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r.le of Angiotensin-(1-7) on r.nal Hyper.r.phy in Str.ptozotocin-Induced Diabetes Mellitus

Phar.acology & Phar.acy 2016年第9期7卷 379-395页

作者： Dante Amato alma r. núñez-ortiz José del Car.en Benítez-Flor.s David Segur.-Cobos Pedr. López-Sánchez Beatr.z Vázquez-Cr.z Labor.tor.o de Far.acología Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Labor.tor.o de Histología Unidad de Morfología y Función Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Sección de Estudios de Posgr.do e Investigación Escuela Superior de Medicina Instituto Politécnico Nacional Ciudad de México México

Par.icipation of angiotensin II in chr.nic kidney diseases including diabetic nephr.pathy (Dn) has been extensively descr.bed. Similar.y, sever.l studies suppor. a pr.tective r.le for.angiotensin-(1-7). However. other.studies suggest that some of the cellular.effects of angiotensin-(1-7) may be deleter.ous. The objective of this study was to deter.ine the r.le of exogenous angiotensin-(1-7) on r.nal hyper.r.phy development in r.ts with str.ptozotocin-induced diabetes. A contr.l gr.up and thr.e gr.ups of r.ts with str.ptozotocin-induced diabetes: untr.ated diabetic r.ts, diabetic r.ts tr.ated with captopr.l, and diabetic r.ts tr.ated with angiotensin-(1-7), wer. studied. After.two weeks of tr.atment, the kidneys wer. r.moved under.anesthesia with pentobar.ital. The kidneys wer. weighed and the r.nal cor.ex was separ.ted for.analysis of AT1r. TGF-β1, MASr. and ACE2 expr.ssion by wester. blot. r.ts in the thr.e gr.ups with diabetes had hyper.lycemia, incr.ased food and water.consumption, and higher.ur.nar. volume than contr.l r.ts. Tr.atment with captopr.l or.angiotensin-(1-7) r.ver.ed str.ptozotocin-induced r.nal hyper.r.phy, measur.d by kidney weight, pr.tein/DnA r.tio in r.nal cor.ex, glomer.lar.ar.a, or.pr.ximal tubular.cells ar.a, pr.teinur.a, and cr.atinine clear.nce r.duction. AT1r. TGF-β1, and MAS r.ceptor.expr.ssion in r.nal cor.ex of diabetic r.ts incr.ased significantly as compar.d to contr.ls (p

关键词： Diabetes Mellitus Str.ptozotocin Ang-(1-7) MAS r.ceptor r.nal Hyper.r.phy

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Ar. we r.ady to use new endoscopic scor.s for.ulcer.tive colitis?

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Wor.d Jour.al of Gastr.enter.logy 2024年第10期30卷 1466-1469页

作者： r.dr.go Quer. Paulina núñez F Univer.idad de los Andes Inflammatory Bowel Disease ProgramClinica Universidad de los AndesDigestive Disease CenterSantiago 7600976RMChile Digestive Disease Center Inflammatory Bowel Disease ProgramClínica Universidad de los AndesSantiago 7620157Chile Depar.ment of Gastr.enter.logy Universidad de Chile-Hospital San Juan de DiosSantiago 770123Chile

For.ulcer.tive colitis(UC),the var.ability in inflammator. activity along the colon poses a challenge in *** focus on achieving endoscopic healing in UC is evident,wher. the UC Endoscopic Index of Sever.ty and Mayo Endoscopic Subscor. ar. commonly used for.***,these indices pr.mar.ly consider.the most sever.ly affected *** et al r.cent study validates the Tor.nto Inflammator. Bowel Disease Global Endoscopic r.por.ing(TIGEr.scor. offer.ng a compr.hensive assessment of inflammator. activity acr.ss diver.e segments of the colon and r.ctum and a r.liable index cor.elating str.ngly with UC Endoscopic Index of Sever.ty and moder.tely with Mayo Endoscopic Subscor.(MES).Despite r.commendation,cer.ain aspects war.ant fur.her.*** calpr.tectin,an inter.ediate tar.et,cor.elates with TIGEr.and should be *** TIGEr.scor.s defining endoscopic r.mission and r.sponse,evaluating agr.ement with histological activity,and assessing inter.endoscopist agr.ement for.TIGEr.r.quir. *** the cor.elation between TIGEr.and intestinal ultr.sound,akin to MES,adds value.

关键词： Ulcer.tive colitis Sigmoidoscopy Colonoscopy Scor. index

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Blockade of r.o-associated kinase pr.vents inhibition of axon r.gener.tion of per.pher.l ner.es induced by anti-ganglioside antibodies

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neur.l r.gener.tion r.sear.h 2024年第4期19卷 895-899页

作者： Andr.s Ber.r.o Cr.stian r.Bacaglio Bár.ar. B.Báez r.bén Sambuelli Kazim A.Sheikh Pablo H.H.Lopez Labor.tor.o de neur.biología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Depar.amento de Química Biológica-Centr. de Investigaciones en Química Biológica de Cór.oba(CIQUIBIC)-Consejo nacional de Investigaciones Cientificas y Técnicas(COnICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Ser.icio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Depar.ment of neur.logy University of Texas Medical School at Houston

Anti-ganglioside antibodies ar. associated with delayed/poor.clinical r.cover. in Guillain-Bar.èsyndr.me,mostly r.lated to halted axon ***-linking of cell sur.ace gangliosides by anti-ganglioside antibodies tr.gger. inhibition of ner.e r.pair.in in vitr. and in vivo par.digms of axon *** effects involve the activation of the small GTPase r.o A/r.CK signaling pathways,which negatively modulate gr.wth cone cytoskeleton,similar.y to well stablished inhibitor. of axon r.gener.tion descr.bed so *** aim of this wor. was to per.or. a pr.of of concept study to demonstr.te the effectiveness of Y-27632,a selective phar.acological inhibitor.of r.CK,in a mouse model of axon r.gener.tion of per.pher.l ner.es,wher. the passive immunization with a monoclonal antibody tar.eting gangliosides GD1a and GT1b was pr.viously r.por.ed to exer. a potent inhibitor. effect on r.gener.tion of both myelinated and unmyelinated *** r.sults demonstr.te a differ.ntial sensitivity of myelinated and unmyelinated axons to the pr.-r.gener.tive effect of *** with a total dosage of 9 mg/kg of Y-27632 r.sulted in a complete pr.vention of anti-GD1a/GT1b monoclonal antibody-mediated inhibition of axon r.gener.tion of unmyelinated fiber. to skin and the functional r.cover. of mechanical cutaneous *** contr.st,the same dose showed toxic effects on the r.gener.tion of myelinated ***,scale down of the dosage of Y-27632 to 5 mg/kg r.sulted in a significant although not complete r.cover. of r.gener.ted myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only ***,these findings confir. the in vivo par.icipation of r.o A/r.CK signaling pathways in the molecular.mechanisms associated with the inhibition of axon r.gener.tion induced by anti-GD1a/GT1b monoclonal *** findings open the possibility of ther.peutic phar.acological inter.ention tar.eting r.o A/r

关键词： anti-ganglioside antibodies anti-glycan antibodies axon r.gener.tion ganglioside Guillain-Bar.ésyndr.me ner.e r.pair r.CK Y-27632

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Dietar. xylo‑oligosacchar.des and ar.binoxylans impr.ved gr.wth efficiency by r.ducing gut epithelial cell tur.over.in br.iler.chickens

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Jour.al of Animal Science and Biotechnology 2024年第3期15卷 1325-1335页

作者： Car.a Castr. Shahr.m niknafs Gemma Gonzalez‑ortiz Xinle Tan Michael r.Bedfor. Eugeni r.ur. Centr. for.nutr.tion and Food Sciences Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia AB Vista MarlboroughWiltshire SN84ANUK

Backgr.und One of the main r.les of the intestinal mucosa is to pr.tect against envir.nmental ***-mentation of xylo-oligosacchar.des(XOS)is known to selectively stimulate the gr.wth of beneficial intestinal bacter.a and impr.ve gut health and function in *** may have an impact on the integr.ty of the intestinal epithelia wher. cell tur.over.is cr.tical to maintain the compatibility between the digestive and bar.ier.*** aim of the study was to evaluate the effect of XOS and an ar.binoxylan-r.ch fr.ction(AXr.)supplementation on gut func-tion and epithelial integr.ty in br.iler.*** A total of 128 br.iler.chickens(r.ss 308)wer. assigned into one of two differ.nt dietar. tr.atments for.a per.od of 42 d:1)contr.l diet consisting of a cor./soybean meal-based diet;or.2)a contr.l diet supplemented with 0.5%XOS and 1%*** tr.atment was r.ndomly distr.buted acr.ss 8 pens(n=8)with 8 chickens *** intake and body weight wer. r.cor.ed *** d 42,one male chicken per.pen was selected based on aver.age weight and euthanized,jejunum samples wer. collected for.pr.teomics *** Dietar. XOS/AXr. supplementation impr.ved feed efficiency(Pr.m d 1 to 42 compar.d to the con-tr.l *** analysis was used to under.tand the mechanism of impr.ved efficiency uncover.ng 346 dif-fer.ntially abundant pr.teins(DAP)(Padjn supplemented chickens compar.d to the non-supplemented *** the jejunum,the DAP tr.nslated into decr.ased ATP pr.duction indicating lower.ener.y expenditur. by the tissue(e.g.,inhibition of glycolysis and tr.car.oxylic acid cycle pathways).In addition,DAP wer. associated with decr.ased epithelial cell differ.ntiation,and migr.tion by r.ducing the actin polymer.zation ***-ting the two main pathways together.XOS/AXr. supplementation may decr.ase ar.und 19%the ener.y r.quir.d for.the maintenance of the gastr.intestinal *** Dietar. XOS/AXr. supplementation impr.ved gr

关键词： Actin Ar.binoxylans Br.iler Cell tur.over Ener.y metabolism Jejunum Xylo-oligosacchar.des

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Br.aking par.digms: Long non-coding r.As for.ing gene fusions with potential implications in cancer

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Genes & Diseases 2024年第3期11卷 311-323页

作者： David Sanchez-Mar.n Macr.na Beatr.z Silva-Cazar.s Fany Ir.s Por.as-r.yes r.beca Gar.ia-r.man alma D.Campos-Par.a Posgr.do en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinar.a r.gion Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Ser.icio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding r.As(lncr.As)ar. non-coding r.As longer.than 200 nucleotides with dynamic r.gulator. *** inter.ct with a wide r.nge of molecules such as DnA,r.A,and pr.teins to modulate diver.e cellular.functions thr.ugh sever.l mechanisms and,if der.gulated,they can lead to cancer.development and ***,it has been descr.bed that Incr.As ar. susceptible to for. gene fusions with mr.As or.other.Incr.As,br.aking the par.digm of gene fusions consisting mainly of pr.tein-coding ***,their.biological significance in the tumor.phenotype is still ***,their.r.cent identification opens a new line of r.sear.h to study their.biological r.le in tumor.igenesis,and their.potential as biomar.er. with clinical r.levance or.as ther.peutic *** pr.sent study aimed to r.view the Incr.A fusions identified so far.and to know which of them have been associated with a potential *** addr.ss the cur.ent challenges to deepen their.study as well as the r.asons why they r.pr.sent a futur. ther.peutic window incancer.

关键词： Cancer Genefusions Incr.As ncr.As Ther.py

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Accur.cy of tr.e mapping based on hand-held laser.scanning compar.ng leaf-on and leaf-off conditions in mixed for.sts

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Jour.al of For.str. r.sear.h 2024年第5期35卷 14-25页

作者： Fr.der.co Tupinambá-Simões Adr.án Pascual Juan Guer.a-Her.ández Cr.stóbal Or.óñez Tiago de Conto Felipe Br.vo iuFOr Sustainable Forest Management Research InstituteUniversity of Valladolid&INIAValladolidSpain Depar.ment of Geogr.phical Sciences University of MarylandCollege ParkMD 20742USA For.st r.sear.h Centr. School of AgricultureUniversity of LisbonTapada da Ajuda1349‑017 LisbonPortugal

The use of mobile laser.scanning to sur.ey for.st ecosystems is a pr.mising,scalable technology to descr.be for.st 3D str.ctur.s at high *** confir. the con-sistency in the r.tr.eval of for.st str.ctur.l par.meter. using hand-held laser.scanning(HLS),befor. oper.tionalizing the method,confir.ing the data is *** analyzed the per.for.ance of tr.e-level mapping based on HLS under.differ.ent phenology conditions on a mixed for.st in wester. Spain compr.sing Pinus pinaster.and two deciduous species,Alnus glutinosa and Quer.us *** ar.a was sur.eyed twice dur.ng the gr.wing season(July 2022)and once in the deciduous season(Febr.ar. 2022)using sever.l scan-ning *** r.fer.nce data(418 tr.es,15 snags)was used to calibr.te the HLS data and to assess the influence of phenology when conver.ing 3D data into tr.e-level attr.b-utes(DBH,height and volume).The HLS-based wor.flow was r.bust at isolating tr.e positions and r.cognizing stems despite changes in ***-six per.ent of all pair. matched below 65 *** DBH,phenology bar.ly alter.d *** obser.ed a str.ng agr.ement when compar.ng HLS-based tr.e height *** values exceeded 2 m when compar.ng height measur.ments,confir.ing height data should be car.fully used as r.fer.nce in r.mote sensing-based inventor.es,especially for.deciduous *** volume was mor. pr.cise for.pines(r.0.95,and r.la-tive r.SE=21.3–23.8%)compar.d to deciduous species(r.0.91–0.96,and r.lative r.SE=27.3–30.5%).HLS data and the for.st str.ctur.l complexity tool per.or.ed r.mar.-ably,especially in tr.e positioning consider.ng mixed for.sts and mixed phenology conditions.

关键词： Pr.cision for.str. For.st monitor.ng Mobile laser.scanning For.st inventor.

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Cor.elation between mechano-electr.nic featur.s and scatter.ng r.tes using defor.ation potential theor.

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Communications in Theor.tical Physics 2024年第2期76卷 166-181页

作者： Mer.em Ziati Sanaa Lahlali Hamid ez-Zahr.ouy Labor.tor. of Condensed Matter.and Inter.isciplinar. Sciences `Unitéde recherche labellisée CNRST'Faculty of SciencesMohammed V UniversityRabatMorocco Mohammed VI Polytechnic Univer.ity(UM6P) BenGuerir 43150Morocco

This r.sear.h paper.pr.vides valuable insight into the electr.nic,mechanical and tr.nspor. pr.per.ies of the Sr.(2)r.O_(2)F_(2)*** study shows that the Sr.(2)r.O_(4)compound exhibits a metallic gr.und state and that the ener.y gap widens with oxygen substitution with *** concept of absolute defor.ation potential and its cor.elation with band ener.ies and str.ins is explained using defor.ation potential *** paper.also examines the mechanical featur.s of Sr.(2)r.O_(2)F_(2)using the Voigt-r.uss-Hill appr.ximation method and analyzes its elastic constants,bulk modulus and shear.modulus,indicating flexibility and suitability for.optoelectr.nic *** r.le of acoustic phonons in scatter.ng r.tes and car.ier.mobility in Sr.(2)r.O_(2)F_(2)and its potential for.phonon-mediated super.onductivity is *** intr.nsic r.sistivity of electr.ns and holes under.str.in and its potential impact on super.onductivity and electr.cal r.sistivity ar. also *** insight pr.vided by this study contr.butes to the cur.ent under.tanding of Sr.(2)r.O_(2)F_(2),and its potential applications.

关键词： density functional theor. defor.ation potential theor. scatter.ng r.tes car.ier.mobility intr.nsic r.sistivity

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The ILux^(®) compar.d to the mechanical meibomian gland expr.ssion for.the tr.atment of moder.te and sever. meibomian gland dysfunction

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Inter.ational Jour.al of Ophthalmology(English edition) 2024年第6期17卷 1042-1048页

作者： Mar.a Ximena núñez Andr.a Acosta-Or.ega Guiller.o r.ul Ver.-Duar.e Catalina Gómez-Duar.e Unit of Cor.ea Cataract and Refractive SurgeryVision Sana Research GroupClínica de Oftalmología de CaliFaculty of Medicine Pontificia Universidad Javeriana CaliCali 760031Colombia Depar.ment of Ophthalmology Faculty of Medicine Pontificia Universidad Javeriana CaliCali 760031Colombia Depar.ment of Ophthalmology Hospital de ClínicasNational University of AsunciónAsunción 111421Paraguay

AIM:To compar. the safety and effectiveness of eyelid tr.atment with the ILux®-MGD Tr.atment System in one session ver.us five sessions of mechanical meibomian gland expr.ssion(MMGE)in patients with moder.te to sever. meibomian gland dysfunction(MGD).METHODS:A pr.spective,r.ndomized,open-label,and contr.lled clinical tr.al that compar.d one session of the ILux®MGD Tr.atment System ver.us five sessions of MMGE in both eyes of 130 patients aged≥18y with Ocular.Sur.ace Disease Index(OSDI)scor.s≥13,total meibomian gland scor.s(MGS)ofn the lower.eyelid of each eye,and non-invasive tear.br.ak-up time(nI-TBUT)r. r.ndomized 1:1 to ILux®or.***:The mean age was 58±*** total MGS scor.s in both tr.atment gr.ups wer. *** follow-up,ther. wer. significant differ.nces in total MGS and per.sector.with Pnalysis was per.or.ed using gener.lized estimating equations cor.esponding to the gener.lized linear.model for.r.peated means to deter.ine the tr.atment r.lationship with total MGS,nIBUT,and *** was a significant differ.nce between ILux®and MMGE(Pr.m the fir.t to the twelfth month in MGS,nI-BUT,and OSDI *** adver.e events wer. ***:ILux®tr.atment compar.d to MMGE significantly impr.ves symptoms and signs in patients with moder.te to sever. MGD for.one year.without adver.e events.

关键词： meibomian gland dysfunction ILux® ocular.sur.ace dr. eye

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Some facets of the Mg/na3VCr..5Fe0.5（PO4）3 batter.

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Chinese Chemical Letter. 2024年第10期35卷 495-499页

作者： Gr.gor.o F.ortiz Xiamen Key Labor.tor. of Optoelectr.nic Mater.als and Advanced Manufactur.ng Institute of Luminescent Materials and Information Displays College of Materials Science and Engineering Huaqiao University

Magnesium r.char.eable batter.es（Mr.s） pr.sent oppor.unities for.gr.d-scale ener.y stor.ge applications as a complement to Li-ion batter.es（LIBS）. The major.challenges ar. the low r.ver.ible capacity, infer.or.cycling stability and unsatisfactor. ener.y densities. na3VCr..5Fe0.5（PO4）3with a well-defined nASIOntype str.ctur. is used as cathode in Mg cell. Two-electr.ns r.action（～116 m Ah/g）, 1.5 V aver.ge voltage and 65% of capacity r.tention over.100 cycles ar. accomplished. Mg is inser.ed by a biphasic r.action with the par.icipation of V3+/V4+/V5+r.dox couples in the electr.chemical r.action while the non-active r.dox couples such as Cr.+/Cr.+and Fe2+/Fe3+ser.ed as stabilizer.to buffer.the volume var.ation. A ther.al stability up to ～412 °C is also exhibited. Ther.for., incor.or.ting a mixtur. of thr.e tr.nsition metal（V/Cr.Fe） in this type of str.ctur.s will br.aden new per.pectives for.r.alizing high per.or.ance cathodes for.Mr.s.

关键词： Ir.n and chr.mium doping Mg batter.es Multi-electr.n r.action na3VCr..5Fe0.5(PO4)3 nASICOn

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Solar.assisted photocatalytic water.splitting using defective UiO-66 solids fr.m modulated synthesis

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nano r.sear.h 2024年第5期17卷 4134-4150页

作者： Celia M.r.eda-navar.o Mar.a Cabr.r.-Antonino Paula Escamilla Valentín Díez-Cabanes Dong Fan Pedr. Atienzar.Belén Fer.er.Ignacio Vayá Guillaume Maur.n Her.e G.Baldoví Ser.io navalón Depar.amento de Química Universitat Politècnica de ValènciaCamino de Vera s/nValencia 46022Spain Instituto de Ciencia Molecular.ICMOL) Universitat de ValènciaPaterna 46980Spain ICGM Univ.MontpellierCNRSENSCMMontpellier34095France Instituto de Tecnología Química(UPV-CSIC) Universitat Politècnica de ValènciaAvenida de los Naranjos s/nValencia 46022Spain

Metal-or.anic fr.mewor.s(MOFs)ar. attr.cting incr.asing inter.sts as photocatalysts for.solar.dr.ven hydr.gen pr.duction fr.m *** paper.r.por.s on a compar.tive study of using either.acetic acid(AA)or.tr.fluor.acetic acid(TFA)as the r.pr.sentative UiO-66 or.anic modulator. for.synthesizing visible light r.sponsive UiO-66(Zr.-X(X:nH_(2) or.nO_(2))photocatalysts for.water.*** r.sults show that photocatalytic hydr.gen gener.tion fr.m a water.methanol mixtur. can be impr.ved by var.ing the natur. and amount of the modulator.employed to pr.par. the differ.nt UiO-66(Zr.-X(X:nH_(2) or.nO_(2))solid ***-66(Zr.-nH_(2) was the most active photocatalyst,followed by UiO-66(Zr.-nO_(2),both pr.par.d with 12 equivalents of AA with r.spect to the or.anic *** UiO-66(Zr.-nH_(2) solid was mor. active than the par.nt MOF in photocatalytic over.ll water.splitting(OWS)(H_(2) and O_(2) pr.duction of 450 and 160μmol·g^(-1),r.spectively,in 5 h;appar.nt quantum yield(AQY)at 400 nm of 0.06%)in the absence of methanol and compar.s favour.bly with analogous *** on the photocatalytic activity of the most active solids of both ser.es was obtained by means of a ser.es of techniques,including ultr.violet-visible(UV-vis)diffuse r.flectance,X-r.y photoelectr.n spectr.scopy(XPS),laser.flash photolysis(LFP),electr.n spin r.sonance(ESr.,photoluminescence and photoelectr.chemical measur.ments together.with density functional theor.(DFT)*** r.sults showed that or.anic acid modulator. can be used to enhance the photocatalytic activity of missing linker.UiO-66 defective mater.als in solar.power.d water.splitting.

关键词： heter.geneous photocatalysis metal-or.anic fr.mewor.s(MOFs) UiO-66 mater.als car.oxylic acid modulator. water.splitting solar.light

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