检索结果-南通市图书馆

Effective Utilization of Government-Provided CTI by Small Businesses within the Defense Industrial Base

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Information Security 2024年第2期15卷 196-217页

作者： Josiah Dykstra Lawrence A. Gordon martin P. Loeb Benjamin Wall Lei Zhou National Security Agency Fort Meade MD USA Robert H. Smith School of Business University of Maryland College Park MD USA

There are two broad objectives of the research reported in this paper. First, we assess whether government-provided cyber threat intelligence (CTI) is helpful in preventing, or responding to, cyber-attacks among small businesses within the U.S. Defense Industrial Base (DIB). Second, we identify ways of improving the effectiveness of government-provided CTI to small businesses within the DIB. Based on a questionnaire-based survey, our findings suggest that government-provided CTI helps businesses within the DIB in preventing, or responding to, cyber-attacks providing a firm is familiar with the CTI. Unfortunately, a large percentage of small firms are not familiar with the government-provided CTI feeds and consequently are not utilizing the CTI. This latter situation is largely due to financial constraints confronting small businesses that prevent firms from having the wherewithal necessary to effectively utilize the government-provided CTI. However, we found a significant positive association between a firm’s familiarity with the government-provided CTI and whether a firm is being periodically reviewed by the Defense Counterintelligence and Security Agency (DCSA) or is compliant with the Cybersecurity Maturity Model Certification (CMMC) program. The findings from our study also show that the participating firms believe that external cyber threats are more likely to be the cause of a future cybersecurity breach than internal cybersecurity threats. Finally, our study found that the portion of the IT budget that small businesses within the DIB spend on cybersecurity-related activities is dependent on the perception that a firm would be the target of an external cyber-attack.

关键词： Government-Provided CTI Small Businesses Defense Industrial Base

The Influence of Biomass Cokes on the Microstructure and Thermal Shock Resistance of MgO-C Refractories

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China's Refractories 2024年第3期33卷 9-14页

作者： Patrick GEHRE Magzhan KAPESSOV Stefan GUHL martin GRÄBNER Christos G.ANEZIRIS Institute of Ceramics Refractories and Composite MaterialsTU Bergakademie FreibergFreiberg 09599Germany Institute of Energy Process Engineering and Chemical Engineering TU Bergakademie FreibergFreiberg 09599Germany

In this study,biomass cokes from sunflower seed hull(SFSH)and wood pellets(WP)were added to a MgO-C batch(3 mass%C)to replace 1.1 mass%of *** hardening and carbonizing the samples,the influence of the biomass cokes on the microstructure and thermal shock resistance was *** replacement of flaky graphite by carbonized WP and SFSH reduced the bulk density and increased the apparent porosity after pressing and carbonization,but the degree was only *** was confirmed by SEM investigations,where the biomass-coke containing samples exhibited a microstructure with a higher amount of pores between the fine MgO *** thermal shock resistance of the porous wood pellet coke containing MgO-C is at the same level as the reference sample but not superior to it.

关键词： MgO-C carbon biomass microstructure thermal shock

Message from the Best Paper Award Committee

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computational Visual Media 2024年第3期10卷 397-397页

作者： Ming C.Lin Baoquan Chen Ying He Wenping Wang Kun Zhou Ralph martin Associate Editor-in-Chief University of Maryland at College Park USA 不详

Following the success of the past eight years,Tsinghua University Press has continued to sponsor an annual award for the best papers published in Computational Visual *** papers in 2023 from Computational Visual Media were recommended by Associate Editors as candidate papers for the Best Paper *** Editors-in-Chief Ming *** and Ralph martin led the Best Paper Award Committee to select the Best *** careful deliberation,the following paper was chosen with the unanimous consensus as the winner.

关键词： Visual Award Message

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

非常规项目的创新解决方案

流程工业 2024年第6期 42-43页

作者： martin Jager 星德科技术公司

应该将两个储罐放置在几米高的地面上?还是应该在最短的时间内为新产品更换完备的制剂系统?有些药企的问题乍看似乎无法解决,但通过相应的专业知识、灵活性和创造力,还是有机会克服这些挑战的。本文通过介绍杨森疫苗公司与星德科合作多... 详细信息

应该将两个储罐放置在几米高的地面上?还是应该在最短的时间内为新产品更换完备的制剂系统?有些药企的问题乍看似乎无法解决,但通过相应的专业知识、灵活性和创造力,还是有机会克服这些挑战的。本文通过介绍杨森疫苗公司与星德科合作多年的案例证明了这一点。

关键词：无菌灌装配液系统现代化改造灵活性

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

学说中国话,一场奇妙的冒险

初中生 2024年第29期 28-31页

作者： martin Haase 不详

martin Haase,中文名马丁,是一位来自加拿大的“中国迷”。他热爱中医和太极拳,对《道德经》《黄帝内经》等经典著作了如指掌。17岁那年,他开始学习太极拳,成为陈式太极拳第十三代传人。马丁希望用自己的知识和经验,促进中国和加拿大之... 详细信息

martin Haase,中文名马丁,是一位来自加拿大的“中国迷”。他热爱中医和太极拳,对《道德经》《黄帝内经》等经典著作了如指掌。17岁那年,他开始学习太极拳,成为陈式太极拳第十三代传人。马丁希望用自己的知识和经验,促进中国和加拿大之间的交流。这位外国友人眼中的中国是怎样的呢?在中国生活的17年时光里,他又有着哪些有趣的故事呢?

关键词：外国友人《黄帝内经》太极拳中文名《道德经》知识和经验加拿大

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

AI时代的数据安全策略发展趋势

软件和集成电路 2024年第2期 30-31页

作者： martin Creighan Commvault亚太地区

未来,企业需要考虑在以NIST标准为代表的安全框架下开展网络防御工作(包括威胁识别、检测、响应工作及数据保护工作),并在受到攻击后迅速恢复自身业务流程。2023年,我们目睹了科技领域发生的一系列安全事件,如针对知名企业的勒索软件攻... 详细信息

未来,企业需要考虑在以NIST标准为代表的安全框架下开展网络防御工作(包括威胁识别、检测、响应工作及数据保护工作),并在受到攻击后迅速恢复自身业务流程。2023年,我们目睹了科技领域发生的一系列安全事件,如针对知名企业的勒索软件攻击、针对广泛使用的应用程序的攻击、AI驱动的新型网络攻击等。可以预见的是,技术对人们工作和生活的影响越来越广泛,网络安全形势也将变得更加严峻,企业领导者必须带领团队早作准备、准确洞察、果断行动,才能掌握主动权,实现可持续发展。AI让网络安全形势更加严峻在AI的加持下,网络攻击方式变得越发隐蔽,攻击规模变得更大,攻击频率大幅提升。

关键词：网络安全形势数据保护网络防御应用程序安全框架网络攻击勒索软件安全事件

维普期刊数据库

Toxicity of a seafood toxin， domoic acid， in the retina via modulation of the NRF2 and NF-κB pathways

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Gabriel Mbuta Tchivelekete Yanqun Cao Mohammad Almarhoun Xinzhi Zhou Agostinho Francisco Cachapa Sebasti?o Tumitangua James Reilly Patricia E.martin Xinhua Shu Department of Biological and Biomedical Sciences， Glasgow Caledonian University Department of Marine Biology， Faculty of Natural Science， University of Namibe Puai Medical School， Shaoyang University Department of Vision Science， Glasgow Caledonian University

Domoic acid (DA)， a biotoxin， is produced by several species of marine dinoflagellate and diatom during harmful algal bloom events. DA is a neurotoxin， in humans and non-human primates， oral exposure to DA results in gastrointestinal effects， while DA at higher doses leads to neurological symptoms， seizures and memory deficiency. Exposure of humans to DA occurs mainly through consumption of contaminated seafoods containing an accumulation of the toxin. Previously， it was unclear if DA can have toxic effects on the retina. We assessed the toxicity of DA in human retinal cells (ARPE-19) and in zebrafish embryos. DA significantly lowered ARPE-19 cell viability dose-dependently， and decreased anti-oxidative capacity， increased inflammation， and promoted cell death， possibly through modulating the NRF2 and NF-κB signalling pathways. Zebrafish embryos exposed to DA for four days from one day post fertilization (dpf) had an increase in mortality and a decrease in both hatching and heartbeat rate and exhibited morphological abnormalities. DA treatment also significantly downregulated expression of antioxidant genes and upregulated expression of inflammation mediators， as well as causing photoreceptor death in zebrafish embryos. The results demonstrate that consuming seafood containing DA will have potential toxic effects in human retinas.

关键词：

TMB相关免疫浸润调控评分(MOTIF)预测免疫治疗响应并指导联合增效

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2024年第6期69卷 803-822页

作者：钱政宇潘艺芊李薛鑫陈衍行吴灏祥刘泽先 martin Kosar Jiri Bartek 王梓贤徐瑞华 Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Provincial Clinical Research Center for CancerResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal CancerChinese Academy of Medical SciencesGuangzhou 510060China Science for Life Laboratory Division of Genome BiologyDepartment of Medical Biochemistry and BiophysicsKarolinska InstituteStockholm S-17121Sweden Department of General Surgery The Fourth Affiliated HospitalChina Medical UniversityShenyang 110032China Bioinformatics Platform Sun Yat-sen University Cancer CenterGuangzhou 510060China Zhejiang University-University of Edinburgh Institute Zhejiang University School of MedicineHaining 314400China Edinburgh Medical School Biomedical SciencesCollege of Medicine and Veterinary MedicineThe University of EdinburghEdinburgh EH11LTUK Danish Cancer Society Research Center Copenhagen DK-2100Denmark Laboratory of Artificial Intelligence and Data Science Sun Yat-sen University Cancer CenterGuangzhou 510060China

Patients with high tumor mutational burden(TMB)levels do not consistently respond to immune checkpoint inhibitors(ICIs),possibly because a high TMB level does not necessarily result in adequate infiltration of CD8^(+)T *** bulk ribonucleic acid sequencing(RNA-seq)data from 9311 tumor samples across 30 cancer types,we developed a novel tool called the modulator of TMB-associated immune infiltration(MOTIF),which comprises genes that can determine the extent of CD8^(+)T cell infiltration prompted by a certain TMB *** confirmed that MOTIF can accurately reflect the integrity and defects of the cancer-immunity *** analyzing 84 human single-cell RNA-seq datasets from 32 types of solid tumors,we revealed that MOTIF can provide insights into the diverse roles of various cell types in the modulation of CD8^(+)T cell *** pretreatment RNA-seq data from 13 ICI-treated cohorts,we validated the use of MOTIF in predicting CD8^(+)T cell infiltration and ICI *** the components of MOTIF,we identified EMC3 as a negative regulator of CD8^(+)T cell infiltration,which was validated via in vivo ***,MOTIF provided guidance for the potential combinations of programmed death 1 blockade with certain immunostimulatory drugs to facilitate CD8^(+)T cell infiltration and improve ICI efficacy.

关键词： Tumor mutational burden Immunotherapy Cancer-immunity cycle Treatment efficacy prediction CD8^(+)T cell infiltration Combination therapy

维普期刊数据库

Single-cell transcriptome atlases of soybean root and mature nodule reveal new regulatory programs that control the nodulation process

在线全文

学校读者我要写书评

暂无评论

Plant Communications 2024年第8期5卷 69-91页

作者： Sergio Alan Cervantes-Perez Prince Zogli Sahand Amini Sandra Thibivilliers Sutton Tennant Md Sabbir Hossain Hengping Xu Ian Meyer Akash Nooka Pengchong Ma Qiuming Yao Michael J.Naldrett Andrew Farmer Olivier martin Samik Bhattacharya Jasper Klaver Marc Libault Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNE 68503USA Division of Plant Science and Technology College of AgricultureFoodand Natural ResourcesUniversity of Missouri-ColumbiaColumbiaMO 65211USA Interdisciplinary Plant Group of Missouri-Columbia ColumbiaMO 65211USA School of Computing University of Nebraska-LincolnLincolnNE 68503USA Proteomics and Metabolomics Facility Center for BiotechnologyUniversity of Nebraska-LincolnLincolnNE 68588USA National Center for Genome Resources Santa FeNM 87505USA INRAE UniversiteParis-SaclayInstitut des Sciences des Plantes de Paris SaclayIPS2Batiment 630 Plateau du MoulonRue Noetzlin91192 Gif sur Yvette CedexFrance Resolve Biosciences Monheim am RheinGermany Present address:The School of Plant Sciences University of ArizonaTucsonAZ 85721USA Present address:GALY Co. 100 Hood Park Dr.BostonMA 02126USA

The soybean root system is *** addition to being composed of various cell types,the soybean root system includes the primary root,the lateral roots,and the nodule,an organ in which mutualistic symbiosis with N-fixing rhizobia occurs.A mature soybean root nodule is characterized by a central infection zone where atmospheric nitrogen is fixed and assimilated by the symbiont,resulting from the close cooperation between the plant cell and the *** date,the transcriptome of individual cells isolated from developing soybean nodules has been established,but the transcriptomic signatures of cells from the mature soybean nodule have not yet been *** single-nucleus RNA-seq and Molecular Cartography technologies,we precisely characterized the transcriptomic signature of soybean root and mature nodule cell types and revealed the co-existence of different sub-populations of ***-infected cells in the mature soybean nodule,including those actively involved in nitrogen fixation and those engaged in *** of the single-cell-resolution nodule transcriptome atlas and the associated gene co-expression network confirmed the role of known nodulation-related genes and identified new genes that control the nodulation *** instance,we functionally characterized the role of GmFWL3,a plasma membrane microdomain-associated protein that controls rhizobial *** study reveals the unique cellular complexity of the mature soybean nodule and helps redefine the concept of cell types when considering the infection zone of the soybean nodule.

关键词： soybean root nodule single-cell RNA-seq nanodomains