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Electro-anatomic mapping of the right atrium:anatomic abnormality is an important substrate

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Chinese medical Journal 2003年第3期116卷 22-26页

作者：方丕华 Nancy L Radtke Tony W Simmons Wesley K Haisty Jr Karthik Ramaswamy David m.fitzgerald Department of Cardiology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Wake Forest University School of medicine Winston-Salem North Carolina 27157 USA

Objective To map and compare the right atrium in patients with AF to those with atrioventricular nodal reentrant tachycardias (AVNRT, as control group) and to investigate the anatomical and electrophysiological abnormality of the right atrium in *** The anatomy and electrophysiology of right atrium and cavotricuspid isthmus were evaluated in 20 patients with AF (16 m/4 F, mean age 55.9±10.68 years) and 26 patients with AVNRT (9 m/17 F, mean age 47.50±19.56 years) during coronary sinus pacing at 600 ms prior to ablation with electro-anatomical mapping system. Right atrial volume (RAV), the length and width of cavotricuspid isthmus (IsL, IsW), unipolar and bipolar voltage in the right atrium (UniV-RA, BiV-RA) were measured and compared between patients with AF and those with AVNRT. Results RAV, IsL, IsW, UniV-RA, and BiV-RA were 143.22±40.72 vs 104.35±21.06 ml, 39.31±8.10 vs 32.42±9.77 mm, 30.54±7.48 vs 23.15±6.61 mm, 1.96±1.24 vs 1.53±0.91 mv and 1.47±1.47 vs 1.29±1.12 mv in AF and AVNRT *** The right atrial volume is larger; both the length and width of cavotricuspid isthmus are greater. Unipolar and bipolar voltages in the right atrium are higher in AF than in AVNRT, suggesting that the enlarged right atrium, increased length and width of cavotricuspid isthmus, and concomitant atrial hypertrophy are important substrates for initiation and perpetuation of typical AF.

关键词： atrial flutter right atrium electrophysiology

Performance Framework for Virtual machine migration in Cloud Computing

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Computers, materials & Continua 2023年第3期74卷 6289-6305页

作者： Tahir Alyas Taher m.Ghazal Badria Sulaiman Alfurhood munir Ahmad Ossma Ali Thawabeh Khalid alissa Qaiser Abbas Department of Computer Science Lahore Garrison UniversityLahore54000Pakistan School of Information Technology Skyline University CollegeUniversity City SharjahSharjah1797UAE Center for Cyber Security Faculty of Information Science and TechnologyUniversiti Kebansaan Malaysia(UKM)Bangi43600SelangorMalaysia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversitySaudi Arabia School of Computer Science National College of Business Administration&EconomicsLahore54000Pakistan Dean of Student Affairs Skyline University CollegeUniversity City SharjahSharjah1797UAE Networks and Communications Department College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityDammam31441Saudi Arabia Faculty of Computer and Information Systems Islamic University madinah Madinah42351Saudi Arabia

In the cloud environment,the transfer of data from one cloud server to another cloud server is called *** can be delivered in various ways,from one data centre to *** research aims to increase the migration performance of the virtual machine(Vm)in the cloud *** allow cloud customers to store essential data and ***,server usage has grown dramatically due to the virtualization of computer systems,resulting in higher data centre power consumption,storage needs,and operating *** Vms on one data centre manage share resources like central processing unit(CPU)cache,network bandwidth,memory,and application ***-cloud,Vmmigration addresses the performance degradation due to cloud server configuration,unbalanced traffic load,resource load management,and fault situations during data *** speed is influenced by the size of the Vm,the dirty rate of the running application,and the latency ofmigration *** a result,evaluating Vm migration performance while considering all of these factors becomes a difficult *** effort of this research is to assess migration problems on *** simulation results in matlab show that if the Vmsize grows,themigration time of Vms and the downtime can be impacted by three orders *** dirty page rate decreases,themigration time and the downtime grow,and the latency time decreases as network bandwidth increases during the migration time and post-migration overhead calculation when the Vmtransfer is *** the simulated cases of Vms migration were performed in a fuzzy inference system with performance graphs.

关键词： Latency cloud computing dirty page ratio storage migration performance

Treatment of unresectable malignant pleural mesothelioma in 2021: emerging standards in immunotherapy

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Journal of Cancer metastasis and Treatment 2021年第1期7卷 737-747页

作者： Bailey G.fitzgerald Lee m.Krug Tisch Cancer Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA AstraZeneca GaithersburgMD 20878USA

Patients with unresectable malignant pleural mesothelioma(mPm)have historically poor outcomes and treatment,and their treatments have been limited to palliative *** efforts to improve prognosis for these patients by adding angiogenesis inhibitors to chemotherapy led to significant ***,the emergence of immunotherapy combinations for the front-line treatment has upended the standard of care and has led to the first new FDA approvals for the treatment of mPm in nearly two *** review aims to cover the main clinical trials in unresectable mPm with VEGF inhibitors and immunotherapy which have led to paradigm shifts in current *** clinical trials exploring the combination of chemo and immunotherapies show a great deal of promise,and continued support for ambitious,large-scale well-designed trials remain vital for defining the future outcomes of patients diagnosed with mPm.

关键词： malignant pleural mesothelioma VEGF chemotherapy immunotherapy PD-L1 CTLA-4

The role of the unfolded protein response in myelination

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Neural Regeneration Research 2016年第3期11卷 394-395页

作者： michelle C.Naughton Jill m.mcmahon Una F.fitzgerald NCBES Galway Neuroscience CentreNational University of Ireland Galway

The production,transport and integration of myelin components into the membrane during development is a highly coordinated and regulated process that relies heavily on the endoplasmic reticulum（ER）,a sub-cellular organelle that is the principal site of membrane *** on the rough ER allow translation of proteins such as proteolipid protein（PLP）prior to correct folding,

关键词： endoplasmic translational reticulum prior folding assembly coordinated myelin correct tracts

Biomimetic gold nanocomplexes for gene knockdown： Will gold deliver dividends for small interfering RNA nanomedicines？

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Nano Research 2015年第10期8卷 3111-3140页

作者： Jianfeng Guo Kamil Rahme Kathleen A. fitzgerald Justin D. Holmes Caitriona m. O'Driscoll PharmacodeliveryGroup SchoolofPharmacyUniversityCollegeCorkCorkIreland DepartmentofSciences FacultyofNaturalandAppliedScienceNotreDameUniversity(Louaize)ZoukMosbeh1200Lebanon materialsChemistryandAnalysisGroup DepartmentofChemistryandtheTyndallNationalInstituteUniversityCollegeCorkCorkIreland AdvancedmaterialsandBioEngineeringResearch(AmBER) CentreforResearchonAdaptiveNanostructuresandNanodevices(CRANN)TrinityCollegeDublinDublin2Ireland

RNA interference （RNAi） effectors such as small interfering RNA （siRNA） and micro RNA （miRNA） can selectively downregulate any gene implicated in the pathology of a disease. Therefore, RNAi-based therapies have immense potential for the treatment of a wide range of diseases. However, pharmacokinetic and pharmacodynamic studies have revealed that these therapeutic agents have poor bioactivity due to a number of factors, including insufficient plasma drug levels, short plasma half-lives, renal clearance, and hepatic metabolism. Non-viral delivery may facilitate the clinical application of siRNA-based therapeutics by helping to overcome these barriers. Recently, the potential of gold nanoparticles （AuNPs） as multifunctional carriers for transporting drugs, proteins, and genetic materials has been demonstrated. In this review, some of the key properties of AuNPs relevant to siRNA delivery, such as physical properties and surface chemistry have been described. In addition, the ability of AuNP-based formulation strategies to successfully overcome delivery barriers associated with siRNA, and the potential for this material to translate into safe and effective nanomedicines are critically discussed.

关键词： siRNA delivery RNA interference (RNAi)-based therapeutics,mulfifunctionalnanoparficles,nanotoxicity of goldnanoparticles

Temporal trends in 6-minute walking distance for older Japanese adults between 1998 and 2017

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Journal of Sport and Health Science 2021年第4期10卷 462-469页

作者： Grant R.Tomkinson Tetsuhiro Kidokoro Trevor J.Dufner Shingo Noi John S.fitzgerald Holly m.Brown-Borg Department of Education Health and Behavior StudiesUniversity of North DakotaGrand ForksND 58202USA Alliance for Research in Exercise Nutrition and Activity(ARENA)School of Health SciencesUniversity of South AustraliaAdelaideSA 5000Australia Department of Health&Physical Education International Christian UniversityTokyo 181-8585Japan Nippon Sport Science University Tokyo 158-8508Japan Department of Biomedical Sciences University of North DakotaGrand ForksND 58202USA

Background:The 6-minute walking distance(6mWD)is an excellent measure of both functional endurance and *** primary aim of this study was to estimate temporal trends in 6mWD for older Japanese adults between 1998 and 2017;the secondary aim was to estimate concurrent trends in body size(i.e.,height and mass)and self-reported participation in exercise/***:Adults aged 65-79 years were *** nationally representative 6mWD data(n=103,505)for the entire period were obtained from the Japanese ministry of Education,Culture,Sports,Science and *** trends in means(and relative frequencies)were estimated at the gender-age level by best-fitting sample-weighted linear/polynomial regression models,with national trends estimated by a post-stratified population-weighting *** trends in distributional variability were estimated as the ratio of coefficients of ***:Between 1998 and 2017 there was a steady,moderate improvement in mean 6mWD(absolute=45 m(95%confidence interval(95%CI):43-47);percent=8.0%(95%CI:7.6%-8.4%);effect size=0.51(95%CI:0.48-0.54)).Gender-and age-related temporal differences in means were *** in 6mWD declined substantially(ratio of coefficients of variation=0.89,95%CI:0.87-0.92),with declines larger for women compared to men,and for 75-79-year-olds compared to ***,there were moderate and negligible increases in mean height and mass,respectively,and negligible increases in the percentage who participated in exercise/sport at least 3 days per week and at least 30 min per ***:There has been a steady,moderate improvement in mean 6mWD for older Japanese adults since 1998,which is suggestive of corresponding improvements in both functional endurance and *** substantial decline in variability indicates that the temporal improvement in mean 6mWD was not uniform across the *** in 6mWD are probably influenced by correspond

关键词： Aerobic exercise Aged Fitness testing Physical fitness Secular change

N-Set Distance-Labelings for Cycle Graphs

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Open Journal of Discrete mathematics 2022年第3期12卷 64-77页

作者： alissa Shen Jian Shen St. Stephen’s Episcopal School Austin TX USA Department of mathematics Texas State University San Marcos TX USA

Let G = (V, E) be a graph and Cm be the cycle graph with m vertices. In this paper, we continued Yeh’s work [1] on the distance labeling of the cycle graph Cm. An n-set distance labeling of a graph G is the labeling of the vertices (with n labels per vertex) of G under certain constraints depending on the distance between each pair of the vertices in G. Following Yeh’s notation [1], the smallest value for the largest label in an n-set distance labeling of G is denoted by λ1(n)(G). Basic results were presented in [1] for λ1(2)(Cm) for all m and λ1(n)(Cm) for some m where n ≥ 3. However, there were still gaps left unstudied due to case-by-case complexities. For these uncovered cases, we proved a lower bound for λ1(n)(Cm). Then we proposed an algorithm for finding an n-set distance labeling for n ≥ 3 based on our proof of the lower bound. We verified every single case for n = 3 up to n = 500 by this same algorithm, which indicated that the upper bound is the same as the lower bound for n ≤ 500.

关键词： Graph Channel Assignment Distance Labeling Cycle Graph