancreatic cancer. A number of inflammatory cytokines are known to involve in pro-moting pancreatic pathogenesis that lead pancreatic fibrosis. Pancreatic fibrosis is a dynamic phenomenon that requires an intricate network of several autocrine and paracrine signaling pathways. In this review, we have provided the details of various cytokines and molecular mechanistic pathways(i.e., Transforming growth factor-β/SMAD, mitogen--activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) that have a critical role in the activation of PSCs to promote chronic pancreatitis and trigger the phenomenon of pancreatic fibrogenesis. In this review of literature, we discuss the involvement of several pro-inflammatory and anti-inflammatory cytokines, such as in interleukin(IL)-1, IL-1β, IL-6, IL--8 IL-10, IL-18, IL--33 and tumor necrosis factor-α, in the pathogenesis of disease. Our review also highlights the significance of several experimental animal models that have an important role in dissecting the mechanistic pathways operating in the development of chronic pancreatitis, including pancreatic fibrosis. Additionally, we provided several intermediary molecules that are involved in major signaling pathways that might provide target molecules for future therapeutic treatment strategies for pancreatic p

关键词： Pancreatitis Pancreatic stellate cells Transforming growth factor-β/SMAD Janus kinase/signal transducers and activators Mitogen-activated protein kinases

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Biphasic reduction model for predicting the impacts of dye-bath constituents on the reduction of tris-azo dye Direct Green-1 by zero valent iron(Fe^0)

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Journal of Environmental Sciences 2017年第2期29卷 160-169页

作者： Raja kumar alok Sinha Department of Environmental Science&Engineering Indian School of MinesDhanbad 826004JharkhandIndia

Influence of common dye-bath additives, namely sodium chloride, ammonium sulphate,urea, acetic acid and citric acid, on the reductive decolouration of Direct Green 1 dye in the presence of Fe0 was investigated. Organic acids improved dye reduction by augmenting Fe0 corrosion, with acetic acid performing better than citric acid. Na Cl enhanced the reduction rate by its ‘salting out’ effect on the bulk solution and by Cl-anion-mediated pitting corrosion of iron surface.（NH4）2SO4induced ‘salting out’ effect accompanied by enhanced iron corrosion by SO42-anion and buffering effect of NH4＋ improved the reduction ***, at 2 g/L（NH4）2SO4concentration, complexating of SO42-with iron oxides decreased Fe0 reactivity. Urea severely compromised the reduction reaction, onus to its chaotropic and‘salting in’ effect in solution, and due to it masking the Fe0 surface. Decolouration obeyed biphasic reduction kinetics（R2〉 0.993 in all the cases） exhibiting an initial rapid phase,when more than 95% dye reduction was observed, preceding a tedious phase. Maximum rapid phase reduction rate of 0.955/min was observed at p H 2 in the co-presence of all dye-bath constituents. The developed biphasic model reckoned the influence of each dye-bath additive on decolouration and simulated well with the experimental data obtained at pH 2.

关键词： Biphasic kinetics/model Direct Green 1 Dye-bath additives Fe0

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Herbal antioxidant in clinical practice:A review

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Asian Pacific Journal of Tropical Biomedicine 2014年第1期4卷 78-84页

作者： Shashi alok Sanjay kumar Jain Amita verma Mayank kumar alok Mahor Monika Sabharwal Institute Of Pharmacy Bundelkhand University Department of Pharmaceutical Sciences Faculty of Health SciencesSam Higginbottom Institute of AgricultureTechnology and Sciences-DeemedUniversity Society of Pharmaceutical Sciences and Research

Antioxidant-the word itself is *** the antioxidant concept as a spearhead in proposed mechanisms for staving off so-called"free-radical"reactions,the rush is on to mine claims for the latest and most effective combination of free-radical scavenging *** must acknowledge that such"radicals"have definitively been shown to damage all biochemical components such as DNA/HNA,carbohydrates,unsaturated lipids,proteins,and micronutrients such as carotenoids(alpha and beta carotene,lycopene),vitamins A,B_6,B_(12),and *** strategies against such aggressive radical species include enzymes,antioxidants that occur naturally in the body(glutathione,uric acid,ubiquinol-10,and others)and radical scavenging nutrients,such as vitamins A,C,and E,and *** paper will present a brief discussion of some well-and little-known herbs that may add to the optimization of antioxidant status and therefore offer added preventive values for overall *** is important to state at the outset that antioxidants vary widely in their free-radical quenching effects and each may be individually attracted to specific cell *** evidence of the specialized nature of the carotenoids is demonstrated by the appearance of two carotenoids in the macula region of the retina where beta-carotene is totally

关键词： Antioxidant Carotenoid Free-radical Herb

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Powder mixed electrochemical discharge process for micro machining of C103 niobium alloy

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Defence Technology（防务技术） 2023年第8期26卷 84-101页

作者： Niladri Mandal Nitesh kumar alok kumar Das Defence Research&Development Laboratory(DRDL)-DRDO HyderabadIndia Department of Mechanical Engineering Indian Institute of Technology(ISM)DhanbadIndia

This work demonstrates the viability of the powder-mixed micro-electrochemical discharge machining(PMECDM) process to fabricate micro-holes on C103 niobium-based alloy for high temperature *** processes are involved simultaneously *** erosion,chemical etching,and abrasive grinding for removal of material while the classical electrochemical discharge machining process involves double actions *** erosion,and chemical *** powder-mixed electrolyte process resulted in rapid material removal along with a better surface finish as compared to the classical microelectrochemical discharge machining(MECDM).Further,the results are optimized through a multiobjective optimization approach and study of the surface topography of the hole wall surface obtained at optimized *** the selected range of experimental parameters,PMECDM shows a higher material removal rate(MRR) and lower surface roughness(R_(a))(MRR:2.8 mg/min and R_(a) of 0.61 μm) as compared to the MECDM process(MRR:2.01 mg/min and corresponding Raof 1.11 μm).A detailed analysis of the results is presented in this paper.

关键词： Micro-electrochemical discharge machining C103 niobium alloy Surface integrity Material removal rate Hybrid powder mixed ECDM

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Study of damage behavior and repair effectiveness of patch repaired carbon fiber laminate under quasi-static indentation loading

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Defence Technology（防务技术） 2024年第4期34卷 29-41页

作者： alok kumar Chinmaya kumar Sahoo A.Arockiarajan Department of Applied Mechanics Indian Institute of Technology MadrasChennai 600036India

Damage caused due to low-velocity impacts in composites leads to substantial deterioration in their residual strength and eventually provokes structural *** work presents an experimental investigation on the effects of different patch and parent laminate stacking sequences on the enhancement of impact strength of Carbon Fiber Reinforced Polymers(CFRP)composites by utilising the adhesively bonded external patch repair *** evolution study is also performed with the aid of Acoustic Emission(AE).Two different quasi-isotropic configurations were selected for the parent laminate,viz.,[45°/45°/0°/0°]s and[45°/0°/45°/0°]*** Static Indentation(QSI)test was performed on both the pristine laminates,and damage areas were detected by using the C-scan inspection *** laminates were repaired by using a single-sided patch of two different configurations,viz.,[45°/45°/45°/45°]and[45°/0°/0°/45°],and employing a circular plug to fill the damaged *** different combinations of repaired laminates with two configurations of each parent and patch laminate were produced,which were further subjected to the QSI *** results reveal the effectiveness of the repair method,as all the repaired laminates show higher impact resistance compared to the respective pristine *** of[45°/0°/0°/45°]configuration when repaired by taking[45°/45°/0°/0°]s and[45°/0°/45°/0°]s as parents exhibited 68%and 73%higher peak loads,respectively,than the respective pristine ***,parent and patch of configuration[45°/0°/45°/0°]s and[45°/0°/0°/45°],respectively,attain the highest peak load,whereas[45°/45°/0°/0°]s and[45°/45°/45°/45°]combinations possess the most gradual decrease in the load.

关键词： Carbon fiber reinforced polymers(CFRP) Quasi-isotropic laminate Quasi static indentation(QSI) Acoustic emission(AE) Composite repair

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Experimental investigation for machinability aspects of graphene oxide/carbon fiber reinforced polymer nanocomposites and predictive modeling using hybrid approach

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Defence Technology（防务技术） 2021年第5期17卷 1671-1686页

作者： Jogendra kumar Rajesh kumar verma Department of Mechanical Engineering Madan Mohan Malaviya University of TechnologyGorakhpur273010India

This article explores the drilling behavior of polymer nanocomposites reinforced by Graphene oxide/Carbon fiber using a hybrid method of Grey theory and Principal component analysis(GR-PCA).An online digital dynamometer was employed for the evaluation of Thrust Force and *** image processing technique computes the *** surface methodology(RSM)considers the parameters,namely,drilling speed(S),feed rate(F),Graphene Oxide wt.%(G)in designing the experimentation *** component analysis(PCA)was used to tackle the response priority weight during the combination of multiple *** of variance(ANOVA)scrutinized the influence of parameters and intended the regression models to predict the ***-PCA evaluated the optimal parametric setting and remarked that feed rate acts as the most predominant *** higher feed rate and wt.%of G is responsible for surface damages like fiber pull-out,fiber fracture and cracks.A significant improvement in drilling responses has been obtained and also validates through confirmatory test and microstructure investigations.

关键词： Graphene oxide Polymer Carbon fiber RSM ANOVA GR-PCA

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Dual-Core Photonic Crystal Fiber Plasmonic Refractive Index Sensor: A Numerical Analysis

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Photonic Sensors 2019年第2期9卷 151-161页

作者： alok kumar PAUL Ajay Krishno SARKAR Department of Electrical & Electronic Engineering Rajshahi University of Engineering & Technology Rajshahi-6204 Bangladesh

A numerical analysis on dual core photonic crystal fiber (DC-PCF) based surface plasmon resonance (SPR) refractive index sensor is presented. The guiding parameters and required sensing performances are examined with finite element method (FEM) based software under MATLAB environment. According to simulation, it is warranted that the proposed refractive index sensor offers the maximum amplitude sensitivity of 554.9 refractive index unit (RIU-1) and 636.5 RIU 1 with the maximum wavelength sensitivity of 5800nm/RIU and 11 500nm/RIU, and the sensor resolutions of 1.72 ×10^-5RIU and 8.7× 10^-6 RIU, at analyte refractive index (RI) of 1.40 for x- and y-polarized modes, respectively. As the sensing performance in different wavelength ranges is quite high, the proposed sensor can be used in simultaneous detection for different wavelength ranges. Therefore, the proposed device is of a suitable platform for detecting biological, chemical, biochemical, and organic chemical analytes.

关键词： Photonic crystal fiber biosensor refractive index sensor finite element method plasmonic material

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Surface Modification Aspects for Improving Biomedical Properties in Implants:A Review

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 213-241页

作者： J.Sharath kumar Rakesh kumar Rajeev verma Industrial and Production Department Dr B R Ambedkar National Institute of Technology JalandharJalandharPunjab144008India

The primary focus during surgery is to ensure successful implantation by achieving long-term and stable fixation of *** surgery is now more focused on the development of novel biomaterials intended to improve implant *** obtain a better understanding of metal implants,this article investigated the causes of material failures in certain cases and analysed a few case *** interaction between the implant and bone tissue was a crucial aspect of successful implantation,and this study explored the factors influencing this interaction as well as ways to improve *** modern approaches used for modifying implant surfaces were systematically illustrated and briefly *** spray coatings were often favoured because of their wide range of coating materials,but other substantial surface modifications(such as friction stir processing and laser surface texturing)were also used for a selection of ***,implant surfaces with desirable features,such as biocompatibility,antibacterial properties,corrosion resistance,and wear resistance,were essential for optimising implant *** systematic review's main aim is to provide exhaustive reference information and a broad overview to advance the production and design of orthopaedic implants.

关键词： Biomaterials Surface treatments Thermal spray coatings Antibacterial Biocompatibility Corrosion resistance Wear resistance

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Optimal ordering policy for short life-cycle products under credit financing with dynamic adoption in supply chain

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Journal of Management Analytics 2019年第3期6卷 269-301页

作者： Udayan Chanda alok kumar Department of Management BITS PilaniPilaniIndia FORE School of Management New DelhiIndia

Traditional inventory models are mostly ignorant of the life cycle dynamics of a technology product;hence,they often fail to identify different dimensions of inventory *** paper attempts to investigate the relationship between adoption behavior of customers using life cycle dynamics and associated trade credit policies in order to optimize the total inventory *** demand model used in this paper treats sales as a function of awareness diffusion and *** is considered as a function of feedback effects from users/***’s optimal strategies for short life cycle product under credit financing were determined ***,numerical examples have been used to support the theoretical *** results have further been used to gain some managerial insights.

关键词： inventory stage-wise diffusion unfavorable information short life cycle trade credit

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