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Journal of Mountain Science 2020年第4期17卷 801-823页

作者： Barsa acharya Kripamoy SARKAR Ashok Kumar SINGH Sowmiya CHAWLA Department of Applied Geology Indian Institute of Technology(Indian School of Mines)Dhanbad826004India Department of Civil Engineering Indian Institute of Technology(Indian School of Mines)Dhanbad826004India

Identification of failure susceptible slopes through different rock engineering approach is highly valuable in landslide risk management along crucial highway corridors in the high mountainous region. In this study, a critical highway(NH-5) segment in higher Himalaya has been investigated using the various rock mass characterization schemes based on detailed field observations. Since the highway corridor is highly susceptible to discontinuities-driven failures, consisting of jointed rock masses;Mean and Combined kinematic feasibility analysis has been performed for 20 highway slopes. Observed slope mass classes have been compared to the feasibility percentage of discontinuities driven failures(wedge, toppling, and planar) and accordingly the kinematic feasibility zonation along highway segment has been done for each as well as overall failure types. Based on the slope mass conditions and discontinuities driven failures probability(%), responsive remedial measures have been proposed for individual highway slopes to ensure safe and uninterrupted transportation.

关键词： Slope characterization Kinematic analysis Failure zonation map Himalayan highways Landslide Slope stability

Non-coding RNAs and stem cells:the dream team for neural regeneration in Parkinson’s disease?

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Neural Regeneration Research 2021年第10期16卷 2017-2018页

作者： Shubhra acharya Andrew I.Lumley Yvan Devaux Cardiovascular Research Unit Department of Population HealthLuxembourg Institute of HealthL-1445 StrassenLuxembourg Faculty of Science Technology and MedicineUniversity of LuxembourgL-4365 Esch-sur-AlzetteLuxembourg

Parkinson’s disease(PD)is a widely spread neurodegenerative movement disorder,affecting approximately 10 million people *** is primarily caused by the loss of dopaminergic neurons in the substantia nigra,which causes decreased secretion of dopamine leading to tremors,bradykinesia and rigid muscle *** development of PD is complex and needs to be better *** treatment strategies primarily involve targeting disease symptoms,however,since there is a continuous loss of dopaminergic neurons in the brain,PD appears to be ***,treatment strategies often carry severe side effects related to dopamine production,where too little or too much can cause debilitating issues such as *** pool of neural stem/progenitor cells(NSCs)located in sub-ventricular zone and hippocampal dentate gyrus,proliferate and are responsible to give rise to neurons and glia in response to any cellular *** this activation of NSCs is highly regulated,it is insufficient to overcome the loss of dopaminergic neurons in *** this line,non-coding RNAs(ncRNAs)are involved in the underlying mechanisms of PD and are known to have important functional roles in neural regeneration(acharya et al.,2020).Thus,the study of ncRNAs in NSC activation and adult neurogenesis post PD development is an extremely attractive area of research with significant clinical application potential.

关键词： neural primarily overcome

Chronic Refractory Idiopathic Urticaria

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Journal of Biosciences and Medicines 2023年第11期11卷 13-22页

作者： Indira acharya Ashik Pokharel Ashbina Pokharel Lanaya Williams Smith Department of Internal Medicine MedStar Union Memorial Hospital Baltimore Maryland USA Department of Internal Medicine William Beaumont Hospital Royal Oak Michigan USA Department of Internal Medicine MedStar Good Samaritan Hospital Baltimore Maryland USA

Background: Chronic spontaneous urticaria (CSU) is a complex medical condition characterized by substantial morbidity and a negative impact on one’s quality of life. There are several treatment approaches available, tailored to the severity of the condition, which can enhance overall quality of life. Aim: In this article, we outline a systematic approach to managing chronic urticaria, while also elucidating the available treatment strategies for cases that prove resistant to conventional therapies. To illustrate our points, we present a clinical case as a practical example. Case Presentation: Here, we present a patient with CSU since childhood who presented in the context of refractory hives and generalized arthralgia that responded well to omalizumab therapy with no further relapse. Conclusion: Omalizumab is a biological agent that offers a potential treatment option for CSU. It is available for individuals twelve years and older who have not responded well to conventional treatments. It has demonstrated good efficacy with a relatively low rate of clinically significant adverse effects. Nonetheless, there is a dearth of research regarding the optimal method for tapering the dosage and determining the duration of treatment.

关键词： Omalizumab Biological Agent Chronic Spontaneous Urticaria (CSU) Conventional Treatment Relapse

Interpreting atomization of agricultural spray image patterns using latent Dirichlet allocation techniques

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Artificial Intelligence in Agriculture 2020年第1期4卷 253-261页

作者： Hongfei Li Steven Cryer John Raymond Lipi acharya Department of Statistics University of Illinois at Urbana-ChampaignChampaignILUSA Data Science Corteva AgriscienceIndianapolisINUSA

Breakup patterns of agricultural formulations are explored using unsupervised learning techniques to elucidate themechanics of atomization for oil-in-water *** researchers have shown these formulations succumb to a different breakup mechanism than conventional formulations,beginning with inhomogeneities within the liquid sheet that nucleate holes within the material being sprayed,beginning themechanism responsible for breaking the sheet into *** Latent Dirichlet Allocation(LDA),a Bayesian hierarchical model,is used to explore unsupervised learning relationships between image analysis metrics on spray video data and the resulting atomization droplet *** factors discovered by LDA were used for classification of video segments and achieved 99.9%accuracy(3-fold cross validation).Seventy-five videos were used for regression where each video had a unique measured droplet size distribution(D10,D50,and D90 values)for *** using the features learnt by Latent Dirichlet Allocation used with regression have extremely good results(R^2~0.995 in 3-fold cross validation,R^2~0.963 on never-seen videos),which serves as evidence for the potential use of this model in image analysis of agricultural spray *** has huge potential in both learning and predicting atomization patterns[e.g.,driftable fines(drops<150μm)]when used with images based on the breakup phenomena in agricultural *** small drop sizes that occur during atomization have the greatest propensity for off-target movement through wind induced *** proved useful in characterizing current and future formulation designs using only images as witnessed by observations and excellent predictions summarized in this *** fact,thesemethods offer potential for use under field conditions to address spray performance based upon images of spray patterns at the nozzle without the need for expensive light scattering equipment often used to measure this phenomenon

关键词： atomization formulation image

Vibration of an infinite inhomogeneous transversely isotropic viscoelastic medium with cylindrical hole

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Applied Mathematics and Mechanics(English Edition) 2008年第3期29卷 367-378页

作者： D.P.acharya Indrajit Roy P.K.Biswas 109/3 Kailash Roy Chowdhury RoadBarrackporeKolkata 700120WBIndia Brahmapara SimuraliNadia 741248WBIndia Department of Mathematics Kanchrapara CollegeKanchraparaWBIndia

This paper investigates the influences of higher order viscoelasticity and the inhomogeneities of the transversely isotropic elastic parameters on the disturbances in an infinite medium, caused by the presence of a transient radial force or twist on the surface of a cylindrical hole with circular cross section. Following Voigt＇s model for higher order viscoelasticity, the nonvanishing stress components valid for a transversely isotropic and higher order viscoelastic solid medium have been deduced in terms of radial displacement component. Considering the power law variation of elastic and viscoelastic parameters, the stress equation of motion has been developed. Solving this equation under suitable boundary conditions, due to transient forces and twists, radial displacement and relevant stress components have been determined in terms of modified Bessel functions. The problem for the presence of transient radial force has been numerically analysed. Modulations of displacement and stresses due to different order of viscoelasticity and inhomogeneity have been graphically depicted. The numerical study of the disturbance caused by the presence of twist on the surface may be similarly done but is not pursued in this paper.

关键词： higher order viscoelasticity inhomogeneity and transversely isotropy transient force and twist radial displacement stress components modified Bessel functions

Dynamic behavior of sandwich beams with different compositions of magnetorheological fluid core

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International Journal of Smart and Nano Materials 2021年第1期12卷 88-106页

作者： Subash acharya Vipin J Allien Puneet N P Hemantha Kumar Department of Mechanical Engineering NITK SurathkalMangaloreKarnatakaIndia

Magnetorheological fluid(MRF)sandwich beams belong to a class of adaptive beams that consists of MRF sandwiched between two or more face layers and have a great prospective for use in semi-active control of beam vibrations due to their superior vibration suppression *** composition of MRF has a strong influence on the MRF properties and hence affects the vibration characteristics of the *** this work,six MRF samples(MRFs)composed of combination of two particle sizes and three weight fractions of carbonyl iron pow-der(CIP)were prepared and their viscoelastic properties were *** MRFs were used to fabricate different MRF core sandwich ***,a sandwich beam with commer-cially available MRF 132DG fluid as core was *** modal parameters of the cantilever MRF sandwich beams were determined at different magnetic ***,sinusoidal sweep excitation tests were performed on these beams at different magnetic fields to investigate their vibration suppres-sion *** having larger particle size and higher weight fraction of CIP resulted in higher damping ratio and vibration ***,optimal particle size and weight fraction of CIP were determined based on the maximization of damping ratio and minimization of weight of MRF.

关键词： Smart materials adaptive sandwich beam damping ratio vibration suppression complex shear modulus

Brain targeted delivery of paclitaxel using endogenous ligand

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 427-438页

作者： Sanjeev R.acharya Padmanabha R.V.Reddy Department of Pharmacognosy Nirma University Department of Pharmacy Institute of Pharmacy Nirma University

The objective of the present investigation was to formulate nanoparticles constructed using PLGA polymer for the effective targeted delivery to brain via nasal route. The PLGA nanoparticles were optimized using novel design of experiment technique by 23 full factorial design. Drug: polymer ratio（X1）, surfactant concentration（X2） and stirring speed（X3） were identified as critical process parameters, and its impact on particle size（Y1） and % entrapment efficiency（Y2） was studied. The optimized nanoparticle formulation was conjugated with glutathione as an endogenous ligand by using carbodiimide chemistry using(1-Ethyl-3-（3-dimethylaminopropyl）carbodiimide)（EDAC） as linker molecule. From Ellman's assay,it was found that a total of 691.27 ± 151 units of glutathione were conjugated upon each PLGA nanoparticle. The in vitro release studies as well as ex vivo studies revealed biphasic pattern of drug release with initial burst release followed by slow exponential release of drug over a period of 24 h. The in vivo biodistribution studies were conducted on rat following nasal administration of the nanoparticle formulation（conjugated and unconjugated）and were compared with plain paclitaxel suspension. The results clearly demonstrated that the brain targeting efficiency was enhanced with the glutathione conjugated formulation（387.474%） as compared to the unconjugated nanoparticle formulation（224.327%）. Further,the in vitro in vivo correlation studies revealed good relationship（R2> 0.95） as obtained from the levy plot. Glutathione proves to be an efficient vector for the successful transport of poor bioavailable drug to the brain.

关键词： Glutathione Biodistribution PLGA nanoparticles In vitro in vivo correlation (IVIVC)

Transient cortical blindness in fat embolism syndrome—a diagnostic enigma

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Chinese Journal of Traumatology 2021年第2期24卷 79-82页

作者： Kiyana Mirza Prashant Upendra acharya Jose Austine Department of Orthopaedic Surgery Father Muller Medical College HospitalMangalore575002India Department of Orthopaedic Surgery Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherry605006India

Fat embolism syndrome(FES)is a serious life-threatening manifestation of the fat embolism phenomenon characterized by Bergman’s triad of dyspnea,petechiae and mental *** fat embolization into systemic circulation is common,FES occurs in a meagre 0.05%e3%of patients having isolated long bone *** visual symptoms are commonly attributed to fat embolism retinopathy and is a later occurrence,it may not always be the *** blindness has been seldom reported in association with FES,and less so as a presenting ***,no previous literature has described the same in context of an isolated tibia *** report a 20-year-old gentleman with an isolated right tibia shaft fracture who developed sudden onset diminution of vision in both eyes less than 24 h following trauma with no other *** of any remarkable ophthalmoscopic findings or other symptoms left us with a diagnostic *** later went on to develop altered mentation,hypoxia and generalized tonic-clonic seizures with subsequent MRI revealing multiple cerebral fat emboli also involving both occipital *** measures were instituted and his general condition as well as vision gradually improved following which he underwent plate fixation of the fracture under spinal *** perioperative period was uneventful and he was discharged following staple *** one month of follow-up,the patient had no residual visual field defects or neurological *** FES is rare among isolated tibia fractures,this clinical catastrophe may strike in any unsuspected setting thereby warranting a high index of suspicion to ensure early diagnosis and improved patient outcomes.

关键词： Fat embolism Cortical blindness Bone fractures

氧化铝（γ-Al2O3）和锶对Al-20Si合金显微组织和力学性能的影响（英文）

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Transactions of Nonferrous Metals Society of China 2019年第7期29卷 1353-1364页

作者： Mihira acharya Animesh MANDAL School of Minerals Metallurgical and Materials Engineering Indian Institute of Technology Bhubaneswar

为得到细晶硅,向铸造Al-20Si合金中加入4%(质量分数,下同)γ-Al2O3和0.1%Sr。在铸造过程中,γ-Al2O3的作用是细化初晶硅,其添加量为0.5%~6%,而锶的作用是改性共晶硅,其添加量为0.05%~0.1%。结果表明,当添加4%γ-Al2O3时,初晶硅的平均尺... 详细信息

为得到细晶硅,向铸造Al-20Si合金中加入4%(质量分数,下同)γ-Al2O3和0.1%Sr。在铸造过程中,γ-Al2O3的作用是细化初晶硅,其添加量为0.5%~6%,而锶的作用是改性共晶硅,其添加量为0.05%~0.1%。结果表明,当添加4%γ-Al2O3时,初晶硅的平均尺寸为24μm。当添加0.1%Sr时,共晶硅的形状因子约为0.6,平均长度约为1.2μm。热分析发现γ-Al2O3可以作为潜在的异质形核点。而且,与在Al-20Si合金中同时添加P和Sr一样,同时添加γ-Al2O3和Sr不会污染γ-Al2O3颗粒和抑制他们的形核效率。与铸态Al-20Si合金相比,Al-20Si-4γ-Al2O3-0.1%Sr合金的极限抗拉强度提高了20%,伸长率提高了23%。抗拉强度的提高可归因于初晶硅的细化、共晶硅的改性,以及合金中由于共晶转变而析出的α(Al)。

关键词：铝-硅合金 γ-Al2O3 细化改性初晶硅

Lacustrine Record of 1954 Flood Event on Begnas and Rupa Lake, Central Nepal

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Acta Geologica Sinica(English Edition) 2020年第3期94卷 717-724页

作者： Sudip acharya LI Can-Ge JI Kejia SUN Zhe WANG Mingda HOU Juzhi Key Laboratory of Alpine Ecology Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing 100101China

In recent decades, there have been discussions and predictions regarding the impact of climate on floods, due to its socioeconomic and environmental consequences. For accurate prediction of future flood events and their impacts, it is crucial to have an improved understanding on past flood events. Lacustrine sediments have been used as a natural archive to study the past flood events. Here, we study the impact of 1954 flood event on the lacustrine environment of Bengas and Rupa Lake in central Nepal based on X-ray fluorescence spectrometry(XRF) element analysis, magnetic susceptibility(MS), total organic carbon(TOC) and the biomarker molecular compositions. Results showed that 1954 flood event had significant impacts on the two lakes in terms of detrital input, organic matter deposition and aquatic production. Before the flood event, both two studied lakes had relatively lower catchment erosion rate, lower organic matter deposition and aquatic production. During the flood event, catchment erosion and aquatic production increased in both lakes due to mass transport deposits and the increased nutrition loading attributed to flood event. Following the flood event, Begnas Lake showed the sharp increase in organic matter deposition, whereas in the Rupa Lake organic matter deposition showed minor changes. The difference in organic matter deposition in lakes during flooding event is likely due to detrital material brought and deposited by the flood activity. Overall our results suggest that lacustrine sediments are sensitive to the extreme event and would be an ideal archive for the reconstruction of flood events.

关键词： flood lacustrine environment Begnas Lake Rupa Lake Central Nepal