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Tissue-resident T cells lose their SIP_1 exit visas

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Cellular & Molecular Immunology 2014年第3期11卷 221-223页

作者： allan j.zajac Laurie E Harrington Department of Microbiology University of Alabama at Birmingham Birmingham AL 35294 United States Department of Cell Developmental and Integrative Biology University of Alabama at Birmingham Birmingham AL. 35294 United States

CD8 T cells play critical roles in controlling intracellular pathogensand tumors. To accomplish this the small number of antigen-inexperienced naive CD8 T cells that are capable of recognizing the antigen of interest must first become primed. These initial activaion events occur while the responding T cells are sequestered within lymph nodes, but many of the cells subsequently egress into the periphery and migrate into other organs where they can fulfill their principle mission of identifying and eliminating infected or malignant target cells.

关键词： Tissue-resident S1P_1 exit visas the departure

Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy

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Bone Research 2024年第1期12卷 95-106页

作者： Tian Nie Varun S.Venkatesh Suzanne Golub Kathryn S.Stok Haniyeh Hemmatian Reena Desai David j.Handelsman jeffrey D.zajac Mathis Grossmann Rachel A.Davey Department of Medicine Austin HealthUniversity of MelbourneHeidelbergVIC 3084Australia Department of Biomedical Engineering University of MelbourneParkvilleVIC 3010Australia ANZAC Research Institute University of Sydney and AndrologyConcord Repatriation General HospitalConcordNSW 2137Australia

The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent trans girls are *** address this knowledge gap,we developed a mouse model to simulate male-to-female transition in human adolescents in whom puberty is first arrested by using gonadotrophin-releasing hormone analogs with subsequent estradiol *** was suppressed by orchidectomy in male mice at 5 weeks of *** 3 weeks post-surgery,male-to-female mice were treated with a high dose of estradiol(~0.85 mg)by intraperitoneal silastic implantation for 12 *** included intact and orchidectomized males at 3 weeks post-surgery,vehicle-treated intact males,intact females and orchidectomized males at 12 weeks *** to male controls,orchidectomized males exhibited decreased peak bone mass accrual and a decreased maximal force the bone could withstand prior to *** treatment in orchidectomized male-to-female mice compared to mice in all control groups was associated with an increased cortical thickness in the mid-diaphysis,while the periosteal circumference increased to a level that was intermediate between intact male and female controls,resulting in increased maximal force and *** trabecular bone,estradiol treatment increased newly formed trabeculae arising from the growth plate as well as mineralizing surface/bone surface and bone formation rate,consistent with the anabolic action of estradiol on osteoblast *** data support the concept that skeletal integrity can be preserved and that long-term fractures may be prevented in trans girls treated with GnRHa and a sufficiently high dose of *** study is needed to identify an optimal dose of estradiol that protects the bone without adverse side effects.

关键词： treatment treatment strength

Correlation between the surface characteristics of carbon supports and their electrochemical stability and performance in fuel cell cathodes

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Carbon Energy 2021年第4期3卷 654-665页

作者： Ignacio jiménez-Morales Alvaro Reyes-Carmona Marc Dupont Sara Cavaliere Marlene Rodlert Flavio Mornaghini Mikkel j.Larsen Madeleine Odgaard jerzy zajac Deborah j.jones jacques Rozière ICGM Universitéde Montpellier CNRSENSCMMontpellierFrance Institut Universitaire de France(IUF) ParisFrance Imerys Graphite and Carbon BodioSwitzerland IRD Fuel Cells A/S Odense SØDenmark

In this paper,an extensive characterisation of a range of carbon blacks(CB)with similar surface area but different surface chemistry is carried out by flow calorimetry,Raman spectroscopy,dynamic water vapour sorption,instrumental gas analysis,nitrogen adsorption/desorption and high potential *** these carbon materials as supports,Pt/CB electrocatalysts are prepared by microwave-assisted polyol-mediated synthesis in gram ***,morphological and electrochemical properties of the prepared electrocatalysts are evaluated by X-ray diffraction,transmission electron microscopy,rotating disc electrode and in situ fuel cell characterisation of the corresponding membrane-electrode *** obtained results allow to establish a relationship between surface chemistry and electrochemical properties useful for the design of Pt/C catalyst layers with high performance and stability.

关键词： carbon black electrocatalyst support fuel cell cathodes surface properties

通过脂肪抑制自旋回波和FLASH－2D序列改善胰腺癌的诊断

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放射学实践 1995年第2期10卷 54-55页

作者： zajac,M 李小刚荆沙市第一人民医院

胰腺癌因症状出现晚，诊断受到极大限制。ＭＲＴ是否将改善此状况，目前尚难肯定。

关键词：胰腺肿瘤 VMR 血管造影

雄激素受体基因CAG多态性与前列腺癌的关系

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临床泌尿外科杂志 2001年第2期16卷 51-53页

作者：陈越 Beilin j.zajac j D Favaloro j N Davey R Byron K Harewood H 唐涌志孟荟上海市静安区中心医院泌尿外科上海200040 澳大利亚皇家墨尔本医院内科澳大利亚皇家墨尔本医院分子生物实验室澳大利亚皇家墨尔本医院泌尿外科

目的 :进一步探讨雄激素受体 (AR)基因 CAG多态性与前列腺癌的关系。方法 :采用分子生物学方法对 35 8例前列腺癌患者 AR基因 CAG进行测试 ,分析 CAG长度与临床各种指标的关系。结果 :经统计学分析 ,显示 AR基因 CAG与年龄之间呈高相关... 详细信息

目的 :进一步探讨雄激素受体 (AR)基因 CAG多态性与前列腺癌的关系。方法 :采用分子生物学方法对 35 8例前列腺癌患者 AR基因 CAG进行测试 ,分析 CAG长度与临床各种指标的关系。结果 :经统计学分析 ,显示 AR基因 CAG与年龄之间呈高相关性 (P =0 .0 0 7,γ=0 .114) ,但与 PSA、肿瘤分级及分期无显著相关性。结论 :AR基因 CAG的长度与患者年龄成正比 ,即前列腺癌患者年龄越轻 ,其 CAG长度越短。

关键词：雄激素受体 CAG片断前列腺癌基因多态性

7α-O-IA-DPN:特异性碘标记阿片配体的研制和评价

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北京医科大学学报 1998年第3期30卷 210-212页

作者：王荣福魏锦泉北京医科大学第一医院核医学科福建省漳州市医院同位素科

目的：研制和评价新碘标阿片受体显像剂７αＯｉｏｄｏａｌｙｌｄｉｐｒｅｎｏｒｐｈｉｎｅ（７αＯＩＡＤＰＮ）。方法：选用阿片肽拮抗剂ＤＰＮ经碘代锡烷标记法成功地获得了一个原始的碘标阿片肽类似物，并对其进行理化... 详细信息

目的：研制和评价新碘标阿片受体显像剂７αＯｉｏｄｏａｌｙｌｄｉｐｒｅｎｏｒｐｈｉｎｅ（７αＯＩＡＤＰＮ）。方法：选用阿片肽拮抗剂ＤＰＮ经碘代锡烷标记法成功地获得了一个原始的碘标阿片肽类似物，并对其进行理化性能、药理作用和生物学功能评价。结果：体外和体内阿片受体结合分析表明这一新的阿片配体具有非常高的亲和力（Ｋｉ＝４×１０－４μｍｏｌ／Ｌ）。注药后２０ｍｉｎ动物脑内的特异性结合占６３％，且其在脑内滞留时间较长而有利于成像。阿片抑制试验和抗痛活性研究分别反映碘标７αＯＩＡＤＰＮ可能对３种阿片受体（μ，δ，κ）都有亲和力，并保持了原有的药理特性和生物学功能。结论：碘标７αＯＩＡＤＰＮ作为新阿片受体显像剂较适于今后ＳＰＥＣＴ阿片受体研究。

关键词：受体碘标记 IA-DPN 阿片受体