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Modeling the effect of time delay in implementation of mitigation policies on the control of atmospheric greenhouse gases

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生物数学学报:英文版 2023年第8期16卷 75-108页

作者： alok Kumar Verma Maitri Verma Department of Mathematics School of Physical and Decision Science Babasaheb Bhimrao Ambedkar University Lucknow India

Mitigation of the enhanced greenhouse gas(GHG)concentrations in the Earth's atmosphere is imperative to meet the climate change mitigation *** of many countries are developing and implementing various mitigation strategies to reduce their GHG ***,a time delay between the formulation and implementation of these mitigation policies can affect their effectiveness in controlling greenhouse gas levels in the *** work presents a nonlinear mathematical model to investigate the effect of application of mitigation strategies and the delay involved in their implementation over the reduction of atmospheric greenhouse *** model formulation,it is assumed that the mitigation strategies work two-fold;first they reduce the GHG emission rate from the anthropogenic source and second they increase the removal rate of greenhouse gas from the atmosphere.A comprehensive stability analysis of the proposed model system is made to examine its long-term *** model analysis shows that an increase in the implementation rate of mitigation strategies and their efficiencies to cut down the GHG emission rate from point sources and increase the GHG uptake rate lead to reduction in equilibrium GHG *** is found that a long delay in the execution of mitigation policies can destabilize the system dynamics and leads to the generation of periodic *** expression for the threshold value of the delay parameter at which periodic oscillations arise via Hopf-bifurcation is *** stability and direction of bifurcating periodic solutions are discussed.A sensitivity analysis is performed to investigate the effect of changes in key parameters over system dynamics.

关键词： Mathematical model greenhouse gases global warming mitigation strategies time delay Hopf-bifurcation

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Is Regular Probiotic Practice Safe for Management of Sepsis?

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Chinese Journal of Integrative Medicine 2022年第2期28卷 185-192页

作者： Rishabh Kumar alok Shiomurti Tripathi Nidhi Sharma Gaaminepreet Singh Lucy Mohapatra Department of Pharmacology ISF College of PharmacyMoga(Punjab)India Department of Pharmacology Amity Institute of PharmacyAmity UniversityLucknow(UP)India

For decades,the gut has been thought to play an important role in sepsis *** is a serious life-threatening,chronic condition of an infection caused by dysregulated host immune response in most of the intensive care unit *** have dual roles in polymicrobial sepsis *** may induce sepsis in many cases and may prevent its prognosis in many *** evidence from both pre-clinical and clinical studies have demonstrated that probiotic therapy ameliorates various inflammatory mediators such as tumor necrosis factor,interleukin-10(IL-10),IL-6,etc.,in *** addition,probiotic use was also found to reduce the severity of pathological conditions associated with irritable bowel disorder and prevent development of endocarditis in *** contrary,probiotic therapy in neonatal and athymic adult mice fail to provide any beneficial effects on mortality and sepsis-induced ***,in few clinical trials probiotic use was found to aggravate sepsis by promoting inflammatory cascade rather than suppressing *** review discusses various studies regarding the beneficial or harmful effects associated with probiotic therapy in sepsis.

关键词： sepsis probiotics microbial flora immune system

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Exploring phytochemicals of Withania somnifera from different vicinity for functional foods

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未来食品学报(英文) 2023年第3期3卷 278-287页

作者： Pooja Dhama Xianting Ding alok Sharma Department of Pharmacognosy ISF College of PharmacyPunjab 142001India School of Biomedical Engineering Med-X Research InstituteShanghai Jiao Tong UniversityShanghai 200030China

The well-known relation between food and bioactives explores the great prospective of innovative and novel food to maintain or improve health,increasing the demand investigating advance products with medicinal *** somnifera also known as‘Ashwagandha’in India,is one of the most utilized plants in different ancient medicine *** present work is an effort to develop a knowledge-based concept and a quality control approach for the development of functional *** study took into account the standardization criteria and examined how different geographies or different field sites(of India)would influence the phytoconstituents and their distribution in the different samples of *** level were strongly influenced by soil quality,cultivar,and growing *** increase in phenolic content,flavonoid content,antioxidants and the quality yield,were all correlated with increased phytoconstituent *** highest hydro-methanolic extract yield(by reflux(Soxhlet),sonication(20 min)and maceration(16 h)was from the sample collected from Rajasthan(18.61%,m/m)followed by West Bengal(11.21%)and Madhya Pradesh(12.67%)*** methanolic extract of Rajasthan sample(produced by the reflux(Soxhlet)extraction method)had the highest concentrations of flavonoids(65.32 mg quercetin equivalent(QE)/g)and the total phenols(60.35 mg gallic acid equivalent(GAE)/g),while Madhya Pradesh sample(distilled water reflux(Soxhlet))extract had the highest antioxidant content(74.13%).High performance thin layer chromatography(HPTLC)method was also utilized for identification of withanolides *** separations were carried out using V(ethyl acetate):V(toluene):V(acetic acid)=9.1:1:0.6 as the mobile *** gas chromatograph-mass spectrometer(GC-MS)study of hydro-methanolic Soxhlet extract of *** from 3 different regions of India was done and the total phytochemical substances identified were 132 in sample from Rajasthan,107

关键词： Withania somnifera Bioactives Gas chromatograph-mass spectrometer(GC-MS) Quality Functional foods

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Conservation aquaculture of Ompok bimaculatus (Butter catfish), a near threatened catfish in India

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Aquaculture and Fisheries 2023年第1期8卷 1-17页

作者： Pradyut Biswas alok Kumar Jena Soibam Khogen Singh Department of Aquaculture College of FisheriesCentral Agricultural University(Imphal)LembucherraTripura(W)792210India Aquaculture Division ICAR-Central Institute of Fisheries EducationMumbai400061India

The butter catfish,Ompok bimaculatus,belonging to the silurid family,is widely regarded as an important food fish for aquaculture diversification in ***,the species poses a threat due to habitat degradation and other anthropogenic factors,and has been categorised as“near threatened”,therefore,its culture promotion is *** establish a successful breeding programme,a precise understanding of the life history,and biology(reproductive/feeding)of the fish will assist hatchery managers and *** in these areas have been undertaken by several groups over the years,but without much coherence,the data are still *** attempts on the culture attributes of this catfish have been performed under both mono-and polyculture systems to bring about parallel promotion through aquaculture in a larger part of the *** this,we have tried to analyse and present a consolidated account of the morphological characteristics,feeding habits,reproductive biology,early developmental ontogeny,and culture potentials of *** in *** review was also prompted by the paucity of information on the cultural aspects of the ***,based on the reported studies,future directions and perspectives of the culture promotion of the species are proffered to ensure future research initiatives.

关键词： Ompok bimaculatus Ontogeny Polyculture Reproductive biology Threatened

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Spatial variability of soil hydraulic and physical properties in erosive sloping agricultural fields

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Water Science and Engineering 2023年第1期16卷 57-66页

作者： Deepak Singh alok Kumar Mishra Sridhar Patra Sankar Mariappan Nisha Singh Saswat Kumar Kar ICAR-Indian Institute of Soil and Water Conservation Dehradun 248195India Sam Higginbottom University of Agriculture Technology and SciencesPrayagraj 211007India Hemvati Nandan Bahuguna Garhwal University Srinagar(Garhwal)246174India

It is essential to minimize soil quality degradation in sloping agricultural fields through stabilization and improvement of soil hydraulic properties using sustainable soil *** study aimed to analyze the impact of different tillage practices,including conventional tillage(CT),minimum tillage(MT),and zero tillage(ZT),on soil hydraulic conductivity in a sloping agricultural field under maizeewheat *** results showed that the highest runoff volume(257.40 m3),runoff coefficient(42.84%),and soil loss(11.3 t)were observed when the CT treatment was *** contrast,the lowest runoff volume(67.95 m3),runoff coefficient(11.35%),and soil loss(1.05 t)were observed when the ZT treatment was *** soil organic carbon and aggregate mean weight diameter were found to be significantly greater(with mean values of 0.79%and 1.19 mm,respectively)with the ZT treatment than with the CT *** the tilled treatments(CT and MT),substantial changes in the saturated soil hydraulic conductivity(ks),near-saturated soil hydraulic conductivity(k),and water-conducting porosity(ε)were observed between two crop *** three soil parameters were significantly higher in the period after maize harvesting than in the wheat growing *** contrast,no significant difference in these soil parameters was found when the untilled treatment(ZT)was carried *** regard to the slope positions,ks,k,andεshowed different behaviors under different *** toe slope position showed significantly lower ks andεvalues than the summit and middle slope *** the evaluated tillage practices,ZT was found to be the most promising means to improve the soil hydro-physical properties and effectively reduce surface runoff and soil erosion.

关键词： Hydraulic conductivity Macropore Conservation tillage Spatiotemporal variability Soil erosion

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Potential of Essential Oils as Alternative Permeation Enhancers for Transdermal Delivery

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 258-269页

作者： Jayshree Mahanty Sofi Haamid Rasheed Sudhir Kumar Harjeet Singh alok Sharma Department of Pharmacognosy ISF College of PharmacyMogaPunjab CCRAS Ministry of AYUSHJhansiUttar PradeshIndia

Transdermal drug delivery plays a significant part in the drug delivery system when compared to other routes of drug *** function of the stratum corneum(SC)is a ***,numerous methods have been thrived to improve the perforation of drugs across the *** most effective method is to use enhancers since these agents enhance skin *** penetration enhancers like essential oils demonstrate higher enhancement activity and are more widely accepted than synthetic penetration *** potential in the expansion and interaction with the SC intercellular lipids has led to an increasing interest in these oils as penetration *** article gives an overview of a few essential oils,including their mode of action and important parameters for permeation *** present work can provide essential oils as alternative enhancers,and this could be useful in transdermal administration.

关键词： Essential oil natural permeation enhancers skin stratum corneum transdermal drug delivery

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Biphasic reduction model for predicting the impacts of dye-bath constituents on the reduction of tris-azo dye Direct Green-1 by zero valent iron(Fe^0)

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Journal of Environmental Sciences 2017年第2期29卷 160-169页

作者： Raja Kumar alok Sinha Department of Environmental Science&Engineering Indian School of MinesDhanbad 826004JharkhandIndia

Influence of common dye-bath additives, namely sodium chloride, ammonium sulphate,urea, acetic acid and citric acid, on the reductive decolouration of Direct Green 1 dye in the presence of Fe0 was investigated. Organic acids improved dye reduction by augmenting Fe0 corrosion, with acetic acid performing better than citric acid. Na Cl enhanced the reduction rate by its ‘salting out’ effect on the bulk solution and by Cl-anion-mediated pitting corrosion of iron surface.（NH4）2SO4induced ‘salting out’ effect accompanied by enhanced iron corrosion by SO42-anion and buffering effect of NH4＋ improved the reduction ***, at 2 g/L（NH4）2SO4concentration, complexating of SO42-with iron oxides decreased Fe0 reactivity. Urea severely compromised the reduction reaction, onus to its chaotropic and‘salting in’ effect in solution, and due to it masking the Fe0 surface. Decolouration obeyed biphasic reduction kinetics（R2〉 0.993 in all the cases） exhibiting an initial rapid phase,when more than 95% dye reduction was observed, preceding a tedious phase. Maximum rapid phase reduction rate of 0.955/min was observed at p H 2 in the co-presence of all dye-bath constituents. The developed biphasic model reckoned the influence of each dye-bath additive on decolouration and simulated well with the experimental data obtained at pH 2.

关键词： Biphasic kinetics/model Direct Green 1 Dye-bath additives Fe0

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Magnitude and Determinants of Mortalities Related to COVID-19:Evidence from 94 Countries Using Regression Techniques

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Fudan Journal of the Humanities and Social Sciences 2022年第4期15卷 475-499页

作者： Ashis Kumar Pradhan Ronny Thomas Sandhyarani Rout alok Kumar Pradhan Department of Humanities and Social Sciences Maulana Azad National Institute of TechnologyBhopalMadhya PradeshIndia Rajagiri Business School(RBS)and Rajagiri College of Social Sciences(RCSS) Rajagiri Valley CampusKakkanadKochiKeralaIndia Department of Social Science Fakir Mohan UniversityBalasoreOdishaIndia Indian Institute of Management Nagpur DahegaonIndia

This study attempts to investigate the factors determining COVID-19 deaths during the pandemic across countries by employing a rich dataset sourced from 94 countries updated till 6 February,*** empirical analysis,the study makes use of cross-sectional linear regression technique in the first part and after required diagnostic tests use 2SLS regression technique for correcting possible endogeneity bias in the second *** from the study indicate that factors like total reported cases,population size,population over 70 years of age,extreme poverty,and human development index play significant role in determining COVID-19-related ***,to check the robustness of the findings the present study employed LASSO *** from the study highlight the possibility of government intervention to devise appropriate policies to control COVID-related incidence and death.

关键词： COVID-19 deaths Mortality risks Infectious diseases LASSO regression Pandemic

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Update on the preclinical and clinical assessment of Withania somnifera: from ancient Rasayana to modern perspectives

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Traditional Medicine Research 2022年第5期7卷 50-64页

作者： Akanksha Rashmi Singh Atiqul Islam Rimpi Arora Harjeet Singh alok Sharma Department of Pharmacognosy ISF College of PharmacyMogaPunjab 142001India Department of Pharmacology ISF College of PharmacyMogaPunjab 142001India CCRAS Ministry of AYUSHJhansiUttar Pradesh 212658India

The Rasayana plant Withania somnifera(***)Dunal,also known as“Ashwagandha”,has been mentioned in various classical Ayurvedic texts,such as Charaka Samhita,Sushruta Samhita,and *** Ayurvedic drug has been referred to as a tonic that renews the body,provides physical and mental vigor in weakened states,and promotes endurance and *** possesses notable biological activity in many ailments,such as diabetes,conjunctivitis,insomnia,senile dementia,Parkinson’s disease,nervous system disorders,rheumatism,and *** pharmacological activities are due to the presence of diverse active components and their *** lead compounds are found to be effective against anxiety and other central nervous system *** has been proven to be effective and safe for a wide range of ailments from ancient to modern *** reported properties represent the traditional use of *** as indicated in the literature;furthermore,*** is one of the most important prescribed drugs in Ayurveda for its multimodal *** current review highlights the bioactive present and provides an overview of the toxicological and pharmacological studies on ***,including preclinical and clinical *** its earliest utilization to its current application,*** has been recognized to be effective at clinical levels for human health and *** attention to the safety and efficacy of *** would provide more scientific evidence,promoting global acceptance of the Ayurvedic plant.

关键词： Withania somnifera Ayurveda Rasayana pharmacological profile preclinical study clinical study

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An AI-driven microstructure optimization framework for elastic properties of titanium beyond cubic crystal systems

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npj Computational Materials 2023年第1期9卷 1217-1226页

作者： Yuwei Mao Mahmudul Hasan Arindam Paul Vishu Gupta Kamal Choudhary Francesca Tavazza Wei-keng Liao alok Choudhary Pinar Acar Ankit Agrawal Department of Electrical and Computer Engineering Northwestern UniversityEvanstonILUSA Virginia Tech BlacksburgVAUSA Materials Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Theiss Research La JollaCA 92037USA

Materials design aims to identify the material features that provide optimal properties for various engineering applications,such as aerospace,automotive,and *** of the important but challenging problems for materials design is to discover multiple polycrystalline microstructures with optimal *** paper proposes an end-to-end artificial intelligence(AI)-driven microstructure optimization framework for elastic properties of *** this work,the microstructure is represented by the Orientation Distribution Function(ODF)that determines the volume densities of crystallographic *** framework was evaluated on two crystal systems,cubic and hexagonal,for Titanium(Ti)in Joint Automated Repository for Various Integrated Simulations(JARVIS)database and is expected to be widely applicable for materials with multiple crystal *** proposed framework can discover multiple polycrystalline microstructures without compromising the optimal property values and saving significant computational time.

关键词： microstructure cubic crystal

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