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Hidden risks associated with conventional short intermittent hemodialysis:A call for action to mitigate cardiovascular risk and morbidity

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World Journal of Nephrology 2022年第2期11卷 39-57页

作者： Bernard Canaud Jeroen P Kooman Nicholas M Selby Maarten Taal Andreas Maierhofer Pascal Kopperschmidt Susan Francis allan collins Peter Kotanko Global Medical Office Fresenius Medical CareBad Homburg 61352Germany Department of Nephrology Montpellier UniversityMontpellier 34000France Department of Internal Medicine Maastricht UniversityMaastricht 6229 HXNetherlands Centre for Kidney Research and Innovation Academic Unit for Translational Medical SciencesSchool of MedicineUniversity of NottinghamDerby DE223DTUnited Kingdom Global Research Development Fresenius Medical CareSchweinfurt 97424Germany University of Nottingham Nottingham NG72RDUnited Kingdom Renal Research Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10065United States

The development of maintenance hemodialysis(HD)for end stage kidney disease patients is a success story that continues to save many ***,intermittent renal replacement therapy is also a source of recurrent stress for *** thrice weekly short HD is an imperfect treatment that only partially corrects uremic abnormalities,increases cardiovascular risk,and exacerbates disease *** cycles of fluid loading associated with cardiac stretching(interdialytic phase)and then fluid unloading(intradialytic phase)likely contribute to cardiac and vascular *** unphysiologic treatment profile combined with cyclic disturbances including osmotic and electrolytic shifts may contribute to morbidity in dialysis patients and augment the health burdenof treatment. As such, HD patients are exposed to multiple stressors including cardiocirculatory,inflammatory, biologic, hypoxemic, and nutritional. This cascade of events can be termed thedialysis stress storm and sickness syndrome. Mitigating cardiovascular risk and morbidityassociated with conventional intermittent HD appears to be a priority for improving patientexperience and reducing disease burden. In this in-depth review, we summarize the hidden effectsof intermittent HD therapy, and call for action to improve delivered HD and develop treatmentschedules that are better tolerated and associated with fewer adverse effects.

关键词： End stage kidney disease Cardiovascular mortality Dialytic morbidity Circulatory stress Biologic storm Dialysis sickness Personalized medicine

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应用认知科学

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心理学报 1986年第2期 149-156页

作者： Edward E.Smith ,allan collins

人与复杂系统的相互作用是现代认知科学的一个重要着眼点,这些系统包括计算机和电子系统。日益复杂的系统充斥美国社会,设计操作和修理这些系统的技术已成为我们社会运转的必要条件。教会人们使用这些系统,并设计易于使用的系统是应用... 详细信息

人与复杂系统的相互作用是现代认知科学的一个重要着眼点,这些系统包括计算机和电子系统。日益复杂的系统充斥美国社会,设计操作和修理这些系统的技术已成为我们社会运转的必要条件。教会人们使用这些系统,并设计易于使用的系统是应用认知心理学的重要目标。在本文中,我们提出了一个了解认知科学关于人与系统相互作用研究的框架,并介绍这一领域中一些出色的研究工作。

关键词：文本编辑计算器领域正文编辑认知科学解释性

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Advances of biomarkers in nasopharyngeal carcinoma’s early detection

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Science Bulletin 2024年第2期69卷 141-145页

作者： Xiao-Hui Zheng allan Hildesheim Wei-Hua Jia State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Costa Rican Agency for Biomedical Investigation INCIENSA FoundationSan Jose 10108Costa Rica

Nasopharyngeal carcinoma(NPC),a highly invasive and metastatic cancer,is widely prevalent in South China,Southeast Asia,and North *** patients with stages I and II are often ***,NPC patients are usually diagnosed with advanced-stage(stages III and IV)at their first *** of NPC at early stage is the key to improve the survival of ***-Barr virus(EBV)plays an essential role in NPC occurrence in endemic ***-based biomarkers,including EBV antibody in serum and EBV DNA in plasma,have been specifically proposed for NPC early ***,we summarize recent advances in biomarkers for the early detection of NPC.

关键词： patients nasopharyngeal Nasopharyngeal

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探究教学的认知理论

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远程教育杂志 2006年第2期24卷 16-23页

作者： allan M.collins 褚献华美国西北大学浙江大学教育学院浙江杭州310028

本文选用多学科教学实例来说明教师如何运用探究教学的十种策略促使学生解决各种问题。在这一过程中,学生既学习知识领域的具体理论,又学习各种推理技能,包括构建假设、验证假设、提出预测、选择验证理论的合适的案例、提出反例和假设... 详细信息

本文选用多学科教学实例来说明教师如何运用探究教学的十种策略促使学生解决各种问题。在这一过程中,学生既学习知识领域的具体理论,又学习各种推理技能,包括构建假设、验证假设、提出预测、选择验证理论的合适的案例、提出反例和假设案例、区别必要条件和充分条件、考虑不同的假设、熟悉规则或理论可能的形式、知道提问的策略等。在某种意义上,探究法为学生展示了一个造就科学家的模拟过程。这种教学模式对学生的学习有特别的激励作用。

关键词：探究教学认知理论学习方式

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死亡飞行

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丛书名：科林斯历史探案小说

2000年

作者：（美）马克斯·艾伦·科林斯（Max allan collins）刘盛林译

本书讲述了艾米莉·埃尔哈特，美国最早的女飞行员，一生中创造了数不清的飞行纪录，是早期航空飞行领域的开拓者之一。一九三七年七月，她在做环球飞行时，在太平洋上空神秘失踪的故事。

ISBN: (纸本)7531712083

关键词：侦探小说地点:中国年代:现代长篇小说地点:美国

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Enhancing hourly heat demand prediction through artificial neural networks:A national level case study

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Energy and AI 2024年第1期15卷 288-299页

作者： Meng Zhang Michael-allan Millar Si Chen Yaxing Ren Zhibin Yu James Yu James Watt School of Engineering University of GlasgowGlasgowG128QQUK University of Lincoln Brayford PoolLincolnLN67TSUK Scottish Power GlasgowG28DQUK

Meeting the goal of zero emissions in the energy sector by 2050 requires accurate prediction of energy consumption,which is increasingly ***,conventional bottom-up model-based heat demand forecasting methods are not suitable for large-scale,high-resolution,and fast forecasting due to their complexity and the difficulty in obtaining model *** paper presents an artificial neural network(ANN)model to predict hourly heat demand on a national level,which replaces the traditional bottom-up model based on extensive building simulations and *** ANN model significantly reduces prediction time and complexity by reducing the number of model input types through feature selection,making the model more realistic by removing non-essential *** improved model can be trained using fewer meteorological data types and insufficient data,while accurately forecasting the hourly heat demand throughout the year within an acceptable error *** model provides a framework to obtain accurate heat demand predictions for large-scale areas,which can be used as a reference for stakeholders,especially policymakers,to make informed decisions.

关键词： Heating demand in buildings National level forecast Feature selection Machine learning Artificial neural network

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放纵时刻

引用

丛书名：科林斯历史探案小说

2000年

作者：（美）马克斯·艾伦·科林斯（Max allan collins）刘冬颖译

本书讲述了二战期间，巴哈马富豪哈利爵士聘请内森·黑勒为其调查女婿玛瑞尼伯爵对婚姻的不忠行为时发生的故事。

ISBN: (纸本)7531712091

本书讲述了二战期间，巴哈马富豪哈利爵士聘请内森·黑勒为其调查女婿玛瑞尼伯爵对婚姻的不忠行为时发生的故事。

关键词：侦探小说地点:美国年代:现代长篇小说

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泰坦尼克谋杀案

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丛书名：科林斯历史探案小说

2000年

作者：（美）马克斯·艾伦·科林斯（Max allan collins）张爱琴译

杰奎斯.福特尔是二十世纪初美国最著名的侦探小说家。他的作品对阿加莎.克里斯蒂的小说产生了深远的影响。1912年4月10日，福特尔登上了泰坦尼克号；在四月十四日夜晚与十五日凌晨，他同那个时代的许多名人及一千五百余名乘客一同沉入... 详细信息

ISBN: (纸本)7531712210

杰奎斯.福特尔是二十世纪初美国最著名的侦探小说家。他的作品对阿加莎.克里斯蒂的小说产生了深远的影响。1912年4月10日，福特尔登上了泰坦尼克号；在四月十四日夜晚与十五日凌晨，他同那个时代的许多名人及一千五百余名乘客一同沉入了冰冷的大西洋底。福特尔在侦破犯罪案件方面具有卓越的才华，而他一生中面临的最后一次挑战，也是泰坦尼克号上最大的秘密，却是沉船之前的两桩谋杀案......

关键词：侦探小说地点:美国年代:现代长篇小说

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DNA methylation controlling abscisic acid catabolism responds to light to mediate strawberry fruit ripening

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Journal of Integrative Plant Biology 2024年第8期66卷 1718-1734页

作者： Yunfan Sun Xiaofang Yang Rongrong Wu Shouzheng Lv Yunduan Li Haoran Jia Yuying Yang Baijun Li Wenbo Chen Andrew C.allan Guihua Jiang Yan-Na Shi Kunsong Chen College of Agriculture&Biotechnology Zhejiang UniversityZijingang CampusHangzhou 310058China Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiang 310021China Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang UniversityZijingang CampusHangzhou 310058China The State Agriculture Ministry Laboratory of Horticultural Plant Growth Development and Quality ImprovementZhejiang UniversityZijingang CampusHangzhou 310058China New Zealand Institute for Plant&Food Research Limited Private Bag 92169AucklandNew Zealand School of Biological Sciences University of AucklandPrivate Bag 92019AucklandNew Zealand

Phytohormones,epigenetic regulation and environmental factors regulate fruit ripening but their interplay during strawberry fruit ripening remains to be *** this study,bagged strawberry fruit exhibited delayed ripening compared with fruit grown in normal light,correlating with reduced abscisic acid(ABA) *** of the key ABA catabolism gene,ABA 8′-hydroxylase FaCYP707A4,was induced in bagged *** light exclusion whole genome DNA methylation levels were up-regulated,corresponding to a delayed ripening process,while DNA methylation levels in the promoter of FaCYP707A4 were suppressed,correlating with increases in transcript and decreased ABA *** indicated FaCRY1,a blue light receptor repressed in bagged fruit and FaAGO4,a key protein involved in RNA-directed DNA methylation,could bind to the promoter of *** interaction between FaCRY1 and FaAGO4,and an increased enrichment of FaAGO4 directed to the FaCYP707A4 promoter in fruit grown under light suggests FaCRY1 may influence FaAGO4 to modulate the DNA methylation status of the FaCYP707A4 ***,transient overexpression of FaCRY1,or an increase in FaCRY1 transcription by blue light treatment,increases the methylation level of the FaCYP707A4 promoter,while transient RNA interference of FaCRY1 displayed opposite *** findings reveal a mechanism by which DNA methylation influences ABA catabolism,and participates in light-mediated strawberry ripening.

关键词： ABA catabolism DNA methylation light ripening strawberry

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Plant growth and metabolism of exotic and native Crotalaria species for mine land rehabilitation in the Amazon

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Journal of Forestry Research 2024年第1期35卷 143-154页

作者： Hemelyn Soares das Chagas Rafael Silva Guedes Markus Gastauer Paula Godinho Ribeiro allan Klynger da Silva Lobato Cecílio Frois Caldeira Fabrício William deÁvila AndréRodrigues dos Reis Silvio Junio Ramos Instituto Tecnológico Vale Rua Boaventura da Silva955BelémPA 66055-090Brazil Universidade Federal do Sul e Sudeste do Pará XinguaraPABrazil Núcleo de Pesquisa Vegetal Básica e Aplicada Universidade Federal Rural da AmazôniaParagominasPABrazil Departamento de Engenharia Florestal Universidade Estadual do Centro-Oeste/UNICENTROIratiPRBrazil School of Sciences and Engineering São Paulo State University(UNESP)TupãSP.CEP 17602-496Brazil

Despite its enormous benefits,mining is respon-sible for intense changes to vegetation and soil ***,after extraction,it is necessary to rehabilitate the mined areas,creating better conditions for the establishment of plant species which is *** study evaluated mineral and organic fertilization on the growth,and carbon and nitrogen(N)metabolism of two Crotalaria species[Cro-talaria spectabilis(exotic species)and Crotalaria maypu-rensis(native species from Carajás Mineral Province(CMP)]established on a waste pile from an iron mine in CMP.A control(without fertilizer application)and six fertilization mixtures were tested(i=NPK;ii=NPK+micronutrients;iii=NPK+micronutrients+organic compost;iv=PK;v=PK+micronutrients;vi=PK+micronutrients+organic compost).Fertilization contributed to increased growth of both species,and treatments with NPK and micronutrients had the best results(up to 257%***),while organic fertilization did not show *** Crotalaria had a greater number of nodules,higher nodule dry mass,chlorophyll a and b contents and showed free ammonium as the predominant N form,reflecting greater increments in biomass compared to native *** having lower growth,the use of this native species in the rehabilitation of mining areas should be considered,mainly because it has good development and meets current government legislation as an opportunity to restore local biodiversity.

关键词： Biological nitrogen fixation Mining Nitrogen metabolism Plant nutrition

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