检索结果-南通市图书馆

Detection of circulating tumour cells in colorectal cancer:Emerging techniques and clinical implications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2021年第12期12卷 1169-1181页

作者： alka yadav Ashok Kumar Mohammad Haris Siddiqui Department of Surgical Gastroenterology Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia Department of Bioengineering Integral UniversityLucknow 226026India

Despite several advances in oncological management of colorectal cancer,morbidity and mortality are still high and *** diagnostic evaluation by endoscopy is cumbersome,which is uncomfortable to *** of the intra-and inter-tumour heterogeneity and changing tumour dynamics,which is continuous in nature,the diagnostic biopsy and assessment of the pathological sample are difficult and also not *** manifestation of the disease and delayed diagnosis may lead to relapse or *** of the keys to improving the outcome is early detection of cancer,ease of technology to detect with uniformity,and its therapeutic implications,which are yet to come."Liquid biopsy"is currently the most recent area of interest in oncology,which may provide important tools regarding the characterization of the primary tumour and its metastasis as cancer cells shed into the bloodstream even at the early stages of the *** using this approach,clinicians may be able to find out information about the tumour at a given *** of the following three types of sampling of biological material can be used in the"liquid biopsy".These are circulating tumour cells(CTCs),circulating tumour DNA,and *** most commonly studied amongst the three is *** with their different applications and prognostic value has been found useful in colorectal cancer detection and *** this review,we will discuss various markers for CTCs,the core tools/techniques for detection,and also important findings of clinical studies in colorectal cancer and its clinical implications.

关键词： Circulating tumour cells Colorectal cancer Tools and techniques Clinical implications

Artificial intelligence in rectal cancer:What is the future?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artificial Intelligence in Cancer 2023年第2期4卷 11-22页

作者： alka yadav Ashok Kumar Department of Surgical Gastroenterology Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow 226014UPIndia

Colorectal cancer(CRC)is the third most prevalent cancer in both men and women,and it is the second leading cause of cancer-related deaths *** 60%-70%of CRC patients are diagnosed at advanced stages,with nearly 20%having liver *** is noteworthy that the 5-year survival rates decline significantly from 80%-90%for localized disease to a mere 10%-15%for patients with metastasis at the time of *** diagnosis,appropriate therapeutic strategy,accurate assessment of treatment response,and prognostication is essential for better *** has been significant technological development in the last couple of decades to improve the outcome of rectal cancer including Artificial intelligence(AI).AI is a broad term used to describe the study of machines that mimic human intelligence,such as perceiving the environment,drawing logical conclusions from observations,and performing complex *** present AI has demonstrated a promising role in early diagnosis,prognosis,and treatment outcomes for patients with rectal cancer,a limited role in surgical decision making,and had a bright future.

关键词： Rectal cancer Artificial intelligence Role in treatment Current status Future implications

Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第1期32卷 73-94页

作者： VIGNESH BALAJI E DIVYA RAMESH MANISHA CHUNGAN SHAJU AKSHARA KUMAR SAMYAK PANDEY RAKSHA NAYAK V.alka SRISHTI MUNJAL AMIR SALIMI K.SREEDHARA RANGANATH PAI SHANKAR M.BAKKANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

A Trailblazing Framework of Security Assessment for Traffic Data Management

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intelligent Automation & Soft Computing 2023年第8期37卷 1853-1875页

作者： Abdulaziz Attaallah Khalil al-Sulbi Areej Alasiry Mehrez Marzougui Neha yadav Syed Anas Ansar Pawan Kumar Chaurasia alka Agrawal Department of Computer Science Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Computer Science Al-Qunfudah Computer CollegeUmm Al-Qura UniversityMeccaSaudi Arabia College of Computer Science King Khalid UniversityAbha61421Saudi Arabia Department of Information Technology Babasaheb Bhimrao Ambedkar UniversityLucknow226025Uttar PradeshIndia Department of Computer Applications Babu Banarasi Das UniversityLucknow226028Uttar PradeshIndia

Connected and autonomous vehicles are seeing their dawn at this *** provide numerous benefits to vehicle owners,manufacturers,vehicle service providers,insurance companies,*** vehicles generate a large amount of data,which makes privacy and security a major challenge to their *** complicated machine-led mechanics of connected and autonomous vehicles increase the risks of privacy invasion and cyber security violations for their users by making them more susceptible to data exploitation and vulnerable to cyber-attacks than any of their *** could have a negative impact on how well-liked CAVs are with the general public,give them a poor name at this early stage of their development,put obstacles in the way of their adoption and expanded use,and complicate the economic models for their future *** the other hand,congestion is still a bottleneck for traffic management and *** research paper presents a blockchain-based framework that protects the privacy of vehicle owners and provides data security by storing vehicular data on the blockchain,which will be used further for congestion detection and *** devices placed along the road are used to communicate with passing cars and collect their *** collected data will be compiled periodically to find the average travel time of vehicles and traffic density on a particular road ***,this data will be stored in the memory pool,where other devices will also store their *** a predetermined amount of time,the memory pool will be mined,and data will be uploaded to the blockchain in the form of blocks that will be used to store traffic *** information is then used in two different ***,the blockchain’s final block will provide real-time traffic data,triggering an intelligent traffic signal system to reduce ***,the data stored on the blockchain will provide historical,statistical data that can facilitate the

关键词： Connected and autonomous vehicles(CAVs) traffic data management ethereum blockchain road side units smart cities

Formation of E-cyanomethamine in a nitrile rich environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2017年第1期17卷 1-10页

作者： Shivani alka Misra Poonam Tandon Department of Mathematics & Astronomy University of Lucknow Lucknow India Department of Physics University of Lucknow Lucknow 226007 India

Recently a new molecule, cyanomethamine, has been detected towards Sagittarius B2（N）（Sgr B2（N））. Studying the formation mechanisms of complex interstellar molecules is difficult. Hence, a theoretical quantum chemical approach for analyzing the reaction mechanism describing the forma- tion of interstellar cyanomethamine through detected interstellar molecules and radicals （NCCN＋H） is discussed in the present work. Calculations are performed by using quantum chemical techniques, such as Density Functional Theory （DFT） and Mφ11er-Plesset perturbation （MP2） theory with a 6-311G（d,p） basis set, both in the gas phase and in icy grains. The proposed reaction path （NCCN＋H＋H） has exother- micity with no barrier which indicates the possibility of cyanomethamine formation in the interstellar medium.

关键词： interstellar medium: abundances general - general: extraterrestrial intelligence - mete-orites - individual: Sgr B2(N) region

Theoretical approach to study the formation of C2H4O2 isomers in interstellar medium through reaction between interstellar formaldehyde molecules

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2020年第1期20卷 124-136页

作者： Aftab Ahmad Shivani alka Misra Poonam Tandon Department of Mathematics&Astronomy University of LucknowLucknowIndia Department of Physics University of LucknowLucknowIndia

The three isomers of C2H4O2,viz.,glycolaldehyde(HCOCH2 OH),acetic acid(CH3 COOH)and methyl formate(HCOOCH3),have been detected in copious amounts in the interstellar medium(ISM).The possibility for formation of these molecules through interstellar formaldehyde(HCHO)has been explored by using the quantum chemical approach described by density functional theory(DFT)and second order Moller-Plesset perturbation(MP2)theory with a 6–311 G(d,p)basis set in the gas phase as well as in icy *** associated molecule-molecule interactions have been discussed to study the formation of isomers of C2H4O2 in *** reactions of two formaldehyde molecules exhibit a considerable potential barrier but due to quantum tunneling,these reactions could be possible in *** chemical pathway is exothermic,which gives rise to a high probability for the formation of all three isomers,***,methyl formate and acetic acid,in interstellar *** rotational vibration,centrifugal distortion constants and coupling constants are also calculated and results suggest that the vibrations are harmonic in nature.

关键词： ISM:molecules astrochemistry astrobiology abundances

Quantum chemical analysis for the formation of glycine in the interstellar medium

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2013年第8期13卷 912-920页

作者： Amresh Singh Shivani alka Misra Poonam Tandon Department of Mathematics & Astronomy University of Lucknow Department of Physics University of Lucknow

Glycine （C2H5NO2） was the first amino acid to be detected in space by the stardust space probe in Comet Wild2, and is used by living organisms to make proteins. We discuss three different reaction paths for the formation of glycine in interstellar space from some simpler molecules detected in the interstellar medium. The possibility of the formation of glycine in interstellar space is considered by radicalradical and radical-molecule interaction schemes using quantum chemical calculations with density functional theory at the B3LYP/6-31G （d,p） level. In the chemical pathways we discuss, a few reactions are found to be totally exothermic and barrierless while others are endothermic with a very small reaction barrier, thus giving rise to a high probability of forming glycine in interstellar space.

关键词： astrobiology - astrochemistry - ISM: abundances - ISM: molecules

Formation of cyanoallene(buta-2, 3-dienenitrile) in the interstellar medium: a quantum chemical and spectroscopic study

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2014年第3期14卷 275-284页

作者： Amresh Singh Shivani alka Misra Poonam Tandon Department of Mathematics & Astronomy University of Lucknow Department of Physics University of Lucknow

The interstellar medium, filling the vast space between stars, is a rich reser-voir of molecular material ranging from simple diatomic molecules to more com-plex, astrobiologically important molecules such as vinylcyanide, methylcyanodiac-cetylene, cyanoaUene, etc. Interstellar molecular cyanoallene is one of the most stableisomers of methylcynoacetylene. An attempt has been made to explore the possibilityof forming cyanoallene in interstellar space by radical-radical and radical-moleculeinteraction schemes in the gaseous phase. The formation of cyanoallene starting fromsome simple, neutral interstellar molecules and radicals has been studied using densityfunctional theory. The reaction energies and structures of the reactants and productsshow that the formation of cyanoallene is possible in the gaseous phase. Both of theconsidered reaction paths are totally exothermic and barrierless, thus giving rise to ahigh probability of occurrence. Rate constants for each step in the formation processof cyanoallene in both the reaction paths are estimated. A full vibrational analysishas been attempted for cyanoallene in the harmonic and anharmonic *** spectroscopic parameters such as rotational constants, rotation-vibrationcoupling constants and centrifugal distortion constants have been calculated.

关键词： astrochemistry techniques: spectroscopic ISM: abundances ISM: molecules

Grid Tied Solar PV System with Power Quality Enhancement Using Adaptive Generalized Maximum Versoria Criterion

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2023年第2期9卷 722-732页

作者： Manoj Badoni alka Singh Ankit Kumar Singh Hemant Saxena Rajeev Kumar Delhi Technological University Delhi 110042India.A.K.Singh is with Netaji Subhas University of TechnologyDelhi 110078India Netaji Subhas University of Technology Delhi 110078India Electrical and Electronics Engineering Department KIET Group of InstitutionsGhaziabadIndia Electrical Engineering Department Jamia Millia IslamiaNew DelhiIndia

A three phase grid tied solar photovoltaic(PV)system with power quality compensation features is presented in this *** system is used to transfer power generated from a solar PV array to feed linear and nonlinear loads along with compensation for several power quality(PQ)issues,such as harmonics,redundant reactive power and load *** generated DC power from the PV array is converted into AC by implementing a three-phase voltage source converter(VSC).In order to transfer active power and mitigate PQ problems,an efficient control technique is required for the grid tied solar PV *** study presents the use of an adaptive generalized maximum Versoria criterion(AGMVC)controller for VSC used in a solar PV energy conversion *** utilization of the solar PV array is accomplished by using the Perturb and Observe based maximum power point tracking(MPPT)*** experimental setup of the grid integrated PV system is implemented in the laboratory using an IGBT based VSC and DSP(dSPACE DS-1202).The performance of the AGMVC control technique is verified experimentally using laboratory *** control technique is compared with different conventional controllers,such as synchronous reference frame theory(SRFT)and instantaneous reactive power theory(IRPT)along with recently developed weight-based controllers viz.,least mean square(LMS),least mean mixed norm(LMMN)and normalized kernel least mean fourth-neural network(NKLMFNN).Numerous terms,such as fundamental weight convergence,steady state error,computational complexity,phase lock loop(PLL)requirement and harmonic compensation capability,are considered for comparison purposes of AGMVC with the above listed control *** system performance is verified according to the IEEE-519 standard.

关键词： Harmonics maximum versoria criterion power factor corection(PFC) solar photovoltaic