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World Journal of Gastroenterology 2024年第13期30卷 1780-1790页

作者： Katsuhiro Kita allen burdowsk. Department of Biology St.Francis CollegeBrooklynNY 11201United States

Colorectal cancer(CRC)has remained the second and the third leading cause of cancer-related death worldwide and in the United States,*** significant improvement in overall survival has been achieved,death in adult populations under the age of 55 appears to have increased in the past *** new classes of therapeutic strategies such as immunotherapy have emerged,their application is very limited in CRC so ***(MT)inhibitors such as taxanes,are not generally successful in *** may be some way to make MT inhibitors work effectively in *** potential advantage that we can take to treat CRC may be the combination of optical techniques coupled to an endoscope or other fiber optics-based devices.A combination of optical devices and photo-activatable drugs may allow us to locally target advanced CRC cells with highly potent MT-targeting *** this Editorial review,we would like to discuss the potential of optogenetic approaches in CRC management.

关键词： Colorectal cancer Chemotherapy Microtubule Combretastatin Photopharmacology

Physiology of medicinal and aromatic plants under drought stress

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The Crop Journal 2024年第2期12卷 330-339页

作者： Zohreh Emami Bistgani allen V.Barker Masoud Hashemi Isfahan Agricultural and Natural Resources Research and Education Center Agricultural Research Education and Extension Organization(AREEO)Isfahan 81748-35117Iran Stockbridge School of Agriculture University of MassachusettsAmherstMA 01002USA

Drought poses a significant challenge,restricting the productivity of medicinal and aromatic *** strain induced by drought can impede vital processes like respiration and photosynthesis,affecting various aspects of plants’growth and *** response to this adversity,medicinal plants employ mechanisms such as morphological and structural adjustments,modulation of drought-resistant genes,and augmented synthesis of secondary metabolites and osmotic regulatory substances to alleviate the *** water scarcity can lead to leaf wilting and may ultimately result in plant *** cultivation and management of medicinal plants under stress conditions often differ from those of other *** is because the main goal with medicinal plants is not only to increase the yield of the above-ground parts but also to enhance the production of active ingredients such as essential *** elucidate these mechanisms of drought resistance in medicinal and aromatic plants,the current review provides a summary of recent literature encompassing studies on the morphology,physiology,and biochemistry of medicinal and aromatic plants under drought conditions.

关键词： Drought stress Medicinal and aromatic plants Phytochemistry Physiology

Convergent plate boundary environments for formation of≥3800 Ma mafic-ultramafic assemblages(Isua area,Greenland):Implications for early global geodynamics

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Geoscience Frontiers 2024年第3期15卷 119-136页

作者： allen P.Nutman Clark R.L.Friend Vickie C.Bennett School of Earth Atmospheric and Life SciencesUniversity of WollongongWollongongNSW 2522Australia Glendale TiddingtonOxon OX92LQUK Research School of Earth Sciences Australian National UniversityCanberraACT 2601Australia

In the gneiss terrane on the south side of the Eoarchean Isua supracrustal belt,ultramafic rocks with relict abyssal peridotite mineralogy(Bennett et al.,2002;Friend et al.,2002;Nutman et al.,2007;Rollinson,2007;van de Löcht et al.,2020),layered gabbros with cumulate ultramafic rocks,basalts and associated siliceous sedimentary rocks were tectonically-imbricated,prior to and during intrusion of ca.3800 Ma *** with3800 Ma basalts in the Outer Arc Group of the nearby Isua supracrustal belt,the composition of all these mafic rocks(e.g.,Th-Hf-Nb systematics,high Th/Yb,Ba/Nb,Ba/Yb ratios and negative Nb and Ti anomalies)shows affinity with modern suprasubduction rocks whose genesis involved fluid fluxing of the upper ***,the majority of these samples have Ba/Nb and Ba/Yb values less than in modern island arc magmas,but similar to many backarc basin magmas(e.g.,Pearce and Stern,2006).It is unknown whether these ca.3800 Ma mafic rocks are,(i)arc rocks where the Ba/Nb and Ba/Yb signatures reflect lower surficial Ba in Eoarchean oceanic settings,or(ii)in direct comparison with Phanerozoic suites,these signatures reflect a back-arc setting with interplay between fluid fluxing and decompressional *** tectonic intercalation of upper mantle with lower and upper crustal rocks,combined with the fluid-fluxing influences seen in chemistry of all the mafic rocks is best accommodated in a compressional Eoarchean convergent plate boundary setting within a mobile-lid *** stagnant lid scenarios of crust formation,if operative,must have co-existed or alternated with mobile-lid regimes by 3800 Ma.

关键词： Eoarchean Fluid-fluxing Plate tectonics Suprasubduction Crustal evolution

Dual innervation method to preserve erectile function following prostatectomy

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 159-160页

作者： Nadia Hui Shan Sim allen Sim Dayna Sim Bien-Keem Tan allen Wei-Jiat Wong Plastic Reconstructive and Aesthetic Surgery ServiceSengkang General Hospital544886Singapore Department of Urology Mount Alvernia Hospital Singapore574623Singapore Department of General Surgery Sengkang General Hospital544886Singapore Department of Plastic Reconstructive and Aesthetic SurgerySingapore General Hospital169608Singapore

Prostate cancer is the second most prevalent cancer in ***-assisted radical prostatectomy(RARP)has altered the landscape of prostate cancer *** the excellent oncological outcomes associated with RARP,the rate of erectile dysfunction(ED)remains *** repair of disrupted cavernous nerves with interpositional nerve grafts has been described;however,the outcomes have been *** hypothesize that this is attributed to Schwann cell atrophy and axonal regeneration limitations caused by long nerve *** proposed the use of nerve transfer to support axonal regrowth via an inter-positional graft with additional donor axons.A cadaveric study was performed to evaluate the anatomical feasibility of a vastus lateralis nerve(VLN)transfer to the distal recipient cavernous nerve *** VLN is long with multiple branching patterns that allow tension-free coaptation of the cavernous *** postulate that a dual innervation method using VLN nerve transfer together with interpositional nerve graft repair of the transacted cavernous nerves may improve the outcomes of ED post-RARP.

关键词： Erectile dysfunction Prostatectomy Interposition nerve graft Nerve transfer Vastus lateralis nerve

Enhancing Mutual Trust and Tapping into New Areas and Potentials for Bilateral Cooperation——Exclusive Interview with Namibian Ambassador to China,Elia George Kaiyamo

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China's Foreign Trade 2024年第5期 17-18页

作者： allen Zhang 不详

The 2024 Forum on ChinaAfrica Cooperation Summit was held in Beijing from September 4 to *** and trade cooperation serves as the"ballast stone"and"propeller"of China-Africa *** an exclusive interview with China's Foreign Trade conducted in Beijing recently,Namibian Ambassador to China,Elia George Kaiyamo,discussed Namibian-China bilateral trade and twoway investment,stating that since the establishment of diplomatic relations in1990,China and Namibia have made remarkable achievements in both economic and trade cooperation,which have become the most dynamic and potential components of bilateral relations.

关键词： investment interview cooperation

Stand dynamics of old-growth hemlock forests in central Bhutan are shaped by natural disturbances

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Forest Ecosystems 2024年第4期11卷 434-447页

作者： Karma Tenzin Craig R.Nitschke Kathryn J.allen Raphael Trouve Thiet V.Nguyen Patrick J.Baker School of Agriculture Foodand Ecosystem SciencesUniversity of Melbourne500 Yarra BlvdRichmondVictoriaAustralia School of Geography Planningand Spatial SciencesUniversity of TasmaniaSandy BayTasmaniaAustralia Forest Science Institute of South Vietnam 1 Pham Van Hai StreetTan Binh DistrictHo Chi Minh CityViet Nam

Understanding how past disturbances have influenced the development of forests is critical for deciphering their current structure and composition and forecasting future *** this study,dendrochronological methods were applied to uncover the disturbance history of old-growth hemlock-dominated forests in central *** of tree-ring samples from two old-growth hemlock stands,located in two different topographic settings,identified the importance of gap-phase dynamics in facilitating recruitment and growth releases and producing complex,multi-aged structure s over *** site showed evidence of a near stand-replacing disturbance in the late 1700s,while the other showed no evide nce of high-severity disturbance at any time over the last 400 *** both sites low-to medium-severity disturbances,some of which appear to be associated with cyclones originating in the Bay of Bengal,dominated the disturbance *** hemlock stands exhibited a significant positive association between cyclone occurrence and growth release events and between recruitment pulses and growth release *** 1800 to 1970 there was an increase in recruitment of angiosperm tree species at most sites and a corresponding decline in conifer *** the past 50 years there has been little new recruitment;this may be due to light limitation in the understory from shade-tolerant angiosperms and bamboo in the lower strata of these *** variations in disturbance dynamics and recruitment were observed across the study sites,suggesting that other factors,such as topography and climate,may be influencing long-term stand development *** study highlights the complex interplay between historical disturbance regimes and tree recruitment in shaping the age and size structures of old-growth hemlock forests in central *** also provides new insights into the dynamics of these forests that can be used to support effective forest conservation and management i

关键词： Forest structure Hemlock forest Himalaya Natural disturbance

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微塑料和纳米塑料威胁青藏高原环境

Science Bulletin 2024年第5期69卷 589-592页

作者：张玉兰康世昌罗犀 Tanuj Shukla 高坛光 Deonie allen Steve allen Melanie Bergmann State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000China School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham 200003UK Ocean Frontiers Institute Dalhousie UniversityHalifax B3H 4R2Canada Alfred-Wegener-Institut Helmholtz-Zentrum für Polar-und Meeresforschung Bremerhaven D-27515Germany University of Chinese Academy of Sciences Beijing 100049China

Plastic pollution is a planetary level threat which affects Earth’s environment and *** the poles to deep ocean basins,the growth of plastic waste has already exceeded its *** projected increase of plastic production and waste generation over the coming years makes the situation even more *** after stagnation in 2020 due to the COVID-19 pandemic,the global plastic production has also increased from 335 to 391 million metric tons(Mt)between 2016 and 2021(Fig.S1 online);yet currently post-consumer recycled and bio-based/attributed plastics only accounts~9%of the world’s plastic production[1].Statistically.

关键词：微塑料 attributed plastics

Low phase noise K-band signal generation using polarization diverse single-soliton integrated microcombs

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Photonics Research 2024年第6期12卷 1175-1185页

作者： ALWALEED ALDHAFEERI HSIAO-HSUAN CHIN TRISTAN MELTON DONG IL LEE allen CHU WENTING WANG MINGBIN YU PATRICK GUO-QIANG LO DIM-LEE KWONG CHEE WEI WONG Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCalifornia 90095USA Institute of Microelectronics A*STARSingapore 117865Singapore State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technologyand Shanghai Industrial Technology Research InstituteShanghai 200050China

Frequency microcombs with microwave and millimeter-wave repetition rates provide a compact solution for coherent communication and information *** implementation of these microcombs using a CMOS-compatible platform further paves the way for large-scale photonic integration and ***,we demonstrate free-running soliton microcombs with K-band repetition rates with very low phase noise over a 4 GHz pump detuning range reaching−117(−123)dBc/Hz at 10 kHz offset for a 19.7(10)GHz carrier without active pump stabilization,exceeding commercial electronic microwave oscillators at frequency offsets above 40 *** minimum laser noise to soliton microwave signal transduction factor observed is−*** noise performance is achieved using a hybridized dual-mode for soliton generation to achieve passive thermal stabilization and minimal soliton spectrum shift from prior Raman scattering and dispersive wave *** further examine the locking of the repetition rate to an external ultrastable photonic oscillator to illustrate the feasibility of phase noise suppression below the thermorefractive noise limits of microresonator frequency combs.

关键词： pump polarization millimeter

Exploring the Reasons for Selfie-Taking and Selfie-Posting on Social Media with Its Effect on Psychological and Social Lives:A Study among Indian Youths

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International Journal of Mental Health Promotion 2024年第5期26卷 389-398页

作者： Divya P.Vijayan Tokani Ghuhato Eslavath Rajkumar allen Joshua George Romate John John Abraham Department of Psychology Central University of KarnatakaKalaburagi585367India Department of Liberal Arts Indian Institute of Technology BhilaiChhattisgarh491002India Liberal Arts&Sciences Indian Institute of Management RanchiJharkhand834001India Department of Family Medicine/Geriatrics St.John’s National Academy of Health SciencesBangalore560034India

‘Selfie’taking was introduced to the common people by smartphones and has become a common practice across the globe in no *** technological advancement and the popularity of smartphones,selfie-taking has grown rapidly within a short *** light of the new trend set by the generation,this study aimed to explore reasons for selfie-taking and selfie-posting on social media and their effects on the social and psychological lives of young adults.A purposive sampling method was adopted to select 20 Indian citizens,between 18 and 24 *** data were collected through semi-structured interviews and analysed using thematic ***-taking and posting on social media give positive feelings,and it acts as a mood modifier dependent mostly on the favourability and feedback about the post which in turn affects emotions and self-satisfaction.

关键词： Selfie social media social networking sites obsessive selfie-taking Indian youth

Improving a Patient’s CVD Risk Assessment—Updating the Interpretation of the Lipid Profile

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World Journal of Cardiovascular Diseases 2024年第9期14卷 515-520页

作者： David S. Schade allen Adolphe Robert Philip Eaton Department of Internal Medicine University of New Mexico Health Sciences Albuquerque USA Department of Internal Medicine School of Medicine University of New Mexico Albuquerque USA

The lipid profile remains an important laboratory assessment to prevent cardiovascular disease. Interpretation of the non-fasting lipid profile has significantly changed based on new information concerning the pathogenesis of atherosclerosis. In particular, the assessment of risk from cholesterol containing particles following triglyceride metabolism (termed remnant cholesterol) can now be done from a lipid profile. In addition, non-HDL cholesterol as calculated from the lipid profile will provide a complete assessment of total circulating cholesterol containing particles. Furthermore, the formula for measurement of LDL cholesterol from a lipid profile has now been revised so that triglyceride levels exert less interference. Finally, the old concept that the “higher the HDL-c, the better” is no longer tenable. New data indicate that the optimal high density lipoprotein level is below 100 mg/dl for both male and female patients. Correct interpretation of the lipid profile will optimize anti-atherosclerotic therapy and reduce the number one cause of death in the United States.

关键词： Lipid Profile Atherosclerotic Risk Cardiovascular Disease High Density Lipoprotein Low Density Lipoprotein