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Using intracellular plasmonics to characterize nanomorphology in human cells

Microsystems & Nanoengineering 2020年第1期6卷 49-62页

作者： Ahmad Sohrabi Kashani alisa piekny Muthukumaran Packirisamy Optical Bio-Microsystem Lab Micro-Nano-Bio-Integration CenterDepartment of MechanicalIndustrial and Aerospace EngineeringConcordia University1455 De Maisonneuve Blvd.W.MontrealQC H3G 1M8Canada Department of Biology Concordia University7141 Sherbrooke Street W.MontrealQC H4B 1R6Canada

Determining the characteristics and localization of nanoparticles inside cells is crucial for nanomedicine design for cancer *** imaging is a fast,straightforward,reliable,and accurate method to study the interactions of nanoparticles and intracellular *** a hyperspectral image,we could collect spectral information consisting of thousands of pixels in a short *** hyperspectral images,in this work,we developed a label-free technique to detect nanoparticles in different regions of the *** technique is based on plasmonic shifts taking place during the interaction of nanoparticles with the surrounding *** unique optical properties of gold nanoparticles,localized surface plasmon resonance bands,are influenced by their *** LSPR properties of nanoparticles,hence,could provide information on regions in which nanoparticles are *** examine the potential of this technique for intracellular detection,we used three different types of gold nanoparticles:nanospheres,nanostars and Swarna Bhasma(SB),an Indian Ayurvedic/Sidha medicine,in A549(human non-small cell lung cancer)and HepG2(human hepatocellular carcinoma)*** three types of particles exhibited broader and longer bands once they were inside cells;however,their plasmonic shifts could change depending on the size and morphology of *** technique,along with dark-field images,revealed the uniform distribution of nanospheres in cells and could provide more accurate information on their intracellular microenvironment compared to the other *** region-dependent optical responses of nanoparticles in cells highlight the potential application of this technique for subcellular diagnosis when particles with proper size and morphology are chosen to reflect the microenvironment effects properly.

关键词： diagnosis bands properly

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