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Characterization of monocarboxylate transporter activity in hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第33期20卷 11780-11787页

作者： Venncio Af Alves Céline Pinheiro filipa Morais-Santos aloisio f.lipe-silva Adhemar Longatto-filho fátima Baltazar Laboratory of Medical Investigation (LIM) 14 Department of Pathology University of S?o Paulo School of Medicine S?oPaulo SP 1246-903 Brazil Life and Health Sciences Research Institute (ICVS) School of Health Sciences University of Minho 4704-553 Braga Portugal ICVS/3B’s-PT Government Associate Laboratory 4710-057 Braga/ Guimar?es Portugal Barretos School of Health Sciences Dr. Paulo Prata-FACISB Barretos S?o Paulo SP 13083-970 Brazil Molecular Oncology Research Center Barretos Cancer Hospital Barretos Sao Paulo 14780-000 Brazil Molecular Oncology Research Center Barretos Cancer Hospital Pio XII Foundation Barretos 14780-000 Brazil

AIM: To assess the immunoexpression of hypoxia-related markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma (HCC).

关键词： Hepatocellular carcinoma Monocarboxylate transporters Glycolysis Cirrhosis Glucose transporter-1

Tribological behaviour of sintered iron based self-lubricating composites

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friction 2017年第3期5卷 285-307页

作者： Jose Daniel Biasoli DE MELLO Cristiano BINDER Gisele HAMMES Roberto BINDER aloisio Nelmo KLEIN Laboratorio de Materiais(LabMat) Universidade Federal de Santa Catarina Florianópolis 88.040-900 SC BrazilLaboratorio de Tribologia e Materiais Universidade Federal de Uberl(a)ndia Uberl(a)ndia 38.400-902 MG Brazil Laboratorio de Materiais(LabMat) Universidade Federal de Santa Catarina Florianópolis 88.040-900 SC Brazil Whirlpool Embraco Unit Joinville 89.219-900 SC Brazil

This work is a review of previous works,presenting and discussing the most important results obtained by an ongoing research program towards the development of innovative,low-cost,self-lubricating composites with a low friction coefficient and high mechanical strength and wear *** emphasis is given to uniaxial die pressing of solid lubricant particles mixed with matrix powders and to metal injection moulding associated with in situ generation of solid lubricant ***,a microstructural model/processing route (powder injection moulding followed by plasma-assisted debinding and sintering) produced a homogeneous dispersion of in situ generated solid lubricant *** nodules of graphite with diameter smaller than 20 μm were formed,constituting a nanostructured stacking of graphite foils with nanometric *** Raman analysis indicated that the graphite nodules were composed of turbostratic 2D graphite having highly misaligned graphene planes separated by large interlamellae *** interplanar distance between the graphene foils and misalignment of these foils were confirmed by transmission electron microscopy and were,probably,the origin of the outstandingly low dry friction coefficient (0.04).The effect of sintering temperature,precursor content,metallic matrix composition and surface finish is also ***,the influence of a double-pressing/double-sintering (DPDS) technique on the tribological performance of self-lubricating uniaxially die-pressed hBN + graphite-fe-Si-C-Mo composite is also ***,the tribological behaviour of die-pressed fe-Si-C matrix composites containing 5,7.5 and 10 wt％ solid lubricants (hBN and graphite) added during the mixing step is analysed in terms of mechanical properties and wear ***,the synergy between solid lubricant particles dispersed in a metallic matrix and fluid lubricants in a cooperative mixed lubrication regime is presented.

关键词： tribological behaviour powder metallurgy iron based self-lubricating composites turbostratic graphite

Ibuprofen-Maltodextrin Interaction: Study of Enantiomeric Recognition and Complex Characterization

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Pharmacology & Pharmacy 2013年第1期4卷 18-30页

作者： Claudia Garnero Carolina aloisio Marcela Longhi Departamento de farmacia Facultad de Ciencias Químicas Universidad Nacional de Córdoba Ciudad Universitaria Córdoba Argentina

The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance spectroscopy experiments and solubility studies. The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state. The freeze-drying method was used to prepare solid complexes, while physical mixtures were obtained by simple blending. These solid systems were characterized in the solid state using differential scanning calorimetry, thermogravimetric analysis, fourier Transform-Infrared spectroscopy, scanning electron microscopy and X-ray diffractometry. Detailed nuclear magnetic resonance studies provided evidence of the influence of the type and concentration of the maltodextrin host on the chiral recognition of racemic ibuprofen, indicating that these linear ligands act as chiral selectors.

关键词： Ibuprofen Maltodextrin Chiral Recognition Complex Characterization Nuclear Magnetic Resonance Spectroscopy Solubility Studies

Effect of temperature and atmosphere on the tribological behavior of a polyether ether ketone composite

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friction 2015年第4期3卷 259-265页

作者： f.lipe Darabas RZATKI Diego Vinicius Dalevedo BARBOZA Renan Muller SCHROEDER Guilherme Mariz de Oliveira BARRA Cristiano BINDER aloisio Nelmo KLEIN JoséDaniel Biasoli DE MELLO federal University of Santa Catarina-UfSC Mechanical Engineering DepartmentMaterials LaboratoryFlorianópolisSCBrazil Whirlpool/Embraco JoinvilleSCBrazil

Polyether ether ketone(PEEK)is a high-performance thermoplastic,which is often selected for high-temperature tribological applications under chemically aggressive *** present work investigates the tribological behavior of a high-performance PEEK composite under conditions that are often found inside hermetic ***,an AMTI tribometer equipped with a hermetic chamber and a heating system was used to conduct sliding tests of PEEK cylinders on AISI 304 stainless steel polished discs(S_(q)force of 175 *** tribological behavior of the PEEK/AISI 304 stainless steel system was investigated as a function of ambient temperature(30℃ and 80℃)and atmosphere(atmospheric air and tetrafluoroethane).Wear and surface roughness analyses were performed with white light interferometry and optical *** spectroscopy was used to investigate transfer films on the counter body *** was observed to have a strong influence on the tribological behavior of the samples tested under atmospheric air,with a 25%decrease in the friction coefficient associated with a 100%increase in the wear ***,the friction measured from the samples tested under a tetrafluoroethane atmosphere showed no significant temperature dependence.

关键词： solid lubricant thermoplastics environment temperature

Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1589-1597页

作者： Leonardo Mastropasqua Silvio Di Staso Rossella D’aloisio Alessandra Mastropasqua Luca DiAntonio Alfonso Senatore Marco Ciancaglini Marta Di Nicola Giuseppe Di Martino DanieleTognetto Lisa Toto Department of Medicine and Science of Ageing OphthalmologyClinicUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy Department of Life Health and Environmental SciencesOphthalmology ClinicUniversity of L’AquilaL’Aquila67100Italy Department of Medicine Surgery and Health SciencesEyeClinicUniversity of TriesteTrieste34129Italy Department of Medical Oral and Biotechnological SciencesLaboratory of BiostatisticsUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy Department of Medicine and Science of Ageing School ofHygiene and Preventive MedicineUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy

AIM: To investigate the efficacy and safety of ranibizumab(RZB group) and dexamethasone implant(DEX group) intravitreal treatments in patients with treatment-na?ve center involved diabetic macular edema(DME) by means of functional and morphological ***: This retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity(BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness(CMT) by means of structural optical coherence tomography(OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all ***: functional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups witha greater increase in the DEX group compared to the RBZ group(P=0.030). Microperimetry significantly differed during follow-up between the two treatments(P=0.031). In both groups CMT significantly decreased(Pficant differences between the two groups. A statistically significant increase of deep capillary plexus density was detected in both groups at 30 d after therapy. The retreatment rate was 0.70±0.10 and 0.65±0.10 in the RBZ group and 0.65±0.10 and 0.50±0.11 in DEX group at 120 and 180 d respectively. Two out of 25 patients in DEX group showed intraocular pressure increase requiring hypotonic eye ***: Both treatments are very effective for DME treatment during 6 mo of follow-up with a lower retreatment rate in DEX group.

关键词： optical coherence tomography angiography diabetic macular edema intravitreal dexamethasone implant intravitreal ranibizumab injections

Colorectal cancer screening in countries of European Council outside of the EU-28

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World Journal of Gastroenterology 2016年第20期22卷 4946-4957页

作者： Emma Altobelli francesco D'aloisio Paolo Matteo Angeletti Department of Life Health and Environmental Sciences University of L’Aquila Epidemiology and Biostatistics Unit AUSL Teramo University of L’Aquila

AIM: To provide an update on colorectal cancer(CRC) screening programmes in non-European Union(EU)-28 Council of Europe member states as of December 2015. METHODS: The mission of the Council of Europe is to protect and promote human rights in its 47 member countries. Its 19 non-EU member states are Albania, Andorra, Armenia, Azerbaijan, Bosnia and Herzegovina, Republika Srpska, Georgia, Iceland, Liechtenstein, Republic of Moldova, Monaco, Montenegro, Norway, Russian federation, San Marino, Serbia, Switzerland, fYR of Macedonia, Turkey, and Ukraine(EU-19). The main data source were GLOBOCAN, IARC, WHO, EUCAN, NORDCAN, ENCR, volume X of the CI5, the ministerial and Public Health Agency websites of the individual countries, Pub Med, EMBASE, registries of some websites and the ***, Scopus, ***, ***, Research gate, Google and data extracted from screening programme results. RESULTS: Our results show that epidemiological data quality varies broadly between EU-28 and EU-19 countries. In terms of incidence, only 30% of EU-19 countries rank high in data quality as opposed to 86% of EU-28 states. The same applies to mortality data, since 52% of EU-19 countries as against all EU-28 countries are found in the high ranks. Assessment of the method of collection of incidence data showed that only 32% of EU-19 countries are found in the top three quality classes as against 89% of EU-28 countries. for the mortality data, 63% of EU-19 countries are found in the highest ranks as opposed to all EU-28 member states. Interestingly, comparison of neighbouring countries offering regional screening shows, for instance, that incidence and mortality rates are respectively 38.9 and 13.0 in Norway and 29.2 and10.9 in Sweden, whereas in finland, where a national organised programme is available, they are respectively 23.5 and 9.3. CONCLUSION: Cancer screening should be viewed as a key health care tool, also because investing in scr

关键词： Colorectal cancer Screening EU-28 EU-19 European Union Early detection European Council

Impacts of COVID-19 on children and adolescents:A systematic review analyzing its psychiatric effects

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World Journal of Psychiatry 2022年第11期12卷 1313-1322页

作者： Italo Wanderson de Moura Gabriel Danielly Gonçalves Sombra Lima Jeully Pereira Pires Nélio Barreto Vieira aloisio Antonio Gomes de Matos Brasil Yara Talita Gomes Pereira Erika Galvao de Oliveira HildsonLeandro de Menezes Nadia Nara Rolim Lima Alberto Olavo Advíncula Reis Ruan Neto Pereira Alves Uanderson Pereira da silva Jucier Gonçalves Junior Modesto Leite Rolim-Neto School of Medicine Faculty of Medicine of Juazeiro do Norte-FMJ/IDOMEDJuazeiro do Norte 63040-360CearaBrazil School of Medicine Federal University of CaririBarbalha 63048-080CearaBrazil Mais Médicos Program Federal Government of Brazil-Ministry of HealthIguatu 63048-080CearaBrazil Julio Alves de Lira Hospital and Maternity Hospital HALHMBelo Jardim 55157-290PernambucoBrazil Nursing Department Doctor Leão Sampaio University Center-UNILEAOJuazeiro do Norte 63.041-140CearaBrazil Julio Alves de Lira Hospital and Maternity Hospital JALHMBelo Jardim 55157-290PernambucoBrazil Graduate Program(Post-Doctoral)in Neuro-Psychiatry UFPERecife 50670-901PernambucoBrazil Postgraduate Program(Master’s and Doctorate)in Public Health University of São Paulo-USPSão Paulo 01246-904São PauloBrazil School of Education USPSão Paulo 05508-040São PauloBrazil Internal Medicine-Division of Rheumathology at Hospital das Clínicas São Paulo UniversitySão Paulo 01246-903São PauloBrazil

OBJECTIVE To summarize the most relevant data from a systematic review on the impact of COVID-19 on children and adolescents,particularly analyzing its psychiatric *** This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA)guidelines and included experimental studies(randomized-individually or pooled-and non-randomized controlled trials),observational studies with a group for internal comparison(cohort studies-prospective and retrospective-and case-control)and qualitative studies in the period from 2021 to *** The search identified 325 articles;we removed 125 *** selected 200 manuscripts,chosen by title and selected *** excluded 50 records after screening titles and abstracts,as they did not meet the inclusion *** retrieved 150 records selected for a full *** excluded 90 text articles and we selected 25 records for the(n)***:Due to the short period of data collection,from 2021 to 2022,there is a possibility of lack of relevant studies related to the mental health care of children and *** addition,there is the possibility of publication bias,such as only significant findings being *** The impact of COVID-19 on the mental health of children and adolescents is of great concern to child and youth *** such as fear,anxiety,panic,depression,sleep and appetite disorders,as well as impairment in social interactions caused by psychic stress,are punctual markers of pain and psychic suffering,which have increasing impacts on the mental health panorama of children and adolescents globally,particularly in vulnerable and socially at-risk populations.

关键词： Child psychiatry Adolescent psychiatry Mental health COVID-19 Kids Teens

Rebound Tonometry in Cataract Surgery: Comparison with Goldmann Applanation Tonometry

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Open Journal of Ophthalmology 2018年第1期8卷 1-11页

作者： Chiara De Giacinto Rossella D’aloisio Sara Trovarelli Agostino Accardo Odilla Vattovani Daniele Tognetto Department of Medicine Surgery and Health Sciences University of Trieste Trieste Italy Department of Industrial and Information Technology University of Trieste Trieste Italy

Purpose: to compare the rebound tonometer ICare? (RT) with the Goldmann applanation tonometer (GAT) in cataract surgery and to assess the influence of central corneal thickness (CCT) on intraocular pressure (IOP) measurements. Design: retrospective, comparative study. Methods: a total of 472 patients underwent IOP measurement using RT (time 0 = RTa). GAT IOP measurement was performed 5 minutes later, followed by a second RT IOP measurement after other 5 minutes (RTa + 10 min = RTb). CCT was obtained by ultrasound pachymetry. In 106 patients IOP was measured by means of RT and GAT before clear corneal cataract surgery (RT1 and GAT1) and at one day postoperatively (RT2 and GAT2). Results: RT IOP values > 5 mmHg were overestimated, while RT IOP values Conclusion: our results showed a good agreement between measurements obtained with RT and GAT in pre and postoperative cataract surgery, although a significant statistically difference was found between RT and GAT measurements performed postoperatively. Moreover, CCT is a parameter to be considered for the IOP measurement, especially for values obtained with RT.

关键词： Applanation Tonometer Cataract Surgery Intraocular Pressure Pachymetry Rebound Tonometer

flexible fully organic indirect detector for megaelectronvolts proton beams

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npj flexible Electronics 2023年第1期7卷 513-523页

作者： Sabrina Calvi Laura Basiricò Sara M.Carturan Ilaria fratelli Antonio Valletta Alberto aloisio Stefania De Rosa felix Pino Marcello Campajola Andrea Ciavatti Luca Tortora Matteo Rapisarda Sandra Moretto Matteo Verdi Stefano Bertoldo Olivia Cesarini Paolo Di Meo Massimo Chiari francesco Tommasino Ettore Sarnelli Luigi Mariucci Paolo Branchini Alberto Quaranta Beatrice fraboni INfN Sezione di RomaTreVia Della Vasca Navale 8400146 RomaItaly CNR-Institute for Microelectronics and Microsystems(IMM)Via Del fosso Del Cavaliere 10000133 RomeItaly Department of Physics and Astronomy University of BolognaViale C.Berti Pichat 6/240127 BolognaItaly INfN Sezione di BolognaViale C.Berti Pichat 6/240127 BolognaItaly Department of Physics and Astronomy University of PadovaVia Marzolo 8PadovaItaly INfN-Laboratori Nazionali di Legnaro Viale dell’Università2LegnaroItaly University of Naples federico II Department of PhysicsComplesso Univ.di Monte S.AngeloEdificio GVia Cintia80126 NapoliItaly INfN-Sezione di Napoli-Complesso Univ.di Monte S.Angelo Edificio GVia Cintia80126 NapoliItaly CNR-SPIN Via Campi Flegrei3480078 PozzuoliNAItaly Task force di Bioelettronica University of Naples Federico IINapoliItaly Department of Sciences Roma Tre UniversityVia della Vasca Navale 8400146 RomaItaly INfN Sezione di PadovaVia Marzolo 8PadovaItaly INfN Sezione di FirenzeVia G.Sansone 150019 Sesto FiorentinoFlorenceItaly Department of Physics University of TrentoVia Sommarive 1438123 TrentoPovoItaly INfN-TIfPA Via Sommarive 1438123 TrentoPovoItaly Department of Industrial Engineering University of TrentoVia Sommarive 938123 TrentoPovoItaly

A flexible,fully organic detector for proton beams is presented *** detector operates in the indirect mode and is composed of a polysiloxane-based scintillating layer coupled to an organic phototransistor,that is assessed for flexibility and low-voltage operation(V=−1 V),with a limit of detection of 0.026 Gy min^(−1).We present a kinetic model able to precisely reproduce the dynamic response of the device under irradiation and to provide further insight into the physical processes controlling *** detector is designed to target real-time and in-situ dose monitoring during proton therapy and demonstrates mechanical flexibility and low power operation,assessing its potential employment as a personal dosimeter with high comfort and low risk for the *** results show how such a proton detector represents a promising tool for real-time particle detection over a large area and irregular surfaces,suitable for many applications,from experimental scientific research to innovative theranostics.

关键词： fully limit insight