检索结果-南通市图书馆

Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 311-323页

作者： David Sanchez-Marin Macrina Beatriz Silva-Cazares Fany Iris Porras-Reyes Rebeca Garcia-Roman alma D.Campos-Parra Posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are non-coding RNAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DNA,RNA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRNA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

Fate and Behavior of Tetracycline Resistance Genes in Activated Carbon Adsorption

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Water Resource and Protection 2024年第1期16卷 1-16页

作者： Sri Anggreini alma Rizky Aurellya Wenqing Li Fusheng Li Graduate School of Engineering Gifu University Gifu Japan Graduate School of Natural Science and Technology Gifu University Gifu Japan River Basin Research Center Gifu University Gifu Japan

The accessibility of tetracycline resistance gene (tetG) into the pores of activated carbon (AC), as well as the impact of the pore size distribution (PSD) of AC on the uptake capacity of tetG, were investigated using eight types of AC (four coal-based and four wood-based). AC showed the capability to admit tetG and the average reduction of tetG for coal-based and wood-based ACs at the AC dose of 1 g·L-1 was 3.12 log and 3.65 log, respectively. The uptake kinetic analysis showed that the uptake of the gene followed the pseudo-second-order kinetics reaction, and the uptake rate constant for the coal-based and wood-based ACs was in the range of 5.97 × 10-12 - 4.64 × 10-9 and 7.02 × 10-11 - 1.59 × 10-8 copies·mg-1·min-1, respectively. The uptake capacity analysis by fitting the obtained experiment data with the Freundlich isotherm model indicated that the uptake constant (KF) values were 1.71 × 103 - 8.00 × 109 (copies·g-1)1-1/n for coal-based ACs and 7.00 × 108 - 3.00 × 1010 (copies·g-1)1-1/n for wood-based ones. In addition, the correlation analysis between KF values and pore volume as well as pore surface at different pore size regions of ACs showed that relatively higher positive correlation was found for pores of 50 - 100 Å, suggesting ACs with more pores in this size region can uptake more tetG. The findings of this study are valuable as reference for optimizing the adsorption process regarding antibiotic resistance-related concerns in drinking water treatment.

关键词： Antibiotic Resistance Genes Adsorption Activated Carbon Drinking Water Treatment

Childhood Papillary Thyroid Carcinoma: A Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2024年第4期13卷 108-114页

作者： alma Al Mansour Hayder Makki Hamadi Mahmoud Elshafey Mohamed Maryam Alkhatry Alqassemi Hospital Emirates Health Services Sharjah UAE Ibrahim Bin Hamad Obaidulla Hospital Ras Al Khaimah UAE

Background: Thyroid cancer is a rare disease yet the most common endocrine malignancy in pediatrics. Unlike adult patients, children with thyroid nodules typically don’t complain of pain, soreness, or difficulty swallowing. Additionally, using the recommended therapy for adults to treat paediatrics is not appropriate. There is an unmet need for updated unique guidelines for the management of papillary thyroid carcinoma (PTC) in paediatrics and adolescents. Case Report: A 12-year-old girl had an atypical presentation of metastatic PTC in lymph nodes. She was treated initially with hemi-thyroidectomy, followed by total thyroidectomy. A multidisciplinary team followed her up till successful results were found. Conclusion: Due to the difference in pathophysiology between thyroid tumors in children and adults, a unique approach to PTC management is to be implemented. Further trials are required for a better understanding of risk factors, the likelihood of recurrence, and the long-term side effects of the chosen management plan.

关键词： Papillary Thyroid Carcinoma Childhood Thyroidectomy Case Report

Process for the Obtention of Coumaric Acid from Coumarin: Analysis of the Reaction Conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Chemical Engineering and Science 2013年第3期3卷 195-201页

作者： Néstor N. López-Castillo alma D. rojas-rodríguez Brenda M. Porta M. Javier Cruz-Gómez Chemical Engineering Department of the Faculty of Chemistry Universidad Nacional Autónoma de México (UNAM) Coyoacan D. F. México México

Coumaric acid can be obtained from basic hydrolysis of coumarin, through a reaction process consisting on opening the lactone ring and cis-trans isomerization. Parameters such as reaction time, temperature, NaOH concentration, solvent and reaction atmosphere, have been thoroughly studied and analyzed, in order to determine the appropriate conditions for the maximum conversion efficiency of coumarin into coumaric acid. Experimental results show that the best conditions are a 1 hour reaction time, at 160℃, with a 20% sodium hydroxide aqueous solution, and in an inert reaction atmosphere.

关键词： Coumarin Coumaric Acid Ester Hydrolysis

Authors and Open Access:Effective Ways to Achieve OA in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

图书情报工作 2005年第12期49卷 17-25页

作者： alma Swan Key Perspectives Ltd. 48 Old Coach Road Playing PlaceTruroTR3 6ETUnited Kingdom

Although there are effective methods available to authors for providing open access to their work, more than half are still not doing so and provision in China is poorer than in many other countries. There are a number of issues and concerns that dissuade authors from making their work open access: some are still unaware of the concept and of the increased visibility and impact that open access brings; many are unfamiliar with open access journals and how they work; many are uninformed about self-archiving and for some of those who are aware of the possibility of providing open access by this means, concerns about copyright and technical issues *** all these worries can be addressed with simple facts that reassure and encourage authors to adopt open access to benefit themselves,their research and their teaching. There is also a wealth of resources now available to authors that provide information and advice on open access and its effects. As institutions and research funders, both with a strong interest in maximising the visibility and impact of research they support, begin to develop formal policies on open access, models for its provision are emerging. The optimal model is a frills' variant) or by service providers who add functionality or selectivity to provide users with value-enhanced products.

关键词：中国 OA 信息资源网格技术学术材料资源共享

The effect of fasting and body reserves on cola tolerance in 2 pit-building insect predators

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2017年第3期63卷 287-294页

作者： Inon SCHARF alma DANIEL Heath Andrew MACMILLAN Noa KATZ Department of Zoology Faculty of Life Sciences Tel Aviv University POB 39040 69978 Tel Aviv Israel Department of Biology York University 4700 Keele St. Toronto Ontario Canada

Pit-building antlions and wormlions are 2 distantly-related insect species, whose larvae construct pits in loose soil to trap small arthropod prey. This convergent evolution of natural histories has led to additional similarities in their natural history and ecology, and thus, these 2 species encounter similar abiotic stress （such as periodic starvation） in their natural habitat. Here, we measured the cold tolerance of the 2 species and examined whether recent feeding or food deprivation, as well as body composition （body mass and lipid content） and condition （quantified as mass-to-size residuals） affect their cold tolerance. In contrast to other insects, in which food deprivation either enhanced or impaired cold tolerance, prolonged fasting had no effect on the cold tolerance of either species, which had similar cold tolerance. The 2 species differed, however, in how cold tolerance related to body mass and lipid content： although body mass was positively correlated with the wormlion cold tolerance, lipid content was a more reliable predictor of cold tolerance in the antlions. Cold tolerance also underwent greater change with ontogeny in wormlions than in antlions. We discuss possible reasons for this lack of effect of food deprivation on both species＇ cold tolerance, such as their high starvation tolerance （being sit-and-wait predators）.

关键词： chill coma deprivation ecophysiology fat content food hunger morphometrics Myrmeleontidae Vermileonidae.

Marine Metagenome as A Resource for Novel Enzymes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2015年第5期13卷 290-295页

作者： Amani D.alma'abadi Takashi Gojobori Katsuhiko Mineta Computational Bioscience Research Center (CBRC) King Abdullah University of Science and Technology (KAUST)

More than 99% of identified prokaryotes, including many from the marine environment, cannot be cultured in the laboratory. This lack of capability restricts our knowledge of microbial genetics and community ecology. Metagenomics, the culture-independent cloning of environmental DNAs that are isolated directly from an environmental sample, has already provided a wealth of information about the uncultured microbial world. It has also facilitated the discovery of novel bio- catalysts by allowing researchers to probe directly into a huge diversity of enzymes within natural microbial communities. Recent advances in these studies have led to a great interest in recruiting microbial enzymes for the development of environmentally-friendly industry. Although the metage- nomics approach has many limitations, it is expected to provide not only scientific insights but also economic benefits, especially in industry. This review highlights the importance of metagenomics in mining microbial lipases, as an example, by using high-throughput techniques. In addition, we dis- cuss challenges in the metagenomics as an important part of bioinformatics analysis in big data.

关键词： Microbial diversity Culture-independent studies Catalysis Lipase Biotechnology

Using dummy data for RFID tag and reader authentication

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Digital Communications and Networks 2022年第5期8卷 804-813页

作者： Baha’A.Alsaify Dale R.Thompson Abdallah alma'aitah Jia Di Department of Network Engineering and Security Jordan University of Science and TechnologyIrbid21163Jordan Computer Science and Computer Engineering Department University of ArkansasFayetteville72701ARUSA

Radio-Frequency IDentification(RFID)technology is an essential enabler of a multitude of intelligent *** robust authentication of RFID system components is critical in providing trustworthy data delivery from/to *** this paper,we propose an authentication protocol based on monitoring the transmissions between readers and tags in the *** proposed authentication scheme is based on injecting decoys within the exchanged communications(between RFID readers and tags)and is used in the authentication ***,the proposed authentication scheme is mathematically modeled and validated using extensive *** simulations results show that the proposed scheme provides a 100%confidence level in the authentication of tags and detection of compromised readers.

关键词： RFID Authentication Dummy data Security Decoys

Estimation in the Complementary Exponential Geometric Distribution Based on Progressive Type-II Censored Data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Mathematics and Statistics 2020年第4期8卷 409-441页

作者： Ozlem Gürünlüalma Reza Arabi Belaghi Department of Statistics Faculty of SciencesMuğla SıtkıKoçman UniversityMuğlaTurkey Department of Statistics Faculty of Mathematical SciencesUniversity of TabrizTabrizIran

Complementary exponential geometric distribution has many applications in survival and reliability *** to its importance,in this study,we are aiming to estimate the parameters of this model based on progressive type-II censored *** do this,we applied the stochastic expectation maximization method and Newton-Raphson techniques for obtaining the maximum likelihood *** also considered the estimation based on Bayesian method using several approximate:MCMC samples,Lindely approximation and Metropolis-Hasting *** addition,we considered the shrinkage estimators based on Bayesian and maximum likelihood ***,the HPD intervals for the parameters are constructed based on the posterior samples from the Metropolis-Hasting *** the sequel,we obtained the performance of different estimators in terms of biases,estimated risks and Pitman closeness via Monte Carlo simulation *** paper will be ended up with a real data set example for illustration of our purpose.

关键词： Bayesian analysis Complementary exponential geometric(CEG)distribution Progressive type-II censoring Maximum likelihood estimators SEM algorithm Shrinkage estimator