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Rootstock effects on scion phenotypes in a‘Chambourcin’experimental vineyard

Horticulture Research 2019年第1期6卷 992-1004页

作者： ZoëMigicovsky Zachary N.Harris Laura LKlein Mao Li Adam McDermaid Daniel H.Chitwood Anne Fennell Laszlo G.Kovacs Misha Kwasniewski jason P.Londo Qin Ma allison j.miller Department of Plant and Animal Sciences Faculty of AgricultureDalhousie UniversityTruroNS B2N 5E3Canada Department of Biology Saint Louis University3507 Laclede AvenueSt.LouisMO 63103-2010USA Donald Danforth Plant Science Center 975 North Warson RoadSt.LouisMO 63132-2918USA Department of Math&Statistics BioSNTRSouth Dakota State UniversityBrookingsSD 57006USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Department of Computational Mathematics Science and EngineeringMichigan State UniversityEast LansingMI 48824USA Department of Agronomy Horticulture&Plant ScienceBioSNTRSouth Dakota State UniversityBrookingsSD 57006USA Department of Biology Missouri State University901S.National AvenueSpringfieldMO 65897USA Department of Food Science University of Missouri221 Eckles HallColumbiaMO 65211USA United States Department of Agriculture Agricultural Research Service:Grape Genetics Research Unit630 West North StreetGenevaNY 14456-1371USA

Understanding how root systems modulate shoot system phenotypes is a fundamental question in plant biology and will be useful in developing resilient agricultural *** is a common horticultural practice that joins the roots(rootstock)of one plant to the shoot(scion)of another,providing an excellent method for investigating how these two organ systems affect each *** this study,we used the French-American hybrid grapevine‘Chambourcin’(Vitis L.)as a model to explore the rootstock–scion *** examined leaf shape,ion concentrations,and gene expression in‘Chambourcin’grown ungrafted as well as grafted to three different rootstocks(‘SO4’,‘1103P’and‘3309C’)across 2 years and three different irrigation *** found that a significant amount of the variation in leaf shape could be explained by the interaction between rootstock and *** ion concentrations,the primary source of variation identified was the position of a leaf in a shoot,although rootstock and rootstock by irrigation interaction also explained a significant amount of variation for most ***,we found rootstock-specific patterns of gene expression in grafted plants when compared to ungrafted ***,our work reveals the subtle and complex effect of grafting on‘Chambourcin’leaf morphology,ionomics,and gene expression.

关键词： Root grafted irrigation

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ShapeShifter： a novel approach for identifying and quantifying stable lariat intronic species in RNAseq data

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Frontiers of Electrical and Electronic Engineering in China 2018年第3期6卷 267-274页

作者： allison j Taggart William G Fairbrother Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRI 02912USA Center for Computational Molecular Biology Brown UniversityProvidenceRI 02912USA

Background： Most intronic lariats are rapidly turned over after splicing. However, new research suggests that some introns may have additional post-splicing functions. Current bioinformatics methods used to identify lariats require a sequencing read that traverses the lariat branchpoint. This method provides precise branchpoint sequence and position information, but is limited in its ability to quantify abundance of stabilized lariat species in a given RNAseq sample. Bioinformatic tools are needed to better address these emerging biological questions. Methods： We used an unsupervised machine learning approach on sequencing reads from publicly available ENCODE data to learn to identify and quantify lariats based on RNAseq read coverage shape. Results： We developed ShapeShifter, a novel approach for identifying and quantifying stable lariat species in RNAseq datasets. We learned a characteristic ＂lariat＂ curve from ENCODE RNAseq data and were able to estimate abundances for introns based on read coverage. Using this method we discovered new stable introns in these samples that were not represented using the older, branchpoint-traversing read method. Conclusions： ShapeShifter provides a robust approach towards detecting and quantifying stable lariat species.

关键词： splicing RNA lariat

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A novel approach to Parkinson's disease treatment with a potentially dual-acting therapeutic agent that targetsα-synuclein aggregation and neuron death

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Neural Regeneration Research 2024年第12期19卷 2577-2578页

作者： allison RBalaj Hiroaki Kaku Department of Investigative Medicine Western Michigan University Homer Stryker MD School of MedicineKalamazooMIUSA

Parkinson's disease(PD),a prevalent neurodegenerative disorder,is chara cterized by the loss of dopaminergic neurons and the aggregation ofα-synuclein protein into Lewy *** the current standards of therapy have been successful in providing some symptom relief,they fail to address the underlying pathophysiology of PD and as a result,they have no effect on disease progression.

关键词： aggregation death therapeutic

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Macrophage polarization in response to wear particles in vitro

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Cellular & Molecular Immunology 2013年第6期10卷 471-482页

作者： joseph K Antonios Zhenyu Yao Chenguang Li allison j Rao Stuart B Goodman Orthopaedic Research Laboratories Department of Orthopaedic Surgery Stanford University School of Medicine Stanford CA USA

Total joint replacement is a highly successful surgical procedure for treatment of patients with disabling arthritis and joint dysfunction. However, over time, with high levels of activity and usage of the joint, implant wear particles are generated from the articulating surfaces. These wear particles can lead to activation of an inflammatory reaction, and subsequent bone resorption around the implant （periprosthetic osteolysis）. Cells of the monocyte/macrophage lineage orchestrate this chronic inflammatory response, which is dominated by a pro-inflammatory （M 1） macrophage phenotype rather than an anti-inflammatory pro-tissue healing （M2） macrophage phenotype. While it has been shown that interleukin-4 （IL-4） selectively polarizes macrophages towards an M2 anti-inflammatory phenotype which promotes bone healing, rather than inflammation, little is known about the time course in which this occurs or conditions in which repolarization through I L-4 is most effective. The goal of this work was to study the time course of murine macrophage polarization and cytokine release in response to challenge with combinations of polymethyl methacrylate （PMMA） particles, lipopolysaccharide （LPS） and IL-4 in vitro. Treatment of particle-challenged monocyte/macrophages with IL-4 led to an initial suppression of pro-inflammatory cytokines and inducible nitric oxide synthase （iNOS） production and subsequent polarization into an M2 anti-inflammatory phenotype. This result was optimized when IL-4 was delivered before PMMA particle challenge, to an M 1 phenotype rather than to uncommitted （MO） macrophages. The effects of this polarization were sustained over a 5-day time course. Polarization of M1 macrophages into an M2 phenotype may be a strategy to mitigate wear particle associated periprosthetic osteolysis.

关键词： IL-4 macrophage polarization osteolysis PMMA particles total joint replacement

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Re: Errors in Zhao et al(2015), Impact of enteral nutrition on energy metabolism in patients with Crohn's disease

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World journal of Gastroenterology 2016年第9期22卷 2867-2868页

作者： Kathryn A Kaiser Brandon j George david B allison Office of Energetics School of Public Health University of Alabama at Birmingham

We report invalidating errors related to the statistical approach in the analysis and data inconsistencies in a published single cohort study of patients with Crohn's disease. We provide corrected calculations from the available data and request that a corrected analysis be provided by the authors. These errors should be corrected.

关键词： statistical error differences in nominal significance data inconsistency

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Mechanistic insights of enhanced spin polaron conduction in CuO through atomic doping

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npj Computational Materials 2018年第1期4卷 154-161页

作者： Tyler j.Smart allison C.Cardiel Feng Wu Kyoung-Shin Choi Yuan Ping Department of Physics University of CaliforniaSanta CruzCA 95064USA Department of Chemistry University of WisconsinMadisonWI 53706USA Department of Chemistry and Biochemistry University of CaliforniaSanta CruzCA 95064USA

The formation of a“spin polaron”stems from strong spin-charge-lattice interactions in magnetic oxides,which leads to a localization of carriers accompanied by local magnetic polarization and lattice *** example,cupric oxide(CuO),which is a promising photocathode material and shares important similarities with high Tc superconductors,conducts holes through spin polaron hopping with flipped spins at Cu atoms where a spin polaron has *** formation of these spin polarons results in an activated hopping conduction process where the carriers must not only overcome strong electron−phonon coupling but also strong magnetic ***,these effects cause low carrier conduction in CuO and hinder its *** overcome this fundamental limitation,we demonstrate from first-principles calculations how doping can improve hopping conduction through simultaneous improvement of hole concentration and hopping mobility in magnetic oxides such as ***,using Li doping as an example,we show that Li has a low ionization energy that improves hole concentration,and lowers the hopping barrier through both the electron−phonon and magnetic couplings'reduction that improves hopping ***,this improved conduction predicted by theory is validated through the synthesis of Li-doped CuO electrodes which show enhanced photocurrent compared to pristine CuO *** conclude that doping with nonmagnetic shallow impurities is an effective strategy to improve hopping conductivities in magnetic oxides.

关键词： conduction doping polaron

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Is changing footstrike pattern beneficial to runners?

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journal of Sport and Health Science 2017年第2期6卷 146-153页

作者： joseph Hamill allison H.Gruber Biomechanics Laboratory Department of KinesiologyUniversity of MassachusettsAmherstMA 01003USA Biomechanics Laboratory Department of KinesiologyIndiana UniversityBloomingtonIN 47405USA

Some researchers, running instructors, and coaches have suggested that the "optimal" footstrike pattern to improve performance and reduce running injuries is to land using a mid-or forefoot strike. Thus, it has been recommended that runners who use a rearfoot strike would benefit by changing their footstrike although there is little scientific evidence for suggesting such a change. The rearfoot strike is clearly more prevalent. The major reasons often given for changing to a mid-or forefoot strike are(1) it is more economical;(2) there is a reduction in the impact peak and loading rate of the vertical component of the ground reaction force; and(3) there is a reduction in the risk of a running-related injuries. In this paper,we critique these 3 suggestions and provide alternate explanations that may provide contradictory evidence for altering one's footstrike *** have concluded, based on examining the research literature, that changing to a mid-or forefoot strike does not improve running economy, does not eliminate an impact at the foot-ground contact, and does not reduce the risk of running-related injuries.

关键词： Epidemiology Footfall patterns Forefoot Ground reaction force Impacts Midfoot Rearfoot Running economy

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Plasma-polymerized pericyte patches improve healing of murine wounds through increased angiogenesis and reduced inflammation

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Regenerative Biomaterials 2021年第4期8卷 21-32页

作者： Hannah M.Thomas Parinaz Ahangar Robert Fitridge Giles T.S.Kirby Stuart j.Mills allison j.Cowin Future Industries Institute University of South AustraliaMawson Lakes SA 5095Australia Cell Therapy Manufacturing Cooperative Research Centre Adelaide SA 5000Australia Faculty of Health and Medical Sciences University of AdelaideAdelaide SA 5005Australia

Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;however,the efficacy of any cell therapy relies on the successful delivery of intact and functioning ***,the effect of delivering pericytes on wound repair was assessed alongside the development of a surface-functionalized pericyte *** polymerization(PP)was used to functionalize the surface of silicone patches with heptylamine(HA)or acrylic acid(AA)*** pericytes were subsequently delivered to murine excisional wounds by intradermal injection or using the pericyte-laden patches and the comparative effects on wound healing,inflammation and revascularization *** AA surface provided the superior transfer of the cells to de-epidermized *** murine wounds treated either with pericytes injected directly into the wound or with the pericyte-laden AA patches showed improved healing with decreased neutrophil infiltration and reduced numbers of macrophages in the *** delivery also enhanced angiogenesis through a mechanism independent of VEGF ***,when delivered to wounds,improved healing responses by dampening inflammation and promoting *** of pericytes using PP-AA-functionalized patches was equally as effective as direct injection of pericytes into ***-functionalized dressings may therefore be a clinically relevant approach for the treatment of wounds.

关键词： pericytes cell therapy wound healing plasma polymerization advanced surfaces

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Co-delivery of PARP and PI3K inhibitors by nanoscale metal-organic frameworks for enhanced tumor chemoradiation

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Nano Research 2019年第12期12卷 3003-3017页

作者： Megan j.Neufeld allison N.DuRoss Madeleine R.Landry Hayden Winter Andrea M.Goforth Conroy Sun Department of Pharmaceutical Sciences College of PharmacyOregon State UniversityPortlandOregon 97201USA Department of Chemistry Portland State University1719 SW 10th AvePortlandOregon 97201USA Department of Radiation Medicine Oregon Health&Science University3181 S.W.Sam Jackson Park RdPortlandOregon 97239USA

Due to their complementary activity,the use of DNA damage repair(DDR)inhibitors during radiotherapy(RT)has yielded promising ***,this approach is often hindered by toxicity and poor in vivo stability of the DDR in *** scale metal-organic frameworks(nMOFs)represent an emerging class of crystalline materials which exhibit advantageous properties over traditional nanomaterials and demonstrate great potential in ***,a unique,synergistic treatment strategy for enhancing the therapeutic efficacy of RT vianMOF-mediated drug delivery and RT enhancement was evaluated.A nMOF containing the high-Zelement Hf and the ligand 1,4-dicarboxybenzene(Hf-BDC)was synthesized and loaded with the two DDR inhibitor drugs,talazoparib and buparlisib(TB@Hf-BDC-PEG).TB@Hf-BDC-PEGaugmented RT by increasing reactive oxygen species generation and thus DNA damage of which repair was inhibited *** enhancement was demonstrated in vivo where the combination of concurrent radiation with in travenous TB@Hf-BDC-PEG administration resulted in improved tumor control and increased ***,no apparent toxicity was observed with nMOF treatment,supporting its potential as an attractive candidate over traditional nano *** work provides the first report of nMOFs employed to enhance thetherapeutic response to RT through DDR inhibitor delivery and physical radiation dose enhancement.

关键词： nano scale metal-organic frameworks chemoradiotherapy DNA damage repair inhibitors drug delivery radiation dose enhancement

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Current applications of artificial intelligence for intraoperative decision support in surgery allison

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Frontiers of Medicine 2020年第4期14卷 369-381页

作者： j.Navarrete-Welton Daniel A.Hashimoto Surgical Artificial Intelligence and Innovation Laboratory Massachusetts General HospitalBostonMA 02114USA Harvard Medical School BostonMA 02114USA

Research into medical artificial intelligence(AI)has made significant advances in recent years,including surgical *** scoping review investigated AI-based decision support systems targeted at the intraoperative phase of surgery and found a wide range of technological approaches applied across several surgical *** the twenty-one(n=21)included papers,three main categories of motivations were identified for developing such technologies:(1)augmenting the information available to surgeons,(2)accelerating intraoperative pathology,and(3)recommending surgical *** many of the proposals hold promise for improving patient outcomes,important methodological shortcomings were observed in most of the reviewed papers that made it difficult to assess the clinical significance of the reported performance *** limitations,the current state of this field suggests that a number of opportunities exist for future researchers and clinicians to work on AI for surgical decision support with exciting implications for improving surgical care.

关键词： artificial intelligence decision support clinical decision support systems intraoperative deep learning computer vision machine learning surgery

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