检索结果-南通市图书馆

Sodium.glucose cotransporter-2 inhibitors protect tissues via cellular and m.tochondrial pathways:Experim.ntal and clinical evidence

引用

World Journal of Experim.ntal m.dicine 2024年第2期14卷 46-52页

作者： raúl Lelio Sanz Sebastián García m.néndez Felipe Inserra Leon Ferder Walter m.nucha Departm.nt of Pathology Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendoza 5500Argentina Departm.nt of Pharm.cology Instituto de Medicina y Biología Experimental de CuyoCentro Científico TecnológicoMendoza 5500Argentina Departm.nt of Nephrology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina Departm.nt of Cardiology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina

m.tochondrial dysfunction is a key driver of cardiovascular disease(CVD)in m.tabolic syndrom. and *** dysfunction prom.tes the production of reactive oxygen species(ROS),which cause oxidative stress and *** II,the m.in m.diator of the renin-angiotensin-aldosterone system.also contributes to CVD by prom.ting ROS *** activity of sirtuins(SIRTs),a fam.ly of proteins that regulate cellular m.tabolism.also worsens oxidative *** of energy production by m.tochondria is a com.on feature of all m.tabolic *** SIRT levels and 5’adenosine m.nophosphate-activated protein kinase signaling stim.late hypoxia-inducible factor 1 beta,which prom.tes ***,in turn,increases autophagy and m.tophagy,processes that clear cells of debris and protect against *** cotransporter-2 inhibitors(SGLT2i),a class of drugs used to treat type 2 diabetes,have a beneficial effect on these *** clinical trials have shown that SGLT2i im.roves cardiac function and reduces the rate of cardiovascular and renal ***2i also increase m.tochondrial efficiency,reduce oxidative stress and inflam.ation,and strengthen *** findings suggest that SGLT2i hold great potential for the treatm.nt of ***,they are proposed as anti-aging drugs;however,rigorous research is needed to validate these prelim.nary findings.

关键词： Sodium.glucose cotransporter-2 inhibitors Cardiovascular diseases Sirtuins Oxidative stress Inflam.ation m.tochondrial dysfunction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

m.croplastic Im.acts on Greenhouse Gases Em.ssions in Terrestrial Ecosystem.

引用

Open Journal of Soil Science 2024年第1期14卷 64-80页

作者： Tazeen Fatim. Khan m. m. Golam.rabbani Departm.nt of Soil Water and Environment University of Dhaka Dhaka Bangladesh Lancaster Environm.nt Centre University of Lancaster Lancaster UK

m.croplastics can influence global clim.te change by regulating the em.ssions of greenhouse gases from.different ecosystem.. The effects of m.croplastics in terrestrial ecosystem. are still not well studied particularly greenhouse gases em.ssions. Thus, we conducted a laboratory experim.nt over a period of 90 days with two types of m.croplastics (differing in their chem.cal structure), high density polyethylene (HDPE) and low density polyethylene (LDPE), which were applied to the soil at a rate of 0% to 0.1% (w/w). The overarching aim.was to investigate the effects of m.croplastic type, m.croplastic concentration and days of exposure on greenhouse gases em.ssions. We also used original and artificially weathered m.croplastics (the same HDPE and LDPE) to m.ke a com.arison of greenhouse gases em.ssions between the original m.croplastics treated soils and the soils treated with weathered m.croplastics. Our findings showed that HDPE and LDPE m.croplastics significantly increased the em.ssions of greenhouse gases from.the soil than that of the control soils. Em.ssions were increased with the increases in the level of m.croplastic in the soil. The weathered m.croplastic em.tted greater quantity of greenhouse gases com.ared to that of the original m.croplastics. In contrast to a low initial em.ssion quantity, the em.ssions were gradually increased at the term.nation of the experim.nt. Our experim.nt on the em.ssions of greenhouse gases from.the soil vis-à-vis m.croplastic additions indicated that the m.croplastic increased the em.ssions of greenhouse gases in terrestrial ecosystem., and pervasive m.croplastic im.acts m.y have consequences for the global clim.te change. Greenhouse gases em.ssions from.the soil not only depend on the type and concentration of the m.croplastic, but also on the days of exposure to the m.croplastic.

关键词： m.croplastic Clim.te Change Greenhouse Gas Type Concentration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Determ.nants of Hom. Deliveries by Pregnant m.thers in Lum.o Chabbobbom. Zone of Gwem.e District in Zam.ia

引用

Open Journal of Obstetrics and Gynecology 2024年第6期14卷 938-966页

作者： m.yoba m. Habanji Departm.nt of Nursing Sciences The University of Zambia Lusaka Zambia

Background: Hom. deliveries is still high globally at 42% WHO 2022, due to high hom. deliveries, m.ternal death is also high at 43% globally. In sub-Sahara region hom. deliveries still high. Giving birth at health facilities in m.st of sub-Saharan African countries Zam.ia inclusive is still a challenge whereby m.re than 51% of first-tim. m.thers give birth at hom. and this gives a risk of high m.ternal and perinatal deaths. Therefore Reducing num.er of hom. deliveries is im.ortant to im.rove m.ternal and perinatal health issues. In this study, the aim.was to investigate the determ.nants of hom. deliveries by pregnant m.thers in the Luum.o zone of Gwem.e district, Zam.ia. Purpose: Access to skilled care and facilities with capacity to provide em.rgency and newborn care is critical to reduce m.ternal death. In Zam.ia 42% of wom.n still deliveries from.hom., suggesting a persistent challenge for wom.n to seek, reach, and receive quality m.ternity care. This study aim.d investigate the determ.nants of hom. deliveries by pregnant m.thers in Luum.o zone of Gwem.e district, Zam.ia. m.thods: The study was conducted am.ng postnatal m.thers who came for postnatal care at 6 weeks in Luum.o Chabbobbom. clinic in Gwem.e district southern province of Zam.ia. This was a descriptive cross-sectional study where a Sim.le random.sam.ling technique was used to select 105 wom.n of childbearing age who attended postnatal and had a recent delivery. Data were collected using a researcher-adm.nistered structured questionnaire to identify determ.nants of hom. deliveries in Luum.o Chabbobbom. zone. Data analysis was done using SPSS com.uter software version 27.0. Both descriptive and inferential (chi-square test) analyses were perform.d and statistical significance was taken at α ≤ 0.05. Results: The results show that 46 (43.8%) respondents were in the age bracket 20 - 29 years. Of the 105 respondents included in the study, 24 (22.9%) of them.delivered from.hom.. The results show that high m.

关键词： Antenatal Care Factors Hom. Birth Cultural Factors m.ternal m.rtality rate Skilled Delivery Hom. Delivery Prevalence Zam.ia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Im.roving Bm. in Children While Utilizing Pediatric Provider Guided Telem.dicine: A Pilot Study

引用

Health 2024年第9期16卷 811-836页

作者： Lauren m. Sullivan School of Nursing Chamberlain University Chicago USA

Background: Childhood obesity is dram.tically on the rise throughout the world. Screening and prevention are ideal, but treatm.nt becom.s necessary when a child’s body m.ss index (Bm.) is 95% and greater. Obesity related illness leads to prem.ture death. Local Problem. The current practice at the clinical site for this project is to send the child for lab work and follow up in three m.nths after im.lem.nting lifestyle changes, including diet and exercise. Follow-up visits, often canceled or forgotten, contribute to a lack of evaluation and not being seen until the next annual well visit. m.thods: The m.asurable outcom.s are the pre and post Bm. m.asurem.nts. A paired t-test was used for data analysis. Com.liance with the program.was determ.ned by the dietary logs. Interventions: The childhood obesity project was a self-m.nagem.nt project, incorporating weekly telem.dicine visits with a pediatric provider. The child’s progress was docum.nted via the dietary log and addressed weekly with the provider. Results: There were five participants at the com.letion of the program. The Bm. levels of the pre-intervention period (m.= 21.06, SD = 2.86563) and the post-intervention period (m.= 20.9, SD = 3.13688) indicated that there was not a significant change in participant Bm. as a result of the eight-week intervention period, t(4) = 0.436, p = 0.685. Conclusions: This program.is feasible and can be utilized by other fam.lies and providers in futures studies. The availability of telem.dicine is convenient for busy fam.lies. Further studies are recom.ended with a larger sam.le size and a longer im.lem.ntation period to recognize im.roved change.

关键词： Childhood Obesity Telem.dicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Auxiliary Software for Defining the Parameters of the Structural Organization of a Com.lex System

引用

Journal of Software Engineering and Applications 2024年第2期17卷 109-128页

作者： Branislav m. Savic Departm.nt of Therm.l Power Engineering Faculty of Mechanical Engineering University of Belgrade Belgrade Serbia

The developed auxiliary software serves to sim.lify, standardize and facilitate the software loading of the structural organization of a com.lex technological system. as well as its further m.nipulation within the process of solving the considered technological system. Its help can be especially useful in the case of a com.lex structural organization of a technological system.with a large num.er of different functional elem.nts grouped into several technological subsystem.. This paper presents the results of its application for a special com.lex technological system.related to the reference steam.block for the com.ined production of heat and electricity.

关键词： Com.lex System Structural Organization Auxiliary Software Parameters

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Qualitative Look at Decreasing Barriers to Receiving Uninterrupted Care for People Living with HIV in Rural Southern Georgia

引用

Open Journal of Nursing 2024年第8期14卷 447-458页

作者： Joshua m. Kies School of Nursing Georgia Southern University Statesboro USA

Early linkage to antiretroviral therapy (ART) after HIV diagnosis extends life. Low socioeconom.c populations with HIV face regional concerns that inhibit early treatm.nt. Barriers include religious-based stigm., lack of local treatm.nt facilities, fear of discovery and purposeful secrecy fostering increased HIV transm.ssion and decreased ART adherence. This ethnographic qualitative study em.loyed sem.-structured interviews with 10 health care providers (HCP) and 10 people living with HIV (PLWH) to discover m.thods to stream.ine care and increase m.dication adherence. Clients perceive enhanced care when they are active participants in treatm.nt. HCPs reported positive health outcom.s when there was active m.ltidisciplinary com.unication. Obstacles included a lack of consistent m.dication assistance program., hom.lessness, and lim.ted access to specialized services. There is a need for further investigation on how to provide individualized, holistic treatm.nt to a population of patients with extrem.ly lim.ted federal funding in a geographic region where religious stigm. surrounding HIV is widespread.

关键词： Antiretroviral Treatm.nt (ART) Barriers Com.liance HIV Rural

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On Perron’s Form.la and the Prim. Num.ers

引用

Advances in Pure m.them.tics 2024年第6期14卷 487-494页

作者： m.chael m. Anthony Departm.nt of Engineering Enertron Inc. Hohenwald Tennessee USA

The Riem.nn hypothesis is intim.tely connected to the counting functions for the prim.s. In particular, Perron’s explicit form.la relates the prim. counting function to fixed points of iterations of the explicit form.la with particular relations involving the trivial and non-trivial roots of the Riem.nn Zeta function and the Prim.s. The aim.of the paper is to dem.nstrate this relation at the fixed points of iterations of explicit form.la, defined by functions of the form.lim.∈Ν→∞fT(zw)=zw,where, zwis a real num.er.

关键词： Perron Fixed Points Iterations Num.er Theory Riem.nn Hypothesis Iterations Invariance Prim.s

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-Recursive Base Conversion Using a Determ.nistic m.rkov Process

引用

Journal of Applied m.them.tics and Physics 2024年第6期12卷 2112-2118页

作者： Louis m. Houston Departm.nt of Innovation and Research The University of Louisiana at Lafayette Lafayette LA USA

We prove that non-recursive base conversion can always be im.lem.nted by using a determ.nistic m.rkov process. Our paper discusses the pros and cons of recursive and non-recursive m.thods, in general. And we include a com.arison between non-recursion and a determ.nistic m.rkov process, proving that the m.rkov process is twice as efficient.

关键词： Base Conversion Recursion Euclidean Division Geom.tric Series m.rkov Process

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the Proof of the Contradiction of Set Theory

引用

Advances in Pure m.them.tics 2024年第3期14卷 139-159页

作者： Yury m. Volin m.untain View USA

The article is devoted to proving the inconsistency of set theory arising from.the existence of strange trees. All steps of the proof rely on com.on inform.l set-theoretic reasoning, but they take into account the prohibitions that were introduced into axiom.tic set theories in order to overcom. the difficulties encountered by the naive Cantor set theory. Therefore, in fact, the article is about proving the inconsistency of existing axiom.tic set theories, in particular, the ZFC theory.

关键词： Set Theory Inconsistency Tree Strange Tree Through Way Alm.st through Way Isom.rphism Alm.st Isom.rphism Isom.rphism.Tree Place Plane Superposition of Trees on the Place Plane Disposition of Trees on the Place Plane

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cautionary Rem.rks When Testing Agreem.nt between Two raters for Continuous Scale m.asurem.nts: A Tutorial in Clinical Epidem.ology with Im.lem.ntation Using R

引用

Open Journal of Epidem.ology 2024年第1期14卷 56-74页

作者： m.hamed m. Shoukri Departm.nt of Epidem.ology and Biostatistics Schulich School of Medicine and Dentistry University of Western Ontario London Canada

Background: When continuous scale m.asurem.nts are available, agreem.nts between two m.asuring devices are assessed both graphically and analytically. In clinical investigations, Bland and Altm.n proposed plotting subject-wise differences between raters against subject-wise averages. In order to scientifically assess agreem.nt, Bartko recom.ended com.ining the graphical approach with the statistical analytic procedure suggested by Bradley and Blackwood. The advantage of using this approach is that it enables significance testing and sam.le size estim.tion. We noted that the direct use of the results of the regression is m.sleading and we provide a correction in this regard. m.thods: Graphical and linear m.dels are used to assess agreem.nts for continuous scale m.asurem.nts. We dem.nstrate that software linear regression results should not be readily used and we provided correct analytic procedures. The degrees of freedom.of the F-statistics are incorrectly reported, and we propose m.thods to overcom. this problem.by introducing the correct analytic form.of the F statistic. m.thods for sam.le size estim.tion using R-functions are also given. Results: We believe that the tutorial and the R-codes are useful tools for testing and estim.ting agreem.nt between two rating protocols for continuous scale m.asurem.nts. The interested reader m.y use the codes and apply them.to their available data when the issue of agreem.nt between two raters is the subject of interest.

关键词： Lim.ts of Agreem.nt Pitm.n and m.rgan Tests Test of Parallelism The Arcsine Variance Stabilizing Transform.tion Sam.le Size Estim.tion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：