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Pomegranate extract inhibits EMT in clear cell renal cell carcinoma in a NF-κB and JNK dependent manner

Asian Journal of Urology 2015年第1期2卷 38-45页

作者： Jiabin An Yanchuan Guo Ting Wang allan J.pantuck Matthew B.Rettig Department of Medicine Division of Hematology-OncologyVA Greater Los Angeles Healthcare SystemLos AngelesCA90073USA Technical Institute of Physics and Chemistry Chinese Academy of ScienceBeijing100190China Department of Urology David Geffen School of Medicine at UCLALos AngelesCA90095USA Department of Medicine Division of Hematology-OncologyDavid Geffen School of Medicine at UCLALos AngelesCA90095USA

Objective:Clear cell renal cell carcinoma(ccRCC)is the most common subtype of renal cell carcinoma(RCC)and is characterized by biallelic inactivation of the von Hippel-Lindau(VHL)tumor suppressor *** effect of VHL inactivation is hypoxia inducible factor alpha(HIFa)-independent constitutive activation of nuclear factor kappa B(NF-κB)and c-jun N-terminal kinase(JNK).Both NF-κB and JNK drive ccRCC growth and epithelial to mesenchymal transition(EMT).The purpose of this study was to determine the biochemical effects of pomegranate juice extracts(PE)on RCC cell ***:The pre-clinical effects of PE on NF-κB,JNK,and the EMT phenotype were assayed,including its effect on proliferation,anchorage-independent growth,and invasion of pVHLdeficient ***:PE inhibits the NF-κB and JNK pathways and consequently inhibits the EMT phenotype of pVHL-deficient *** effects of PE are concentration-dependent and affect not only biochemical markers of EMT(i.e.,cadherin expression)but also functional manifestations of EMT,such as *** effects are manifested within days of exposure to PE when diluted *** dilute concentrations of PE(106 dilution),which do not impact these pathways in the short term,were found to have NF-κB and JNK inhibitory effects and ability to reverse the EMT phenotype following prolonged ***:These findings suggest that PE may mediate inhibition growth of pVHL-deficient ccRCCs and raises the possibility of its use as a dietary adjunct to managing patients with active surveillance for small,localized,incidentally identified renal tumors so as to avoid more invasive procedures such as nephrectomy.

关键词： Pomegranate extract von Hippel-Lindau(VHL)tumor suppressor Clear cell renal cell carcinoma c-Jun N-terminal kinase Epithelial to mesenchymal transition Nuclear factor kappa B

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Saw Palmetto-Based Nutritional Supplement Prostataplex Relieves Symptoms of Benign Prostatic Hyperplasia (BPH) in Patients with Mild to Moderate BPH

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Open Journal of Urology 2012年第3期2卷 104-108页

作者： Qingwen Xie Jing Leng Jianwei Lv allan pantuck Lawrence Yen Mina Shariff Kenneth Kami Jianyu Rao Rong Shi Department of Pathology and Laboratory Medicine David Geffen School of Medicine University of California Los Angeles USA Department of Preventive Medicine School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China Department of Research DRM Resources Costa Mesa USA Department of Urology David Geffen School of Medicine University of California Los Angeles USA Department of Urology Shanghai Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

The goal of this study was to assess the efficacy of the saw palmetto-based nutritional supplement, Prostataplex, for relieving the symptoms associated with benign prostatic hyperplasia (BPH) in men with mild to moderate degrees of BPH. A randomized, double-blind, placebo-controlled trial was performed in Shanghai, China. Eighty patients with BPH were randomly assigned to either the intervention group (39 cases) or control group (41 cases). Patients in the intervention group were administered Prostataplex orally and placebos were given to patients in the control group. The duration of treatment was 12 weeks in both groups. Following the intervention of Prostataplex, the maximum urinary flow rates (MFR), total scores of International Prostate Symptom Score (IPSS) and quality of life indicators were significantly better among the patients in the intervention group than those in the control group (P < 0.01 for all variables). Significant improvement of symptoms including dysuria, reducing nocturnal polyuria and increasing urinary flow rate was seen after two months of intervention, especially for the improvement of incomplete bladder emptying. Prostataplex has positive effects on improving symptoms as well as quality of life in men with mild to moderate BPH.

关键词： Saw Palmetto Prostataplex Benign Prostatic Hyperplasia Intervention

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