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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Sex steroids and glucose metabolism

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Asian Journal of Andrology 2014年第2期16卷 232-238,I0008页

作者： Carolyn A allan Prince Henry's Institute Clayton Australia Monash Health Clayton Australia Department of Obstetrics and Gynaecology Monash University Clayton Australia Andrology Australia c/o School of Public Health and Preventive Medicine Monash University Prahran Australia

Testosterone levels are lower in men with metabolic syndrome and type 2 diabetes mellitus （T2DM） and also predict the onset of these adverse metabolic states. Body composition （body mass index, waist circumference） is an important mediator of this relationship. Sex hormone binding globulin is also inversely associated with insulin resistance and T2DM but the data regarding estrogen are inconsistent. Clinical models of androgen deficiency including Klinefelter＇s syndrome and androgen deprivation therapy in the treatment of advanced prostate cancer confirm the association between androgens and glucose status. Experimental manipulation of the insulin/ glucose milieu and suppression of endogenous testicular function suggests the relationship between androgens and insulin sensitivity is bidirectional. Androgen therapy in men without diabetes is not able to differentiate the effect on insulin resistance from that on fat mass, in particular visceral adiposity. Similarly, several small clinical studies have examined the efficacy of exogenous testosterone in men with T2DM, however, the role of androgens, independent of body composition, in modifying insulin resistance is uncertain.

关键词： androgen glucose metabolism sex steroids testosterone

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SURFACE MODIFICATION OF POLYMERS

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Chinese Journal of Polymer Science 1995年第3期13卷 195-203页

作者： allan S.Hoffman Center for Bioengineering FL-20 University of WashingtonSeattle WA 98195 USA

The principal objectives and methods of surface modification of polymers are reviewed inthis paper. The methods covered include physical, chemical, mechanical and biological.

关键词： Surface modification Polymers Biomolecules

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Commentary: Endogenous glucocorticoids control host resistance to viral infection through tissue-specific regulation of PD-1 expression on NK cells

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Cellular & Molecular Immunology 2019年第3期16卷 203-204页

作者： allan Randrup Thomsen Department of Immunology and Microbiology University of CopenhagenCopenhagenDenmark

The key purpose of the immune system is to protect the host from infectious ***,it has long been known that the induced host response in many cases represents a double-edged sword,and proper regulation of the magnitude and the temporal and spatial context of this response is critical to avoid immunemediated bystander tissue damage.A classical model of such damage is intracerebral infection of immunocompetent mice with the noncytolytic arenavirus lymphocytic choriomeningitis *** T-cell-deficient mice suffer little or no disease following infection by any route,immunocompetent mice succumb to Tcell-mediated lethal meningitis.1,2 Peripheral infection of such immunocompetent mice is associated with limited disease,and the same type of effector T cells that cause lethal disease are also central in controlling viral infection in organs.

关键词： infection damage organs

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Watershed science:Linking hydrological science with sustainable management of river basins

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Science China Earth Sciences 2021年第5期64卷 677-690页

作者： Chansheng HE L.allan JAMES Department of Geography Western Michigan UniversityKalamazooM149008USA Center for Dryland Water Resources Research and Watershed Science Key Laboratory of West China’s Environmental System(Ministry of Education)College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Department of Geography University of South CarolinaColumbiaSC 29208USA

Over the past decades,a number of water sciences and management programs have been developed to better understand and manage the water cycles at multiple temporal and spatial scales for various purposes,such as ecohydrology,global hydrology,sociohydrology,supply management,demand management,and integrated water resources management(IWRM).At the same time,rapid advancements have also been taking place in tracing,mapping,remote sensing,machine learning,and modelling technologies in hydrological *** those programs and advancements,a water crisis is intensifying *** missing link is effective interactions between the hydrological research and water resource management to support implementation of the UN Sustainable Development Goals(SDGs)at multiple spatial *** the watershed is the natural unit for water resources management,watershed science offers the potential to bridge this missing *** study first reviews the advances in hydrological research and water resources management,and then discusses issues and challenges facing the global water ***,it describes the core components of watershed science:(1)hydrological analysis;(2)water-operation policies;(3)governance;(4)management and *** framework takes into account water availability,water uses,and water quality;explicitly focuses on the storage,fluxes,and quality of the hydrological cycle;defines appropriate local water resource thresholds through incorporating the planetary boundary framework;and identifies specific actionable measures for water resources *** provides a complementary approach to the existing water management programs in addressing the current global water crisis and achieving the UN SDGs.

关键词： Water crisis Hydrology Watershed science Integrated water resources management(IWRM)

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Quality assurance and quality control in the laboratory andrology

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Asian Journal of Andrology 2010年第1期12卷 21-25页

作者： allan A. Pacey School of Medicine and Biomedical Sciences Academic Unit of Reproductive and Developmental Medicine the Universityof Shejfield the Jessop Wing Tree Root Walk Sheffield S102SF UK

Quality assurance （QA） and quality control （QC） are fundamental aspects of any laboratory measurement. However, in comparison with other medical disciplines, the need for QA and QC in laboratory andrology has been recognized only recently. Furthermore, there is evidence that the effort required to undertake QA and QC has not been wholly welcomed by some clinicians. Nevertheless, accrediting bodies and regulatory authorities increasingly require evidence that laboratories have effective QA and QC measures in place because both are central to the quality management processes. Following the publication of the 5th edition of the World Health Organization Laboratory Manual, existing QA and QC systems will need to be updated to take into account some of the methodological changes recommended by the manual. Three of these are discussed in this commentary; they relate to：（i） the move to infer semen volume from its weight; （ii） the re-classification of sperm motility grades from four to three; and （iii） the publication of a lower reference limit for morphology of 4% （with a corresponding 95% confidence interval of 3%-4%）. The importance of QA and QC in all laboratory tests, including up and coming new tests to assess sperm DNA integrity, is discussed. The need for adequate initial training and continuing professional development programmes to support laboratory scientists performing andrology is also described.

关键词： andrology health care quality assurance quality control semen analysis

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Are sperm counts declining？ Or did we just change our spectacles？

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Asian Journal of Andrology 2013年第2期15卷 187-190,I0005页

作者： allan A Pacey Academic Unit of Reproductive and Devebpmental Medicine Department of Human Metabolism University of Sheffield Sheffield S10 2SF UK

The popular and scientific debates about a possible decline in semen quality over ti^e past decades are largely based on retrospective analyses of semen analysis data performed in the past. This article will argue that the conclusions from such analyses are significantly weakened because the methods of laboratory andrology have changed considerably since the 1950s. In the last 20-30 years, there have been significant developments in training and competence,

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Elementary statistics : 5th ed.

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2004年

作者： allan G. Bluman.

Includes indexes.

ISBN: (数字)0072880716

ISBN: (纸本)0072549076

Includes indexes.

关键词： Statistics.

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A new vaccination strategy to trigger specific CD4 T-cell response in chronic viral infection

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Cellular & Molecular Immunology 2018年第9期15卷 868-869页

作者： allan Randrup Thomsen Department of Immunology and Microbiology University of CopenhagenPanum InstituteCopenhagen DK-2200Denmark

Persistent viral infections such as HIV and hepatitis C virus pose a severe health risk to the human population,which so far cannot be addressed by efficient prophylactic *** treatment is expensive and often associated with significant adverse *** vaccination could therefore represent an important addition to current treatment ***,vaccination of chronically infected hosts has mostly fallen short of *** important reason for this is that during the development of a chronic infection,normal memory T cells do not develop.1 Instead,some specificities of virusspecific T cells are eliminated while others develop into a dysfunctional cell type termed exhausted cells.

关键词： vaccination infection treatment

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Electrical engineering : principles and applications / 2nd ed.

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2002年

作者： Hambley allan R.

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