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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 34-34页

作者： Rossebφ A.B. Pedersen t.R. allen C. 赵君 Dr.Division of Cardiology Aker UniversityHospital Oslo Norway

主动脉瓣狭窄和动脉粥样硬化性疾病有很多共同的危险因素,尤其是高胆固醇血症。在组织学上,病变的瓣膜似乎具有与动脉粥样硬化斑块非常相似的炎症区域。降脂治疗对主动脉瓣狭窄(AS)进展的影响尚不清楚,而且尚没有相关的随机治疗试验评... 详细信息

主动脉瓣狭窄和动脉粥样硬化性疾病有很多共同的危险因素,尤其是高胆固醇血症。在组织学上,病变的瓣膜似乎具有与动脉粥样硬化斑块非常相似的炎症区域。降脂治疗对主动脉瓣狭窄(AS)进展的影响尚不清楚,而且尚没有相关的随机治疗试验评价这类患者中的心血管发病率和死亡率。SEAS(辛伐他汀和依泽替米贝应用于主动脉瓣狭窄)是一项随机、双盲、安慰剂对照的多中心研究,旨在在至少4年的研究期内观察辛伐他汀40m g/d或依泽替米贝10m g/d的降脂治疗对跨瓣射血峰值速度为2.5～4.0m/s的无症状AS患者的作用。主要的疗效指标为主动脉瓣手术和缺血性血管事件,包括心血管疾病死亡;次要终点为利用超声心动图观察的对AS进展的影响。

关键词：主动脉瓣狭窄 SEAS 降脂治疗心血管发病率次要终点高胆固醇血症粥样硬化斑块随机治疗疗效

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冠心病和其他动脉粥样硬化性血管疾病二级预防指南：2006年版（摘要）

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岭南心血管病杂志 2008年第2期14卷 126-126,129页

作者： SMItH S C allen J BLAIR S N BONOW R O BRASS L M FONAROW G C GRUNDY S M HIRAtZKA L JONES D KRUMHOLZ H M MOSCA L PAStERNAK R C PEARSON t PFEFFER M A tAUBERt K A

美国心脏学会（American College of Cardiology，ACC）与美国心脏病协会（American Heart ***）关于二级预防的共识声明自2001年更新以来，许多临床试验提供了重要证据．进一步支持和拓展了对冠心病和其他动脉粥样硬化性血管疾病（包... 详细信息

美国心脏学会（American College of Cardiology，ACC）与美国心脏病协会（American Heart ***）关于二级预防的共识声明自2001年更新以来，许多临床试验提供了重要证据．进一步支持和拓展了对冠心病和其他动脉粥样硬化性血管疾病（包括外周动脉疾病、动脉粥样硬化性主动脉疾病和颈动脉疾病）进行积极控制危险因素治疗的重要性。证据不断涌现，证实对这些患者进行积极而全面的危险因素干预治疗能够改善生存率，减少事件复发以及对介入治疗的需要．并提高生活质量。

关键词：动脉粥样硬化性血管疾病二级预防冠心病危险因素治疗美国心脏病协会摘要指南美国心脏学会

Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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Journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion Spencer J.allen Stephanie M.Ntoukas Gordon J.Bell Jessica McNeil Qinggang Wang Margaret L.McNeely Jeff K.Vallance Lin Yang S.Nicole Culos-Reed Leanne Dickau John R.Mackey Christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:this study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(pty(p=0.009),significant fatigue(p=0.008),any symptom(ptiple symptoms(ptrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

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the amazing potential of fungi:50 ways we can exploit fungi industrially

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Fungal Diversity 2019年第4期97卷 1-136页

作者： Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong allen Grace t.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.tennakoon Ramamoorthy Siva Wasan Sriprom t.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach thitipone Suwunwong Benjarong thongbai Naritsada thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.PaPaeA.Mae TaengChiang Mai 50150Thailand Aix Marseille Université INRAUMR1163 BBF13288 Marseille Cedex 09France Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Center of Plant and Environment ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Center of Chemical Innovation for Sustainability Mae Fah Luang UniversityTasudMuangChiang Rai 57100Thailand Center of Excellence in Microbial Diversity and Sustainable Utilization Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Center for Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Institute of Fungal Research School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Department Microbial Drugs Helmholtz Centre for Infection Researchand German Centre for Infection Research(DZIF)partner site Hannover-BraunschweigInhoffenstrasse 738124 BrunswickGermany Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Chemistry and Biochemistry The Ohio State UniversityColumbusOH 43210USA Department of Chemistry University of Science and TechnologyBannuKhyber PakhtunkhwaPakistan Department of Crop Physiology University of Agricultural SciencesGKVKBengaluruKarnataka 560065India Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai Univers

Fungi are an understudied,biotechnologically valuable group of *** to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival *** unique attributes of fungi thus herald great promise for their application in biotechnology and ***,fungi can be grown with relative ease,making production at scale *** search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel *** manuscript reviews fifty ways in which fungi can potentially be utilized as *** provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable *** also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential *** have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential.

关键词： Biocontrol Biodiversity Biotechnology Food Fungi Mushrooms

the Origination and Reality of Askin tumor

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Journal of Nanjing Medical University 2000年第1期14卷 7-10页

作者： Fan Qinhe(范钦和) Philip W allen\+1\ Xu tianrong(徐天蓉) Zhang Zhihong(张智弘)\ Zheng Zhaoxun(郑肇巽) Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China \+1Flinders Medical Center, SA 504 Department of Pathology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029P. R. China Flinders Medical Center SA 5042 Australia

Objective\ to study the origination and reality of Askin tumor. Methods\ twenty two cases of these lesions have been studied by clinical pathologic observation, immunohistochemistry, electron microscopy, and cytogenics in this paper. Results\ the results revealed the positiveness of MIC2(CD99), NSE, Chromogranin A(CgA) by immunohistochemistry, neurosecretory granules by electron microscopy, and the specific genotypic translocation of t (11∶22) (q24∶q12) by cytogenetic analysis, which were identical to the malignant primitive neuroectodermal tumor (PNEt). Conclusion\ We conclude that this lesion is actually the one member of the PNEt/Ewing′s sarcoma family, except the special location. Differential diagnoses between this tumor and other small round cell sarcomas such as lymphoma, embryonal rhabdomyosarcoma, rhabdoid tumor, round cell liposarcoma and desmoplastic small round cell tumor were also discussed in this article.

关键词： Askin tumor PNEt/Ewing′s sarcoma immunohistochemistry electron microscopy cytogenetic analysis

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Resilience, the 6th Vital Sign: Conceptualizing, Contextualizing, and Operationalizing All Six Vital Signs

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Health 2024年第7期16卷 657-673页

作者： Rose E. Constantino Betty J. Braxter Chi Ching Vivian Hui Larissa C. allen Lillian J. Wolfe Katherine H. Endres Jezyl Cempron Cutamora Laurence L. Garcia Daisy R. Palompon Kathleen thimsen Brayden N. Kameg Margarete L. Zalon Department of Health and Community Systems School of Nursing University of Pittsburgh Pittsburgh PA USA Undergraduate Affairs School of Nursing University of Pittsburgh Pittsburgh PA USA the Hong Kong Polytechnic University Hong Kong China School of Nursing Adjunct Faculty at the University of Pittsburgh Pittsburgh PA USA School of Nursing University of Pittsburgh Pittsburgh PA USA Department of Health Promotion and Development School of Nursing University of Pittsburgh Pittsburgh PA USA College of Nursing Cebu Normal University Cebu City Philippines School of Nursing University of Nevada Las Vegas USA Department of Health and Community Systems University of Pittsburgh PA USA Department of Nursing University of Scranton Scranton PA USA

there are five vital signs that healthcare providers assess: temperature, pulse, respiration, blood pressure, and pain. Normal levels for the five vital signs are published by the American Heart Association, and other specialty organizations, however, the sixth vital sign (resilience) which adopts the measure of immune resilience is suggested in this paper. Resilience is the ability of the immune system to respond to attacks and defend effectively against infections and inflammatory stressors, and psychological resilience is the capacity to resist, adapt, recover, thrive, and grow from a challenge or a stressor. Individuals with better optimal immune resilience had better health outcomes than those with minimal immune resilience. the purpose of this paper is to conceptualize, contextualize, and operationalize all six vital signs. We suggest measuring resilience subjectively and objectively. Subjectively, use a 5-item guided interview revised from the Connor-Davidson Resilience Scale (CDRC), a scale of 10 items. the revised CDRC scale is a 5-item scale. the scale is rated on a 5-point Likert scale from 0 (not true) to 4 (true all the time). the total score ranges from 0 to 20, with higher total scores indicating greater resilience. the scale demonstrated good construct validity and internal consistency (α = 0.85) during the development of the scale. the CD-RISC had a good Cronbach’s alpha level of 0.85. the Revised CD-RISC can be completed in 2 - 4 minutes. to measure resilience objectively, we suggest using Immune Resilience (IR) levels, the level of resilience to preserve and/or rapidly restore immune resilience functions that promote disease resistance and control inflammation and other inflammatory stress. IR levels are gauged with two peripheral blood metrics that quantify the balance between CD8 and CD4 t-cell levels and gene expression signatures tracking longevity-associated immunocompetence and mortality- or entropy-associated inflammation. IR deregulation i

关键词： Conceptualization Contextualization Operationalization Body temperature Pulse Respiration Blood Pressure Pain Resilience

Delayed healing is common in in-situ urethroplasty patients after artificial sphincter cuff erosion

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Uroprecision 2024年第3期 95-99页

作者： Ethan L.Matz Banahene K.Glover Aaron M.Krug Brian t.Langford Bryce P.Franzen Steven Hudak Maia Van Dyke allen F.Morey Department of Urology University of Texas Southwestern Urology Clinical of North texas

Introduction: Urethral erosion is a known complication of artificial urinary sphincter(AUS) surgery. We performed an in-situ urethroplasty(ISU) to reduce the healing time and time to reimplantation of the AUS. We sought to assess urethral integrity one month after ISU and to identify factors associated with delayed healing in our high-volume tertiary referral center ***: A retrospective review of our AUS database from 2009 to 2023 was conducted to identify all ISU cases. Patients were stratified as healed or nonhealed based on the absence of extravasation on voiding cystourethrogram(VCUG) obtained 4 weeks postoperatively. Background characteristics were evaluated including age, body mass index, diabetes, hypogonadism and smoking history. Operative variables included degree of erosion, location of defect, and the number of stitches required for ***: Among 98 patients undergoing an ISU, 61 underwent VCUG at one month. Of these, 34.4%(21/61) had evidence of delayed healing on VCUG requiring prolonged catheterization. Although a higher average number of repair sutures were used in ISU, this was not significant(p = 0.381). the most common complication in both groups was urinary tract infection(UtI). Nonhealed patients had a higher rate of UtI, without significant predilection towards fistula, stricture or diverticulum. No other patient or operative characteristic was significantly different between ***: Despite an aggressive approach to management via ISU, many patients still require prolonged catheterization after AUS erosion to ensure complete healing of the defect.

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采用沙格列汀与二甲双胍作为降糖起始治疗可提供持久的血糖控制且在2型糖尿病患者耐受性好76周结果

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采用沙格列汀与二甲双胍作为降糖起始治疗可提供持久的血糖控制且...

采用沙格列汀与二甲双胍作为降糖起始治疗可提供持久的血糖控制且在2型糖尿病患者耐受性好:76周结果

中华医学会第十一次全国内分泌学学术会议

作者： A.Pfutzner E.Paz-Pacheco N.Berglind E.allen B.Frederich R.Chen Institute for Clinical Research and Development MainzGermany the Medical City Pasig CityPhilippines AstraZeneca WilmingtonDEUSA Bristol-Myers Squibb PrincetonNJUSA

背景和目的:沙格列汀(SAXA)是一种高效的选择性二肽基肽脢-4(DPP-4)抑制剂,适用于成人2型糖尿病(t2DM)的治疗。本研究是一项多中心随机双盲阳性对照24周短期治疗(主要治疗期),加上52周的长期延长治疗(LtE;总共76周),在尚未用药且糖化血...

背景和目的:沙格列汀(SAXA)是一种高效的选择性二肽基肽脢-4(DPP-4)抑制剂,适用于成人2型糖尿病(t2DM)的治疗。本研究是一项多中心随机双盲阳性对照24周短期治疗(主要治疗期),加上52周的长期延长治疗(LtE;总共76周),在尚未用药且糖化血红蛋白(HbA1c)较高的t2DM患者中评估SAXA和MEt作为起始治疗糖尿病,以及SAXA或MEt单药治疗的疗效和耐受性。

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采用沙格列汀与二甲双胍作为降糖起始治疗可提供持久的血糖控制且...