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Development of an in vitro macrophage screening system on the immunomodulating effects of feed components

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Journal of Animal Science and biotechnology 2021年第2期12卷 639-648页

作者： S.E.Sivinski L.K.Mamedova R.A.Rusk C.C.Elrod T.H.Swartz J.M.McGill b.J.bradford Department of Animal Sciences and Industry Kansas State UniversityManhattan 66506USA Department of Diagnostic Medicine/Pathobiology Kansas State UniversityManhattan 66506USA Natural biologics NewfieldNY 14867USA 2265K Anthony Hall 474 S.Shaw LaneEast LansingMI 48824USA

background:While feed components capable of modulating the immune system are highly sought after and marketed,often little evidence is available to support functional immune response ***,a high-throughput in vitro cell screening system was developed to test these compounds for innate immune signaling effects,using Saccharomyces cerevisiae and its cell wall components in addition to lauric acid and its esters as models in two separate *** screening system utilized RAW 264.7 murine macrophages to assess live *** cells and ***-derived cell wall componentsβ-glucan,mannan,and zymosan(a crude cell wall preparation containing bothβ-glucan and mannan).D-mannose was also evaluated as the monomer of *** also examined the effect of a saturated fatty acid(C12:0,lauric acid)and its esters(methyl laurate and glycerol monolaurate)on innate immune cell activation and cellular *** cells were transfected with a vector that drives expression of alkaline phosphatase upon promoter activation of nuclear factorκ-light-chain-enhancer of activated b cells(NFκb),a major inflammatory/immune transcription *** cells were incubated with 0.01,0.1 or 1 mg/mL of yeast compounds alone or RAW cells were challenged with LPS and then incubated with yeast *** a separate experiment,RAW cells were incubated with 0,0.5,2.5,12.5,62.5,and 312.5μmol/L of lauric acid,methyl laurate,or glycerol monolaurate alone,or RAW cells were challenged with LPS and then incubated with fatty acid ***:Treatment with zymosan orβ-glucan alone induced NFκb activation in a dose-dependent manner,whereas treatment with D-mannose,mannan,or live *** cells did ***-treatment with mannan after an LPS challenge decreased NFκb activation,suggesting that this treatment may ameliorate LPS-induced *** increases in NFκb activation were found when fatty acid treatments were applied in the absence of LPS,yet substantial reductio

关键词： Inflammation In vitro screening system NFκb

Discovery of Radiolarian Fossils from the Aiketik Group Distributed at the Western End of the South Tianshan Mountains of China and Its Implications

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Discovery of Radiolarian Fossils from the Aiketik Group Dist...

Quantifying Operational Impacts of Variations in Work Zone Setups, Traffic Demand, and Traffic Composition: A Case Study

中国科学院地质与地球物理研究所2002学术年会

作者： LI Yuejun~(a,b),WANG Zhaoming~b,WU Haoruo~a,HUANG Zhibin~b, TAN Zejin~b and LUO Juncheng~b a.Institute of Geology and Geophysics,Chinese Academy of Sciences,beijing 100029 b.Tarim Oil Field Company,PetroChina,Korla,Xinjiang 841000

The Aiketik Group,distributed at the western end of the South Tianshan Mountains, China,is an important lithostratigraphic unit involved in the South Tianshan *** is separated from the adjacent rocks by ***,the geologists classified it into the Upper Carboniferous according to the fossils Pseudostaffella sp.,Profusulinella sp and Fusulinella *** from the limestone and sandy limestone of *** radiolarian fossils were obtained from the chert samples collected from the Haladaok section located at the upper stream of Tuoshihan *** fossils mainly include Albaillella undulata Deflandre,Albaillella paradoxa Deflandre,Albaillella sp. *** Deflandre,Albaillella *** Gourmelon,Albaillella sp.,Albaillella excelsa Ishiga,Kito and Imoto(?),belowea variabilis(Ormiston et lane),Callella cf.C. parvispinosa Won,Entactinia *** Ormiston et lane,Entactinia aff *** Ormiston et lane,Entactinia variospina Won,Entactinia sp.,Eostylodictya rota(Won),Latentifistula impella (Ormistone et lane)(?),Latentifistula turgida Omiston et lane,Latentifistulidae *** Polyentactinia *** *** them,Albaillella excelsa Ishiga,Kito and Imoto(?) is a Late Permian species with some elements uncertain as there is only one unwell-preserved individual fossil of this species found so *** two radiolarian assemblages can be identified out from the other *** is the early Early Carboniferous assemblage represented by Albaillella undulata Deflandre, Albaillella paradoxa and Albaillella *** *** the other is the late Early Carboniferous assemblage represented by Eostylodictya rota(Won).This is the first discovery of radiolarian fossils in the Aiketik Group,also the first discovery of Late Permian radiolarian fossils in the South Tianshan ***,this is the current westernmost sampling site of radiolarian fossils in the South Tianshan Mountains.

关键词： western end of the South Tianshan Mountains the Aiketik Group radiolarian Late Permian Early Carboniferous Middle Carboniferous

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Journal of Transportation Technologies 2023年第1期13卷 18-37页

作者： A b M Tausif Ullah Chy Virginia P. Sisiopiku Department of Civil Construction and Environmental Engineering University of Alabama at Birmingham Birmingham USA

The presence of work zones due to pavement repair and rehabilitation is very common in highway facilities. lane closures associated with work zones result in capacity reduction, which, in turn, often leads to increased congestion at such locations. This paper documents findings from a study that investigated the performance of freeway facilities in the presence of work zones under various Temporary Traffic Control (TTC) and lane closure scenarios while taking under consideration traffic composition and driving behaviors. The study site was an approximately 10-mile freeway segment of Interstate 65 (I-65) located in birmingham, AL. The testbed was coded in PTV VISSIM, a microscopic simulation analysis platform, for: 1) baseline conditions (i.e., no work zone presence) and 2) work zone conditions with single lane closure (i.e., 3-to-2 lane closure). Work zone scenarios were coded for two TTC strategies, namely, early merge and late merge control and for three different positions of the lane closure (i.e., left, right, and center lane closures). The length of the work zones varied from 1000 to 2000, and 3000 ft. Sensitivity analysis was performed to document the operational impacts of varying heavy vehicle percentages, changes in drivers’ aggressiveness, and projected traffic demand changes. The impacts were quantified using linked-based measures of effectiveness (MOEs) such as travel time, and travel time index. The study results show that there is no significant change in travel time index due to the variation of work zone length across the study corridor. Under similar traffic control and demand conditions, a center lane closure consistently results in significantly higher travel time index than a left or right lane closure and should be avoided. Consideration of operational impacts of changes in truck percentage indicates that the corridor can absorb an increase in truck percentage from 10% to 15%, while performance rapidly deteriorates when a higher percentage of t

关键词： Work Zone Placement Late Merge Control PTV VISSIM

A bioactivity Versus Ethnobotanical Survey of Medicinal Plants from Nigeria, West Africa

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Natural Products and bioprospecting 2014年第1期4卷 1-19页

作者： Lydia L.Lifongo Conrad V.Simoben Fidele Ntie-Kang Smith b.babiaka Philip N.Judson Chemical and bioactivity Information Centre Department of ChemistryFaculty of ScienceUniversity of BueaBueaCameroon Chemical and bioactivity Information Centre 22-23 Blenheim TerraceWoodhouse LaneLeeds LS29HDUK Chemical and bioactivity Information Centre Granary Wharf House2 Canal WharfLeeds LS115PYUK

Traditional medicinal practices play a key role in health care systems in countries with developing *** aim of this survey was to validate the use of traditional medicine within local Nigerian *** this review,we examine the ethnobotanical uses of selected plant species from the Nigerian flora and attempt to correlate the activities of the isolated bioactive principles with known uses of the plant species in African traditional ***-three(33)plant species were identified and about 100 out of the 120 compounds identified with these plants matched with the ethnobotanical uses of the plants.

关键词： African traditional medicine bioactivity Ethnobotany Medicinal plants Nigeria

POPULATION ECOLOGY OF MACACA ASSAMENSIS MCCLELLAND, 1839 IN DARJEELEVG

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POPULATION ECOLOGY OF MACACA ASSAMENSIS MCCLELLAND, 1839 IN ...

Tailoring precipitation/properties and related mechanisms for a high-strength aluminum alloy plate via low-temperature retrogression and re-aging processes

The Xixth Congress The International Primatological Society

作者： SangitaMitra J.R.b.Alfred Zoological Survey of India 32A HaraMohan Ghosh LaneCalcutta-700085 INDIA Zoological Survey of India M-Block New Alipore Calcutta-700053 INDIA

＜正＞ Investigations were carried out on the free ranging groups of Assamese macaque （Macaca assamensis） during 1996-99 in different parts of Darjeeling district in West bengal. Observations were made on several aspects like group size;group composition;natality;mortality;sex ratio;growth rate;group size regulation and population density. Methodologies adapted in the present study are the long-term moni-

关键词： Assamese Darjeeling Focal

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Journal of Materials Science & Technology 2022年第25期120卷 15-35页

作者： L.G.Hou H.Yu Y.W.Wang L.You Z.b.He C.M.Wu D.G.Eskin L.Katgerman L.Z.Zhuang J.S.Zhang State Key Laboratory for Advanced Metals&Materials University of Science&Technology BeijingBeijing 100083China bCAST Brunel University LondonKingston LaneUxbidge Middlesex UB83PHUnited Kingdom Institute of mineral resources Chinese Academy of Geological SciencesBeijing 100037China Nanjing Advanced Transportation Equipment New Technology Research Institute Nanjing 211800China Tomsk State University Tomsk634050Russian Federation Katgerman Aluminium Technology van Beuningenlaan 102334CC LeidenNetherlands Department of Materials Science and Engineering Delft University of TechnologyMekelweg 22628CD Delftthe Netherlands

The retrogression and re-aging(RRA)processes,aimed mainly at tailoring intergranular precipitates,could significantly improve the corrosion resistance(i.e.,stress corrosion cracking resistance)without considerably decreasing the strength,which signifies that an efficient control of the size,distribution and evolution of intergranular and intragranular precipitates becomes critical for the integrated properties of the(mid-)thick high-strength Al alloy *** to RRA process with retrogression at200℃ (T77),this study investigated the impact of a modified RRA process(MT77)with lower retrogression temperatures(155-175℃ )and first-stage under-aging on the properties of a high-strength AA7050 Al alloy,in combination with detailed precipitate *** study showed that the strength/microhardness of the RRA-treated alloys decreased with raising retrogression temperature and/or prolonging retrogression time,along with the increased electrical *** rapid responsiveness of microstructure/property typical of retrogression at 200℃ was obviously postponed or decreased by using MT77 process with longer retrogression time that was more suitable for treating the(mid-)thick *** the other hand,higher retrogression temperature facilitated more intragranularηprecipitates,coarse intergranular precipitates and wide precipitate free zones,which prominently increased the electrical conductivity alongside a considerable strength loss as compared to the MT77-treated *** the preferred MT77 process,the high strength approaching T6 level as well as good corrosion resistance was ***,though a relatively homogeneous through-thickness strength was obtained,some small discrepancies of properties between the central and surface areas of an 86-mm thick 7050 Al alloy plate were observed,possibly related to the quenching *** precipitate evolution and mechanistic connection to the properties were discussed and reviewed for high-strengt

关键词： Aluminum alloy Heat treatment Precipitation Strength Grain boundary

Evaluation of Dilemma Zone Protection on High-Speed Arterials with Signal Coordination

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Journal of Traffic and Transportation Engineering 2022年第3期10卷 104-117页

作者： b.Naik J.Appiah L.R.Rilett Department of Civil Engineering Ohio University1 Ohio UniversityAthensOhio 45701-2979USA Virginia Transportation Research Council 530Edgemont RoadCharlottesvilleVirginia22903USA University of Nebraska-Lincoln 262D Whittier Research CenterP.O.Box 830851LincolnNebraska68583USA

In the *** worldwide,driver behavior within an area close to high-speed signalized intersections-the dilemma zone,can be a major safety concern especially for heavy trucks.A variety of mechanisms are available as countermeasures for the dilemma zone *** Nebraska,the Department of Roads has developed and implemented an Actuated Advance Warning dilemma zone protection *** system has being effective at improving traffic safety in isolated ***,the system is yet to be used at signalized intersections operating in the coordinated *** paper presents results from a simulation study that assessed the potential deployment of the system on arterials where the signals are closely spaced and operate in a coordinated *** analysis indicated that,on average,there were 30%,7%and 30%reductions in the number of rear-end,lane change and crossing *** system also improved relative productivity by processing more vehicles.

关键词： Dilemma zone advance warning simulation safety

Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 713C and SARS-CoV-2 main protease

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Acta Pharmaceutica Sinica b 2022年第10期12卷 3924-3933页

作者： bo Qin Gregory b.Craven Pengjiao Hou Julian Chesti Xinran Lu Emma S.Child Rhodri M.L.Morgan Wenchao Niu Lina Zhao Alan Armstrong David J.Mann Sheng Cui NHC Key Laboratory of Systems biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100076China Department of Life Sciences Imperial College LondonSouth Kensington CampusLondon SW72AZUK Department of Chemistry Imperial College LondonMolecular Sciences Research HubWhite City CampusWood LaneLondon W120BZUK CAS Key Laboratory for biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsUniversity of Chinese Academy of SciencesBeijing 100049China

RNA viruses are critically dependent upon virally encoded proteases to cleave the viral polyproteins into functional *** of these proteases exhibit a similar fold and contain an essential catalytic cysteine,offering the opportunity to inhibit these enzymes with electrophilic small *** we describe the successful application of quantitative irreversible tethering(qIT)to identify acrylamide fragments that target the active site cysteine of the 3C protease(3Cpro)of Enterovirus 71,the causative agent of hand,foot and mouth disease in humans,altering the substrate binding ***,we re-purpose these hits towards the main protease(Mpro)of SARS-CoV-2 which shares the 3C-like fold and a similar active *** hit fragments covalently link to the catalytic cysteine of Mpro to inhibit its *** demonstrate that targeting the active site cysteine of Mpro can have profound allosteric effects,distorting secondary structures to disrupt the active dimeric unit.

关键词： SARS-CoV-2 Protease inhibitors Covalent fragments Allosteric inhibition EV71

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基于2层粒子滤波的智能车辆道路检测

上海交通大学学报 2009年第12期43卷 1852-1857页

作者：夏庭锴杨明杨汝清上海交通大学机器人研究所上海200240 上海交通大学自动化系上海200240

针对室外环境中基于单目视觉的道路检测算法很难在效率和鲁棒性之间达到平衡的问题,提出了基于2层粒子滤波数据融合的道路检测框架.通过道路检测算法的2个主要模块:特征提取和道路参数估计,同时引入粒子滤波算法,并以支持向量机(SVM)识... 详细信息

针对室外环境中基于单目视觉的道路检测算法很难在效率和鲁棒性之间达到平衡的问题,提出了基于2层粒子滤波数据融合的道路检测框架.通过道路检测算法的2个主要模块:特征提取和道路参数估计,同时引入粒子滤波算法,并以支持向量机(SVM)识别道路模型、初始化粒子滤波器提高算法的环境适应性,以期找到基于机器视觉的道路检测算法在鲁棒性和实时性之间更好的平衡点.实验和实际系统的测试运行表明,该方法在城市环境的半结构化道路检测中可以获得较为理想的效果.

关键词：道路检测粒子滤波机器视觉智能车辆