<正>From day to day the energy of oscillation of the electron stream divergence in the ionosphere was considered at the period range from 2 to 180 *** 8 months *** found out:the energy changes practically synchronou...
<正>From day to day the energy of oscillation of the electron stream divergence in the ionosphere was considered at the period range from 2 to 180 *** 8 months *** found out:the energy changes practically synchronous at the period range and increases during geomagnetic disturbances.
Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and *** bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to Augus...
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Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and *** bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private *** complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for *** breakthroughs were made including the making available of ready-to-go DnA diagnostic tests for Marker Assisted Breeding,development of new,dense SnP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank *** also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection *** FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the *** review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond.
nonalcoholic fatty liver disease (nAPLD) is consistently associated with features of the metabolic syndrome, a condition carrying a high risk of cardiovascular events. We measured the vasodilatory response of the brac...
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nonalcoholic fatty liver disease (nAPLD) is consistently associated with features of the metabolic syndrome, a condition carrying a high risk of cardiovascular events. We measured the vasodilatory response of the brachial artery in response to ischemia (a test of endothelial function) (FMV) as well as cardiovascular risk profile in 52 nAPLD cases and 28 age-and sex-matched controls. The 10-year risk of coronary events was calculated according to the Framingham equation and the scores derived from the PROCAM study and nCEP-ATP III proposals. FMV was 6.33% ± 5.93% in nAFLD versus 12.22% ± 5.05% in controls (P nd higher in pure fatty liver (9.93% ) compared with nonalcoholic steatohepatitis (4.94% ) (P = .010). no differences were observed in flow-independent vasodilation (response to sublingual nitroglycerin). Percent FMV was negatively associated with insulin resistance (homeostasis model assessment) in the whole population (r = - 0.243; P = .030). In logistic regression analysis, nAFLD was associated with a percent FMV in the lower fertile (OR, 6.7; 95% CI, 1.26- 36.1), after adjustment for age, sex, body mass index, and insulin resistance. Among nAFLD patients, low FMV was associated with nonalcoholic steatohepatitis (adjusted OR, 6.8; 95% CI, 1.2- 40.2). The 10-year probability of cardiovascular events was moderately increased in nAFLD, and particularly in nonalcoholic steatohepatitis. In conclusion, our study provides evidence of endothelial dysfunction and increased risk of cardiovascular events in nAFLD. The risk of advanced liver disease is well recognized in nAFLD patients, but the large majority of cases might experience cardiovascular disease in the long term, indirectly limiting the burden of liver failure.
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