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Image-guided locoregional non-intravascular interventional treatments for hepatocellular carcinoma: Current status

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journal of Interventional Medicine 2021年第1期4卷 1-7页

作者： Kun Qian Feng Zhang Stephen K.allison Chuansheng Zheng Xiaoming Yang Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei430022China Department of Radiology Image-Guided Biomolecular Intervention ResearchUniversity of Washington School of MedicineSeattleWA98109USA Division of Interventional Radiology Department of RadiologyUniversity of Washington School of MedicineSeattleWA98109USA

Hepatocellular carcinoma(HCC) is one of the most deadly and frequent cancers worldwide,although great advancement in the treatment of this malignancy have been made within the past few *** continues to be a major health issue due to an increasing incidence and a poor *** majority of patients have their HCC diagnosed at an intermediate or advanced stage in theUSA or *** therapy such as surgical resection or liver transplantation is not considered anoption of treatment at these *** chemoembolization(TACE),the most widely used locoregional therapeutic approach,used to be the mainstay of treatment for cases with unresectable cancer ***,for those patients with hypovascular tumors or impaired liver function reserve,TACE is a suboptimal treatment *** example,embolization does not result in complete coverage of a hypovascular tumor,and may rather promotes postoperative tumor recurrence,or leave residual tumor,in these TACE-resistance *** addition,TACE carries a higher risk of hepatic decompensation in patients with poor liver function or ***-vascular interventional locoregional therapies for HCC include radiofrequency ablation(RFA),microwave ablation(MWA),high-intensity focused ultrasound(HIFU),laser-induced thermotherapy(LITT),cryosurgical ablation(CSA),irreversible Electroporation(IRE),percutaneous ethanol injection(PEI),and *** advancements in these techniques have significantly improved the treatment efficacy of HCC and expanded the population of patients who qualify for *** review embraces the current status of imaging-guided locoregional non-intravascular interventional treatments for HCCs,with a primary focus on the clinical evaluation and assessment of the efficacy of combined therapies using these interventional techniques.

关键词： impaired treatment irreversible

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铁路导航精密单点定位方法改进及性能验证

铁道学报 2020年第12期42卷 82-89页

作者：靳成铭蔡伯根王剑上官伟 allison Kealy 北京交通大学电子信息工程学院北京100044 北京市轨道交通电磁兼容与卫星导航工程技术研究中心北京100044 北京交通大学轨道交通控制与安全国家重点实验室北京100044 皇家墨尔本理工大学自然科学学院墨尔本3001

在铁路导航应用中,通常采用差分GNSS定位的方式,需要在铁路沿线设置差分参考站,从而提高定位精度,建设以及后续的运营维护成本较高。精密单点定位PPP是一种基于卫星导航系统的定位技术,PPP使用非差码和载波相位观测量,可通过在全球广泛... 详细信息

在铁路导航应用中,通常采用差分GNSS定位的方式,需要在铁路沿线设置差分参考站,从而提高定位精度,建设以及后续的运营维护成本较高。精密单点定位PPP是一种基于卫星导航系统的定位技术,PPP使用非差码和载波相位观测量,可通过在全球广泛分布的参考站提供纠正参数,进而完成高精度的位置解算。PPP可实现动态分米级、静态厘米级的定位精度,而且精度不随着距离的增加而出现明显降级,不需要自建参考站。基于加拿大自然资源部的CSRS-PPP软件,介绍了传统组合精密单点定位的解算原理。通过典型场景分析PPP在铁路导航应用中存在的实时性、可用性和安全性问题。提出一种改进的基于PPP和惯性导航系统INS的扩展卡尔曼滤波EKF组合定位方案,试验结果表明,PPP/INS组合定位方法能够在不降级定位精度的前提下解决因观测量短暂不足导致的可用性问题。

关键词：交通信息工程及控制铁路导航精密单点定位性能分析应用架构卡尔曼滤波

Child Abuse during the Pandemic and Trauma-Informed Care: A Review of Evidence-Based Literature

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Health 2023年第9期15卷 1003-1012页

作者： allison j. DiPlacido Linda Leitzel Brayden Kameg Betty j. Braxter Rose Constantino School of Nursing University of Pittsburgh Pittsburgh USA

Abuse of infants and children is a public health problem that warrants immediate attention. It is estimated that over 7 million children are affected by child abuse yearly, with the highest rate of abuse in those less than one year of age. Approximately 60% of child abuse victims are children under the age of three years, making infants and young children a particularly vulnerable population. Interventions targeting the perinatal period can be effective in mitigating child abuse, including parent education programs and trauma-informed care services. This paper provides an overview of the current evidence base related to child abuse following the COVID-19 pandemic, with a focus on prevention and intervention strategies that can be utilized to increase caregiver support and reduce child abuse rates during the perinatal period.

关键词： Neonates Newborn Infant Child Abuse Perinatal Trauma-Informed Care

Some aspects of Chinese-Australian cooperation in Antarctic Research over the past forty years

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Advances in Polar Science 2016年第2期27卷 126-137页

作者： ZHAO Chen Ian allison School of Land and Food University of TasmaniaTasmaniaAustralia Antarctic Climate and Ecosystems Cooperative Research Centre HobartTasmaniaAustralia

China and Australia have been collaborating in Antarctic activities since the early 1980s and that collaboration has grown and become more formalized as China＇s Antarctic program has expanded. This collaboration has involved personnel exchange, logistic support, environmental protection and particularly scientific research. China and Australia have signed a series of memorandums and treaties of friendship and cooperation on Antarctic activities in the past few years. Relevant mechanisms of cooperation between expedition plans and programs have been established, and the exchange and cooperation in people, science and technology, services, and supplies are undertaken across a range of organizations. Here we overview the history of the bilateral collaboration and provide a few examples of the many areas of cooperation. These examples are focused on activities in Hobart, the key centre of the Australian Antarctic program.

关键词： China Australia Antarctic research bilateral collaboration memorandum of understanding

A challenging case of alpha-fetoprotein-result discrepancies in a patient with chronic hepatitis B

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Gastroenterology Report 2020年第6期8卷 484-486,I0003页

作者： Pir A.Shah allison Onken Rizwan Ishtiaq Muhammad H.Maqsood Shyam S.Patel Karen j.Campoverde Reyes Adrianna Z.Herskovits Daryl T.Y.Lau Department of Medicine Liver CenterDivision of GastroenterologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Department of Pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Introduction Alpha-fetoprotein(AFP)is the most abundant serum protein found in the human fetus,produced by the yolk sac and the liver[1].The levels of maternal serum AFP reach a peak value at28-32 weeks of gestation and decrease rapidly after birth and usually drop to the normal at 8-12 months of *** normal serum AFP level for an adult is<20 ng/mL[2].In contrast,livertumor cells usually synthesize and secrete an increased level of *** ultrasound and AFP are generally recommended as the screening modality for HCC for patients at risk for development of hepatocellular carcinoma(HCC)[1].AFP-L3,an isoform of AFP that binds Lens culinaris agglutinin,can be particularly useful in the early identification of aggressive HCC[2].These assays,however,can generate false-positive and false-negative AFP *** patients with advanced HCC,20%had normal AFP levels,whereas some patients with liver diseases had significant AFP elevation without liver cancer in long-term surveillance[3].Elevated AFP levels could be associated with active liver diseases with hepatocyte regeneration[4,5].In that setting,the AFP level will decline with improvement of the underlying liver *** case illustrated the dilemma and uncertainties as a result of persistent abnormal AFP values after extensive clinical investigations.

关键词：甲胎蛋白 fetus false

Comparison of Amiodarone Compliance Monitoring： Usual Care, Electronic Prescribing Template and Pharmacist-Managed Clinic

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journal of Pharmacy and Pharmacology 2014年第10期2卷 621-626页

作者： jeannie L. Poon allison C. Brenner Michael j. Brenner Veterans Affairs Ann Arbor Healthcare System Ann Arbor 48105 MI USA

Objective： To assess whether adherence to amiodarone monitoring differed pre- and post-amiodarone restriction template and implementation of the pharmacist-managed clinic. Design： This was a retrospective chart review study. Setting： A large, academically-affiliated Veteran Affairs Healthcare System providing primary and tertiary care. Patients： 580 patients were identified as having an active prescription for amiodarone for at least 60 days from january l, 2009 to August 31, 2013 and receiving primary care at the VAAHS （Veterans Affairs Ann Arbor Healthcare System）. Results： Nearly all patients had TSH and LFTs at baseline regardless of study group. Significant associations between baseline rates for CXR, ECG, PFT, and opbthalmologic exams were found, with higher rates in the clinic and template arms compared to usual care. Similar patterns for all monitoring outcome rates were also found for both the 6- and 12-month measures. Conclusions： Patients on amiodarone who are followed by a pharmacist-managed clinic or where a restricted ordering template was used had increased compliance with amiodarone monitoring guidelines compared to usual care. Use of a restricted template may be a reasonable option in place of a pharmacist-managed service.

关键词： Amiodarone pharmacist-managed monitoring Veterans Affairs usual care electronic template.

玩还是不玩:拉美裔和欧裔美国父母儿童博物馆内亲子游戏的多元化动机

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学前教育研究 2016年第12期 15-25页

作者： allison DiBianca Fasoli 周婧景 Department of Psychology Middlebury College 复旦大学文物与博物馆学系上海200433

在美国,一个流行的社会话题是"玩对儿童的学习很重要",并且父母的参与能够最大化地激发亲子游戏的学习潜能。过去的研究已指出持有这种观点的父母更有可能和他们的孩子一起玩耍。本研究调查了在欧裔美国父母和拉美裔美国父母中这种观点... 详细信息

在美国,一个流行的社会话题是"玩对儿童的学习很重要",并且父母的参与能够最大化地激发亲子游戏的学习潜能。过去的研究已指出持有这种观点的父母更有可能和他们的孩子一起玩耍。本研究调查了在欧裔美国父母和拉美裔美国父母中这种观点的流行程度,旨在阐明这种观点能在多大程度上对亲子游戏产生独特而又一致的激励作用。在儿童博物馆通过访谈法和自然观察法,本研究评估了父母的参与模式。结果表明不同的种族群体在亲子游戏中表现出差异性,且这种差异性与父母对亲子游戏的看法保持高度一致。群体分析也表明亲子游戏行为和观点一起组成父母与孩子的游戏模式,而这种亲子游戏模式有着多样化的特点,能够集中反映社会性、文化动态性和个人主体性等问题。当很多拥护者强调亲子游戏带来促进发展的结果时,我们应认识到其他游戏模式的积极性及其对发展价值之外其他价值的优化,如通过共同玩乐加强亲子关系或者通过同伴互动学习等。

关键词：亲子游戏文化模式欧裔和拉关裔美国父母儿童早期教育

Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis

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World journal of Orthopedics 2022年第7期13卷 631-643页

作者： Ian S Hong allison j Rao Tyler L CarlLee joshua D Meade Daniel j Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor james E Fleischli Bryan Michael Saltzman Department of Orthopedic Surgery Atrium Health Musculoskeletal InstituteCharlotteNC 28207United States Department of Sports Medicine Orthocarolina Research InstituteCharlotteNC 28207United States Department of Orthopedic Surgery Columbia University Irving Medical CenterNew York CityNY 10032United States Department of Orthopaedic Surgery Carolinas Medical CenterCharlotteNC 28207United States Department of Orthopedic Surgery OrthoCarolina Sports Medicine CenterCharlotteNC 28207United States

BACKGROUND Rotator cuff pathology is a very common source of shoulder ***,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar *** management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of *** To evaluate if a relationship exists between outcomes of RCR in the setting of *** This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between *** were stratified based on rotator cuff tear size and glenohumeral osteoarthritis *** were paired 1:1 with patients without glenohumeral *** included had a minimum two year *** of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were *** A total of 142 patients were *** number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without *** rotator cuff repair,both groups showed favorable patientreported *** Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis.

关键词： Rotator cuff repair Rotator cuff tear Glenohumeral osteoarthritis Shoulder Arthroscopic Outcomes

Electrospinning nanofiber scaffolds for soft and hard tissue regeneration

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journal of Materials Science & Technology 2020年第24期59卷 243-261页

作者： Xianrui Xie Yujie Chen Xiaoyu Wang Xiaoqing Xu Yihong Shen Atta ur Rehman Khan Ali Aldalbahi allison E.Fetz Gary L.Bowlin Mohamed El-Newehy Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620China Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Biomedical Engineering University of MemphisMemphisTN38152USA

Tissue engineering is an interdisciplinary field that integrates medical,biological,and engineering expertise to restore or regenerate the functionality of healthy tissues and *** three fundamental pillars of tissue engineering are scaffolds,cells,and *** nanofibers have been successfully used as scaffolds for a variety of tissue engineering applications because they are biomimetic of the natural,fibrous extracellular matrix(ECM)and contain a three-dimensional(3D)network of interconnected *** this review,we provide an overview of the electrospinning process,its principles,and the application of the resultant electrospun nanofibers for tissue *** first briefly introduce the electrospinning process and then cover its principles and standard equipment for biomaterial ***,we highlight the most important and recent advances related to the applications of electrospun nanofibers in tissue engineering,including skin,blood vessels,nerves,bone,cartilage,and tendon/ligament ***,we conclude with current advancements in the fabrication of electrospun nanofiber scaffolds and their biomedical applications in emerging areas.

关键词： Nanofibers Electrospinning Tissue engineering Regeneration Biomedical application