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Study of damage behavior and repair effectiveness of patch repaired carbon fiber laminate under quasi-static indentation loading

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Defence Technology（防务技术） 2024年第4期34卷 29-41页

作者： alok kumar Chinmaya kumar Sahoo A.Arockiarajan Department of Applied Mechanics Indian Institute of Technology MadrasChennai 600036India

Damage caused due to low-velocity impacts in composites leads to substantial deterioration in their residual strength and eventually provokes structural *** work presents an experimental investigation on the effects of different patch and parent laminate stacking sequences on the enhancement of impact strength of Carbon Fiber Reinforced Polymers(CFRP)composites by utilising the adhesively bonded external patch repair *** evolution study is also performed with the aid of Acoustic Emission(AE).Two different quasi-isotropic configurations were selected for the parent laminate,viz.,[45°/45°/0°/0°]s and[45°/0°/45°/0°]*** Static Indentation(QSI)test was performed on both the pristine laminates,and damage areas were detected by using the C-scan inspection *** laminates were repaired by using a single-sided patch of two different configurations,viz.,[45°/45°/45°/45°]and[45°/0°/0°/45°],and employing a circular plug to fill the damaged *** different combinations of repaired laminates with two configurations of each parent and patch laminate were produced,which were further subjected to the QSI *** results reveal the effectiveness of the repair method,as all the repaired laminates show higher impact resistance compared to the respective pristine *** of[45°/0°/0°/45°]configuration when repaired by taking[45°/45°/0°/0°]s and[45°/0°/45°/0°]s as parents exhibited 68%and 73%higher peak loads,respectively,than the respective pristine ***,parent and patch of configuration[45°/0°/45°/0°]s and[45°/0°/0°/45°],respectively,attain the highest peak load,whereas[45°/45°/0°/0°]s and[45°/45°/45°/45°]combinations possess the most gradual decrease in the load.

关键词： Carbon fiber reinforced polymers(CFRP) Quasi-isotropic laminate Quasi static indentation(QSI) Acoustic emission(AE) Composite repair

Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2885-2900页

作者： Porkizhi Arjunan Durga Kathirvelu Gokulnath Mahalingam Ashish kumar Goel Uday George Zacharaiah alok Srivastava Srujan Marepally Center for Stem Cell Research(A Unit of inStem Bengaluru)Christian Medical College CampusBagayamVellore 632002Tamil NaduIndia Manipal academy for higher education Mangalore 576104KarnatakaIndia Department of Hematology Christian Medical College&HospitalVellore 632004Tamil NaduIndia Department of Hepatology Christian Medical College&HospitalVellore 632004Tamil NaduIndia

Inherited genetic disorders of the liver pose a significant public health *** transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive *** overcome these limitations,nucleic acid therapy provides a hopeful alternative that enables gene repair,gene supplementation,and gene silencing with suitable *** viral vectors are the most efficient and preferred for gene therapy,pre-existing immunity debilitating immune responses limit their *** a potential alternative,lipid nanoparticle-mediated vectors are being explored to deliver multiple nucleic acid forms,including pDNA,mRNA,siRNA,and ***,we discuss the broader applications of lipid nanoparticles,from protein replacement therapy to restoring the disease mechanism through nucleic acid delivery and gene editing,as well as multiple preclinical and clinical studies as a potential alternative to liver transplantation.

关键词： Lipid nanoparticle Liver disorders Gene therapy Gene editing Nucleic acid delivery pDNA mRNA siRNA ASO Clinical trials

Powder mixed electrochemical discharge process for micro machining of C103 niobium alloy

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Defence Technology（防务技术） 2023年第8期26卷 84-101页

作者： Niladri Mandal Nitesh kumar alok kumar Das Defence Research&Development Laboratory(DRDL)-DRDO HyderabadIndia Department of Mechanical Engineering Indian Institute of Technology(ISM)DhanbadIndia

This work demonstrates the viability of the powder-mixed micro-electrochemical discharge machining(PMECDM) process to fabricate micro-holes on C103 niobium-based alloy for high temperature *** processes are involved simultaneously *** erosion,chemical etching,and abrasive grinding for removal of material while the classical electrochemical discharge machining process involves double actions *** erosion,and chemical *** powder-mixed electrolyte process resulted in rapid material removal along with a better surface finish as compared to the classical microelectrochemical discharge machining(MECDM).Further,the results are optimized through a multiobjective optimization approach and study of the surface topography of the hole wall surface obtained at optimized *** the selected range of experimental parameters,PMECDM shows a higher material removal rate(MRR) and lower surface roughness(R_(a))(MRR:2.8 mg/min and R_(a) of 0.61 μm) as compared to the MECDM process(MRR:2.01 mg/min and corresponding Raof 1.11 μm).A detailed analysis of the results is presented in this paper.

关键词： Micro-electrochemical discharge machining C103 niobium alloy Surface integrity Material removal rate Hybrid powder mixed ECDM

Modeling the effect of time delay in implementation of mitigation policies on the control of atmospheric greenhouse gases

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生物数学学报:英文版 2023年第8期16卷 75-108页

作者： alok kumar Verma Maitri Verma Department of Mathematics School of Physical and Decision Science Babasaheb Bhimrao Ambedkar University Lucknow India

Mitigation of the enhanced greenhouse gas(GHG)concentrations in the Earth's atmosphere is imperative to meet the climate change mitigation *** of many countries are developing and implementing various mitigation strategies to reduce their GHG ***,a time delay between the formulation and implementation of these mitigation policies can affect their effectiveness in controlling greenhouse gas levels in the *** work presents a nonlinear mathematical model to investigate the effect of application of mitigation strategies and the delay involved in their implementation over the reduction of atmospheric greenhouse *** model formulation,it is assumed that the mitigation strategies work two-fold;first they reduce the GHG emission rate from the anthropogenic source and second they increase the removal rate of greenhouse gas from the atmosphere.A comprehensive stability analysis of the proposed model system is made to examine its long-term *** model analysis shows that an increase in the implementation rate of mitigation strategies and their efficiencies to cut down the GHG emission rate from point sources and increase the GHG uptake rate lead to reduction in equilibrium GHG *** is found that a long delay in the execution of mitigation policies can destabilize the system dynamics and leads to the generation of periodic *** expression for the threshold value of the delay parameter at which periodic oscillations arise via Hopf-bifurcation is *** stability and direction of bifurcating periodic solutions are discussed.A sensitivity analysis is performed to investigate the effect of changes in key parameters over system dynamics.

关键词： Mathematical model greenhouse gases global warming mitigation strategies time delay Hopf-bifurcation

Spatial variability of soil hydraulic and physical properties in erosive sloping agricultural fields

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Water Science and Engineering 2023年第1期16卷 57-66页

作者： Deepak Singh alok kumar Mishra Sridhar Patra Sankar Mariappan Nisha Singh Saswat kumar Kar ICAR-Indian Institute of Soil and Water Conservation Dehradun 248195India Sam Higginbottom University of Agriculture Technology and SciencesPrayagraj 211007India Hemvati Nandan Bahuguna Garhwal University Srinagar(Garhwal)246174India

It is essential to minimize soil quality degradation in sloping agricultural fields through stabilization and improvement of soil hydraulic properties using sustainable soil *** study aimed to analyze the impact of different tillage practices,including conventional tillage(CT),minimum tillage(MT),and zero tillage(ZT),on soil hydraulic conductivity in a sloping agricultural field under maizeewheat *** results showed that the highest runoff volume(257.40 m3),runoff coefficient(42.84%),and soil loss(11.3 t)were observed when the CT treatment was *** contrast,the lowest runoff volume(67.95 m3),runoff coefficient(11.35%),and soil loss(1.05 t)were observed when the ZT treatment was *** soil organic carbon and aggregate mean weight diameter were found to be significantly greater(with mean values of 0.79%and 1.19 mm,respectively)with the ZT treatment than with the CT *** the tilled treatments(CT and MT),substantial changes in the saturated soil hydraulic conductivity(ks),near-saturated soil hydraulic conductivity(k),and water-conducting porosity(ε)were observed between two crop *** three soil parameters were significantly higher in the period after maize harvesting than in the wheat growing *** contrast,no significant difference in these soil parameters was found when the untilled treatment(ZT)was carried *** regard to the slope positions,ks,k,andεshowed different behaviors under different *** toe slope position showed significantly lower ks andεvalues than the summit and middle slope *** the evaluated tillage practices,ZT was found to be the most promising means to improve the soil hydro-physical properties and effectively reduce surface runoff and soil erosion.

关键词： Hydraulic conductivity Macropore Conservation tillage Spatiotemporal variability Soil erosion

Is Regular Probiotic Practice Safe for Management of Sepsis?

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Chinese Journal of Integrative Medicine 2022年第2期28卷 185-192页

作者： Rishabh kumar alok Shiomurti Tripathi Nidhi Sharma Gaaminepreet Singh Lucy Mohapatra Department of Pharmacology ISF College of PharmacyMoga(Punjab)India Department of Pharmacology Amity Institute of PharmacyAmity UniversityLucknow(UP)India

For decades,the gut has been thought to play an important role in sepsis *** is a serious life-threatening,chronic condition of an infection caused by dysregulated host immune response in most of the intensive care unit *** have dual roles in polymicrobial sepsis *** may induce sepsis in many cases and may prevent its prognosis in many *** evidence from both pre-clinical and clinical studies have demonstrated that probiotic therapy ameliorates various inflammatory mediators such as tumor necrosis factor,interleukin-10(IL-10),IL-6,etc.,in *** addition,probiotic use was also found to reduce the severity of pathological conditions associated with irritable bowel disorder and prevent development of endocarditis in *** contrary,probiotic therapy in neonatal and athymic adult mice fail to provide any beneficial effects on mortality and sepsis-induced ***,in few clinical trials probiotic use was found to aggravate sepsis by promoting inflammatory cascade rather than suppressing *** review discusses various studies regarding the beneficial or harmful effects associated with probiotic therapy in sepsis.

关键词： sepsis probiotics microbial flora immune system

Conservation aquaculture of Ompok bimaculatus (Butter catfish), a near threatened catfish in India

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Aquaculture and Fisheries 2023年第1期8卷 1-17页

作者： Pradyut Biswas alok kumar Jena Soibam Khogen Singh Department of Aquaculture College of FisheriesCentral Agricultural University(Imphal)LembucherraTripura(W)792210India Aquaculture Division ICAR-Central Institute of Fisheries EducationMumbai400061India

The butter catfish,Ompok bimaculatus,belonging to the silurid family,is widely regarded as an important food fish for aquaculture diversification in ***,the species poses a threat due to habitat degradation and other anthropogenic factors,and has been categorised as“near threatened”,therefore,its culture promotion is *** establish a successful breeding programme,a precise understanding of the life history,and biology(reproductive/feeding)of the fish will assist hatchery managers and *** in these areas have been undertaken by several groups over the years,but without much coherence,the data are still *** attempts on the culture attributes of this catfish have been performed under both mono-and polyculture systems to bring about parallel promotion through aquaculture in a larger part of the *** this,we have tried to analyse and present a consolidated account of the morphological characteristics,feeding habits,reproductive biology,early developmental ontogeny,and culture potentials of *** in *** review was also prompted by the paucity of information on the cultural aspects of the ***,based on the reported studies,future directions and perspectives of the culture promotion of the species are proffered to ensure future research initiatives.

关键词： Ompok bimaculatus Ontogeny Polyculture Reproductive biology Threatened

Magnitude and Determinants of Mortalities Related to COVID-19:Evidence from 94 Countries Using Regression Techniques

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Fudan Journal of the Humanities and Social Sciences 2022年第4期15卷 475-499页

作者： Ashis kumar Pradhan Ronny Thomas Sandhyarani Rout alok kumar Pradhan Department of Humanities and Social Sciences Maulana Azad National Institute of TechnologyBhopalMadhya PradeshIndia Rajagiri Business School(RBS)and Rajagiri College of Social Sciences(RCSS) Rajagiri Valley CampusKakkanadKochiKeralaIndia Department of Social Science Fakir Mohan UniversityBalasoreOdishaIndia Indian Institute of Management Nagpur DahegaonIndia

This study attempts to investigate the factors determining COVID-19 deaths during the pandemic across countries by employing a rich dataset sourced from 94 countries updated till 6 February,*** empirical analysis,the study makes use of cross-sectional linear regression technique in the first part and after required diagnostic tests use 2SLS regression technique for correcting possible endogeneity bias in the second *** from the study indicate that factors like total reported cases,population size,population over 70 years of age,extreme poverty,and human development index play significant role in determining COVID-19-related ***,to check the robustness of the findings the present study employed LASSO *** from the study highlight the possibility of government intervention to devise appropriate policies to control COVID-related incidence and death.

关键词： COVID-19 deaths Mortality risks Infectious diseases LASSO regression Pandemic

Potential of Essential Oils as Alternative Permeation Enhancers for Transdermal Delivery

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 258-269页

作者： Jayshree Mahanty Sofi Haamid Rasheed Sudhir kumar Harjeet Singh alok Sharma Department of Pharmacognosy ISF College of PharmacyMogaPunjab CCRAS Ministry of AYUSHJhansiUttar PradeshIndia

Transdermal drug delivery plays a significant part in the drug delivery system when compared to other routes of drug *** function of the stratum corneum(SC)is a ***,numerous methods have been thrived to improve the perforation of drugs across the *** most effective method is to use enhancers since these agents enhance skin *** penetration enhancers like essential oils demonstrate higher enhancement activity and are more widely accepted than synthetic penetration *** potential in the expansion and interaction with the SC intercellular lipids has led to an increasing interest in these oils as penetration *** article gives an overview of a few essential oils,including their mode of action and important parameters for permeation *** present work can provide essential oils as alternative enhancers,and this could be useful in transdermal administration.

关键词： Essential oil natural permeation enhancers skin stratum corneum transdermal drug delivery