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the Prognostic Value of Myocardial Deformation in Patients with Congenital Aortic Stenosis

Congenital Heart Disease 2021年第3期16卷 221-232页

作者： Roderick W.J.van Grootel allard t.van den hoven Dan Bowen tijmen Ris Jolien W.Roos-Hesselink Annemien E.van den Bosch Department of Cardiology Erasmus Medical CentreRotterdamThe Netherlands

Aims:to assess the prognostic value of left ventricular(LV)global longitudinal strain(GLS)and global longitudinal early diastolic strain rate(GLSre)with regard to cardiovascular events,as congenital aortic stenosis(AoS)is associated with significant mortality and morbidity but predictors for clinical outcome are *** analysis provides a robust and reproducible method for early detection of LV dysfunction,which might be of prognostic ***:this prospective study,included clinically stable patients with congenital AoS between 2011–*** GLS and GLSre was performed in the apical 4,3 and 2-chamber views using tomtec *** endpoint was a composite of death,heart failure,hospitalization,arrhythmia,thrombo-embolic events and ***:In total 138 patients were included(33[26–43]years,86(62%)male),NYHA class I:134(97%).Mean LV GLS was–15.3±3.2%,GLSre 0.66±0.18 s–*** correlated with Nt-proBNP,LV volumes and ejection fraction(strongest LV GLS with LV EF:r–0.539,ptrongest LV GLSre with age:r–0.376,pthe endpoint occurred in 53(38%)patients:4 patients died,9 developed heart failure,22 arrhythmias,8 thrombo-embolic events and 35 *** LV GLS(standardized HR(sHR 0.62(95%CI 0.47–0.81)and GLSre(sHR 0.62(95%CI 0.47–0.83)were associated with the *** multivariable analysis showed that both GLS and GLSre were associated independent of left atrial volume,Nt-proBNP and prior ***:Left ventricular GLS and GLSre are reduced in adult patients with congenital *** markers are associated with adverse cardiac events and have clear clinical relevance.

关键词： Speckle tracking echocardiography congenital aortic stenosis strain prognosis

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Systolic and Diastolic Strain Measurements Show Left Ventricular Dysfunction in Women with turner Syndrome

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Congenital Heart Disease 2021年第4期16卷 357-368页

作者： allard t.van den hoven Sultan Yilmazer Lidia R.Bons Roderick W.Jvan Grootel L.W.Geenen An M.van Berendoncks Anthonie L.Duijnhouwer Hans-Marc J.Siebelink Jolien W.Roos-Hesselink Annemien E.van den Bosch Department of Congenital Cardiology Erasmus MCRotterdamNetherlands Department of Cardiology Radboud University Medical CenterNijmegenNetherlands Department of Cardiology Leiden University Medical CenterRotterdamNetherlands

Aim:this study aimed to describe the systolic left ventricular global longitudinal strain(LvGLS)and left ventricular peak early diastolic strain rate(Sre)in adult women with turner syndrome(tS)and to determine its relationship with exercise capacity and clinical ***:In this cross-sectional cohort study,consecutively included adult tS women underwent an electrocardiogram,transthoracic echocardiogram(ttE)and cardiopulmonary exercise test(CPEt)on the same *** and Sre were measured using 2D speckle tracking analysis(StE)and compared with age-matched healthy female ***:Ninety-four adult women(age 36±13 years)with tS and 32 healthy age-matched female controls were *** with tS had a significantly impaired/reduced systolic LvGLS(–17.82±2.98%vs.–21.80±1.85%,p0.001),compared to healthy female ***,tS women had reduced diastolic function as measured by conventional echocardiographic parameters:A higher A-wave(ptio(p=0.001),longer deceleration time(p=0.006),and a higher E/E’-ratio(pth tS also had a significantly reduced maximal workload(p=0.033),reduced oxygen uptake(pt rate(pthat Age,karyotype and Qt-duration were significantly associated with Sre,but not with LvGLS,in the tS ***:Systolic and diastolic strain and exercise capacity were significantly reduced in tS women compared to healthy *** correlation between strain itself and exercise capacity could be demonstrated,but correlations with conventional ttE parameters and baseline characteristics were found.

关键词： turnersyndrome speckletracking echocardiography strain exercise capacity

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经肝动脉^90Y放射性栓塞治疗的新进展

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中华核医学与分子影像杂志 2018年第8期38卷 573-581页

作者：李莉(译) 冯对平(译) 李思进(审校) Arthur J.A.t. Braat Maarten L.J. Smits Manon N.G.J.A. Braat Andor F. van den hoven Jip F. Prince Hugo W.A.M. de Jong Maurice A.A.J. van den Bosch Marnix G.E.H. Lam 山西医科大学第一医院核医学科太原030001 山西医科大学第一医院介入科太原030001

放射性栓塞治疗（RE）是经过10余年探索而建立起来的一种治疗模式，发展迅速。该文对RE领域新进展进行综述，就RE患者选择、疗效判断以及将来的临床应用进行探讨。

关键词：放射性栓塞剂量学肝脏恶性肿瘤肝血管系统 ^90Y

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