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神经损伤与功能重建 2010年第5期5卷 361-372页

作者： alison JENNINGS WILLIAm CARROLL School of Pathology and Laboratory medicine University of Western AustraliaNedlands Department of Neurology Sir Charles Gairdner HospitalPerth

促进来源于少突胶质祖细胞(OP)的少突胶质细胞髓鞘再生,提高内源性修复是改善多发性硬化运动障碍的重要方法之一,其重要前提是明确人类中枢神经系统中有丰富的可分化为少突胶质细胞的OP细胞,而这需要有对中枢神经系统中的OP细胞进行鉴... 详细信息

促进来源于少突胶质祖细胞(OP)的少突胶质细胞髓鞘再生,提高内源性修复是改善多发性硬化运动障碍的重要方法之一,其重要前提是明确人类中枢神经系统中有丰富的可分化为少突胶质细胞的OP细胞,而这需要有对中枢神经系统中的OP细胞进行鉴定的可靠方法。本研究采用多种方法对猫和人的视神经进行染色,根据相关结果获取可用于研究人尸体解剖标本OP细胞表达的抗原表型。OP细胞又被称为NG2细胞,广泛表达NG2蛋白,属于一个独立的胶质细胞亚型,由于其表达OP细胞系的转录因子Olig1和Olig2,因此与少突胶质细胞相关。虽然NG2细胞形态多样,与轴索及其它胶质细胞紧密联系,但所有NG2细胞都可以作为OP细胞进行分化,补充局部丢失的少突胶质细胞。研究发现,在人和猫的视神经及猫脊髓的白质和灰质中,NG2细胞在神经胶质细胞中所占比例不足5%,与少突胶质细胞的比例为1∶10。本研究结果显示,NG2细胞数量特别是相对少突胶质细胞不充足,这可对促进多发硬化内源性修复的方法提供线索。

关键词： NG2细胞神经胶质细胞少突胶质细胞脱髓鞘髓鞘再生

Obesity in middle Age Linked with Dementia

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当代外语研究 2005年第6期 6-7页

作者： alison motluk 李诺

减肥已成为时下流行的话题,这不仅是人们爱美心理的反应,从某种角度看,也是人们对自身健康的一种关注。据最新研究发现,中年肥胖会增加晚年痴呆的可能性,损害人们的认知功能。其潜在的危险是:肥胖流行病与人口老龄化或许会在未来20年内... 详细信息

减肥已成为时下流行的话题,这不仅是人们爱美心理的反应,从某种角度看,也是人们对自身健康的一种关注。据最新研究发现,中年肥胖会增加晚年痴呆的可能性,损害人们的认知功能。其潜在的危险是:肥胖流行病与人口老龄化或许会在未来20年内使痴呆病症大幅增加。请看专家分析。

关键词： Obesity in middle Age Linked with Dementia

中国e抗原阳性慢性乙型肝炎抗病毒治疗方案的经济学评价

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中华肝脏病杂志 2007年第6期15卷 431-436页

作者： Larry Lacey 卢宪中 alison Tan Lacey Solutions Ltd. The Beaches South StrandSkerries Co. Dublin. Rep. of Ireland 葛兰素史克（中国）投资有限公司上海分公司

目的对HBeAg阳性慢性乙型肝炎短期和长期的抗病毒治疗方案进行经济学评价。方法建立包含10个健康状态的markov模型,估计不同方案治疗HBeAg阳性CHB患者的长期效果和费用,并进行增量分析。结果与非抗病毒治疗相比,拉米夫定治疗1年是具... 详细信息

目的对HBeAg阳性慢性乙型肝炎短期和长期的抗病毒治疗方案进行经济学评价。方法建立包含10个健康状态的markov模型,估计不同方案治疗HBeAg阳性CHB患者的长期效果和费用,并进行增量分析。结果与非抗病毒治疗相比,拉米夫定治疗1年是具有高度成本效果的短期治疗方案;拉米夫定治疗必要时换用阿德福韦,或者阿德福韦治疗必要时换用拉米夫定作挽救用药治疗5年,可以更持续地延缓疾病进展。与拉米夫定治疗1年相比,更具成本效果的长期治疗方案则是拉米夫定＋阿德福韦,或者阿德福韦＋拉米夫定作为挽救用药治疗5年,每单位质量调整生命年的增量费用分别为25 115元和35 577元,分别比国际阈值的中国估计值低55．2％和36.5％。结论在HBeAg阳性CHB短期治疗方案中,拉米夫定比IFNα、恩替卡韦、聚乙二醇干扰素α-2a和非抗病毒治疗更具成本效果。在长期治疗方案中,拉米夫定＋阿德福韦或阿德福韦＋拉米夫定挽救治疗均具有成本效果。

关键词：肝炎乙型慢性评价研究经济学药学

Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression

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Cellular & molecular Immunology 2018年第11期15卷 994-997页

作者： Svetlana S.Sakhnevych Inna m.Yasinska alison m.Bratt Ouafa Benlaouer Isabel Gonçalves Silva Rohanah Hussain Giuliano Siligardi Walter Fiedler Jasmin Wellbrock Bernhard F.Gibbs Yuri A.Ushkaryov Vadim V.Sumbayev medway School of Pharmacy Universities of Kent and GreenwichChatham MaritimeUK Beamline B23 Diamond Light SourceDidcotUK Department of Oncology Hematology and Bone Marrow Transplantation with Section PneumologyHubertus Wald University Cancer CenterUniversity Medical Center Hamburg-EppendorfHamburgGermany Department of medicine Dermatology and AllergologyUniversity of OldenburgOldenburgGermany

The progression of acute myeloid leukemia(AmL)—the most severe blood/bone marrow cancer—is determined by the ability of malignant cells to escape host immune ***,the systemic regulatory mechanisms underlying this phenomenon remain largely *** this study,we discovered a fundamental systemic biochemical strategy that allows AmL cells to employ physiological systems within the body to survive and escape immune *** found that AmL cells use a crucial human adrenal cortex hormone(cortisol)to induce the expression of neuronal receptor latrophilin 1(LPHN1),which facilitates *** receptor interacts with the blood plasma protein fibronectin leucine rich transmembrane protein 3(FLRT3)to cause secretion of the immune suppressor galectin-9,which impairs the anticancer activities of cytotoxic lymphoid cells.

关键词： acute myeloid cortex

Novel microsatellite markers for Conservation of Australian Native <i>Samadera bidwillii</i>

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Open Journal of Ecology 2018年第2期8卷 75-85页

作者： Vatsal m. Naik Nanjappa Ashwath Robert W. Lamont alison Shapcott School of medical and Applied Science Central Queensland University Rockhampton Australia Genecology Research Centre The University of the Sunshine Coast Maroochydore Australia

microsatellite markers were developed for Samadera bidwillii, a nationally listed vulnerable shrub or small tree, to enable investigation of its genetic structure and diversity within and among populations from its known distribution throughout coastal areas mainly in fragmented and disturbed lands from mackay to Gympie, Queensland, Australia. The loci were tested for cross-amplification in related Samadera species. Ten polymorphic microsatellite markers were isolated and characterised from an enriched library of S. bidwillii, which exhibited di- and trinucleotide repeats. The mean number of alleles per locus ranged from 1.3 to 2.5 and mean expected and observed heterozygosities ranged from 0.06 to 0.33 and from 0.03 to 0.26, respectively in five populations. All loci successfully amplified in six other closely associated Samadera species also reported from Australia. Developed loci can be used in genetic diversity, population structure and gene flow studies with an emphasis on the conservation of S. bidwillii and related species.

关键词： 454 Sequencing Conservation microsatellites Samadera Native Shrub

Serious Spousal Spats Spike Blood Pressure

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当代外语研究 2003年第8期 2-3页

作者： alison mcCook 姜元萍

提示:本文的标题可译:严重的夫妻口角提升血压。血压,看来是非常脆弱的,夫妇间的口角,也会引起血压的提升。本文有一句可以让读者窥见,西方夫妇之间的常见龃龉:...wishing the partner would spend more or less time with in-laws,part... 详细信息

提示:本文的标题可译:严重的夫妻口角提升血压。血压,看来是非常脆弱的,夫妇间的口角,也会引起血压的提升。本文有一句可以让读者窥见,西方夫妇之间的常见龃龉:...wishing the partner would spend more or less time with in-laws,participate more in housework or childcare,spend less money or make changes intheir sex life.(希望对方和姻亲多待一些或少待一些时间,做更多的家务,多关心小孩,少花钱,在性生活方面有些改变)

关键词： Serious Spousal Spats Spike Blood Pressure

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雅思预备教程 2

Variability and change of climate extremes from indigenous herder knowledge and at meteorological stations across central mongolia

2009年

作者：张涓, alison Wong

本书通过对话和形式多样的练习, 重点训练考生掌握雅思口试所需的谈论、表述和讨论技巧, 同时扩大基本词汇量, 掌握常用的表达法和句子结构。

ISBN: (数字)9787561922347

ISBN: (纸本)9787561922347

本书通过对话和形式多样的练习, 重点训练考生掌握雅思口试所需的谈论、表述和讨论技巧, 同时扩大基本词汇量, 掌握常用的表达法和句子结构。

关键词：英语

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Frontiers of Earth Science 2020年第2期14卷 286-297页

作者： Sukh TUmENJARGAL Steven RFASSNACHT Niah BHVENABLE alison PKINGSTON maria EFERNANDEZ-GImENEZ Batjav BATBUYAN melinda JLAITURI martin KAPPAS GADYABADAm ESS-Watershed Science Colorado State UniversityFort Collins ColoradoCO 80523-1476USA Cabinet Secretariat of Government of mongolia State HouseUlaanbaatar City 14201Mongolia Natural Resources Ecology Laboratory Fort Collins ColoradoCO 80523-1499USA Cooperative Institute for Research in the Atmosphere Fort Collins ColoradoCO 80523-1375USA Cartography GIS and Remote Sensing DepartmentInstitute of GeographyGeorg-August Universität GöttingenGöttingen 37007Germany FRS-Rangeland Science Colorado State UniversityFort Collins ColoradoCO 80523-1472USA Center for Nomadic Pastoralism Studies Ulaanbaatar 210620Mongolia Institute of meteorology Hydrology and the EnvironmentUlaanbaatar 210620Mongolia

In semi-arid regions,air temperatures have increased in the last decades more than in many other parts of the *** has an arid/semi-arid climate and much of the population are herders whose livelihoods depend upon limited water resources that fluctuate with a variable *** were surveyed to identify their observations of changes in climate extremes for two soums of central mongolia,Ikh-Tamir in the forest steppe north of the Khangai mountains and Jinst in the desert steppe south of the *** herders’indigenous knowledge of changes in climate extremes mostly aligned with the station-based analyses of *** were warming with more warm days and nights at all *** were fewer cool days and nights observed at the mountain stations both in the summer and winter,yet more cool days and nights were observed in the winter at the desert steppe *** number of summer days is increasing while the number of frost days is decreasing at all *** results of this study support further use of local knowledge and meteorological observations to provide more holistic analysis of climate change in different regions of the world.

关键词： climate change climate extreme indices indigenous knowledge systems temperature precipitation

What can imaging tell us about cognitive impairment and dementia?

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World Journal of Radiology 2016年第3期8卷 240-254页

作者： Leela Narayanan alison Dorothy murray Department of Clinical Radiology NHS Grampian Health Board NHS Foresterhill Health Site Aberdeen Biomedical Imaging Centre Division of Applied Medicine University of Aberdeen Aberdeen Biomedical Imaging Centre Division of Applied Medicine School of Medicine University of Aberdeen

Dementia is a contemporary global health issue with far reaching consequences, not only for affected individuals and their families, but for national and global socio-economic conditions. The hallmark feature of dementia is that of irreversible cognitive decline, usually affecting memory, and impaired activities of daily living. Advances in healthcare worldwide have facilitated longer life spans, increasing the risks of developing cognitive decline and dementia in late life. Dementia remains a clinical diagnosis. The role of structural and molecular neuroimaging in patients with dementia is primarily supportive role rather than diagnostic, American and European guidelines recommending imaging to exclude treatable causes of dementia, such as tumor, hydrocephalus or intracranial haemorrhage, but also to distinguish between different dementia subtypes, the commonest of which is Alzheimer’s disease. However, this depends on the availability of these imaging techniques at individual centres. Advanced magnetic resonance imaging (mRI) techniques, such as functional connectivity mRI, diffusion tensor imaging and magnetic resonance spectroscopy, and molecular imaging techniques, such as 18F fluoro-deoxy glucose positron emission tomography (PET), amyloid PET, tau PET, are currently within the realm of dementia research but are available for clinical use. Increasingly the research focus is on earlier identification of at risk preclinical individuals, for example due to family history. Intervention at the preclinical stages before irreversible brain damage occurs is currently the best hope of reducing the impact of dementia.

关键词： Dementia Alzheimer’s disease magnetic resonance imaging molecular imaging Frontotemporal dementia Lewy body dementia Vascular dementia

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功能性营养品对肉鸡早期生长的影响

饲料研究 2009年第9期32卷 49-50页

作者： alison Leary 奥特奇亚太生物技术研究中心北京怀柔雁栖工业开发区奥特奇公司

肉鸡在出生后的第1周用于生长的能量所占比例最高,用于维持的能量最低(见图1).肉鸡在第1周获得最佳增质量可改善其整个生长期的生长性能和饲料利用率,从而使得肉鸡的遗传潜力得以充分发挥.然而,在肉鸡出生的第1周面临许多应激,限制了自... 详细信息

肉鸡在出生后的第1周用于生长的能量所占比例最高,用于维持的能量最低(见图1).肉鸡在第1周获得最佳增质量可改善其整个生长期的生长性能和饲料利用率,从而使得肉鸡的遗传潜力得以充分发挥.然而,在肉鸡出生的第1周面临许多应激,限制了自身遗传潜力的充分发挥.限制因素之一是用于生长的营养素发生改变,由含可消化的脂肪和蛋白质卵黄转变为以玉米和豆粕为主的饲料.这种突然的转变导致肉鸡还来不及产生足够的消化酶消化开食料,开食料中主要含糖类和新的蛋白质.

关键词：早期生长肉鸡营养品饲料利用率遗传潜力消化酶生长性能蛋白质