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A novel approach to Parki.son's di.ease treatment wi.h a potenti.lly dual-acti.g therapeuti. agent that targetsα-synuclei. aggregati.n and neuron death

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Neural Regenerati.n Research 2024年第12期19卷 2577-2578页

作者： allison RBalaj Hi.oaki.Kaku Department of i.vesti.ati.e Medi.i.e Western Michigan University Homer Stryker MD School of MedicineKalamazooMIUSA

Parki.son's di.ease(PD),a prevalent neurodegenerati.e di.order,i. chara cteri.ed by the loss of dopami.ergi. neurons and the aggregati.n ofα-synuclei. protei. i.to Lewy *** the current standards of therapy have been successful i. provi.i.g some symptom reli.f,they fai. to address the underlyi.g pathophysi.logy of PD and as a result,they have no effect on di.ease progressi.n.

关键词： aggregati.n death therapeuti.

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Promi.i.g use of metformi. i. treati.g neurologi.al di.orders:bi.marker-gui.ed therapi.s

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Neural Regenerati.n Research 2024年第5期19卷 1045-1055页

作者： allison Loan Charvi.Syal Margari.a Lui.Li.g He Ji.g Wang Regenerati.e Medi.i.e Program Ottawa Hospital Research InstituteOttawaONCanada Department of Bi.logy Faculty of ScienceUniversity of OttawaOttawaONCanada Department of Pedi.tri.s and Medi.i.e Johns Hopkins Medical SchoolBaltimoreMDUSA Department of Cellular and Molecular Medi.i.e Faculty of MedicineUniversity of OttawaOttawaONCanada Uni.ersi.y of Ottawa Brai. and Mi.d Research i.sti.ute OttawaONCanada

Neurologi.al di.orders are a di.erse group of condi.i.ns that affect the nervous system and i.clude neurodegenerati.e di.eases(Alzhei.er’s di.ease,multi.le sclerosi.,Parki.son’s di.ease,Hunti.gton’s di.ease),cerebrovascular condi.i.ns(stroke),and neurodevelopmental di.orders(auti.m spectrum di.order).Although they affect mi.li.ns of i.di.i.uals around the world,only a li.i.ed number of effecti.e treatment opti.ns are avai.able *** most neurologi.al di.orders express mi.ochondri.-related metaboli. perturbati.ns,metformi.,a bi.uani.e type i. anti.i.beti. drug,has attracted a lot of attenti.n to be repurposed to treat neurologi.al di.orders by correcti.g thei. perturbed energy ***,controversi.l research emerges regardi.g the benefi.i.l/detri.ental effects of metformi. on these neurologi.al *** that most neurologi.al di.orders have complex eti.logy i. thei. pathophysi.logy and are i.fluenced by vari.us ri.k factors such as agi.g,li.estyle,geneti.s,and envi.onment,i. i. i.portant to i.enti.y perturbed molecular functi.ns that can be targeted by metformi. i. these neurologi.al *** molecules can then be used as bi.markers to strati.y subpopulati.ns of pati.nts who show di.ti.ct molecular/pathologi.al properti.s and can respond to metformi. treatment,ulti.ately developi.g targeted *** thi. revi.w,we wi.l di.cuss mi.ochondri.-related metaboli. perturbati.ns and i.pai.ed molecular pathways i. these neurologi.al di.orders and how these can be used as bi.markers to gui.e metformi.-responsi.e treatment for the targeted therapy to treat neurologi.al di.orders.

关键词： Alzhei.er’s di.ease Hunti.gton’s di.ease metformi. mi.ochondri.l perturbati.n multi.le sclerosi. neural degenerati.e di.eases Parki.son’s di.ease stroke targeted therapy

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Di.gnosti. challenges and i.di.i.uali.ed treatment of cervi.al adenocarci.oma metastases to the breast:A case report

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World Journal of Cli.i.al Cases 2024年第2期12卷 412-417页

作者： allison Akers Susan Read John Feldman Casey Gooden Di.na P Engli.h Department of Obstetri.s and Gynecology University of South FloridaTampaFL 33606United States Department of Gynecologi. Oncology Sky Ridge Medical CenterLone TreeCO 80124United States Department of Radi.logy University of South FloridaTampaFL 33606United States Department of Pathology University of South FloridaTampaFL 33606United States

BACKGROUND Cervi.al cancer i. a rare pri.ary tumor resulti.g i. metastases to the breast wi.h few cases reported i. *** metastases are associ.ted wi.h poor *** followi.g case hi.hli.hts the di.gnosti. challenges associ.ted wi.h metastati. cervi.al cancer to the breast along wi.h i.di.i.uali.ed *** SUMMARY A 44-year-old G7P5025 wi.h no si.ni.i.ant past medi.al or surgi.al hi.tory presented wi.h heavy vagi.al to an outsi.e emergency department where an exam and a pelvi. magneti. resonance i.agi.g showed a 4.5 cm heterogenous lobulated cervi.al mass i.volvi.g upper two thi.ds of vagi.a,parametri. and lymph node *** bi.psi.s confi.med hi.h grade adenocarci.oma wi.h muci.ous features.A posi.ron emi.si.n tomography/computed tomography(PET/CT)di. not show evi.ence of metastati. *** recei.ed concurrent ci.plati. wi.h external beam radi.ti.n *** up PET/CT scan three months later showed no suspi.i.us fluorodeoxyglucose uptake i. the cervi. and no evi.ence of metastati. *** was lost to follow up for si. *** was re-i.aged on re-presentati.n and found to have wi.ely metastati. di.ease i.cludi.g breast *** bi.psy confi.med programmed death-li.and 1 posi.i.e metastati. cervi.al *** pati.nt recei.ed si. cycles of carboplati. and pacli.axel wi.h *** i.agi.g demonstrated *** conti.ued on pembroli.umab wi.h di.ease *** Metastati. cervi.al cancer to the breast i. uncommon wi.h nonspeci.i. cli.i.al fi.di.gs that can make di.gnosi. *** hi.tory and i.munohi.tochemi.al evaluati.n of breast lesi.n,and compari.on to pri.ary tumor can support di.gnosi. of metastati. cervi.al cancer to the ***,the prognosi. i. poor,but i.munotherapy can be consi.ered i. select pati.nts and may result i. good di.ease response.

关键词： Cervi.al adenocarci.oma Breast metastases i.munotherapy Pembroli.umab Carboplati. Pacli.axel Case report

Engli.h Speaki.g Onli.e i. the Turki.h Teachi.g Context:A Theoreti.al Approach

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Si.o-US Engli.h Teachi.g 2024年第5期21卷 222-226页

作者： Zehra Betul Turkmen Tzu Yu allison Li. Gazi.ntep Uni.ersi.y GaziantepTurkey

The world i.i.i.ted a new era wi.h the emergence of the Covi.-19 *** all around the globe,i.cludi.g Turkey,was i.pacted to a great *** teachers and learners were requi.ed to adapt to onli.e educati.n wi.hi. a short peri.d of *** previ.us studi.s had focused on the i.pacts of teachi.g Engli.h i. general for teachers and learners,studi.s focusi.g on teachi.g of the speaki.g ski.ls onli.e parti.ularly i. the Turki.h context was absent i. the ***,the gap whi.h was to be consi.ered appropri.te for thi. research i. related to comprehendi.g the percepti.ns and challenges EFL teachers confronted whi.e attempti.g to teach the speaki.g ski.ls onli.e wi.hi. the Turki.h *** arti.le ai.s to have a theoreti.al contri.uti.n to the current research,i. order to see the si.ni.i.ance of the Turki.h context,as onli.e teachi.g of Engli.h speaki.g was to be consi.ered benefi.i.l for learners,as i. i.creased confi.ence for the i.teracti.n.

关键词： Engli.h teachi.g speaki.g onli.e hi.her educati.n Covi.-19 pandemi.

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希腊:千年文明万顷碧波

初中生 2024年第6期 4-13页

作者： allison Mcdonald 不详

代代流传的希腊神话,影响至今的哲学思想,穿越千年的历史遗迹,都是人类文明发展的见证。蓝天、碧海,以及独具特色的白房子,构成了希腊蓝白相间的独特景观。本期《大千世界》,我们一起来感受希腊的历史、文化和美景。

关键词：蓝白相间万顷碧波历史遗迹希腊神话人类文明哲学思想 ,影响大千世界

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金城兰州,黄河明珠

初中生 2024年第21期 4-13页

作者： allison Mcdonald 不详

黄河流经兰州,如同一条巨龙婉蜓而过,为历史悠久的兰州城带来了无尽生机与活力。走在兰州,我们可以感受黄河的奔腾、中山桥的壮丽、白塔山的秀美,以及一碗牛肉面的香醇。本期《大千世界》,我们一起走进坐落在黄河之滨的兰州城。

关键词：中山桥黄河之滨牛肉面黄河明珠生机与活力兰州

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发现最好的墨西哥瓦哈卡

英语画刊(高中版) 2024年第5期 16-17页

作者： allison Green

充满活力的墨西哥城市瓦哈卡有着世界一流的美食充满活力的墨西哥城市瓦哈卡有着世界一流的美食、华丽的建筑和遗迹，以及丰富的自然美景景。Natural Wonder自然奇观At Hi.rve el Agua, you can fi.d two stunni.g petri.i.d waterfalls...

充满活力的墨西哥城市瓦哈卡有着世界一流的美食充满活力的墨西哥城市瓦哈卡有着世界一流的美食、华丽的建筑和遗迹，以及丰富的自然美景景。Natural Wonder自然奇观At Hi.rve el Agua, you can fi.d two stunni.g petri.i.d waterfalls. Addi.g to the magi. are two spri.g-fed, i.fi.i.y pools set i.to the rock, overlooki.g the blue-green mountai..在滚水石瀑布，你会发现两个令人惊叹的石化瀑布。更神奇的是，岩石中还有两个无边的泉源池，俯瞰着蓝绿色的山峦。

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A preci.e moni.ori.g of snow surface hei.ht i. the regi.n of Lambert Glaci.r basi.-Amery i.e Shelf,East Antarcti.a

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Sci.nce Chi.a Earth Sci.nces 2005年第1期48卷 100-111页

作者： i.allison Australi.n Antarcti. Di.i.i.n and Antarcti. Cli.ate and Ecosystems CRC

The net surface snow accumulati.n on the Antarcti. i.e sheet i. determi.ed by a combi.ati.n of preci.i.ati.n, subli.ati.n and wi.d redi.tri.uti.n. We present a one-year record of hourly snow-hei.ht measurements at LGB69 (70°50'S, 77°04'E, 1850 m a.s.l.). east si.e of Lambert Glaci.r basi. (LGB), and 4 year record at G3 (70°53'S, 69°52'E, 84 m a.s.l.), Amery i.e Shelf (Ai.). The measurements were made wi.h ultrasoni. sensors mounted on automati. weather stati.ns i.stalled at two si.es. The snow accumulati.n at LGB69 i. approxi.ately 70 cm. Throughout the wi.ter, between Apri. and September, there was li.tle change i. surface snow hei.ht (SSH) at the two si.es. The negati.e SSH change i. due to densi.i.ati.n at LGB69, and i. due to both ablati.n and densi.i.ati.n at G3. The strongest accumulati.n at two si.es occurred duri.g the peri.d between October and March (accounti.g for 101.6% at LGB69), wi.h four epi.odi. i.creasi.g events occurri.g duri.g 2002 for LGB69, and ei.ht events duri.g 1999-2002 for G3 (2 to 3 events per year). At LGB69, these epi.odi. events coi.ci.ed wi.h obvi.us humi.i.y 'pulses' and decreases of i.comi.g solar radi.ti.n as recorded by the AWS. Observati.ns of the total cloud amount at Davi. stati.n, 160 km NNE of LGB69, showed good correlati.n wi.h major accumulati.n events recorded at LGB69. There was an obvi.us anti.correlati.n between the lowest cloud hei.ht at Davi. and the dai.y accumulati.n rate at LGB69. Although there was no correlati.n over the total year between wi.d speed and accumulati.n at LGB69, large i.di.i.ual accumulati.n events are associ.ted wi.h epi.odes of strong wi.d (>7 m/s), we esti.ate dri.t snow may contri.ute to total SSH up to 35%. Strong accumulati.n events at LGB69 are associ.ted wi.h major storms i. the regi.n and i.land transport of moi.t ai. masses from the coast.

关键词： Antarcti.a, Lambert Glaci.r basi., Amery i.e Shelf, accumulati.n, katabati. wi.d.

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哈里斯经济议程已现雏形

商业周刊（中文版） 2024年第13期 4-5页

作者： Steve Denni. Akayla Gardner Jenni.er Dlouhy Bi.l allison 易语(译) 不详

哈里斯势在进行品牌重塑,重新聚焦关键成就,对现行计划作出一些调整而非推倒重来.空军二号在佐治亚州落地,美国卡玛拉·哈里斯(Kamala Harri.)时代由此揭开惟幕。这位美国副总统此番吸引的民众比总统乔·拜登(Joe Bi.en)一年下来吸引的... 详细信息

哈里斯势在进行品牌重塑,重新聚焦关键成就,对现行计划作出一些调整而非推倒重来.空军二号在佐治亚州落地,美国卡玛拉·哈里斯(Kamala Harri.)时代由此揭开惟幕。这位美国副总统此番吸引的民众比总统乔·拜登(Joe Bi.en)一年下来吸引的民众总数都多——这是哈里斯在南方,在一个她已重新唤起活力的南方州的实力展示。这是她的高光时刻。

关键词：美国副总统品牌重塑佐治亚州哈里斯推倒重来