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Nonalcoholic fatty liver disease in asymptomatic Brazilian adolescents

World Journal of Gastroenterology 2009年第4期15卷 473-477页

作者： Raquel Rocha Helma Pinchemel Cotrim almir galvo vieira bitencourt Daniel Batista Valente Barbosa Adméia Souza Santos Alessandro de Moura Almeida Bruno Cunha Isabel Guimares Postgraduate Course in Medicine and Health Federal University of BahiaSchool of Medicine Federal University of Bahia School of Medicine NASH Project University Hospital Professor Edgard SantosFederal University of Bahia

AIM:To evaluate the prevalence and clinical characteristics of Nonalcoholic fatty liver disease(NAFLD) among asymptomatic Brazilian adolescents. METHoDS:Transversal observational study included asymptomatic adolescents with central obesity from private and public schools in Salvador-Bahia,northeastern *** children answered a questionnaire that included age,gender,race,and medical history,and were submitted to a complete physical exam and abdominal *** exams included:ALT,AST,GGT,C reactive protein(CRP),fasting glucose,insulin,cholesterol and *** for NAFLD included:the presence of steatosis in ultrasound and/or high level of ALT,negative or occasional historic of intake of alcohol(≤140 g/wk),negative investigation for hepatitis A,B,C,auto-immune hepatitis,Wilson disease and ***:From october,2005 to october,2006,the study included 1801 subjects between 11 and 18 years of age and a mean age of 13.7±2.0 *** hundred ninety-nine had central *** prevalence of NAFLD was 2.3%,most of whom were male and *** resistance(IR)was observed in 22.9% of them and had positive correlations with ALT and GGT(Pobserved in 6.9% of the cases;however,it was not associated with WC,IR or liver enzymes. CoNCLUSIoN:The prevalence of NAFLD in Brazilian adolescents was *** ethnicity may have influence this frequency in the population studied,which had a large proportion of African descendents.

关键词：肥胖疾病青少年脂肪代谢障碍治疗

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Fatty liver disease in severe obese patients:Diagnostic value of abdominal ultrasound

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World Journal of Gastroenterology 2008年第9期14卷 1415-1418页

作者： Alessandro de Moura Almeida Helma Pinchemel Cotrim Daniel Batista Valente Barbosa Luciana Gordilho Matteoni de Athayde Adimeia Souza Santos almir galvo vieira bitencourt Luiz Antonio Rodrigues de Freitas Adriano Rios Erivaldo Alves Faculdade de Medicina da Bahia Universidade Federal da Bahia SalvadorBahia 41830-020Brasil Faculdade de Medicina da Bahia Universidade Federal da BahiaSalvadorBahia 41830-020Brasil Faculdade de Medicina da Bahia Universidade Federal da Bahia SalvadorBahia 41830-020Brasil Faculdade de Medicina da Bahia Universidade Federal da BahiaSalvadorBahia 41830-020 Brasil Núcleo de Cirurgia da obesidade SalvadorBahia 41830-020Brasil

AIM:To evaluate the sensitivity and specificity of abdominal ultrasound (US) for the diagnosis of hepatic steatosis in severe obese subjects and its relation to histological grade of steatosis. METHoDS: A consecutive series of obese patients, who underwent bariatric surgery from october 2004 to May 2005, was selected. Ultrasonography was performed in all patients as part of routine preoperative time and an intraoperative wedge biopsy was obtained at the beginning of the bariatric surgery. The US and histological findings of steatosis were compared, considering histology as the gold standard. RESULTS: The study included 105 patients. The mean age was 37.2 ± 10.6 years and 75.2% were female. The histological prevalence of steatosis was 89.5%. The sensitivity and specificity of US in the diagnosis of hepatic steatosis were, respectively, 64.9% (95% CI: 54.9-74.3) and 90.9% (95% CI: 57.1-99.5). The positive predictive value and negative predictive value were, respectively, 98.4% (95% CI: 90.2-99.9) and 23.3% (95% CI: 12.3-39.0). The presence of steatosis onUS was associated to advanced grades of steatosis on histology (P = 0.016). CoNCLUSIoN: Preoperative abdominal US in our series has not shown to be an accurate method for the diagnosis of hepatic steatosis in severe obese patients. Until another non-invasive method demonstrates better sensitivity and specificity values, histological evaluation may be recommended to these patients undergoing bariatric surgery.

关键词：脂肪肝肥胖病人腹部超声波检查肝脏脂肪变性

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Subcutaneous Model for the Study of Dengue Virus Infection in Immune Competent Mice

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Journal of Biosciences and Medicines 2018年第5期6卷 97-110页

作者： Beatriz Senra Santos Natalia Lima Pessoa Natalia Lucinda Gustavo Cardoso de oliveira Thais Souza Silva Ketyllen Reis Andrade Ketyllen Reis Andrade Bruno galvã o Filho Marcele Neves Rocha Alexandre vieira Machado Pedro Augusto Alves É rica Alessandra Rocha Alves Erna Geessien Kroon Marco Ant&ocirc nio Campos Instituto René Rachou Funda&amp amp ccedil & amp atilde o oswaldo Cruz Fiocruz Belo Horizonte Brazil Departamento de Microbiologia Universidade Federal de Minas Gerais Belo Horizonte Brazil Empresa Brasileira de Pesquisa Agropecuá ria Laborat&amp amp oacute rio de Virologia Brasilia Brazil

Various mouse models to study dengue have been described by different authors, some of them using immunodeficient or some using humanized mice. our group reported previously a deadly murine model, which used the intracranial inoculum of highly virulent Dengue virus (DENV) in immune competent mouse. Here we present a model of immune competent mouse (C57BL/6), infected subcutaneously by the same highly virulent DENV (DENV3 genotype I). In this immunocompetent systemic mice model, the cytokine levels and hematological parameters such as total and differential leukocyte and platelets counts, together with weight loss, were considered important monitoring parameters, allowing a better understanding of the systemic human disease. Mice were inoculated subcutaneously and evaluated by the percentage weight variation as well as the clinical signs. Hematological parameters and cytokines levels were measured and viral titration in brain tissue or serum neutralization was performed to confirm mice infection. The subcutaneously DENV inoculated mice showed weight loss after infection, but they did not show any other clinical signs. The leukocytes and platelets decreased after subcutaneous inoculation. The cytokines TNF alpha and IFN gamma increased after infection in mice. The subcutaneous model provided scope for improved understanding of the dengue pathogenesis, as well as possible mechanism for protection to subsequent mouse infected by intracranial route in mice. This model could be used to study the vertebrate immune response and evaluation of drugs or vaccine against dengue virus.

关键词： Subcutaneous Murine Model Dengue Disease Immune Competent Mouse Cytokines Innate Immune Response

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