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Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis

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World journal of Gastroenterology 2017年第2期23卷 336-344页

作者： Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K jacobson Peter jüsten Pierre Desreumaux Lesaffre Human Care Lesaffre Group Biofortis-Mérieux NutriS ciences Lesaffre Yeast Corporation Lesaffre Group CHU Lille Department of GastroenterologyClaude Huriez Hospital Lille University North of France INSERM U995

AIMTo confirm previous conclusions on Saccharomyces cerevisiae (S. cerevisiae) CNCM I-3856 for irritable bowel syndrome (IBS) *** individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal (GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve (AUC) and weekly means], responder status, and bowel movements (stool frequency and consistency). Statistical analyses were conducted in Intent to Treat (ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline (“IBS-C ≥ 2 subpopulation”).RESULTSS. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC (W5-W8)] with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group (P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group (P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit (a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder (reduction of 1 a.u. of abdominal pain/discomfort) comp

关键词： Irritable bowel syndrome Saccharomyces cerevisiae Constipation Abdominal pain Probiotics

STEM教育视域下虚拟学习环境Omosa项目分析及应用启示

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中国电化教育 2016年第12期 22-30页

作者：韩建华姜强赵蔚 Michael j. jacobson 东北师范大学计算机科学与信息技术学院吉林长春130117 悉尼大学教育和社会工作学院澳大利亚新南威尔士州2006

Omosa是澳大利亚悉尼大学基于STEM理念开发的虚拟学习环境,模拟星球生态系统关系,用于培养学生的知识建构与创新能力。利用模型构建的方法分析了Omosa虚拟学习环境的内部结构模型和外部结构特征,其学习者模块、环境模块、代理模块、事... 详细信息

Omosa是澳大利亚悉尼大学基于STEM理念开发的虚拟学习环境,模拟星球生态系统关系,用于培养学生的知识建构与创新能力。利用模型构建的方法分析了Omosa虚拟学习环境的内部结构模型和外部结构特征,其学习者模块、环境模块、代理模块、事件模块和干预模块协调有序地配合,构筑了浸润式的类似于真实的学习环境,使学生在参与科学探究过程中有意义地建构科学、工程等学科知识。基于Omosa三维环境和二维环境的实现机制、个体代理推理机制和算法机制,实现了一个开放的、复杂的和适应性的智能学习环境,学生可主动地探索虚拟世界中事物之间的关系,寻求解决问题的策略,使学习转变为一个意义建构的生态过程。以Netlogo环境为例,设计了教师教和学生学的双重过程模型,基于5E学习循环模型开展项目活动,通过学习效能量表调查发现学生在自我效能、动机、元认知意识、技能等方面均有提升。此外,虚拟学习环境的认知工具和可视化学习工具及学习资源帮助学生提升了问题解决能力,促进了学习者计算性思维和高阶思维的发展,有助于MOOC学习和创客教育。

关键词：虚拟学习环境 STEM Omosa 问题解决知识建构

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WHO西太区专家组评估中国MDT的报告

中国麻风皮肤病杂志 1993年第1期 2-5页

作者： Abella j Farrugia R Frankel R jacobson R 张国成

麻风在中国已流行2000多年,据文献介绍,过去全国大多数地方的患病率和发病率均很高。1939年估计有一百万病例,到1990年底登记的有50多万。 1949～1950年,中华人民共和国成立时,估计有50万病人。那时没有麻风防治计划,氨苯砜(50年代中期... 详细信息

麻风在中国已流行2000多年,据文献介绍,过去全国大多数地方的患病率和发病率均很高。1939年估计有一百万病例,到1990年底登记的有50多万。 1949～1950年,中华人民共和国成立时,估计有50万病人。那时没有麻风防治计划,氨苯砜(50年代中期以后才被引进中国)也没有得到应用。

关键词：麻风防治病人多菌型皮肤查菌 MDT WHO 专家组中华人民共和国

Spontaneous Imbibition of Water and Determination of Effective Contact Angles in the Eagle Ford Shale Formation Using Neutron Imaging

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journal of Earth Science 2017年第5期28卷 874-887页

作者： Victoria H.DiStefano Michael C.Cheshire joanna McFarlane Lindsay M.Kolbus Richard E.Hale Edmund Perfect Hassina Z.Bilheux Louis j.Santodonato Daniel S.Hussey David L.jacobson jacob M.LaManna Philip R.Bingham Vitaliy Starchenko Lawrence M.Anovitz Physical Sciences Directorate Chemical Sciences Division Oak Ridge National Laboratory Bredesen Center University of Tennessee Energy & Environmental Sciences Directorate Energy & Transportation Sciences Division Oak Ridge National Laboratory Neutron Sciences Directorate Chemical and Engineering Materials Division Oak Ridge National Laboratory Nuclear Science & Engineering Directorate Reactor & Nuclear Systems Division Oak Ridge National Laboratory Department of Earth and Planetary Science University of Tennessee Neutron Sciences Directorate Instrument and Source Division Oak Ridge National Laboratory Physical Measurement Laboratory National Institute of Standards and Technology Energy & Environmental Sciences Directorate Electrical & Electronics Systems Research DivisionOak Ridge National Laboratory

Understanding of fundamental processes and prediction of optimal parameters during the horizontal drilling and hydraulic fracturing process results in economically effective improvement of oil and natural gas extraction. Although modern analytical and computational models can capture fracture growth, there is a lack of experimental data on spontaneous imbibition and wettability in oil and gas reservoirs for the validation of further model development. In this work, we used neutron im- aging to measure the spontaneous imbibition of water into fractures of Eagle Ford shale with known geometries and fracture orientations. An analytical solution for a set of nonlinear second-order diffe- rential equations was applied to the measured imbibition data to determine effective contact angles. The analytical solution fit the measured imbibition data reasonably well and determined effective con- tact angles that were slightly higher than static contact angles due to effects of in-situ changes in veloci- ty, surface roughness, and heterogeneity of mineral surfaces on the fracture surface. Additionally, small fracture widths may have retarded imbibition and affected model fits, which suggests that aver- age fracture widths are not satisfactory for modeling imbibition in natural systems.

关键词： spontaneous imbibition effective contact angle neutron imaging Eagle Ford shale rock fractures.

Towards a downstream passage solution for out-migrating American eel (Anguilla rostrata) on the St. Lawrence River

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Aquaculture and Fisheries 2021年第2期6卷 151-168页

作者： Thomas C.Pratt David R.Stanley Scott Schlueter jake K.L.La Rose Andrew Weinstock Paul T.jacobson Fisheries and Oceans Canada Great Lakes Laboratory for Fisheries and Aquatic Sciences1219 Queen Street EastSault Ste.MarieOntarioP6A 2E5Canada Ontario Power Generation Inc. Environment Division14000 Niagara ParkwayNiagara on the LakeOntarioL0S 1J0Canada United States Fish and Wildlife Service New York Field Office3817 Luker RoadCortlandNY13045USA Ontario Ministry of Natural Resources and Forestry Lake Ontario Management Unit41 Hatchery LanePictonOntarioK0K 2T0Canada New York Power Authority Environment Division123 Main StWhite PlainsNY10601USA Electric Power Research Institute 3420 Hillview AvenuePalo AltoCA94304USA

There is a need to develop safe and effective downstream passage for diadromous anguillid eels on large rivers,where the combination of physical screening and bypass structures that is used to protect eel on smaller rivers is *** Eel Passage Research Center was established in 2013 to address the challenge of providing safe passage for out-migrating silver-stage American eel(Anguilla rostrata)on the *** River,the outflow of the Laurentian Great Lakes,which is spanned by two large,mainstem hydroelectric generating *** Center’s goal is to develop the technology to behaviorally guide eel to a collection point for capture and transfer around the two generating *** achieve this goal,three parallel initiatives were undertaken;1)research into behavioral guidance techniques suitable for guiding out-migrating eel on large,high flow rivers,2)the evaluation of sonar technologies for detection of eel,necessary for assessing in situ guidance,and 3)the commissioning of literature reviews for the most promising guidance technologies.A number of behavioral guidance stimuli,including electricity,flow,sound and electromagnetic fields were examined in laboratory and flume settings for their utility in guiding out-migrating silver-stage *** the techniques examined,only sound showed any promise for *** sonar technologies(Simrad 120 kHz EK60 echosounder,Sound Metrics ARIS Explorer 1800 sonar,and the Kongsberg Mesotech 500 kHz M3 multi-mode multibeam sonar)were evaluated to determine if existing acoustic technologies could be used to estimate the relative abundance and distribution of out-migrating silver-phase American eel in the *** *** the ARIS unit could successfully identify eel targets,and only over a short(<15 m)*** immense volume of sonar data accumulated over a portion of a single outmigration season contributed to the successful development of machine learning tools to automate the identification of American e

关键词： American eel Downstream passage Behavioral guidance Light diversion

SQL Server 2000 Analysis Services学习指南 4

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Comparative functional genomics identifies an iron-limited bottleneck in a Saccharomyces cerevisiae strain with a cytosolic-localized isobutanol pathway

丛书名：微软公司核心技术书库

2001年

作者：（美）Reed jacobson 江帆文化艺术中心译

本书对Microsoft SQL Server 2000的Analysis Services的组件进行了详细的介绍，对多维术语进行了解释。

ISBN: (纸本)7111090063

本书对Microsoft SQL Server 2000的Analysis Services的组件进行了详细的介绍，对多维术语进行了解释。

关键词：关系型数据库学科:数据库管理系统数据库管理系统

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Synthetic and Systems Biotechnology 2022年第2期7卷 738-749页

作者： Francesca V.Gambacorta Ellen R.Wagner Tyler B.jacobson Mary Tremaine Laura K.Muehlbauer Mick A.McGee justin j.Baerwald Russell L.Wrobel john F.Wolters Mike Place joshua j.Dietrich Dan Xie jose Serate Shabda Gajbhiye Lisa Liu Maikayeng Vang-Smith joshua j.Coon Yaoping Zhang Audrey P.Gasch Daniel Amador-Noguez Chris Todd Hittinger Trey K.Sato Brian F.Pfleger DOE Great Lakes Bioenergy Research Center University of Wisconsin-MadisonMadisonWIUSA Department of Chemical and Biological Engineering University of Wisconsin-MadisonMadisonWIUSA Laboratory of Genetics Center for Genomic Science InnovationUniversity of Wisconsin-MadisonMadisonWIUSA Department of Bacteriology University of Wisconsin-MadisonMadisonWIUSA Department of Chemistry University of Wisconsin-MadisonMadisonWIUSA Wisconsin Energy Institute J.F.Crow Institute for the Study of EvolutionUniversity of Wisconsin-MadisonMadisonWIUSA Department of Biomolecular Chemistry University of Wisconsin-MadisonMadisonWIUSA

Metabolic engineering strategies have been successfully implemented to improve the production of isobutanol,a next-generation biofuel,in Saccharomyces ***,we explore how two of these strategies,pathway re-localization and redox cofactor-balancing,affect the performance and physiology of isobutanol producing *** equipped yeast with isobutanol cassettes which had either a mitochondrial or cytosolic localized isobutanol pathway and used either a redox-imbalanced(NADPH-dependent)or redox-balanced(NADH-dependent)ketol-acid reductoisomerase *** then conducted transcriptomic,proteomic and metabolomic analyses to elucidate molecular differences between the engineered *** localization had a large effect on isobutanol production with the strain expressing the mitochondrial-localized enzymes producing 3.8-fold more isobutanol than strains expressing the cytosolic ***-balancing did not improve isobutanol titers and instead the strain with the redox-imbalanced pathway produced 1.5-fold more isobutanol than the balanced version,albeit at low overall pathway *** genomic analyses suggested that the poor performances of the cytosolic pathway strains were in part due to a shortage in cytosolic Fe-S clusters,which are required cofactors for the dihydroxyacid dehydratase *** then demonstrated that this cofactor limitation may be partially recovered by disrupting iron homeostasis with a fra2 mutation,thereby increasing cellular iron *** resulting isobutanol titer of the fra2 null strain harboring a cytosolic-localized isobutanol pathway outperformed the strain with the mitochondrial-localized pathway by 1.3-fold,demonstrating that both localizations can support flux to isobutanol.

关键词： Saccharomyces cerevisiae Isobutanol Functional genomics analysis Pathway localization Fe incorporation

体重指数对正中神经功能、腕管压力和正中神经横断面面积的影响

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世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 53-54页

作者： WernerR.A. jacobson j.A. jamadar D.A. 邓剑平 Dept. of Phys. Med. and Rehab. Univ. of Michigan Medical Cen ter Ann Arbor MI United States Dr.

Obese individuals have slowed conduction in the median nerve across the wrist, but the mechanism for this is not established. This case control study of 27 o bese subjects and 16 thin subjects was designed to test the hypothesis that obes e individuals have higher carpal canal pressures and more median nerve swelling than thin individuals. Allsubjects were asymptomatic for hand symptoms, and had measurements of median and ulnar sensory nerve conduction in the nondominant han d, ultrasound measurement of the median nerve cross sectional area proximal to the carpalcanal, and carpal canal pressure measurement. There was no difference in age or gender ratio between the obese and thin groups. The median nerve cross sectional area was equal in the obese and thin groups (9.3 mm2 vs. 9.4 mm2), a s was the carpal canal pressure (16.2 mmHg vs. 15.5 mmHg, respectively). There w as a strong correlation between median nerve conduction slowing across the wrist and median nerve cross sectional area at the wrist (r = 0.55, P = 0.002). Obes ity does not influence carpal canal pressure or the size of the median nerve at the wrist. However, t here is a strong association between slowed median nerve conduction and increase d nerve size which suggests endoneurial edema as a metabolic mechanism; the cond uction slowing does not appear to be related to mechanical stress.

关键词：正中神经腕管神经内膜水肿尺神经感觉传导速度腕部神经传导速度消瘦者非优势手超声测量

以铂类为主的化疗方案对老年晚期卵巢癌患者的疗效

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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 61-62页

作者： Hershman D. jacobson j.S. McBride R. 张剑萍 Dept. Med. Herbert Irving C. College of Physicians and Surgeons Columbia University 10032 NewYork NYUnited States

Background. Platinum-based chemotherapy is the standard of care for wo men wit h advanced ovarian cancer based on the results of randomized trials. We previous ly showed that only about half of women over the age of 65 years with this disea se received platinum-based chemotherapy, and that the likelihood of receiving i t decreases with age. Methods. We used the Surveillance, Epidemiology, and End R esults (SEER)-Medicare database to identify women diagnosed from 1/1/92 to 12/3 1/96 with stage III or IV ovarian cancer who survived ≥120 days beyond diagnosi s, and were ≥65 years of age. Cox proportional hazards models and propensity sc ores were used to control for known predictors of receiving treatment and to est imate the relative effectiveness of different platinum-based regimens. Results. Of the 1759 patients in the sample who met our eligibility criteria, 53%receiv ed platinum-based therapy. For this sample, the Cox proportional hazard ratio w as 0.72 (95%CI, 0.62-0.91) for mortality associated with the use of any platin um-based therapy, and 0.59 (95%CI, 0.45-0.76) for combination platinum/paclit axel therapy. Similar results were obtained using propensity score modeling. Con clusions. In this population-based study, we found that only about half of wome n with advanced ovarian cancer over age 65 were treated with platinum-based che motherapy; however, survival improved by 38%in treated women, similar to the be nefits described in randomized controlled trials among younger patients, and wer e greatest when platinum was combined with paclitaxel. An effort to increase the utilization of platinum combination therapy among older patients with advanced ovarian cancer is justified.

关键词：晚期卵巢癌联合化疗倾向评分存活期试验研究结果模型评估医疗数据库随机对照试验率更日至