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世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 59-60页

作者： allen V.M. O'Connell C.M. Baskett t.F 柳蕴 Department of Obstetrics and Gynaecology IWK Health Centre 5980 University Avenue Halifax NS B3H 4N1 Canada Dr.

OBJECtIVE: to estimate the maternal morbidity associated with cesarean deliveries performed at term without labor compared with morbidity associated with induction of labor at term. MEtHODS: A 15- year population-based cohort study (1988- 2002) using the Nova Scotia Atlee Perinatal Database compared maternal outcomes in nulliparous women delivering by cesarean delivery without labor and nulliparous women at term undergoing induction of labor for planned vaginal delivery with singleton, cephalic presentation. RESULtS: A total of 5,779 pregnancies satisfied inclusion and exclusion criteria, 879 of which were cesarean deliverieswithout labor. there were no maternal deaths. there was no difference in wound infection, puerperal febrile morbidity, blood transfusion or intraoperative trauma. After controlling for potential confounders, women undergoing cesarean delivery without labor were less likely to have complications of early postpartum hemorrhage (relative risk 0.61, 95% confidence interval 0.42- 0.88, number needed to treat 32) and composite maternal morbidity (relative risk 0.71, 95% confidence interval 0.52- 0.95, number needed to treat 34) compared with women undergoing induction of labor. Subgroup analyses of maternal outcomes after induction of labor in women by method of delivery were also performed and demonstrated additional risks of traumatic morbidity after induction of labor. the highest morbidity was found in the assisted vaginal delivery and cesarean delivery in labor groups. CONCLUSION: Early postpartum hemorrhage and composite maternal morbidity were decreased in cesarean delivery without labor compared with induction of labor. Hemorrhagic and traumatic morbidities with labor induction are increased after assisted vaginal delivery and cesarean delivery in labor compared with cesarean delivery without labor.

关键词：足月引产剖宫产分娩早期产后出血产褥病率孕母头先露阴道助产队列研究产后妇女亚组分析

重度干旱胁迫下燕麦叶片活性氧清除系统对喷施腐植酸水溶肥的响应

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西北植物学报 2022年第5期42卷 803-810页

作者：李英浩刘景辉米俊珍吕品潘越赵宝平 allen Xue 内蒙古农业大学农学院呼和浩特010019 加拿大农业与农产品部渥太华研发中心加拿大渥太华KIA0C6

以燕麦品种‘燕科2号’为试验材料,采用盆栽方式,设置正常供水(CK)、正常供水下喷施腐植酸水溶肥(CKH)、重度干旱胁迫(SS)和重度干旱胁迫下喷施腐植酸水溶肥(SSH)4个处理,对燕麦叶片中活性氧水平、抗氧化酶活性、总抗氧化剂含量及产量... 详细信息

以燕麦品种‘燕科2号’为试验材料,采用盆栽方式,设置正常供水(CK)、正常供水下喷施腐植酸水溶肥(CKH)、重度干旱胁迫(SS)和重度干旱胁迫下喷施腐植酸水溶肥(SSH)4个处理,对燕麦叶片中活性氧水平、抗氧化酶活性、总抗氧化剂含量及产量等进行测定,以明确腐植酸水溶肥(HA)对重度干旱胁迫下燕麦叶片活性氧清除系统的调控效应,并探讨HA对燕麦耐旱性的影响及其作用机制。结果表明:(1)与CK相比,燕麦叶片超氧阴离子(O^(-·)_(2))、羟自由基(·OH)、过氧化氢(H_(2)O_(2))和丙二醛(MDA)含量、以及超氧化物歧化酶(SOD)和过氧化物酶(POD)活性在重度干旱胁迫下显著提高,且均在喷施HA后比重度干旱胁迫处理显著降低,但此时活性氧的水平仍显著高于CK。(2)与CK相比,燕麦叶片过氧化氢酶(CAt)、抗坏血酸过氧化物酶(APX)、谷胱氨肽还原酶(GR)和谷胱氨肽过氧化物酶(GPX)活性在重度干旱胁迫下显著降低,而其总抗氧化能力(t-AOC)显著提高,它们在喷施HA后均比重度干旱胁迫处理显著提高,但各酶活性仍不同程度低于CK。(3)与CK相比,燕麦籽粒产量和生物产量在重度干旱胁迫下显著下降,喷施HA后又比重度干旱胁迫显著升高,但仍显著低于CK。研究认为,喷施HA可有效提高重度干旱胁迫下燕麦叶片抗氧化酶活性,促进抗氧化物质再生,增强叶片的总抗氧化能力,从而有效清除重度干旱胁迫引起的活性氧积累,降低重度干旱胁迫对植物细胞膜的氧化损伤,最终缓解重度干旱胁迫对燕麦造成的伤害,一定程度上能够减少籽粒产量的损失。

关键词：燕麦干旱胁迫腐植酸水溶肥活性氧清除系统

Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and Gd-DOtA

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World Journal of Gastroenterology 2015年第19期21卷 5831-5842页

作者： Hye Rim Cho Youkyung Lee Philip Doble David bishop Dominic Hare Young-Jae Kim Kwang Gi Kim Hye Seung Jung Kyong Soo Park Seung Hong Choi Woo Kyung Moon Department of Radiology Seoul National University College of Medicine Department of Radiation Applied Life Science Seoul National University College of Medicine Department of Radiology College of MedicineHanyang University Hanyang University Guri Hospital Guri Department of Chemistry and Forensic Science University of TechnologySydney Biomedical Engineering Branch Division of Convergence Technology National Cancer Center Department of Internal Medicine Seoul NationalUniversity College of Medicine Center for Nanoparticle Research Institute for Basic Science and School of Chemical and Biological Engineering Seoul National University

AIM: to investigate the performance of Gadofluorine P-enhanced magnetic resonance imaging(MRI) on the diagnosis of diabetes in a streptozotocin(StZ)-induced diabetic rat ***: Fischer 344 rats were treated with *** not treated with StZ served as controls. t1-weighted MRI was performed using a 3t scanner before and after the injection of Gd-DOtA or Gadofluorine P(6 diabetic rats, 5 controls). the normalized signal intensity(SI) and the enhancement ratio(ER) of the pancreas were measured at each time point, and the values were compared between the normal and diabetic rats using the Mann-Whitney test. In addition,the values were correlated with the mean islet *** cut-off values were calculated using a positive test based on receiver operating *** Gd concentration after the injection of each contrast media was measured using laser ablation-inductively coupled plasma-mass spectrometry in a separate set of rats(4 diabetic rats, 4 controls for Gadofluorine P; 2, 2 for Gd-DOtA).RESULtS: the normalized SI and ER of the pancreas using Gd-DOtA were not significantly different between diabetic rats and controls. With Gadofluorine P, the values were significantly higher in the diabetic rats than in the control rats 30 min after injection(P the area under the receiver operating characteristic curve that differentiated diabetic rats from the control group was greater for Gadofluorine P than for Gd-DOtA(0.967 vs 0.667, P = 0.085). An increase in normalized SI 30 min after Gadofluorine P was correlated with a decrease in the mean number of islets(r 2 = 0.510, P = 0.014). Intra-pancreatic Gd was higher in rats with Gadofluorine P injection than Gd-DOtA injection(Gadofluorine P vs Gd-DOtA, 7.37 vs 0.00, P t difference in the concentration of intrapancreatic Gd was observed between the control and diabetic animals that were sacrificed 30 min after Gadofluorine P injection(control vs diabetic, 3.25 ng/g v

关键词： Gadofluorine P Gd-DOtA Magnetic resonancecontrast media type 1 diabetes Pancreas

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别再沉默了,希波克拉底!

新东方英语（中英文版） 2014年第3期 46-49页

作者： Marshall allen 刘芳羽

如果医生存给病人看病时Ⅲ错，病人一般不会知道。但其他医生知道。

关键词：沉默病人医生

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利用直接边界元法求解兴波问题(英文)

船舶力学 2003年第6期7卷 27-36页

作者：缪泉明章梓雄中国船舶科学研究中心江苏无锡214082 香港大学机械工程系

本文描述了利用直接边界元法求解定常兴波问题的理论和数值方法,本方法利用线性化自由面条件,辐射条件基于Dawson的四点差分格式进行处理。本文给出了Wigley船的兴波阻力和波高的数值结果,并与Dawson方法和试验结果进行了比较,结果显示... 详细信息

本文描述了利用直接边界元法求解定常兴波问题的理论和数值方法,本方法利用线性化自由面条件,辐射条件基于Dawson的四点差分格式进行处理。本文给出了Wigley船的兴波阻力和波高的数值结果,并与Dawson方法和试验结果进行了比较,结果显示本文的结果合理可靠。

关键词：直接边界元法船舶兴波兴波阻力四点差分格式 Dawson方法

the generation and evolution of the Archean continental crust:the granitoid story in southeastern Brazil

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Geoscience Frontiers 2022年第4期13卷 144-164页

作者： Rodrigo S.Marimon Chris J.Hawkesworth Elton L.Dantas Rudolph A.J.trouw Wilson teixeira Peter C.Hackspacher allen Fetter Ciro A.Ávila Silvia Volante Atlas V.Corrêa Neto Everton M.Bongiolo Rodrigo Vinagre Maurício Simon Depto.de Geologia IGEOUniversidade Federal do Rio de JaneiroUFRJRio de JaneiroRJBrazil School of Earth Sciences University of BristolBristolUnited Kingdom Instituto de Geociências Universidade de BrasíliaUnBBrasíliaDFBrazil Instituto de Geociências Universidade de São PauloUSPSão PauloSPBrazil Instituto de Geociências e Ciências Exatas Universidade Estadual PaulistaRio ClaroSPBrazil Institute of Geology Mineralogy and GeophysicsRuhr-Universität BochumUniversitätsstraße 15044801 BochumGermany ISOtOPIA Lab School of EarthAtmosphere and EnvironmentMonash UniversityWellington RdClaytonVIC 3800Australia Programa de Pós-Graduação em Geociências IGUniversidade Federal do Rio Grande do SulUFRGSPorto AlegreRSBrazil

the Archean Eon was a time of geodynamic *** evidence of these transitions come from igneous/metaigneous rocks,which dominate cratonic segments *** data for granitoids from an Archean basement inlier related to the Southern S?o Francisco Craton(SSFC),are integrated with geochronological,isotopic and geochemical data on Archean granitoids from the *** rocks are divided into three main geochemical groups with different ages:(1)ttG(3.02–2.77 Ga);(2)mediumto high-K granitoids(2.85–2.72 Ga);and(3)A-type granites(2.7–2.6 Ga).the juvenile to chondritic(Hf-Nd isotopes)ttG were divided into two sub-groups,ttG 1(low-HREE)and 2(high-HREE),derived from partial melting of metamafic rocks similar to those from adjacent greenstone *** compositional diversity within the ttG is attributed to different pressures during partial melting,supported by a positive correlation of Dy/Yb and Sr/Zr,and batch melting *** proposed ttG sources are geochemically similar to basaltic rocks from modern island-arcs,indicating the presence of subduction processes concomitant with ttG ***~2.85 Ga to 2.70 Ga,the dominant rocks were K-rich *** are modeled as crustal melts of ttG,during regional metamorphism indicative of crustal *** compositional diversity is linked to:(i)differences in source composition;(ii)distinct melt fractions during partial melting;and(iii)different residual mineralogies reflecting varying P–t ***-collisional(~2.7–2.6 Ga)A-type granites reflect rifting in that they were closely followed by extension-related dyke swarms,and they are interpreted as differentiation or partial melting products of magmas derived from subduction-modified *** sequence of granitoid emplacement indicates subduction-related magmatism was followed by crustal thickening,regional metamorphism and crustal melting,and post-collisional extension,similar to that seen in younger Wilson *** is compelling evide

关键词： Granitoid petrogenesis Archean geodynamics Crustal evolution ttGs A-types Batch melting calculations

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冰缘沉积物补给的减少会使裂点后退变慢吗?

世界地震译丛 2011年第4期42卷 59-64页

作者： J. D. Jansen D. Fabel P. bishop S. Xu C. Schnabel A. t. Codilean 孙昌斌（译）李德文（校）不详中国地震局地壳应力研究所

在有相对基准面下降良好约束记录的苏格兰西部的4条河流中,冰后期基岩侵蚀的速率可以通过测量溯源裂点以下侵蚀宽谷阶地原地宇宙成因10Be浓度确定。10Be暴露年龄的沿程坡降显示两个不同的趋势:向上游趋于年轻和一致的年龄,对此我们解释... 详细信息

在有相对基准面下降良好约束记录的苏格兰西部的4条河流中,冰后期基岩侵蚀的速率可以通过测量溯源裂点以下侵蚀宽谷阶地原地宇宙成因10Be浓度确定。10Be暴露年龄的沿程坡降显示两个不同的趋势:向上游趋于年轻和一致的年龄,对此我们解释为裂点后退和扩散搬运限制性下切的结果。我们发现,开始基岩河床下切和宽谷阶地的区域发育始于末次冰消期(距今11.5ka)不久,裂点后退速率在早—中全新世达到最大,之后不断下降达两个数量级,在晚全新世降到一个与单位河床面积流能无关的低速率。我们推断这种区域性的冰后期裂点后退变缓是全新世期间冰缘沉积物补给逐渐减少、导致基岩侵蚀缺乏"工具"的结果。我们的研究结果表明,主河流侵蚀时期可能与冰川旋回一致,冰期—间冰期过渡之后沉积物的减少可能是冰川作用区河流基岩侵蚀速率变化的重要原因。

关键词：沉积物退变补给冰缘河流侵蚀 ^10Be 暴露年龄河床下切

A Depth Resolved Insight into Benzoyl CoA Reductase and Benzoate Dioxygenase Gene Copy Numbers within a Marine Sediment Associated with Methane Seepage

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Open Journal of Marine Science 2013年第4期3卷 175-181页

作者： Paul V. Flanagan Brian P. Kelleher Shane S. O’Reilly Michal t. Szpak Xavier Monteys Paul P. Kelly Anna N. Kulakova Leonid A. Kulakov Christopher C. R. allen Geological Survey of Ireland Beggar’s Bush Dublin Ireland School of Biological Sciences Queen’s University Belfast Belfast UK School of Chemical Sciences Dublin City University Dublin Ireland

A marine sediment core obtained from a methane seepage site off the northern coast of Irelandwas analysed, at 3 depths, for catabolic genes associated with the aerobic and anaerobic degradation of aromatic compounds. Catabolic gene copy numbers varied through the core peaking at 2.1 meters below sediment surface (mbsf)-just above the sulphate boundary. Beyond the sulphate boundary gene copy numbers fell considerably, suggesting the boundary may be a critical factor in the degradation of aromatic compounds within marine sediments. At the 2.1 mbsf depth our data also suggest that known benzoyl CoA reductase utilizing bacteria are readily detectable.

关键词： Aromatic Compounds qPCR bcr bdo

Interim results from ongoing PhaseⅢ placebo-controlled,randomized trial of hepcortespenlisimut-L for advanced hepatocellular carcinoma indication

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Hepatoma Research 2020年第1期6卷 11-18页

作者： Aldar S.Bourinbaiar Jigjidsuren Chinburen Purev Batchuluun Chogsom Munkhzaya DandiiOyungerel Dorjiin Dandii Galyna A.Kutsyna Hulan tsogkhuu Marina G.tarakanovskaya Alan A.Reid Vika Borisova allen I.Bain Vichai Jirathitikal Immunitor Inc. VancouverBCV6K 2G8Canada National Cancer Center Ulaanbaatar 14000Mongolia National Center for Public Health Ulaanbaatar 13000Mongolia National Cancer Institute National Institutes of HealthBethesdaMD 20892USA Ekomed LLC Ulaanbaatar 13381Mongolia Immunitor China Ltd. ChaoyangBeijing 100027China

Aim:We aimed to further investigate the role of hepcortespenlisimut-L(Hepko-V5 or V5),a new oral immunotherapy developed by us,for hepatocellular carcinoma(HCC)***:the interim data from ongoing PhaseⅢplacebo-controlled,randomized trial were evaluated on the initial group of patients in advanced stage of HCC with emphasis on liver function and tumor marker alpha-fetoprotein ***,an in vitro study was undertaken to elucidate the mechanism of action of V5 by measuring with flow cytometry the expression of cytokines such as IL-2,INF-γ,and tNF-αand cell activation markers CD69 and Ki67 on CD4-and CD8-positive lymphocytes isolated from peripheral blood of healthy ***:As early as one month after treatment initiation,there was a clear improvement in alanine transaminase,aspartate transaminase,alkaline phosphatase,and bilirubin levels among HCC patients who received daily dose of V5,but not in the placebo ***,alpha-fetoprotein(AFP)levels among V5 recipients decreased,while in the ;placebo group they *** results are in line with in vitro observations indicating immune activation,as evidenced by many-fold enhancement of CD69,Ki67,and INF-γexpression and at the same time marked anti-inflammatory effect resulting in 10-fold decrease in tNF-αoutput and lack of influence on IL-2 ***:Hepcortespenlisimut-L,a tableted oral formulation derived from heat-inactivated pooled blood of patients with HCC and viral hepatitis shows beneficial clinical effect,as demonstrated by improvement in liver function and reduction of tumor marker AFP *** correlate with in vitro observations showing potent activation of the immune response and pronounced oral tolerance effect.

关键词： Hepatocellular carcinoma alpha-fetoprotein alanine transaminase aspartate transaminase IL-2 INF-γ tNF-α CD69 Ki67 CD4 CD8 t lymphocytes