检索结果-南通市图书馆

Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β

Protein & Cell 2010年第6期1卷 552-562页

作者： Xue Gao Alvin P.Joselin Lei Wang Amar kar Payal Ray Andrew Bateman alison M.Goate jane Y.Wu Department of Neurology Lurie Cancer CenterCenter for Genetic Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611USA Division of Experimental Medicine McGill Universityand Endocrine Research LaboratoryRoyal Victoria HospitalMontréalQuébecCanada Department of Psychiatry Washington University School of MedicineSt.LouisMO 63110USA Present address:Cellular and Molecular Medicine University of OttawaOntarioCanada

Progranulin(PGRN)has recently emerged as a key player in a subset of frontotemporal dementias(FTD).Numerous mutations in the progranulin gene have been identified in patients with familial or sporadic frontotemporal lobar degeneration(FTLD).In order to understand the molecular mechanisms by which PGRN deficiency leads to FTLD,we examined activity of PGRN in mouse cortical and hippocampal neurons and in human neuroblastoma SH-SY5Y *** of mouse neurons with PGRN protein resulted in an increase in neurite outgrowth,supporting the role of PGRN as a neurotrophic *** treatment stimulated phosphorylation of glycogen synthase kinase-3 beta(GSK-3β)in cultured *** of PGRN in SH-SY5Y cells impaired retinoic acid induced differentiation and reduced the level of phosphorylated GSK-3β.PGRN knockdown cells were also more sensitized to staurosporineinduced *** results reveal an important role of PGRN in neurite outgrowth and involvement of GSK-3βin mediating PGRN *** of GSK-3βactivation as a downstream event for PGRN signaling provides a mechanistic explanation for PGRN activity in the nervous *** work also suggest that loss of axonal growth stimulation during neural injury repair or deficits in axonal repair may contribute to neuronal damage or axonal loss in FTLD associated with PGRN ***,our study suggests that modulating GSK-3βor similar signaling events may provide therapeutic benefits for FTLD cases associated with PGRN mutations.

关键词： progranulin frontotemporal lobar degeneration glycogen synthase kinase 3 beta(GSK-3β) neurite outgrowth

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：