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Do reactive oxygen species damage or protect the heart in ischemia and reperfusion?Analysis on experimental and clinical data

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The Journal of Biomedical Research 2023年第4期37卷 255-267页

作者： Leonid N.Maslov Natalia V.Naryzhnaya Maria Sirotina Alexandr V.Mukhomedzyanov Boris K.Kurbatov alla a.boshchenko Huijie Ma Yi Zhang Feng Fu Jianming Pei Viacheslav N.Azev Vladimir A.Pereverzev Cardiology Research Institute Tomsk National Research Medical Centerthe Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology Hebei Medical UniversityShijiazhuangHebei 050017China Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China The Branch of the Institute of Bioorganic Chemistry Russian Academy of SciencesPushchinoMoscow Oblast 142290Russia Department of Normal Physiology Belarusian State Medical UniversityMinsk 220083Belarus

The role of reactive oxygen species(ROS)in ischemic and reperfusion(I/R)injury of the heart has been discussed for more than 40 *** has been demonstrated that reperfusion triggers a multiple increase in free radical generation in the isolated *** were found to have the ability to mitigate I/R injury of the ***,it is unclear whether their cardioprotective effect truly depends on the decrease of ROS levels in myocardial *** high doses and high concentrations of antioxidants were experimentally used,it is highly likely that the cardioprotective effect of antioxidants depends on their interaction not only with free radicals but also with other *** has been demonstrated that the antioxidant N-2-mercaptopropionyl glycine or NDPH oxidase knockout abolished the cardioprotective effect of ischemic ***,there is evidence that ROS protect the heart against the I/R injury.

关键词： reactive oxygen species free radicals antioxidants heart reperfusion patients

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A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena

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The Journal of Biomedical Research 2023年第4期37卷 268-289页

作者： Leonid N.Maslov Natalia V.Naryzhnaya Sergey V.Popov Alexandr V.Mukhomedzyanov Ivan A.Derkachev Boris K.Kurbatov Andrey V.Krylatov Feng Fu Jianming Pei Vyacheslav V.Ryabov Evgenii V.Vyshlov Svetlana V.Gusakova alla a.boshchenko Akpay Sarybaev Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Siberian State Medical University TomskTomsk Region 634050Russia National Center of Cardiology and Internal Medicine Bishkek 720040Kyrgyzstan.

The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MVO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this *** intracoronary administration of alteplase has been found to have no effect on the occurrence of MVO in patients with acute myocardial ***,the major events preceding the appearance of MVO in coronary arteries are independent of microthrombi,platelets,and *** cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary ***,reperfusion triggers more pronounced damage,possibly mediated by *** and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial ***,pharmacological agents used to treat MVO should prevent endothelial injury and induce relaxation of smooth *** conditioning protocols have been shown to prevent MVO,with L-type Ca2+channel blockers appearing the most effective in treating MVO.

关键词： heart ischemia reperfusion microvascular obstruction intra-myocardial hemorrhage

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Hemostatic genes in symptomatic and hidden forms of thrombotic complications in obstetrics

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中国现代医学杂志 2014年第19期24卷 1-5页

作者： V.F.Nagorna V.G.Marichereda R.I.Gonta Т.G.boshchenko Odessa National Medical University

Hemostatic genes in symptomatic and hidden forms of thrombotic complications in *** given article we present the results of genetic testing for the factors of hemostasis in 30 patients during pregnancy and postnatal period which constitute a single group due to common mechanisms of complications(thrombosis in placenta,central or peripheral veins)and clinically manifested by severe preeclampsia,intrauterine growth restriction,premature detachment of normally situated placenta,venous thrombosis during pregnancy and after *** detectedС677Тpolymorphism of MTHFR gene in 33.3%,F5 G1691A in23.3%,F1G455A in 36.7%.The most frequent mutations were in genes of anticoagulant system:PAI-1 gene(93.3%in a general group;100%in the group of women with thrombosis),ACE gene(60%),ITGB(40%).In majority of observed cases we defined combinations of mutations of different *** all women of the study complications developed on a background of risk factors such as caesarian section,infection,hormonal therapy,bed *** consider that both genetic polymorphisms and risk factors of thrombosis should be detected in early terms of pregnancy and presence of their combination requires a thromboprophylaxis during pregnancy and after delivery,especially after Cesarean section.

关键词：摘要编辑部编辑工作读者

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