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Delayed healing is common in in-situ urethroplasty patients after artificial sphincter cuff erosion

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Uroprecision 2024年第3期 95-99页

作者： Ethan L.Matz Banahene K.Glover Aaron M.Krug Brian T.Langford Bryce P.franzen Steven Hudak Maia Van Dyke allen f.morey Department of Urology University of Texas Southwestern Urology Clinical of North Texas

Introduction: Urethral erosion is a known complication of artificial urinary sphincter(AUS) surgery. We performed an in-situ urethroplasty(ISU) to reduce the healing time and time to reimplantation of the AUS. We sought to assess urethral integrity one month after ISU and to identify factors associated with delayed healing in our high-volume tertiary referral center ***: A retrospective review of our AUS database from 2009 to 2023 was conducted to identify all ISU cases. Patients were stratified as healed or nonhealed based on the absence of extravasation on voiding cystourethrogram(VCUG) obtained 4 weeks postoperatively. Background characteristics were evaluated including age, body mass index, diabetes, hypogonadism and smoking history. Operative variables included degree of erosion, location of defect, and the number of stitches required for ***: Among 98 patients undergoing an ISU, 61 underwent VCUG at one month. Of these, 34.4%(21/61) had evidence of delayed healing on VCUG requiring prolonged catheterization. Although a higher average number of repair sutures were used in ISU, this was not significant(p = 0.381). The most common complication in both groups was urinary tract infection(UTI). Nonhealed patients had a higher rate of UTI, without significant predilection towards fistula, stricture or diverticulum. No other patient or operative characteristic was significantly different between ***: Despite an aggressive approach to management via ISU, many patients still require prolonged catheterization after AUS erosion to ensure complete healing of the defect.

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Erectile function after urethral reconstruction

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Asian Journal of Andrology 2008年第1期10卷 75-78页

作者： Joshua Carlton Maharshi Patel allen f. morey Department of Urology UT Southwestern Medical Center Dallas Texas 75390-9110 USA

Advances in urogenital plastic surgical tissue transfer techniques have enabled urethral reconstruction surgery to become the new gold-standard for treatment of refractory urethral stricture disease. Questions remain, however, regarding the long-term implications on sexual function after major genital reconstructive surgery. In this article, we review the pathologic features of urethral stricture disease and urologic trauma that may affect erectile function （Ef） and assess the impact of various specific contemporary urethroplasty surgical techniques on male sexual function.

关键词： urethral reconstruction urethral stricture erectile function sexual function

Linking water and nutrients through the vadose zone: a fungal interface between the soil and plant systems

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Journal of Arid Land 2011年第3期3卷 155-163页

作者： Michael f allen Center for Conservation Biology University of California

Plant water availability, use, and management have largely focused on physical processes of infiltration and the role of roots in uptake and transpiration. However, roots and mycorrhizal fungi redistribute water in complex patterns. Here I describe some of our observations and experiments showing that mycorrhizal fungi play key roles in moving water for both transpiration and to facilitate nutrient acquisition under dry conditions. Mycorrhizal fungal hyphae grow from both surface and deep roots even into bedrock to help extract water under dry conditions. In both deep and surface roots, mycorrhizal fungi acquire water from pores too small for roots and root hairs to access, and at distances from roots and root hairs. Mycorrhizal fungi are also able to utilize hydraulic-lifted water from plants to obtain nutrients in extremely dry surface soils. The importance of these root symbionts in water and nutrient dynamics, and as integrators of surface and deeper water dynamics need further investigation.

关键词： mycorrhiza vadose zone hydraulic redistribution drought

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狗群驯化和社会联系的发展

国外科技新书评介 2011年第1期 7-8页

作者： Darcy f.morey（）

本书追溯了狗类从大约15000年前的起源到现代的进化历程，通过比较基于遗传学的不同模型和考古学证明，详细描述了狗类驯化过程。此外，狗类及其祖先——狼群之间的异速生长模型清楚表明狗类所经历的形态学特征的变化。本书重点阐述了... 详细信息

本书追溯了狗类从大约15000年前的起源到现代的进化历程，通过比较基于遗传学的不同模型和考古学证明，详细描述了狗类驯化过程。此外，狗类及其祖先——狼群之间的异速生长模型清楚表明狗类所经历的形态学特征的变化。本书重点阐述了狗类和人类之间一种特殊社会联系的发展，以及狗类和人类的关系如此密切的原因，在最后讨论了狗类在人类社会一些特别的现代角色。

关键词：人类社会驯化过程狗生长模型形态学特征考古学遗传学

Screening antioxidants for the protection of cochlear sensory cells

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Neural Regeneration Research 2018年第1期13卷 62-64页

作者： Dong Gu Hur Arwa Kurabi allen f.Ryan Department of Surgery/Otolaryngology School of Medicine University of CaliforniaSan Diego Department of Otorhinolaryngology Gyeongsang National University Changwon Hospital Research Service Veterans Administration Medical Center

Sensory cell damage is a major cause of hearing loss： Sensorineural hearing loss （SNHL） is a common sensory deficit characterized by tissue damage and/or cell death in the cochlea. Moderate and severe SNHL causes deficits in communication, associated with increased isolation from human relationships, and negativly impacts employabflity. Many etiologies have been associated with SNHL： Noise overexposure, certain drugs, inner or middle ear infection or immune-induced inflammation being common. However, the most prevalent form of SNHL is presbycusis or age-related hearing loss, often aggravated by other factors including a history of noise exposure, diabetes or high blood pressure （Wong and Ryan, 2015）. Though systemic steroids are used in the treatment of sudden SNHL, other drugs to prevent or cure hearing loss have not yet been developed. Cochlear sensory cells, known as hair cells （HCs） and neurons have very limited repair capacity. Moreover since these cells do not regenerate, making any loss permanent, prevention of cell damage is critical to protecting hearing.

关键词： HC Screening antioxidants for the protection of cochlear sensory cells

Chinese NGOs in action against HIV/AIDS

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Cell Research 2005年第Z1期 914-918页

作者： allen f ANDERSON School of Public and Environmental Affairs Indiana University Bloomington Indiana 47405-1701 USA

Chinese nongovernmental organizations (NGOs) have played a significant role in the battle against AIDS in the People’s Republic of China. This article provides a brief overview of the structure of these organizations, as well as an analysis of their principle accomplishments. Of great significance in this analysis is the fact that Chinese NGOs have effectively dealt with many sensitive health education areas that government authorities have felt reluctant to handle directly. As such, they have provided an indispensable component in the HIV/AIDS prevention and control calculus on the mainland.

关键词： HIV/AIDS NGO health education health intervention.

Genetic targeting of astrocytes to combat neurodegenerative disease

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Neural Regeneration Research 2020年第2期15卷 199-211页

作者： Rachel Kéry allen P. f. Chen Gregory W. Kirschen Medical Scientist Training Program MSTP)Stony Brook MedicineStony BrookNYUSA Department of Neurobiology & Behavior Stony Brook UniversityStony BrookNYUSA

Astrocytes, glial cells that interact extensively with neurons and other support cells throughout the central nervous system, have recently come under the spotlight for their potential contribution to, or potential regenerative role in a host of neurodegenerative disorders. It is becoming increasingly clear that astrocytes, in concert with microglial cells, activate intrinsic immunological pathways in the setting of neurodegenerative injury, although the direct and indirect consequences of such activation are still largely unknown. We review the current literature on the astrocyte’s role in several neurodegenerative diseases, as well as highlighting recent advances in genetic manipulation of astrocytes that may prove critical to modulating their response to neurological injury, potentially combatting neurodegenerative damage.

关键词： Alzheimer's disease amyotrophic lateral sclerosis glia immune system inflammation Parkinson's disease reactive astrocyte regeneration

Bone marrow-derived products: A classification proposal – bone marrow aspirate, bone marrow aspirate concentrate or hybrid?

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World Journal of Stem Cells 2020年第4期12卷 241-250页

作者： Joseph Purita Joséfábio Santos Duarte Lana morey Kolber Bruno Lima Rodrigues Tomas Mosaner Gabriel Silva Santos Carolina Caliari-Oliveira Stephany Cares Huber Institute of Regenerative Medicine Boca RatonFL 33432United States Institute of Bone and Cartilage IndaiatubaSP 13334-170Brazil Department of Physical Therapy Nova Southeastern UniversityFort LauderdaleFL 33314United States University of Campinas CampinasSP 13083-970Brazil In Situ Cell Therapy Ribeirao PretoSP 14056-680Brazil

Degenerative musculoskeletal disorders are one of the top causes of pain and disability in the adult *** available alternatives to mitigate symptoms include conservative treatments such as the administration of pharmacological agents and an educative approach towards lifestyle *** use of certain analgesics,such as opiates and corticosteroids,delivers short term results but do not address the etiological source of pain and ***,prolonged use of such medications may cause additional ***,the demand for musculoskeletal tissue regeneration has led to an alternative approach referred to as“orthobiologics”.This alternative is based on cellular and molecular components capable of inducing and promoting tissue *** marrow(BM)aspirate(BMA)and concentrate are well-known orthobiologics used to treat musculoskeletal *** derived from the BM have been discussed in the literature;however,the lack of standardization regarding collection and processing protocols presents a challenge for generalization of study outcomes and determination of *** BM-derived orthobiologics have not yet been classified,to our knowledge,this manuscript proposes the ACH classification system,which speaks to BMA(A),BMA and concentrate(C)and hybrid(H),which combines A and *** classification proposes and describes 8 parameters that are relevant for the quality of biological *** more parameters used would imply greater characterization and complexity of the evaluation of the biological product *** ACH classification envisages a necessary contribution to the comprehension of both clinical procedures and research outcomes,ultimately ushering in a standardization of best practice.

关键词： Bone-marrow classification Bone-marrow aspirate concentrate Regenerativemedicine Stem cells Musculoskeletal disorders Orthobiologics

Porous Medium flow with Both a fractional Potential Pressure and fractional Time Derivative

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Chinese Annals of Mathematics,Series B 2017年第1期38卷 45-82页

作者： Mark allen Luis CAffARELLI Alexis VASSEUR Department of Mathematics The University of Texas at AustinAustinTX 78712USA

The authors study a porous medium equation with a right-hand side. The operator has nonlocal diffusion effects given by an inverse fractional Laplacian *** derivative in time is also fractional and is of Caputo-type, which takes into account"memory". The precise model isD_t~αu- div(u(-Δ)^(-σ)u) = f, 0 f ≥ 0. The existence for weak solutions when f, u(0, x)have exponential decay at infinity is proved. The main result is H¨older continuity for such weak solutions.

关键词： Caputo derivative Marchaud derivative Porous medium equation Hlder continuity Nonlocal diffusion